• Journal of the Korean Institute of Telematics and Electronics A
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• v.32A no.2
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• pp.48-56
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• 1995

The operating characteristics, such as, the threshold gain, lasing frequency, and longitudinal intensity profile, etc., of 1.55$\mu$m DFB laser diode with index and/or gain grating structures and with one side AR-coated mirror have been analyzed. From this analysis, the optimum design parameters have been shown that ${\Delta}{\Omega}$ (the phase difference between index grating and gain grating) is 0 or ${\pi}$, (xL)$_{r}$=1~3 and (xL)$_{i}$=0.5~0.9. It has been also shown that the modal selectivity and intensity uniformity of the DFB lasers with .DELTA..OMEGA.=0 are ~1.2 times better thatn those of the DFB lasers with ${\Delta}{\Omega}$= ${\pi}$.

• Childhood Kidney Diseases
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• v.19 no.2
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• pp.65-70
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• 2015

It is well known that proteins present in the primary urine are reabsorbed in the renal proximal tubules, and that this reabsorption is mediated via the megalin-cubilin complex and the neonatal $Fc{\gamma}$ receptor. However, the reabsorption is also thought to be influenced by an electrostatic interaction between protein molecules and the microvilli of the renal proximal tubules. By analyzing the charge diversity of urinary IgG, we showed that this reabsorption process occurs in a cationic charge-preferential manner. The charge-selective molecular sieving function of the glomerular capillary walls has long been a target of research since Brenner et al. demonstrated the existence of this function by a differential clearance study by using the anionic dextran sulfate polymer. However, conclusive evidence was not obtained when the study was performed using differential clearance of serum proteins. We noted that immunoglobulin (Ig) A and IgG have similar molecular sizes but distinct molecular isoelectric points. Therefore, we studied the differential clearance of these serum proteins (clearance IgA/clearance IgG) in podocyte diseases and glomerulonephritis. In addition, we studied this differential clearance in patients with Dent disease rather than in normal subjects because the glomerular sieving function is considered to be normal in subjects with Dent disease. Our results clearly showed that the charge-selective barrier is operational in Dent disease, impaired in podocyte disease, and lacking in glomerulonephritis.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.31A no.9
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• pp.128-138
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• 1994

In 1.55.mu.m DFB lasers with two non-AR mirrors, I have analyzed the effect of the sturctures of indes and/or gain gratings and mirror positions on the threshold gains, the lasing frequencies, and the beam profiles in longitudinal direction of lasers. I have obtained the optimum condition of static characteristics that ${\Delta}{\Omega}$(the phase difference betweeen index grating and gain grating is 3${\pi}$/4, $({\kappa}L)_{i}$=4~6 in case of $({\kappa}L)_{i}$=0.9 and $({\kappa}L)_{i}$=3~5 in case of $({\kappa}L)_{i}$=0.7. The modal selectivity and intensity uniformity of this optimum condition are 2~2.5 times better than those of the gain-coupled DFB lasers ${\Delta}{\Omega}$=0). The gain-coupled DFB lasers${\Delta}{\Omega}$=0) have 10$^{10) times better modal selectivity and intensity uniformity than the loss-coupled DFB lasers(TEX>${\Delta}{\Omega}$=${\pi}$).

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.1
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• pp.64-72
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• 2021

The feeding habits of the Japanese jack mackerel Trachurus japonicus were studied in the Southern Sea of the Republic of Korea. To assess the effects of season, sampling was conducted in February (winter), May (spring), and August (summer), 2020. The total length of each fish was measured in 1 cm intervals. Diet composition showed the highest species diversity during winter. Diet composition changed from copepods to euphausiids as the total length of jack mackerel increased, except during winter. The most important seasonal prey were copepods in winter and summer and euphausiids in spring. Species diversity of the zooplankton community structure was highest in winter. Among the zooplankton communities, copepods were dominant in all seasons. Species with a high electivity index in all seasons were relatively large zooplankton of ≥2 mm. Jack mackerel had ontogenetic diet change, exhibited diet selectivity depending on size, and its feeding habits were affected by the zooplankton community structure.

• Korean Journal of Ecology and Environment
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• v.33 no.4 s.92
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• pp.319-327
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• 2000

The feeding behavior of 1-year-old silver carp, Hypophthalmichthys molitrix (Val.) on phytoplankton species in a shallow hypertrophic lake was studied from 22 May to 18 September, 1997. Over the experimental period, the filter-pore sizes of the fish, the total biomass of the phytoplankton and the water temperature in each enclosure changed little with time. The fish biomass in each enclosure increased with time, while their percentage of weight gain correlated negatively to the stocking density, due perhaps to competition for prey. An analysis of gut contents of silver carp showed a strong similarity between the algal communities in the foregut and the water, and was significant for the fish enclosure with a low density (p<0.05). The presence of silver carp rarely suppressed the abundance of phytoplankton such as Oscillatoria, Anabaena and Melosira even at high ingestion levels. There were weak relationships between the IU values of each phytoplankton and the selectivity of fish on them (r = 0.001, p>0.5). There was no doubt that the silver carp fed unselectively when cyanobacteria populations were high, even though the selectivity index for diatoms was slightly higher than those for cyanobacteria, green algae and cryptomonads. Improvements in methodologies are needed to clearly understand and generalize the feeding behavior of silver carp.

• Applied Science and Convergence Technology
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• v.24 no.6
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• pp.250-253
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• 2015

High contrast grating (HCG) is the structure made up of the sub-wavelength grating of high-index and the surrounding layer of low-index, which reveals high contrast between two materials. Its advantages include high reflectivity over a broad bandwidth, polarization and wavelength selectivity, optical high-Q resonator, and phase modulation. In this work, the HCG structure comprising of indium tin oxide (ITO) and Silicon (Si), for the surrounding layer and the grating layer respectively, was studied. Its theoretical model was established, and transmittance, phase and optical behavior were calculated by rigorous coupled-wave analysis and finite element method. Furthermore, the established structure was fabricated to validate its feasibility. The fabricated structure shows the focusing capability whose length is about $10{\mu}m$, and the feasibility of the structure was demonstrated. It is also meaningful that ITO layer can contribute to the fabrication of the HCG structure, leading to enable the structure to be electrical-driven.

• Archives of Pharmacal Research
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• v.22 no.6
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• pp.533-541
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• 1999

Many conventional anticancer drugs display relatively poor selectivity for neoplastic cells, in particular for solid tumors. Furthermore, expression or development of drug resistance, increased glutathione transferases as well as enhanced DNA repair decrease the efficacy of these drugs. Research efforts continue to overcome these problems by understanding these mechanisms and by developing more effective anticancer drugs. Cyclophosphamide is one of the most widely used alkylating anticancer agents. Because of its unique activation mechanism, numerous bioreversible prodrugs of phosphramide mustard, the active species of cyclophosphamide, have been investigated in an attempt to improve the therapeutic index. Solid tumors are particularly resistant to radiation and chemotherapy. There has been considerable interest in designing drugs selective for hypoxic environments prevalent in solid tumors. Much of the work had been centered on nitroheterocyclics that utilize nitroreductase enzyme systems for their activation. In this article, recent developments of anticancer prodrug design are described with a particular emphasis on exploitation of selective metabolic processes for their activation.

• Korean Journal of Optics and Photonics
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• v.12 no.5
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• pp.406-413
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• 2001

We report theoretical and experimental results for the wavelength and polarization selectivity of a fiber-to-planar waveguide coupler made of a side polished single mode fiber covered with a planer waveguide incorporating a thin metal film. A simple but exact approach to obtain the modal properties of multilayer planar waveguide with a thin metal film is described. The device was modeled into equivalent 1 dimensional structure and its behaviour was analyzed based on coupled mode theory. The effects of metal film thickness and refractive index of superstrate on the device properties were measured and explained.

• Parasites, Hosts and Diseases
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• v.54 no.2
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• pp.155-161
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• 2016

Toxoplasma gondii is an important opportunistic pathogen that causes toxoplasmosis, which has very few therapeutic treatment options. The most effective therapy is a combination of pyrimethamine and sulfadiazine; however, their utility is limited because of drug toxicity and serious side effects. For these reasons, new drugs with lower toxicity are urgently needed. In this study, the compound, (Z)-1-[(5-nitrofuran-2-yl)methyleneamino]-imidazolidine-2,4-dione (nitrofurantoin), showed anti-T. gondii effects in vitro and in vivo. In HeLa cells, the selectivity of nitrofurantoin was 2.3, which was greater than that of pyrimethamine (0.9). In T. gondii-infected female ICR mice, the inhibition rate of T. gondii growth in the peritoneal cavity was 44.7% compared to the negative control group after 4-day treatment with 100 mg/kg of nitrofurantoin. In addition, hematology indicators showed that T. gondii infection-induced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, biochemical parameters involved in liver injury, were reduced by nitrofurantoin significantly. Moreover, nitrofurantoin exerted significant effects on the index of antioxidant status, i.e., malondialdehyde (MDA) and glutathione (GSH). The nitrofurantoin-treated group inhibited the T. gondii-induced MDA levels while alleviating the decrease in GSH levels. Thus, nitrofurantoin is a potential anti-T. gondii candidate for clinical application.

• Journal of Software Assessment and Valuation
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• v.15 no.2
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• pp.101-109
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• 2019

Lasers for optical broadband communication systems should have excellent frequency selectivity and modal stability. DFB(Distributed Feedback) lasers have low lasing frequency shift during high speed current modulation. In this paper, I have developed a simulation software and analysed threshold gain and lasing frequency of a lasing mode in longitudinal direction of an 1.55um DFB laser with two mirrors and without anti-reflection coatings, that have both an index- and gain-gratings. The grating phase on a left mirror face is fixed as π/2 and the grating phase on a right mirror face is varied. As the phases of the index and gain gratings on the right mirror facet are π and 0, κL should be in the range of 2~6 in order to enhance the frequency stability. In order to reduce the threshold current of a lasing mode, κL should be greater than 8, regardless of the grating phases on the mirror faces.