• Title/Summary/Keyword: scientific investigation

Search Result 800, Processing Time 0.029 seconds

A study on the screening of toxic materials by HPTLC and GC/MS (HPTLC 및 GC/MS를 이용한 유해화학물질의 스크리닝에 관한 연구)

  • Park, Sung-Woo;Jang, Seong-Gil;Park, You-Sin;Lee, Jin-Hoon;Lee, Sang-Ki;You, Jae-Hoon;Kim, Dong-Hwan;Jin, Kwang-Ho;Kim, Ki-Wook;Kim, Yu-Na;Lho, Dong-Seok
    • Analytical Science and Technology
    • /
    • v.13 no.1
    • /
    • pp.108-120
    • /
    • 2000
  • To perform an effective screening for toxic materials of forensic interest detected in high profile criminal case in biological and environmental samples, we tried to construct a searchable computerized database using HPTLC(High Performance Thin Layer Chromatography) and GC/MS. Retardation factor($R_f$) values and UV spectral data of HPTLC were investigated for 160 pesticides, 34 chemicals and 39 explosives of standard grade. The data were compiled in a library. We also analyzed 112 pesticides, 31 chemicals and 17 explosives and 57 volatile organic compounds(VOCs) by GC/MS. The data for RT and characteristic mass ions were also compiled in a library.

  • PDF

Lidocaine Intoxication: Two Fatal Cases

  • Lee, Sang-Ki;Lee, Soo-Yeun;In, Sang-Whan;Choi, Hwa-Kyung;Lim, Mi-Ae;Chung, Kyu-Hyuck;Chung, Hee-Sun
    • Archives of Pharmacal Research
    • /
    • v.26 no.4
    • /
    • pp.317-320
    • /
    • 2003
  • We present two fatal cases, a 41-year-old male (case 1) and his 8-year-old daughter (case 2), resulting from acute lidocaine poisoning. Lidocaine was quantified by gas chromatography (GC) analysis using nitrogen-phosphorus detection. The lidocaine concentrations of cases 1 and 2 were: liver, 27.7 $\mu$ g/g and 24.9 $\mu$g/g; spleen, 70.1 $\mu$g/g and 29.9 $\mu$g/g; and gastric contents, 23.6 $\mu$g/g and 42.8 $\mu$g/g, respectively.

Rapid Screening Method for the Solid-Phase Extraction and GC/MS analysis of Diazepam.

  • Choi, Hwa-Kyung;Lee, Ju-Seon;Choi, Hye-Young;Woo, Sang-Hee;Park, Yoo-Sin;Chung, Hee-Sun
    • Proceedings of the PSK Conference
    • /
    • 2003.10b
    • /
    • pp.118.3-119
    • /
    • 2003
  • Diazepam (DZ) is one of the most frequently prescribed drugs as an antianxiety agent, muscle relaxant, and anticovulsant and sometimes causes intoxication due to accidental overdose, misuse or abuse. Screening or confirmation methods for DZ and NDZ in plasma are very important for clinical and toxicological studies and in forensic cases. GC/MS assay with SPE was developed for the determination of diazepam and its metabolite, nordiazepam in human plasma. Diazepam in plasma was extracted by a rapid and sensitive procedure based on C18 bonded-phase extraction. (omitted)

  • PDF

Colchicine poisoning

  • Lee, Ju-Seon;Choi, Hwak-Yung;Choi, Hye-Young;Woo, Sang-Hee;Park, Yoo-Sin;Chung, Hee-Sun
    • Proceedings of the PSK Conference
    • /
    • 2003.10b
    • /
    • pp.117.1-117.1
    • /
    • 2003
  • Colchicine is a drug well known for its use in the therapy of acute attacks of gouty arthritis. Two death caused by oral ingestion of colchicine was reported. Two persons were all women. The one was 34 years old woman and with his boyfriend in a inn and the other was a housewife. The first one was a alcoholic but his boyfriend was afflicted with gout. So her boy friend carried over about 60 tablets of colchicine, 4 tablets of naltrexone and 22 tablets of fluoxetine. After her death there were remained colchicine, 2 tabs, naltraxone 4 tabs and fluoxetine 22 tabs. (omitted)

  • PDF

Report on the trends of the Drug Abuse and the Mortalities related to Intoxication of Drug-Toxic Substances in the Central Area of Korea in 2001

  • Baeck, Seung-Kyung;Kim, Sun-Chun;Sihn, Sihn-Young;Son, Young-Mi;Park, Yun-Sin;Seo, Joong-Seok
    • Proceedings of the PSK Conference
    • /
    • 2002.10a
    • /
    • pp.280.2-281
    • /
    • 2002
  • This presentation reports the trends of the drug abuses(DA) and the mortalities related to drug-toxicants(MDT) in the Central area of Korea in 2001. We surveyed the DA cases and MDT. which were requested to analyze the drug-toxicants in the Central district office of National Institute of Scientific Investigation. he detected drugs on DA cases were methamphetamine. marihuana. opiates. inhalants(toluene. butane. ropane). dextromethorphane. carisoprodol. benzodiazepines, nalbuphine. fenfluamine. and iscellaneous in order of cases. Men are more liable to drug abuses than women. and the most common age group was 30s. Surveys of MDT shows that the defected toxicants are paraquat(sedative). methomy(insecticide). dicholrvos (insecticide). benxodiaxeqines(anxiolytic), and miscellaneous in order do cases. Men's intoxications by the drug-toxicants are more occured than woman's And most common intoxicated age group was 40s. These trends of the DA cases and the MDT in Central Area fo Korea. can help the forensic toxicologists and government to plan the prevention policy of the DA cases and MDT as well as its future estimation.

  • PDF

A Study on Measuring and Ignition Characteristics of Gunpowder by Using a Revolver (총기사용에 따른 화약잔사 실측 및 발화특성에 관한 연구)

  • Song, Jae-Yong;Choi, Young-Woo;Nam, Jung-Woo;Kim, Dong-Hwan;Kim, Jin-Pyo;Kim, Yoon-Hoi;Kim, Sang-Hyun
    • Proceedings of the Korea Institute of Fire Science and Engineering Conference
    • /
    • 2010.04a
    • /
    • pp.481-486
    • /
    • 2010
  • 본 논문은 실내사격장 화재 원인에 대한 조사를 위하여 권총 사용에 따른 화약잔사 양에 대한 실측 및 발화특성에 관하여 연구하였다. 화약잔사 양의 실측은 1차로 사대 부분을 밀폐한 상태에서 실내사격장에 사용되는 권총과 동일한 구경 0.38인치 권총 및 구경 9mm 권총을 5발 발사하여 총구 및 약실로 분출되는 화약잔사의 양을 측정하였으며, 2차로 사대 개방 후, 구경 0.38인치 권총을 100발 발사하는 경우, 사대 바닥면에 떨어지는 화약잔사의 양을 측정하였다. 화약잔사에 대한 발화특성은 충격 감도, 정전기 감도, 마찰 감도 및 발화점 시험을 실시하였으며, 비교 평가에는 권총에 일반적으로 사용되는 사용전의 화약(ball powder)을 이용하여 화약잔사와 동일한 시험을 실시하였다. 실험결과 충격감도 및 마찰강도는 화약잔사에서 다소 높게 측정되었으며, 발화점 시험에서는 화약잔사가 비교대상인 사용전의 화약에 비해 낮은 온도에서 발화되는 특성을 나타내었다.

  • PDF

Development of rapid. sensitive and reproducible paraquat analysis method in the postmortem specimens.

  • Sihn, Y.S.;Baeck, S.K.;Kim, S.C.;Park, Y.S.
    • Proceedings of the PSK Conference
    • /
    • 2002.10a
    • /
    • pp.284.3-285
    • /
    • 2002
  • Paraquat(methyl viologen) is a bis-quaternary ammonium compound as a wide range herbicide. which was first introduced as an oxidation-reduction indicator dye. When paraquat(fatal dose. 1-2g) was administered to men, the oxido-reduction system of cell was repeatedly acted to perpetuate the cell membrane system, Many death cases had been occurred after ingestion of paraquat around Daejon area for the last six months. (omitted)

  • PDF

Comparative Studies on the Detection of Drug-Toxic Substances in the Formalin Fixedand Unfixed Tissue Specimens

  • Baeck, Seung-Kyung;Sihn, Young-Sihn;Kim, Sun-Chun;Lee, Bong-Woo
    • Proceedings of the PSK Conference
    • /
    • 2002.10a
    • /
    • pp.284.2-284.2
    • /
    • 2002
  • Gastric contents and blood samples are generally analyzed for the detection of the Drug-toxic substances(DTS) in the postmortem specimens, but tissue specimens from postmortem for the detection of the DTS are, especially, required in the cases that analysis of DTS in blood or gastric contents is impossible because of insufficient or inaccessible specimens in special cases. (omitted)

  • PDF