• Title/Summary/Keyword: self -assembly

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Nanowire Patterning for Biomedical Applications

  • Yun, Young-Sik;Lee, Jun-Young;Yeo, Jong-Souk
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.382-382
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    • 2012
  • Nanostructures have a larger surface/volume ratio as well as unique mechanical, physical, chemical properties compared to existing bulk materials. Materials for biomedical implants require a good biocompatibility to provide a rapid recovery following surgical procedure and a stabilization of the region where the implants have been inserted. The biocompatibility is evaluated by the degree of the interaction between the implant materials and the cells around the implants. Recent researches on this topic focus on utilizing the characteristics of the nanostructures to improve the biocompatibility. Several studies suggest that the degree of the interaction is varied by the relative size of the nanostructures and cells, and the morphology of the surface of the implant [1, 2]. In this paper, we fabricate the nanowires on the Ti substrate for better biocompatible implants and other biomedical applications such as artificial internal organ, tissue engineered biomaterials, or implantable nano-medical devices. Nanowires are fabricated with two methods: first, nanowire arrays are patterned on the surface using e-beam lithography. Then, the nanowires are further defined with deep reactive ion etching (RIE). The other method is self-assembly based on vapor-liquid-solid (VLS) mechanism using Sn as metal-catalyst. Sn nanoparticle solutions are used in various concentrations to fabricate the nanowires with different pitches. Fabricated nanowries are characterized using scanning electron microscopy (SEM), x-ray diffraction (XRD), and high resolution transmission electron microscopy (TEM). Tthe biocompatibility of the nanowires will further be investigated.

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Growth Mechanism and Crystal Ordering of Spherulitic Patterns in a Belousov-Zhabotinsky Type Reaction System

  • Yadav, Narendra;Majhi, S.S.;Srivastava, P.K.
    • Bulletin of the Korean Chemical Society
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    • v.33 no.10
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    • pp.3397-3406
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    • 2012
  • Three types of spherulitic morphologies have been investigated in dual substrate mode of Belousov-Zhabotinsky (BZ) type reaction system. Prior to growth of spherulites, three distinct patterning behaviors have been observed sequentially during the reaction process. Initial and the early-phase of reaction showed the emergence of concentric ring-like wave patterns. A colloidal-state of reaction consists of numerous fine solid particles, which forms primarily some nucleation centers of dendritic characters. The nucleation centers were found to grow in sizes and shapes with the progress of reaction. It leads to growth of dendritic-like spherulitic crystal patterns. The resultant spherulites showed transitions in their morphologies, including sea-weeds and rhythmic spherulitic crystal patterns, by the effects substituted organic substrate and in the higher concentration of bromate-initiator respectively. The branching mechanism and crystal ordering of spherulitic textures were studied with help of optical microscope (OPM) and scanning electron microscope (SEM). Characteristics of crystal phases were also evaluated using X-ray diffraction (XRD) and differential thermal analysis (DTA). Results indicated that the compositions of reactants and crystal orderings were interrelated with morphological transitions of spherulites as illustrated and described.

Poly(benzyl-L-histidine)-b-Poly(ethylene glycol) Micelle Engineered for Tumor Acidic pH-Targeting, in vitro Evaluation

  • Lee, Eun-Seong;Youn, Yu-Seok
    • Bulletin of the Korean Chemical Society
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    • v.29 no.8
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    • pp.1539-1544
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    • 2008
  • A polymeric micelle, based on the poly(benzyl-L-histidine)-b-poly(ethylene glycol) (polyBz-His-b-PEG) diblock copolymer, was designed as a tumor-specific targeting carrier. The micelles (particle size: 67-80 nm, critical micelle concentration (CMC); 2-3 $\mu$g/mL) were formed from the diafilteration method at pH 7.4, as a result of self-assembly of the polyBz-His block at the core and PEG block on the shell. Removing benzyl (Bz) group from polyBz-His block provided pH-sensitivity of the micellar core; the micelles were physically destabilized in the pH range of pH 7.4-5.5, depending on the content of the His group free from Bz group. The ionization of His group at a slightly acidic pH promoted the deformation of the interior core. These pHdependent physical changes of the micelles provide the mechanism for pH-triggering anticancer drug (e.g., doxorubicin: DOX) release from the micelle in response to the tumor’s extracellular pH range (pH 7.2-6.5).

Morphology-controlled synthesis of $BaWO_4$ crystals using bidentate ligands (2자리 리간드를 이용한 $BaWO_4$ 결정의 형태 조절 합성)

  • Ryu, Eun-Kyoung;Huh, Young-Duk
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.17 no.4
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    • pp.139-144
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    • 2007
  • [ $BaWO_4$ ] crystals were synthesized using bidentate ligands. The reaction parameters such as the concentration of ligand and molar ratio of $[WO_4^{2-}]/[Ba^{2+}]$ played important roles in the formation of $BaWO_4$ crystals with various morphologies. When TMEDA was used as a ligand, the microrods of $BaWO_4$ crystals with length of $15{\sim}20{\mu}m$ were formed via the self assembly of cross-like plates of 250 nm in width and $2{\sim}3{\mu}m$ in length.

Reaction Characteristics Study of Aluminum-Copper(II) Oxide Composites Initiated by the Electrostatic Discharge (Aluminum-Copper(II) Oxide Composite의 정전기에 의한 반응 특성 연구)

  • Kim, Minjun;Kim, Sung Ho;Kim, Jayoung;Im, Yeseul
    • Journal of the Korea Institute of Military Science and Technology
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    • v.21 no.5
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    • pp.591-598
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    • 2018
  • The reaction characteristics of aluminum-copper(II) oxide composites initiated by the electrostatic discharge were studied as changing the aluminum particle size. Three different sizes of aluminum particles with nano-size copper(II)-oxide particle were used in the study. These composites were manufactured by two methods i.e. a shock-gel method and a self-assembly method. The larger aluminum particle size was, the less sensitive and less violent these composites were based on the electrostatic test. On the analysis of high speed camera about ignition appearances and burning time, the burning speed was faster when aluminum particle size was smaller.

Comparison of Roughnesses of Polycrystalline Gold Electrode Calculated from STM Images, Oxygen Adsorption-Desorption and Adsorption of N-Docosyl-N'-methyl Viologen (STM 이미지와 산소 흡탈착 그리고 N-docosyl-N'-methyl viologen의 흡착으로부터 구한 다결정 금 전극 표면의 거칠기의 비교)

  • Lee Chi-Woo;Jang Jai-Man
    • Journal of the Korean Electrochemical Society
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    • v.3 no.2
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    • pp.104-108
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    • 2000
  • It is very important to know the real roughness of electrode surface in electrochemistry. But it is impossible to know absolute roughness of electrode surface for various reasons. In this work, we compared the roughnesses of polycrystalline gold electrode often used in electrochemistry calculated from the images of scanning tunneling microscopy (STM) and cyclic voltammetry with those of Au (111) and HOPG. The roughness of polycrystalline gold calculated from STM image was $1.1(\pm0.1)$, that from adsorption-desorption of oxygen was $2.4(\pm0.7)$ and that from adsorption of N-docosyl-N'-methyl viologen was $1.6(\pm0.1)$.

녹색형광단백질로 구성된 분자광다이오드의 전자전달 특성

  • Nam, Yun-Seok;Choe, Jeong-U;Lee, Won-Hong
    • 한국생물공학회:학술대회논문집
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    • 2000.04a
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    • pp.149-152
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    • 2000
  • In recent years, various artificial molecular photodiode have been fabricated by mimicking the electron transport function of biological photosynthesis. And now, we have been investigated the protein-organic hetero thin film photodiode using GFP as an sensitizer based on the redox potential difference of functional molecules. In this paper, shows molecular photodiode consisting of green fluorescence protein(GFP). viologen and TCNQ. The TCNQ and viologen were deposited onto ITO coated glass by LB technique. And GFP molecule was adsorption onto the viologen LB film surface by self-assembly method. Finally, The Al deposition onto GFP/viologen/TCNQ film surface was performed to make a top electrode. As a result, The MIM(metal/Insulator/Metal) structured device was constructed. The input light of 460nm wavelength was generated by the xenon lamp system, and then the photocurrent produced from the molecular device was detected through a current-voltage(I-V) measuring unit (SMU Model 236, Keithley, USA). An artificial molecular photodiode using protein(GFP)-adsorbed hetero-LB film is presented as a model system for the bioelectronic device based on the biomimesis.

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AMBIDEBTER Nuclear Complex - A Credible Option for Future Nuclear Energy Applications (AMBIDEXTER 원자력 복합체 - 신뢰성 있는 미래 원자력에너지 이용 방안)

  • 오세기;정근모
    • Proceedings of the Korea Society for Energy Engineering kosee Conference
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    • 1998.05a
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    • pp.235-242
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    • 1998
  • Aiming at one of decisive alternatives for long term aspect of nuclear power concerns, an integral and closed nuclear system, AMBIDEXTER (Advanced Molten-salt Break-even Inherently-safe Dual-mission Experimental and TEst Reactor) concept is under development. The AMBIDEXTER complex essentially comprises two mutually independent loops of the radiation/material transport and the heat/energy conversion, centered at the integrated reactor assembly, which enables one to utilize maximum benefits of nuclear energy under minimum risks of nuclear radiation. And it provides precious radioisotopes and radiation sources from its waste stream. Also the reactor operates at very low level of fission products inventory throughout its lifetime. The nuclear and thermalhydraulic characteristics of the molten TH/$^{233}$ U fuel salt extend the capability of the self-sustaining AMBIDEXTER fuel cycle to enhance resource security and safeguard transparency. The reactor system is consisted of a single component module of the core, heat exchangers and recirculation pumps with neither pipe connections nor active valves in between, which will significantly improve inherent features of nuclear safety. States of the core technologies associated with designing and developing the AMBIDEXTER concept are mostly available in commercialized form and thus demonstration of integral aspects of the concept should be the prime area in future R&D programs.

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Contact Print Lithography for Precise Transplantation of Three-dimensional Microstructures into a Microsystem (표면접촉 인쇄방식을 이용한 극미세 3차원 형상의 이식공정에 관한 연구)

  • Park, Sang-Hu;Jeong, Jun-Ho;Choi, Dae-Geun;Kim, Ki-Don;Altun, Ali Ozhan;Lee, Eung-Sug;Yang, Dong-Yol;Kong, Hong-Jin;Lee, Kwang-Sup
    • Journal of the Korean Society for Precision Engineering
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    • v.24 no.12
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    • pp.136-142
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    • 2007
  • Precise fabrication of three-dimensional (3D) self-standing microstructures on thin glass plates via two-photon induced polymerization (TPP) has been an important issue for innovative 3D nanodevices and microdevices. However, there are still issues remaining to be solved, such as building 3D microstructures on opaque materials via TPP and being able to implant them as functional parts onto practical systems. To settle these issues simply and effectively, we propose a contact print lithography (CPL) method using an ultraviolet (UV)-curable polymer layer. We report some of the possibilities and potential of CPL by presenting our results for transplanting 3D microstructures onto large-area substrates and also our examination of some of the effects of the process parameters on successful transplantation.

A Study of nursing process by Neuman's systems model in Primary Health Care (Neuman 모델에 의한 일차보건의료에서의 간호과정 적용연구)

  • Han Myung Hwa
    • Journal of Korean Public Health Nursing
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    • v.12 no.1
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    • pp.90-102
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    • 1998
  • The primary health care(PHC) movement officially began in 1977 when the 30th World Health Oranization(WHO) Assembly adopted a resolution accepting the goal of attaining a level of health that permitted all citizens of the world to live socially and economically productive lives. As a WHO member nation, Korea has endorsed primary health care as a strategy for achieving the goal of Health For All by the Year 2000. However, PHC, with its empasis on broad strategies, community participation, self reliance, and a multidisciplinary health care delivary team, is not the primary strategy for improving the of Korean. The Neuman's systems model has been described as a grand nursing theory. A grand nursing theory consists of a comprehensive conceptual framework that defines broad perspectives for practice. This model is an example of a conceptual framework that provides structure for development and analysis of an individual or group of patients in the community or in an oranization. One of the model's strength is that it can be useed ina variey of setting. So The Neuman's model is used a nursing process format for community health nursing. The Neuman's model is fully congruent with concept and philosophy of today's PHC.

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