• Title/Summary/Keyword: second transition

Search Result 770, Processing Time 0.036 seconds

Hard Contact Transition Control Laws : :Three Different Approaches

  • Doh, Nakju;Chung, Wankyun;Youm, Youngil
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 1999.10a
    • /
    • pp.17-20
    • /
    • 1999
  • In this paper, we consider on hard contact transition control strategies. Hard contact transition phase can be divided into two definitely different phases,“Pre-Transition Phase”and“Transition Phase”. Here we focus on the“Pre-Transition Phase”and we propose three control methods. First, we propose a novel con-troller named as “Suppression Controller”which is not only stable but also simple to implement. Second, we present passive damper named as“Flexible-Damped Joint”Which is good solution in Circumventing pre-transition Phase. Third, We suggest a stable and simple controller which can maximize joint damping and minimize recontact velocity in flexible-damped joint. It is named as“Joint Damping Controller”.

  • PDF

Predicting Longitudinal Patterns of Emotional and Behavioral Problems in Early Adolescence : A Latent Class and Latent Transition Analysis (초기 청소년기 정서행동문제의 종단적 변화에 따른 잠재프로파일 분류 및 전이 영향요인 분석)

  • Kim, Bitna;Jang, Hyein;Park, Ju Hee
    • Human Ecology Research
    • /
    • v.60 no.1
    • /
    • pp.53-68
    • /
    • 2022
  • Using a person-centered approach, the current study investigated latent profiles for the emotional and behavioral problems of students in sixth-grade in elementary school and second grade of middle school. The aim was to explore latent transition patterns and verify the factors affecting the transitions. The participants were 1,937 adolescents who responded to the 3rd year (6th grade of elementary school; Time 1), 4th year (1st grade of middle school), and 5th year (2nd grade of middle school; Time 2) of the Korean Children Youth Panel Study. Latent profile and latent transition analyses were performed. The results were as follows: first, the latent profile of emotional and behavioral problems changed from Time 1 to Time 2. The latent groups at Time 1 were classified into low, moderate, high, and externalizing-dominant, whereas at Time 2, five groups were identified: low, moderate, high, externalizing-dominant, and withdrawal-dominant. Second, transition analyses revealed that although 22.3-57.0% of latent groups remained unchanged, there were significant changes over time between groups, as a new group ('withdrawal-dominant') emerged in Time 2. Third, different factors influenced the latent profile transition of emotional and behavioral problems depending on the transition pattern. Higher levels of self-esteem, better relationships with peers and teachers, and lower levels of parental inconsistency meant emotional and behavioral problems had not worsened at Time 2. The results suggest that early interventions are needed during the transition from childhood to early adolescence.

Benzidine Induces Epithelial-Mesenchymal Transition of Human Bladder Cancer Cells through Activation of ERK5 Pathway

  • Sun, Xin;Zhang, Tao;Deng, Qifei;Zhou, Qirui;Sun, Xianchao;Li, Enlai;Yu, Dexin;Zhong, Caiyun
    • Molecules and Cells
    • /
    • v.41 no.3
    • /
    • pp.188-197
    • /
    • 2018
  • Benzidine, a known carcinogen, is closely associated with the development of bladder cancer (BC). Epithelial-mesenchymal transition (EMT) is a critical pathophysiological process in BC progression. The underlying molecular mechanisms of mitogen-activated protein kinase (MAPK) pathway, especially extracellular regulated protein kinases 5 (ERK5), in regulating benzidine-induced EMT remains unclarified. Hence, two human bladder cell lines, T24 and EJ, were utilized in our study. Briefly, cell migration was assessed by wound healing assay, and cell invasion was determined by Transwell assay. Quantitative PCR and western blot were utilized to determine both gene expressions as well as protein levels of EMT and MAPK, respectively. Small interfering RNA (siRNA) was transfected to further determine ERK5 function. As a result, the migration and invasion abilities were enhanced, epithelial marker expression was decreased while mesenchymal marker expression was increased in human BC cell lines. Meanwhile, benzidine administration led to activation of ERK5 and activator protein 1 (AP-1) proteins, without effective stimulation of the Jun N-terminal kinase (JNK) or p38 pathways. Moreover, Benzidine-induced EMT and ERK5 activation were completely suppressed by XMD8-92 and siRNAs specific to ERK5. Of note, ERK1/2 was activated in benzidine-treated T24 cells, while benzidine-induced EMT could not be reversed by U0126, an ERK1/2 inhibitor, as indicated by further study. Collectively, our findings revealed that ERK5-mediated EMT was critically involved in benzidine-correlated BC progression, indicating the therapeutic significance of ERK5 in benzidine-related BC.

The Second Demographic Transition in Industrialized Countries (산업국가에서의 제2차 인구변천)

  • Chung, Sung-Ho
    • Korea journal of population studies
    • /
    • v.32 no.1
    • /
    • pp.139-164
    • /
    • 2009
  • The first demographic transition refers to the historical decline in mortality and fertility, as shown from the 18th Century in several European populations, and continuing present in most developing countries. The end point of the first demographic transition(FDT) was supposed to be a stationary and stable population corresponding with replacement fertility and zero population growth. In addition, households in all parts of the world would converge toward the nuclear and conjugal types, composed of married couples and their offspring. The second demographic transition(SDT), on the other hand, sees no such equilibrium as the end-point. Rather, new developments bring sub-replacement fertility, a multitude of living arrangements other than marriage, and the disconnection between marriage and procreation. Populations would face declining sizes if not complemented by new migrants. Over the last decades birth rates have been on the decline in all countries of the world, and it is estimated that already more than half of he world's population has below replacement level fertility. Measured in terms of the Total Fertility Rate (TFR), currently 34 countries have fertility levels of 1.5 or less. Similarly, Korea has been below lowest-low fertility for eight consecutive years since 2001 and below the replacement level for more than twenty years. In explaining the low fertility in Korea, some researchers explain the low fertility as revenge against a male-dominated society and institution, while others focus the impact of the employment instability. These studies share the basic ideas (spread of individualism, delayed marriage and childbearing, high divorce rate etc.) of a second demographic transition in order to explain the low fertility in Korea.

Computational simulations of transitional flows around turbulence stimulators at low speeds

  • Lee, Sang Bong;Seok, Woochan;Rhee, Shin Hyung
    • International Journal of Naval Architecture and Ocean Engineering
    • /
    • v.13 no.1
    • /
    • pp.236-245
    • /
    • 2021
  • In this study, direct numerical and large eddy simulations of transitional flows around studs were conducted to investigate the effectiveness of turbulence stimulators at very low speeds for the minimum propulsion power condition of four knots. For simplicity, the studs were assumed to be installed on a flat plate, while the wake was observed up to 0.23 m downstream behind the second stud. For applicability to a model ship, we also studied the flow characteristics behind the first and second studs installed on a curved plate, which was designed to describe the geometry of a bulbous bow. A laminar-to-turbulent transition was observed in the wake at ReD ≥ 921 (U≥0.290 m/s), and the wall shear stress at ReD = 1162 (U = 0.366 m/s) in the second wake was similar to that of the fully developed turbulent boundary layer after a laminar-to-turbulent transition in the first wake. At ReD = 581 (U = 0.183 m/s), no turbulence was stimulated in the wake behind the first and second studs on the flat plate, while a cluster of vortical structures was observed in the first wake over the curved plate. However, a cluster of vortical structures was revealed to be generated by the reattachment process of the separated shear layer, which was disturbed by the first stud rather than directly initiated by the first stud. It was quite different from a typical process of transition, which was observed at relatively high ReD that the spanwise scope of the turbulent vortical structures expanded gradually as it went downstream.

Two dimensional Phase Transition of Liquid Crystal Film (액정박막에서의 2차원 상전이)

  • Jung, C.S.;Xue, J.Z.;Kim, M.W.
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
    • /
    • 1993.05a
    • /
    • pp.119-121
    • /
    • 1993
  • Two dimensional phase transition and three dimensional propagation of layer structures of liquid crystal film are investigated by using surface second harmonic generation method. We have found a distinctive first order phase transition between a monolayer phase and a stable 3-layer phase of 8CB liquid crystal film.

  • PDF

A Study on the Transition to Parenthood Expectation on Reward/Cost and Martial Relation of First Pregnant Women (초임부의 부부관계와 부모기전이 보상/비용기대감에 관한 연구)

  • 김양희
    • Journal of Families and Better Life
    • /
    • v.17 no.3
    • /
    • pp.1-16
    • /
    • 1999
  • This study focuses on the beginning of transition to parenthood expectation and applies the exchange theory in order to examine reward and cost of transition to parenthood expectation and picks up the main cause effecting it. This study conducted structured questionnaires to total 330 first pregnant women and examined descriptive statistics and t-test F-test analysis by using collected data. And here are the result of research. First the transition to parenthood expectation expected rewards much more than costs and had much importance on individual aspects in parenthood. The more were they aged hardly educated and housewives the higher did they showed expectation of reward. The less did they have high education the more did they expect costs of the transition to parenthood expectation. Second to examined the reward/cost of transition to parenthood expectation according to martial satisfaction the more did they have martial satisfaction the more did they expectation of the rewa ds on transition to parenthood expectation. On the contrary the more did they respect from husbands the less did they cost of transition to parenthood expectation. This study would be helpful to lead family life having childbirth to the positive way be examining the process from childbirth plan to delivery. Also it will be applicable to seek for the methods to help would-be parents as basic data on material on education about transition to parenthood.

  • PDF

Honokiol Suppresses Renal Cancer Cells' Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

  • Li, Weidong;Wang, Qian;Su, Qiaozhen;Ma, Dandan;An, Chang;Ma, Lei;Liang, Hongfeng
    • Molecules and Cells
    • /
    • v.37 no.5
    • /
    • pp.383-388
    • /
    • 2014
  • Renal cell carcinoma (RCC) is associated with a high frequency of metastasis and only few therapies substantially prolong survival. Honokiol, isolated from Magnolia spp. bark, has been shown to exhibit pleiotropic anticancer effects in many cancer types. However, whether honokiol could suppress RCC metastasis has not been fully elucidated. In the present study, we found that honokiol suppressed renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties. In addition, honokiol inhibited tumor growth in vivo. It was found that honokiol could upregulate miR-141, which targeted ZEB2 and modulated ZEB2 expression. Honokiol reversed EMT and suppressed CSC properties partly through the miR-141/ZEB2 axis. Our study suggested that honokiol may be a suitable therapeutic strategy for RCC treatment.

A Study on the Variation Process of Commercial Gentrification Phase in Residential Area in Seoul - Focused on Business Type of Commercial Characteristics - (서울시 주거지역 내 상업 젠트리피케이션의 단계별 변이과정 분석 연구 - 상업 업종의 변화를 중심으로 -)

  • Ryu, Hwa-Yeon;Park, Jin-a
    • Journal of Korea Planning Association
    • /
    • v.54 no.1
    • /
    • pp.40-51
    • /
    • 2019
  • The ultimate aim of this study is to diagnose the process stage and look at the step change of transition process to see how the step changes. Therefore, in this study, cluster analysis was conducted by examining four types of commercial characteristics such as Retail Homogeneity, Share of Neighbourhood store, Share of chain store, and Share of cafe & Western food store. Through the cluster analysis, three types have been identified. Type1 is the first step which can explain the time before gentrification occurs and when the ratio of neighborhood facilities is the highest. Type2 is the second step that can explain boutique stage where the gentrification occurs. At this time, the ratio of Cafes & Western food restaurant increased and the proportion of neighborhood shops decreased. And Type3, third step is when the mature gentrification occurs. In the analysis of the transition period, it is necessary to monitor the change of the industry in the period from the first stage to the second stage. In the transition period from the second stage to the third stage, It is necessary to constantly monitor such factors as the increase of shops.

A Study on the Pumping Performance of a Disk-type Drag Pump (원판형 드래그펌프의 배기특성에 관한 연구)

  • Hwang, Young-Kyu;Heo, Joong-Sik;Choi, Wook-Jin
    • Transactions of the Korean Society of Mechanical Engineers B
    • /
    • v.24 no.6
    • /
    • pp.860-869
    • /
    • 2000
  • Numerical and experimental investigations are performed for the molecular transition and slip flows in pumping channels of a disk-type drag pump. The flow occurring in the pumping channel develops from the molecular transition to the slip flow traveling downstream. Two different numerical methods are used in this analysis: the first one is a continuum approach in solving the Navier-Stokes equations with slip boundary conditions, and the second one is a stochastic approach through the use of the direct simulation Monte Carlo method. In the experimental study, the inlet pressures are measured for various outlet pressures in the range of 0.1{\sim}4Torr. From the present study, the numerical results of predicting the performance, obtained by both methods, agree well with the experimental data for the range of Knudsen number $Kn{\leq}0.1$ (i.e., the slip flow regime). But the results from the second method only agree with the experimental data for Kn>0.1(i.e., the molecular transition regime)