• Journal of Korean Biological Nursing Science
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• 제15권1호
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• pp.15-23
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• 2013

Purpose: The purpose of this study was to identify the relationship among the attitudes on exercise, physical activity and quality of life (QOL) in hemodialysis patients. Methods: A total of 42 patients in a hemodialysis unit participated in this study. Physical activity level was measured directly by 6 minute walking test and grip strength test. Structured questionnaires were also used for measuring their attitudes on exercise, physical activity and QOL. Participants' medical records were reviewed for obtaining their biochemical and clinical information. Statistical analysis was performed using Pearson correlation, and multiple liner regression. Results: A significant positive correlation between participants' attitudes and physical activity level measured by International Physical Activity Questionnaire (IPAQ) was found. And the physical activity level measured by Korea Activity Scale/Index (KASI) was significantly related to QOL. Conclusion: This study shows that QOL of the hemodialysis patients was significantly associated with their physical activity level.

• 대한본초학회지
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• 제22권3호
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• pp.85-91
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• 2007

Objective : In this study, anti-oxidant and cosmeceutical activities of Isatis tinctoria L. extracted from water, ethanol and supercritical fluid condition were confirmed to investigate cosmeceutical activities for utilization as cosmetic ingredient. Methods: Anti-oxidant and cosmeceutical activities were investigated by using electron donating ability, xanthine oxidase, tyrosinase, astringent effect. Result : Isatis tinctoria L. extracts by supercritical fluid, water and ethanol showed good electron donating ability which were 82.7%, 62.6% and 44.8% at the concentration at 1,000ppm, respectively. Xanthine oxidase activity related with purine metabolism was inhibited by ethanol extract about 52.3% at the concentration at 1,000ppm. Tyrosinase inhibition effects, by supercritical fluid extract, ethanol extract and water extract, were 83.3%, 52.9% and 41.2% respectively at 1,000ppm. In the measurement of astringent effect, supercritical fluid extract at the concentration to 5,000ppm showed 85.7% in related activity. The water extract showed 95.9% nitrite scavenging activity at 5,000ppm. Conclusion : According to these results, it is possible that the extract of Isatis tinctoria L. can be used as a new natural material of cosmetic industry.

• Journal of Microbiology and Biotechnology
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• 제33권10호
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• pp.1390-1401
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• 2023

In this study, a 12-week feeding experiment was conducted to characterize the effects of exogenous α-amylase on the growth, feed utilization, digestibility, plasma α-amylase activity, feed degradation rate, and fecal particle size of olive flounder (Paralichthys olivaceus). Diet was supplemented with 0 (AA₀; control), 100 (AA₁₀₀), 200 (AA₂₀₀), or 400 (AA₄₀₀) mg/kg of α-amylase, respectively. Fish (273.1 ± 2.3 g) were stocked into 12 tanks (25 fish/1,000-L tank) and 3 tanks were randomly selected for each diet group. As a result, α-amylase was found to have no significant effects (p ≥ 0.05) on the growth, feed utilization parameters, and whole-body proximate compositions. α-Amylase-treated fish exhibited only a significant increase in the apparent digestibility coefficient of carbohydrates compared to the controls. In addition, in vitro analyses revealed that α-amylase dose-dependently increased (p < 0.05) the feed degradation rate, while photographs of the intestinal content after 2, 4, and 8 h of feeding demonstrated an improved degradation rate in the α-amylase-treated groups. Plasma α-amylase content was higher in the AA₂₀₀ and AA₄₀₀ groups, whereas the control group produced significantly larger-sized fecal particles (90% size class) than these two groups. In the intestine, no changes were observed in the expression levels of the immune-related TNF-α, IL-1β, IL-2, immunoglobulin-M, HSP-70, lysozyme, and amylase alpha-2A. However, growth-related genes IGF-1, IGF-2, TGF-β3, and growth hormone genes were upregulated in muscle tissues. Collectively, exogenous α-amylase has positive roles in the modulation of the digestibility coefficient, blood α-amylase concentration, growth-related gene expression, and diet degradation for improved digestion in olive flounder.

• 생명과학회지
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• 제34권1호
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• pp.28-36
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• 2024

본 연구에서는 현재까지 화장품 소재로써 다양한 연구가 진행되지 않은 현지초 추출물의 효능평가 및 항염 관련 활성 연구를 진행하였다. 현지초 추출물의 항산화능을 확인하기 위해 전자공여능 및 ABTS⁺ 라디칼 소거능을 측정한 결과, 각각 50 ㎍/ml의 농도에서 91%, 94%를 나타내어 항산화능이 우수함을 확인할 수 있었다. 미백활성 측정을 위해 tyrosinase 저해활성 측정을 실시하였으며 최고 농도인 1,000 ㎍/ml에서 24.8%의 저해능이 나타났다. 현지초 추출물의 주름개선 활성을 알아보기 위해 elastase 및 collagenase 저해활성 측정을 실시하였으며 그 결과, 각각 최고 농도인 1,000 ㎍/ml에서 30.6%, 90%의 저해능이 나타났고 collagenase 저해활성에서 우수한 저해능을 확인할 수 있었다. 세포 실험 진행을 위해 현지초 추출물 처리에 따른 대식세포 Raw 264.7의 생존율을 MTT assay에 의거하여 진행하였으며 100 ㎍/ml의 농도에서 83.6% 이상의 세포 생존율을 나타내어 이하의 세포 관련 실험 진행은 100 ㎍/ml 이하의 농도의 현지초 추출물을 가하여 실험을 실시하였다. NO assay에 의하여 현지초 추출물 처리에 따른 NO 생성 저해 활성을 측정한 결과, 100 ㎍/ml의 농도에서 74.9%의 저해율을 확인하였다. 단백질 발현 억제능을 알아보기 위해 western blot을 진행하였으며 현지초 추출물은 COX-2 및 iNOS 두 인자 모두 농도의존적으로 단백질 발현량이 저해됨을 확인할 수 있었다. 이러한 결과들에 의해 현지초 추출물은 항염 관련 기능성 화장품 소재로써 활용 가능성이 있다고 사료된다.

• 한국식품조리과학회지
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• 제27권4호
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• pp.75-87
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• 2011

This study was conducted to examine the effect of children's dietary quality, dietary habits, food behavior and health-related lifestyles according to the mother's lifestyles of health and sustainability (LOHAS). The subjects were 580 children. Mother's LOHAS attitude index was 66.85 points and 100 points was a perfect score. The mother's high LOHAS attitude items that children perceived were "My mother often communicates with the family"(3.99 points) and "My mother thinks that the family's health is more important than her health"(3.93 points). In contrast, the LOHAS attitude items for "My mother does community service activity on weekends"(2.78 points), and "My mother participates in environmental protection service activity for the local community"(2.78 points) were very low. The high LOHAS behavior index of mothers was "resource saving", whereas "social welfare" scored low. When self-perceived health status and monthly income of children was high, the mother's LOHAS score was high. The LOHAS attitude index of mothers had a meaningful impact on the children's dietary quality, dietary habits, food behavior and health-related lifestyles. The most frequent food behavior variables were "high skipping rate", "frequency of snacks is 2~4 times per week", "speed of eating is rapid", and 'meals' amount is sufficient. The highest daily life habits item was "I try to maintain a pleasant and enjoyable life style"(3.42 points). The highest nutrient intake attitude score was "I tend to eat rice everyday."(3.41 points). They were highly recognized with "moderate physical activity", "high exercise preference", "positive posture exercise", "exercise <2 days per week", and "over 30 minutes exercise time per day" for the exercise performance status items. It was verified that the higher mother's LOHAS lifestyle score is, the higher children's food behavior, daily life habits, nutrient intake, exercise performance state score are.

• Journal of Nutrition and Health
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• 제51권4호
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• pp.316-322
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• 2018

Purpose: The Glycyrrhiza uralensis species (Leguminosae) as a medicinal biocompound, and one of its root components, isoliquritigenin (ISL), which is a flavonoid, has been reported to have anti-tumor activity in vitro and in vivo. However, its function in bone formation has not been studied yet. In this study, we tested the effect of Glycyrrhiza uralensis (ErLR) and baked Glycyrrhiza uralensis (EdLR) extracts on osteoblast proliferation, alkaline phosphatase (ALP) activity, and bone-related gene expression in osteoblastic MC3T3-E1 cells. Methods: MC3T3-E1 cells were cultured in various levels of ErLR (0, 5, 10, 15, $20{\mu}g/mL$), EdLR (0, 5, 10, 15, $20{\mu}g/mL$), or ISL (0, 5, 10, 15, $20{\mu}M$) in time sequences (1, 5, and 20 days). Also, isoliquritigenin (ISL) was tested for comparison to those two biocompound extracts. Results: MTT assay results showed that all three compounds (ErLR, EdLR, and ISL) increased osteoblastic-cell proliferation in a concentration-dependent manner for one day. In addition, both ErLR and EdLR compounds elevated the osteoblast proliferation for 5 or 20 days. Extracellular ALP activity was also increased as ErLR, EdLR, and ISL concentration increased at 20 days, which implies the positive effect of Glycyrrhiza species on osteoblast mineralization. The bone-related marker mRNAs were upregulated in the ErLR-treated osteoblastic MC3T3-E1 cells for 20 days. Bone-specific transcription factor Runx2 gene expression was also elevated in the ErLR- and EdLR-treated osteoblastic MC3T3-E1 cells for 20 days. Conclusion: These results demonstrated that Glycyrrhiza uralensis extracts may be useful for preventing osteoporosis by increasing cell proliferation, ALP activity, and bone-marker gene expression in osteoblastic cells.

• 대한화장품학회지
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• 제50권2호
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• pp.131-141
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• 2024

본 연구에서는 흑진미(Oryza sativa cv. Heugjinmi) 추출물을 이용하여 항산화 및 미백 관련 기능성 화장품 소재로서의 활용 가능성을 검증하고자 항산화 및 미백 관련 인자들의 효능을 분석하였다. 그 결과, SOD 유사 활성, FRAP, 환원력, xanthine oxidase 저해 활성, elastase저해 활성에서 대조군과 유사한 활성을 나타내었다. Tyrosinase 저해 활성은 열수 추출물에서는 효과가 없었고 에탄올 추출물에서는 59%의 억제 활성을 나타내었다. 에탄올 추출물은 B16F10 세포주에서 생존율에 영향을 미치지 않을 농도인 25, 50, 100 ㎍/mL 농도에서 cellular tyrosinase와 멜라닌 생합성을 저해하는 것으로 확인되었다. 또한, tyrosinase, TRP-1, TRP-2의 mRNA 발현을 확인한 결과는 최고농도인 100 ㎍/mL에서 각각 37%, 51%, 34%의 억제율을 보였다. 따라서 흑진미(O. sativa) 추출물은 항산화 및 미백 관련 기능성 화장품 소재로서의 활용 가능성이 있을 것으로 판단된다.

• 한국초등과학교육학회지:초등과학교육
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• 제38권1호
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• pp.43-54
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• 2019

In order to organize various places for science experience study, this study gathered and analyzed prior research on science experience study and various science experience perated in school. To that end, a total of 162 relevant prior studies of literature published from 2000 to 2016 were collected and 2,201 cases of science experience study conducted in 2015 were collected and analyzed. The place where the science experiential learning was done is divided into three areas of natural ecology, cultural history, facility experiential learning study, and the characteristics of participating subjects are examined. In terms of the number of articles published in the field of science-related experiential learning areas, 83 ecological experience study sites (51.2%), facilities institution experience study sites 56 (34.6%), and cultural history experience study books 23 (14.2%). Through this study, it was found out that research tendency to analyze science - related attitudes became prominent by setting study subjects using natural objects around and learning to play while playing and playing in nature. There was also an analysis by subjects of participation in science related experience learning centers. Cultural history experiential learning field was significantly lower than previous studies. In the lower grades, nature ecological experience learning was mainly performed. Combining the above findings, it can provide implications for the development of science-related experience activities. First, it is necessary to develop a technology-related experience learning center using local community resources. Second, it is necessary to expand the culture and history experience learning center related to science. Third, we need an education support center to support the expansion and operation of such a technology-related cultural history learning center.

• 동서간호학연구지
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• 제13권1호
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• pp.57-65
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• 2007

Purpose: This study was conducted to explore sexual attitude, sexual behavior and the related factors in chinese-Korean university students. Method: A self-administered questionnaire with cross-sectional design was used. Participants were 271 Chinese undergraduate students in one university in Jilin, China. Correlation coefficiency and t-test were used to find the relationships and to compare sexual attitude and sexual behavior and related factors. Result: Although sexual attitude of participants was moderate, they were more likely to be engaged in sexual behavior. The strong relationship between sexual attitude and sexual behavior suggested that those who have a permissive sexual attitude were more likely to have engaged in sexual behavior. The participants who responded that their parents have a less permissive attitude about sexual activity were less likely to be engaged in sexual behavior. There were significant relationships between sexual behavior and other variables, such as dating, experience of sexual activity, smoking and grades. Conclusion: Students who have a higher score of sexual attitude and had an experience of sexual activity were more likely to be at higher risk of being sexually.

• 한국도서관정보학회지
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• 제38권1호
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• pp.315-339
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• 2007

본 연구에서는 공공도서관의 독서 활성화를 위해서 기존의 독서 교육이나 독서 프로그램과 차별화된 자관만의 특화서비스 프로그램 개발사례를 중심으로 살펴보고자 한다. 이를 위해 기존 공공도서관의 기능에서 확대된 특화서비스 프로그램의 필요성. 프로그램 개발과 구축에 관하여 살펴본 후, 현재 국내 공공도서관의 독서 관련 활동, 한 도서관 한 책읽기 행사 현황과 미국 공공도서관의 독서활동 프로그램을 분석하였다. 또한, 독서 관련 특화서비스 프로그램의 개발 및 구축 사례 분석 결과를 통해 향후 공공도서관의 독서 활성화 방안을 제안하였다.