• 아동학회지
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• 제28권1호
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• pp.55-69
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• 2007

This research examined age differences in the way 3-, 4-, 5-year-old children solve scientific problems involving magnetic and nonmagnetic objects. Their scientific process skills and scientific concepts were examined in 1) hypothesis setting, 2) hypothesis verification and 3) hypothesis application. Data was analyzed by one-way and two-way ANOVA and Scheffe. Children's scientific process skill presented differences by age in each phase of problem solving. That is, the scientific concept level demonstrated by 4-year-olds was higher than that of the 3-year-olds. That of the 5-year-olds was higher than the 4-year-olds. In addition, in all age groups, the children showed a higher level of understanding about magnetic and non-magnetic objects in the hypothesis application phase than in the hypothesis setting phase.

• Toxicological Research
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• 제26권3호
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• pp.233-236
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• 2010

The analytical in vivo chromium ion was searched for using a voltammetric hollow-fiber dialysis sensor via square wave stripping voltammetry (SW), cyclic voltammetry (CV), and chronoamperometry. Under optimum parameters, the analytical results indicated linear working ranges of 50~400 mg/l CV and $10{\sim}80\;{\mu}g/l$ SW within a 30-sec accumulation time. The analytical detection limit (S/N) was $6.0\;{\mu}g/l$. The developed method can be applied to in vivo tissues and in ex vivo toxicity assay, as well as to other materials that require chromium analysis.

• 한국지구과학회지
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• 제25권8호
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• pp.674-683
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• 2004

과학연구를 하는 방법은 매우 다양하다. 과학영재아들로 하여금 본연의 과학연구능력을 개발하고 구현하도록 하는 목적을 달성한다는 것은 이미 알려진 영재교육의 목표이다. 여기서 과학연구능력이라고 할 때 과학연구의 요소는 무엇인가 살펴볼 필요가 생기며 하나의 과학연구가 존재하기 보다는 다양한 연구밥법이 공존한다는 입장이 더 설득력이 있다. 본 연구는 연구능력의 다양한 측면과 특성을 알아보는 탐색연구이며 더 세부적으로 들어가서 과학과정 능력 중 실험설계능력에 초점을 맞추었다. 물론 연구능력이라고 할 때에는 문제발견, 과학지식, 자아통찰 등 다양한 영역이 포함된다. 본 연구에서는 실험설계능력을 보기 위해 1990년 Fowler가 개발한 Diet Cola Test를 국내의 학생들이 사용할 수 있도록 번안하여 사용하였다. 전국 과학영재교육 프로그램에 참여하는 학생 중 총 705명의 초등학교 3학년에서 고등학교 1학년 학생들이 연구대상이 되었으며 과학교육분야에서의 문제중심학습과 창의적 사고력이라는 부분에 초점을 맞추어 연구자료를 해석하였다.

• Journal of the Korean Data and Information Science Society
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• 제16권2호
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• pp.335-348
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• 2005

The purpose of this research is to suggest the roles of government through constructing models of regional scientific technology and information to develop regional innovation system, which can maximize international competitiveness of Korea. To do this, this research compares the characteristics and superiorities of each regional areas in Korea. Constructing DB for scientific technology and information is recognized as a primary factor for constructing scientific technology and information infrastructure. In regional areas, constructing DB for professional scientific technology and information and networks are regarded as a key factor for regional scientific technology and information. Also, the primary problem to be solved in the regional areas is to construct DB for scientific technology and information.

• 기술혁신학회지
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• 제12권3호
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• pp.471-498
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• 2009

과학연구의 분야별 중요도를 판단하고 예산지원을 결정해야 하는 정부나 기업들은 국가의 과학적 위치를 파악할 수 있는 능력을 갖추는 것이 필수적이다. 이 논문에서는 세계 주요국이 연구개발 투자로 얻은 성과를 분석하여 국가 단위에서의 연구역량을 측정하고 국제적 관점에서 비교한다. 연구활동의 결과는 논문으로 발표되고, 이 논문은 새로운 논문의 자료로 인용되게 되는데, 일반적으로 인용할 만한 지식과 정보가 많은 논문일수록 다수의 연구자에 의해 참조되므로 논문의 발표량과 인용된 횟수는 연구 활동을 평가하는 척도로 활용된다. 본 논문에서는 각국의 과학연구 역량을 알아보기 위해 세계 각국의 SCI DB 수록 논문발표수와 그 인용도를 분석하고, 국내의 기관별, 분야별, 학술지별, 개인별 발표 논문수와 그 인용도를 분석한다. 본 연구에서는 논문발표 건수기준으로 세계 30개 국가를 대상으로 분석을 수행한다. 이 국가들은 세계전체 논문발표 건수의 90%를 차지하고 있는 국가들이다. 본 논문은 국가 간의 과학연구 성과를 다양한 시각과 척도로 비교평가하는 것으로 목적으로 한다. 이를 위해 우선 관련연구와 분석방법을 검토하며, 다음으로, 과학연구의 투입특성을 분석한다. 다음으로, 국가별 과학연구의 성과특성을 상세히 분석하고자 한다. 또한 과학연구의 투입과 성과 간의 관계를 확인하기 위해 통계적으로 검토한다. 끝으로, 이러한 분석결과를 바탕으로 결론과 시사점을 도출하고 연구의 한계와 추후과제를 제시한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.689-692
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• 2015

Background: Incorporation of molecular analysis of the epidermal growth factor receptor (EGFR) gene into routine clinical practice has shown great promise to provide personalized therapy of the non-small cell lung cancer (NSCLC) in the developed world. However, the genetic testing of EGFR mutations has not yet become routine clinical practice in territories remote from the central regions of Russia. Therefore, we aimed to study the frequency of major types of activating mutations of the EGFR gene in NSCLC patients residing in West Siberia. Materials and Methods: We examined EGFR mutations in exons 19 and 21 in 147 NSCLC patients (excluding squamous cell lung carcinomas) by real time polymerase chain reaction. Results: EGFR mutations were detected in 28 of the 147 (19%) patients. There were 19 (13%) cases with mutations in exon 19 and 9 cases (6%) in exon 21. Mutations were more frequently observed in women (42%, p=0.000) than in men (1%). A significantly higher incidence of EGFR mutations was observed in bronchioloalveolar carcinomas (28%, p=0.019) and in adenocarcinomas (21%, p=0.024) than in large cell carcinomas, mixed adenocarcinomas, and NOS (4%). The EGFR mutation rate was much higher in never-smokers than in smokers: 38% vs. 3% (p=0.000). The frequency of EGFR mutations in the Kemerovo and Tomsk regions was 19%. Conclusions: The incorporation of molecular analysis of the EGFR gene into routine clinical practice will allow clinicians to provide personalised therapy, resulting in a significant increase in survival rates and improvement in life quality of advanced NSCLC patients.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2005년도 학술발표회(1)
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• pp.129-130
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• 2005

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 추계학술대회 논문집 전기물성,응용부문
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• pp.274-276
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• 2001

This research aims to develop the multiple channel electrochemical DNA chip using microfabrication technology. At first, we fabricated a high integration type DNA chip array by lithography technology. Several probe DNAs consisting of thiol group at their 5-end were immobilized on the sold electrodes. Then target DNAs were hybridized and reacted. Cyclic voltammetry showed a difference between target DNA and control DNA in the anodic peak current values. Therefore, it is able to detect a plural genes electrochemically after immobilization of a plural probe DNA and hybridization of non-labeling target DNA on the electrodes simultaneously. It suggested that this DNA chip could recognize the sequence specific genes.

• 대한지구과학교육학회지
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• 제8권3호
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• pp.399-408
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• 2015

This study is to find out that the effects of a creative experience activity program to scientific concepts and self-directed learning skills. This study has been aimed at 2 class 40 students of 4th grade in D metropolitan city A elementary school in 2015, one class 20 students are the research group to apply Scientific research program using creative experience activity, another class 20 students were comparison groups to apply general science classes. The related class section of this study is 4th grade 2 semester of science 4 chapters, 'The Earth and the moon' This section is in fourth grade elementary science curriculum revision in 2009 is a Sections to learn for the first time about astronomical area. Target research group in club activities as part of the creative activities implemented using scientific inquiry and analyzed the results. In addition, in order to better research based on the results of this study as follows. First, the science curriculum in elementary schools, as well as applied research about the creative experience activity classes in other subjects is required. The ongoing research is needed to classes utilizing the characteristics of creative experience activities in several subjects of the elementary school curriculum. Second, Creative experiential learning is only effective when it is done consistently, it is worth studying for long periods of time.

• 한국초등과학교육학회지:초등과학교육
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• 제30권3호
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• pp.379-393
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• 2011

The purpose of this study was to analyze the complexity of scientific reasoning during open inquiry activities of pre-service elementary school teachers. In this study, 6 pre-service elementary teachers who participated in open-inquiry activities were selected. The data of scientific reasoning during their inquiry process was collected from the video recording of reporting about inquiry process and results, their reports and researcher's notetaking. CSRI Matrix (Dolan & Grady, 2010) was used to analyze the complexity of participants' scientific reasoning. The result showed that the degree of the complexity of their scientific reasoning varied in participants. Particularly the low degree of the complexity of scientific reasoning presented in posing preliminary hypotheses, providing suggestions for future research, communicating and defending finding. Also, The more pre-service teachers' epistemology of inquiry are similar to that of scientists, the more complex scientific reasoning represents. This results suggest that teachers should impress on students the importance of doing the precedent study and providing suggestions for future research, and provide a place for communicating and defending findings.