• Journal of Digestive Cancer Research
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• v.4 no.2
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• pp.127-129
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• 2016

The prognosis for pancreatic cancer patient is very poor. Patients with locally advanced disease have a median survival time of 8 to 12 months, and patients with distant metastases have significantly worse outcomes, with a median survival time of only 3 to 6 months. Approximately 30% of patients with pancreatic cancer present with locally advanced disease defined as unresectable pancreatic cancer without evidence of distant metastatic disease. Primary treatment options in locally advanced pancreatic cancer include chemotherapy and radiotherapy. Here, we reported a patient with locally advanced pancreatic cancer who does not want further chemotherapy because of chemotherapy induced nausea and vomiting. Irreversible electroporation was performed. Irreversible electroporation was well tolerated in this case, and may be a therapeutic modality for selected patients with locally advanced pancreatic cancer.

• Physical Therapy Rehabilitation Science
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• v.12 no.3
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• pp.300-309
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• 2023

Objective: The purpose of this study was to investigate the effects of gastrocnemius neuromuscular electrical stimulation training on ankle mobility and gait in patients with stroke. Design: A randomized controlled trial. Methods: 31 patients with stroke were selected and classified into an experimental group (n=16) and a control group (n=15). Both groups were assessed for ankle mobility using the Knee to Wall Test and gait parameters using G-walk before and after the intervention. The intervention was applied five times a week for four weeks. The experimental group performed gastrocnemius neuromuscular electrical stimulation followed by ankle control exercises, while the control group only applied NMES to the tibialis anterior muscle of the paretic side for 30 min per session five times a week for 4 weeks. Results: Experimental group showed significant improvements in Knee to wall test. and lumbar flexibility after the intervention. both group showed significant improvements in gait parameters after the intervention. However, when comparing between the two groups, the experimental group showed a more significant effect than the control group. Conclusions: Gastrocnemius neuromuscular electrical stimulation training can be considered an effective approach to improve ankle mobility and gait ability in patients with stroke.

• Physical Therapy Rehabilitation Science
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• v.12 no.3
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• pp.268-277
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• 2023

Objective: The purpose of this study was to investigate the effects of Pilates breathing exercises on functional disability and lumbar flexibility in patients with non-specific chronic low back pain. Design: A randomized controlled trial. Methods: 30 patients with non-specific low back pain were selected and classified into an experimental group (n=15) and a control group (n=15). Both groups were assessed for functional disability using the Oswestry Disability Index and flexibility of the lumbar spine using the modified-modified Schober test before and after the intervention. The intervention was applied twice a week for four weeks. The experimental group performed Pilates breathing exercises followed by spinal stabilization exercises, while the control group only performed spinal stabilization exercises. Results: Both groups showed significant improvements in functional disability and lumbar flexibility after the intervention. However, when comparing between the two groups, the experimental group showed a more significant effect than the control group. Conclusions: The combination of Pilates breathing exercises and spinal stabilization exercises can be considered an effective approach to improve low back pain and prevent chronic pain in patients with non-specific chronic low back pain.

• Journal of Korean society of Dental Hygiene
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• v.24 no.2
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• pp.141-148
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• 2024

Objectives: The purpose of this study was to investigate the effect of denture use on the quality of life of cancer patients aged ≥40 years. Methods: Data from the National Health and Nutrition Examination Survey (2013-2018) were used in this study. A total of 302 individuals were selected as the final study participants. Data were analyzed using the chi-square test and logistic regression analysis using SPSS software. Results: The quality of life in the group with dentures was lower than that in the group without dentures. Conclusions: The use of dentures had a significant effect on the quality of life of cancer patients aged ≥40 years. Therefore, national dental care guidelines and policies should be developed to prevent an increase in tooth loss in patients with cancer.

• Journal of Korean Medicine for Obesity Research
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• v.23 no.2
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• pp.86-97
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• 2023

Objectives: The purpose of this study is to review clinical studies related to the effect of Traditional Chinese Medicine (TCM) on moderate to severe obese patients with hypertension. Methods: Clinical studies from the China National Knowledge Infrastructure (CNKI) were searched by specific keywords and criteria. Total of 7 randomized controlled trials were selected and analyzed. Results: Various evaluation methods were used to see the effect of TCM compared to conventional western medicine. Most of the studies used herbal medicine combined with conventional anti-hypertensive western medicine. The effective rate of anti-hypertension was higher when TCM was added to conventional anti-hypertensive medicine. Traditional medicine treatment showed significant effect on lowering blood pressure and body mass index. Conclusions: Based on the results of the clinical studies from China, TCM can be a valuable option for moderate to severe obese patients with hypertension. Applying Traditional medicine has a significant effect on lowering blood pressure and weight loss. Combining herbal medicine can be worthy of clinical promotion and application for moderate and severe obese patients with hypertension.

• PNF and Movement
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• v.22 no.1
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• pp.139-149
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• 2024

Purpose: This study aimed to investigate the effects of gradually increasing treadmill inclination on the electroencephalogram (EEG) of stroke patients during gait training. Methods: Three stroke patients who were diagnosed with stroke within six months and capable of walking on a treadmill were selected as subjects. EEG electrodes were attached at Fp1, Fp2, F3, F4, C3, C4, P3, and P4 positions of the cerebral hemispheres using the International 10-20 system. The intervention involved walking for 2 minutes each at 0 degrees, 15 degrees, and 30 degrees inclination on the treadmill while focusing on a target point located in front during the treadmill gait training. The EEG (Smartingmobi, Serbia) generated when the treadmill gradient gradually increased was measured. In addition, relative alpha and relative beta waves were visualized through the Brain mapping program in the TeleScan program to assess the changes in each brain region for the activity of the EEG. Results: The relative alpha wave value decreased as treadmill inclination increased, while the relative beta wave value increased. Conclusion: Gradually increasing the inclination during treadmill gait training appears to be a crucial parameter for increasing the brain activity levels of stroke patients.

• Korean Journal of Clinical Pharmacy
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• v.34 no.2
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• pp.79-99
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• 2024

Background: There was an important revision of the Korean Clinical Practice Guideline for Stroke (KCPGS) for antithrombotic therapy in patients with acute ischemic stroke in 2022. This review is to provide an updated information in this revision. Methods: The revision history by year after the first announcement was examined for each topic, focusing on antithrombotic therapy during acute phase which was revised in 2022. We compared before and after the revision, and investigated the clinical outcomes presented as evidence. It was also compared with the current U.S. guidelines. Results: The major changes about antiplatelet therapy are a clause stating that dual antiplatelet therapy with clopidogrel and aspirin initiated within 24 hours from the stroke onset and maintained for up to 21-30 days is recommended as an acute treatment, as well as the clause that antithrombotic therapy may be initiated within 24 hours after intravenous thrombolytics and that the use of glycoprotein IIb/IIIa receptor antagonists can be considered in highly selected patients as rescue therapy taking into account of benefit and risk. The change to the use of anticoagulants is that it may be reasonable to start oral anticoagulant between 4 and 14 days after stroke onset for patients with acute ischemic stroke and atrial fibrillation. Conclusions: It will be helpful in improving health outcomes for clinical pharmacists to be aware of the latest information for antithrombotic therapy and to actively use it in pharmaceutical care of stroke patients.

• Hip & pelvis
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• v.35 no.1
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• pp.15-23
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• 2023

Purpose: Hip microinstability is defined as hip pain with a snapping and/or blocking sensation accompanied by fine anatomical anomalies. Arthroscopic capsular plication has been proposed as a treatment modality for patients without major anatomic anomalies and after failure of properly administered conservative treatment. The purpose of this study was to determine the efficacy of this procedure and to evaluate potential predictors of poor outcome. Materials and Methods: A review of 26 capsular plications in 25 patients was conducted. The mean postoperative follow-up period for the remaining patients was 29 months. Analysis of data included demographic, radiological, and interventional data. Calculation of pre- and postoperative WOMAC (Western Ontario and McMaster Universities Osteoarthritis) index was performed. Pre- and postoperative sports activities and satisfaction were also documented. A P<0.05 was considered significant. Results: No major complications were identified in this series. The mean pre- and postoperative WOMAC scores were 62.6 and 24.2, respectively. The WOMAC index showed statistically significant postoperative improvement (P=0.0009). The mean satisfaction rate was 7.7/10. Four patients with persistent pain underwent a periacetabular osteotomy. A lateral center edge angle ≤21° was detected in all hips at presentation. We were not able to demonstrate any difference in postoperative evolution with regard to the presence of hip dysplasia (P>0.05), probably because the sample size was too small. Conclusion: Capsular plication can result in significant clinical and functional improvement in carefully selected cases of hip microinstability.

• Physical Therapy Rehabilitation Science
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• v.13 no.2
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• pp.213-222
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• 2024

Objective: Stroke is a leading cause of disability worldwide, often leaving survivors with significant cognitive and motor impairments. Dual-task (DT), which involves performing cognitive and motor tasks simultaneously, can influence brain activation patterns and functional recovery in stroke patients. Design: A systematic review Methods: Following PRISMA guidelines, databases including MEDLINE, CINAHL, Embase, and Web of Science were searched for studies assessing cortical activation via functional near-infrared spectroscopy (fNIRS) during DT performance in stroke patients. Studies were selected based on predefined eligibility criteria, focusing on changes in hemodynamic responses and their correlation with task performance. Results: Eight studies met the inclusion criteria. Findings indicate that DT leads to increased activation in the prefrontal cortex (PFC), premotor cortex (PMC), and posterior parietal cortex (PPC), suggesting an integrated cortical response to managing concurrent cognitive and motor demands. However, increased activation did not consistently translate to improved functional outcomes, highlighting the complex relationship between brain activation and rehabilitation success. Conclusions: DT interventions may enhance cortical activation and neuroplasticity in post-stroke patients, but the relationship between increased brain activity and functional recovery remains complex and requires further investigation. Tailored DT programs that consider individual neurophysiological and functional capacities are recommended to optimize rehabilitation outcomes.

• Journal of muscle and joint health
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• v.31 no.2
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• pp.65-74
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• 2024

Purpose: This study was conducted to verify fall predictive power and reasonable fall risk assessment tool by a comparative analysis of the sensitivity, specificity, positive forecast and negative forecast of each tool by applying Morse Fall Scale (MFS), Johns Hopkins Fall Risk Assessment Tool (JHFRAT), and Fall Assessment Scale-Korean version (FAS-K) through electronic medical records to adult patients hospitalized in a general hospital in Korea. Methods: We performed a retrospective evaluation study from January to December 2018, 123 fall groups experiencing falls during hospitalization and 123 non-falls groups were selected. Data presented a reasonable assessment tool that predicts and distinguishes fall high-risk patients through area comparison based on the ROC curve for each tool. Results: In the ROC curve analysis by fall risk assessment group, the AUC of MFS is shown to be .706 (good), JHFRAT is shown to be .649 (sufficient) and FAS-K is shown to be .804 (very good). FAS-K at a cut-off score of 4, sensitivity, specificity, and positive and negative prediction values were 83.7%, 60.2%, 67.8%, and 78.7%, respectively. Conclusion: Based on the above findings, it is believed that the FAS-K was presented as a suitable and reasonable tool for predicting falls for adult patients in general hospitals.