• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.1
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• pp.65-70
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• 2020

This paper describes hierarchically stratifying and analyzing haplotrees of haplogroups from haplotypes on the Y and X chromosomes of human cells for genetic and Korean traditional and genealogical trees. The specific region is Chungcheong province, and the Y-DNA of the paternal lines has high frequency of O3a∗ and O2b∗ in the O group, and the mtDNA of the maternal line has a relatively high frequency of D∗ and M∗ in the L3 group. Each combination of these constructs the family tree of the father lines and mother lines. Genetic distances using Nei's standard genetic distance, are very close relatives of less than 0.1 and close relatives of 0.1 to 0.8. Provided, the distance is more than 1.0, it is difficult to estimate relatives. STR has the identified kinship, and SNP has the personal genetic identification. A scientific stratification of the Korean genealogical tree is created by the three factors.

• Journal of Environmental Health Sciences
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• v.48 no.4
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• pp.206-215
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• 2022

Background: Fragrance substances in consumer products can cause adverse health effects such as contact allergy. In South Korea, consumer chemical products must list 26 known fragrance allergens on product labels when they contain more than 0.01%. Fragrance substances are mostly used in combination, so co-exposure can occur via use of a consumer chemical product. Co-exposure to fragrance allergens may show a synergistic effect on the human body. Objectives: The aims of the study were to analyze the characteristics of fragrance allergens in consumer chemical products available on public websites and to identify the co-occurrence patterns of fragrance allergens. Methods: The chemicals in 1,443 ingredient disclosures for consumer chemical products were collected through the Ecolife database. The 26 labelled fragrance allergens were identified by category of consumer chemical product. The co-occurrence patterns of the 26 labelled fragrance allergens were analyzed by frequent pattern mining. The unlabelled fragrance allergens presented by European Union Scientific Committee on Consumer Safety were also identified. Results: Consumer chemical products contained an average of 5.3±4.2 substances among the 26 labelled fragrance allergens. More than 85% of air fresheners, deodorizing agents, and fabric softeners contained at least one of the 26 labelled fragrance allergens. The most frequently contained fragrance allergens were limonene (50.5%), linalool (49.9%), hexyl cinnamal (34.0%), and citronellol (28.3%). 16.7% of consumer chemical products showed a co-occurrence of limonene, linalool, hexyl cinnamal, and citronellol. Thirty-eight unlabelled fragrance allergens were found in the consumer chemical products, with hexamethylindanopyran (25.2%) being the most frequently contained substance. Conclusions: The characteristics and co-occurrence patterns of 26 labelled fragrance allergens would be useful information for the management of co-exposure to fragrance allergens in consumer chemical products. It is necessary for attention to be paid to unlabelled fragrance allergens.

• International Journal of Computer Science & Network Security
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• v.22 no.3
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• pp.364-374
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• 2022

Health information systems (HIS) are facing security challenges on data privacy and confidentiality. These challenges are based on centralized system architecture creating a target for malicious attacks. Blockchain technology has emerged as a trending technology with the potential to improve data security. Despite the effectiveness of this technology, still HIS are suffering from a lack of data privacy and confidentiality. This paper presents a blockchain-based data storage security architecture integrated with an e-Health care system to improve its security. The study employed a qualitative research method where data were collected using interviews and document analysis. Execute-order-validate Fabric's storage security architecture was implemented through private data collection, which is the combination of the actual private data stored in a private state, and a hash of that private data to guarantee data privacy. The key findings of this research show that data privacy and confidentiality are attained through a private data policy. Network peers are decentralized with blockchain only for hash storage to avoid storage challenges. Cost-effectiveness is achieved through data storage within a database of a Hyperledger Fabric. The overall performance of Fabric is higher than Ethereum. Ethereum's low performance is due to its execute-validate architecture which has high computation power with transaction inconsistencies. E-Health care system administrators should be trained and engaged with blockchain architectural designs for health data storage security. Health policymakers should be aware of blockchain technology and make use of the findings. The scientific contribution of this study is based on; cost-effectiveness of secured data storage, the use of hashes of network data stored in each node, and low energy consumption of Fabric leading to high performance.

• Journal of Veterinary Science
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• v.25 no.3
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• pp.40.1-40.19
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• 2024

Importance: The creation of robust maternal-embryonic interactions and implantation models is important for comprehending the early stages of embryonic development and reproductive disorders. Traditional two-dimensional (2D) cell culture systems often fail to accurately mimic the highly complex in vivo conditions. The employment of three-dimensional (3D) organoids has emerged as a promising strategy to overcome these limitations in recent years. The advancements in the field of organoid technology have opened new avenues for studying the physiology and diseases affecting female reproductive tract. Observations: This review summarizes the current strategies and advancements in the field of 3D organoids to establish maternal-embryonic interaction and implantation models for use in research and personalized medicine in assisted reproductive technology. The concepts of endometrial organoids, menstrual blood flow organoids, placental trophoblast organoids, stem cell-derived blastoids, and in vitro-generated embryo models are discussed in detail. We show the incorportaion of organoid systems and microfluidic technology to enhance tissue performance and precise management of the cellular surroundings. Conclusions and Relevance: This review provides insights into the future direction of modeling maternal-embryonic interaction research and its combination with other powerful technologies to interfere with this dialogue either by promoting or hindering it for improving fertility or methods for contraception, respectively. The merging of organoid systems with microfluidics facilitates the creation of sophisticated and functional organoid models, enhancing insights into organ development, disease mechanisms, and personalized medical investigations.

• Journal of Ginseng Research
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• v.48 no.3
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• pp.245-252
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• 2024

Ginseng is a traditional herbal medicine used for prevention and treatment of various diseases as a tonic. Recent scientific cohort studies on life prolongation with ginseng consumption support this record, as those who consumed ginseng for more than 5 years had reduced mortality and cognitive decline compared to those who did not. Clinical studies have also shown that acute or long-term intake of ginseng total extract improves acute working memory performance or cognitive function in healthy individuals and those with subjective memory impairment (SMI), mild cognitive impairment (MCI), or early Alzheimer's disease (AD) dementia who are taking AD medication(s). Ginseng contains various components ranging from classical ginsenosides and polysaccharides to more recently described gintonin. However, it is unclear which ginseng component(s) might be the main candidate that contribute to memory or cognitive improvements or prevent cognitive decline in older individuals. This review describes recent clinical contributors to ginseng components in clinical tests and introduces emerging evidence that ginseng components could be novel candidates for cognitive improvement in older individuals, as ginseng components improve SMI cognition and exhibits add-on effects when coadministered with early AD dementia drugs. The mechanism behind the beneficial effects of ginseng components and how it improves cognition are presented. Additionally, this review shows how ginseng components can contribute to SMI, MCI, or early AD dementia when used as a supplementary food and/or medicine, and proposes a novel combination therapy of current AD medicines with ginseng component(s).

• Journal of Astronomy and Space Sciences
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• v.41 no.1
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• pp.1-15
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• 2024

The Korean heliospheric community, led by the Korea Astronomy and Space Science Institute (KASI), is currently assessing the viability of deploying a spacecraft at the Sun-Earth Lagrange Point L4 in collaboration with National Aeronautics and Space Administration (NASA). The aim of this mission is to utilize a combination of remote sensing and in situ instruments for comprehensive observations, complementing the capabilities of the L1 and L5 observatories. The paper outlines longterm scientific objectives, underscoring the significance of multi-point in-situ observations to better understand critical heliospheric phenomena. These include coronal mass ejections, magnetic flux ropes, heliospheric current sheets, kinetic waves and instabilities, suprathermal electrons and solar energetic particle events, as well as remote detection of solar radiation phenomena. Furthermore, the mission's significance in advancing space weather prediction and space radiation exposure assessment models through the integration of L4 observations is discussed. This article is concluded with an emphasis on the potential of L4 observations to propel advancements in heliospheric science.

• Journal of Digestive Cancer Research
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• v.12 no.2
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• pp.115-130
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• 2024

The incidence of hepatocellular carcinoma (HCC) is continuously increasing worldwide, with approximately 1 million new cases expected annually by 2025. Data from the Korean Central Cancer Registry in 2023 revealed that the survival rate of patients with HCC was only 40%, unlike patients with other major cancers with a 5-year survival rate of up to 80%, highlighting the need for improved outcomes. The prognosis of HCC significantly changed following research on immune checkpoint inhibitors (ICIs). Several studies have demonstrated that the overall survival of patients treated with first-line combination therapies, such as atezolizumab (anti-PD-L1) and bevacizumab (anti-VEGF) or durvalumab (anti-PD-L1) and tremelimumab (anti-CTLA-4), was higher than that of patients treated with sorafenib. Research to identify biomarkers that can predict ICI responses is ongoing, enabling the selection of suitable patients before drug initiation. Moreover, studies of the tumor microenvironment in HCC enhance our understanding of immune responses, helping us identify new therapeutic strategies. Additionally, clinical trials are being conducted for emerging immunotherapies beyond ICIs, such as adoptive cell therapy. Based on these ongoing scientific researches and the development of various therapeutic modalities, multiple options are being established for patients with HCC who do not respond well to first-line treatments. Consequently, treatment options and survival rates of patients with advanced HCC could be significantly enhanced in the future.

• Journal of Korean Academy of Nursing
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• v.26 no.4
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• pp.868-877
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• 1996

This study was done to analyze research trends and to suggest future perspectives for nursing research on fatigue. The author reviewed 31 Korean and foreign research papers which have been published in the literature since 1970. An analysis of the study focused on the type of research subjects, type of study design. measurement instrument, and its correlated parameters. The results of the study are summarized as follows : First, within all of the studies analayzed, 14 studies were publised in Korea and 17 were published abroad. The number of studies done abroad have been increasing rapidly since 1991. Second, an analysis of the research design of the studies showed, eight studies each, Korean and foreign used survey design. Two Korean studies and seven foreign studies used a correlational design. Four comparative studies were done in Korea, but only two experimetal studies were performed abroad. Therefore, it was found that the trend of the study design used is survey design and there are more correlational studies done abroad than in Korea. Third, the type of the study subjects ; 11 Korean and three foreign studies dealt with healthy people. In addition, three Korean and 14 foreign studies investigated patients with various illnesses. It was found that patients with various illnesses were studied more frequently in foreign studies than in Korean studies. Fourth, the measurement tool used in the Korean studies ; 13 studies used a testible tool to assess patients' subjective symtoms or complaints of fatigue. The most commonly used tool used in 10 studies, was the Fatigue Self-Perception Scale, which was designed by the Labor and Health Institute of Japan. The Visual Analogue Scale was used in two studies, and Piper Fatigue Scale, addtional with physiologic parameters, was used in one study. In the foreign studies, subjective measurement tools were used in 16 studies. A combination of a subjective measurement tool with objective parameters was used in ten studies. For the subjective measurement tool used in the foreign studies, a specific measurement tool developed by the researcher which was used in seven studies. Either Rhoten Fatigue Scale or the Visual Analog Scale were used in three studies. Additionally, in order to identify the relationship between fatigue and psychological factors, The Profile of Mood State was used in three studies. Beck Depression Inventory was used in two studies. The Self Rated Depression Scale, developed by Zung, was used in one study and other measurement tools were used to measure various psychological parameters. Rhoten fatigue Checklist was also used to observe behavior patterns. Lastly, nine studies identified correlations between fatigue and other parameters. A significant correlation was found between fatigue and psychological factors such as depression, and pain. As a result of the above findings, it can be said that research trends on fatigue are increasing internationally. The selected study designs are survey studies both in Korea and abroad. There are more correlational studies abroad than in Korea. In addition, subjective measurement tools and objective parameters are used variously and combined with each other. had, there is a significant correlation between fatigue and psychological factors such as depression, and pain. More survey and correlational studies need to be done to identify the relationship of fatigue in patients with various condition or diagnoses and to suggest a scientific basis for nursing interventions with fatigue. Also, a tool to assess patient's subjective, objective, and behavioral aspects on fatigue needs to be developed.

• The Korean Journal of Community Living Science
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• v.15 no.4
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• pp.45-60
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• 2004

The purpose of this study was to set related variables for leadership measurement in the leader of a community organization as an effort to Community development constantly. Therefore, in this study, first, various theories on leadership were reviewed. Second, approaches and variable relationships were reviewed by leadership theory study. Third, leadership measurement variables were set based on Bass's Transformational theory, one of new trend theory, to measure the leadership of the community organization leader. As a follow up, clear and scientific analysis, through empirical analysis, based on the variables set in this study will be made to measure leadership of a community organization after creating investigation tools based on the variables set in this study A literature study was mainly used. 'Human Behavior' by Dr Han-geom Lee, 'Leadership Theory' by Eung-seop Shin, many other related books, articles of the Human Relation Organization Association, and theses and Bass's writings. Major findings of this study, through the literature study, were as follows. As conventional leadership theories, characteristics theory, behavior theory and situational leadership theory were proposed. First, characteristics theory searches the characteristics of an effective leader. It proposes that effective leaders and ineffective leaders have different characteristics, respectively. Therefore, it proposes to study the leader's characteristics. However, there is not a flexed definition for leader's characteristics. Scholars make different definition on leader's characteristics, and they are very subjective. Thus it cannot be a valid theory. Second, behavior theory describes how the leader behaves to his fellows. It studies leader's behavior focusing on what type and what combination is the most effective in all situations. However, it has weakness in that it focuses on a leader's behavior only, and ignores the situational features. Third, situational theory describes the relationship between leadership type and situation. It suggests that there is not a single leadership style that can suit all situations. It emphasizes the relationship between leadership type and situation. Although situational theory considers more variables than characteristics theory or behavior theory, it also sees situations as static and flxed. Although Fiedler's theory tried to comply with situations, he did not analyze interactions between a leader and his fellows.

• Journal of Korean Library and Information Science Society
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• v.45 no.3
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• pp.297-319
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• 2014

This research started from bringing up a problem about special situation of the library and information science, which is not easy to investigate its academic characteristics, although it has settled down as a powerful science studying related phenomena as well as education required for the whole process from production of information to consumption of it. Therefore, the purpose of this research is to questingly investigate whether the personal specialty and the experience of taking courses affect recognition of the term 'library and information', and if so, through which channel it influences. In this background, data were collected from 328 students of Chonnam National University for this research, and the following are the analysis results: first, as for the personal characteristics, differences were not generated according to gender and age, but according to scholastic year the results were different; second, as for the experience of taking courses, there were not differences according to whether or not of the experience, but the results varied according to the number and type of the experience; and third, most of the respondents surveyed understood the meaning of a term 'library and information' as the conception of covering the information contained in literature and information of it, regardless of the personal characteristics and the experience of taking courses. Through these results, it can be identified that the term 'library and information' meant in the library and information science is generally understood as expansion of range, rather than chemical combination of literature and information, it is a terminology with various meanings sometimes understood differently according to the special personal experiences, and it also needs scientific investigation of it.