• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.4
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• pp.141-157
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• 2014

Objectives : The purpose of this study is to investigate the effects of DOGO phreatic water containing germanium on Atopic Dermatitis in NC/Nga mouse. Methods : We made DOGO phreatic water added germanium. After making atopic dermatitis caused by sensitizing NC/Nga mouse to DNCB(dinitrochlorobenzene), we made mouse swim in tanks each filled with distilled water, tap water, DOGO phreatic water, DOGO phreatic water(added germanium) for 30minutes everyday. 3weeks later, we analyzed skin clinical score, total IgE levels(by ELISA), WBC differential counting(Neutrophils, Monocytes), absolute cell number of $Neutrophil^+Gr-1^+$, CCR3 mRNA expressions(by Real-time PCR), IL-4, IFN-${\gamma}$ production levels(by ELISA), histologic test(by H&E staining, toluidine blue staining). Results : The results of making NC/Nga mouse induced atopic dermatitis swim in tanks filled with DOGO phreatic water(contain germanium) are as follows. 1. Skin clinical scores were decreased significantly in comparison to control group. 2. Total IgG levels were decreased significantly in comparison to control group. 3. WBC differential counting(Neutrophils, Monocytes) were decreased significantly in comparison to control group. 4. Absolute cell number of $Neutrophil^+Gr-1^+$ were decreased significantly in comparison to control group. 5. CCR3 mRNA expressions were decreased significantly in comparison to control group. 6. IL-4, IFN-${\gamma}$ production levels were decreased significantly in comparison to control group. 7. The epithelial tissue thickness, leucocytes infiltration, erythema, edema, excoriation, scaling, mast cells infiltrations in dorsal skin were decreased in comparison to control group. Conclusions : These results indicate that DOGO phreatic water(contain germanium) can be used for helping treat atopic dermatitis.

• Journal of Science Education
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• v.42 no.3
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• pp.308-321
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• 2018

The purpose of the study is to develop a questionnaire that examines unskeptical attitudes in scientific inquiry context. The questionnaire items were developed through literature research, expert review, and statistical analyses for validity and the differences in scores were identified by gender and tracks. A total of 363 high school students participated in the study. To explore the validity evidence of items, the Rasch analysis and the reliability of internal consistency were performed, and the two-way ANOVA was performed to compare the scores of the unskeptical attitudes between gender and academic track. Self-reporting and Likert-scaling 23 items were developed to measure unskeptical attitudes in scientific inquiry context. The items were developed in the sub-domain of scientific inquiry: 'questioning and hypothesis generating,' 'experiment designing,' and 'explaining and interpreting.' Second, the validity and reliability of the unskeptical were identified in a rigorous method. The validity of items were identified by multi-dimensional partial score model analysis through the Rasch model, and all 23 items were found to be fit to model. Various reliability evidences were also found to be appropriate. It was found that there were no significant differences of unskeptical attitude score between the gender and academic track except one comparison. The developed questionnaire could be used to check an unskeptical attitude in the course of scientific inquiry and to compare the effects of scientific inquiry classes.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.26 no.3
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• pp.167-182
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• 2021

This study was carried out to investigate temporal and spatial distribution of macrobenthic community and elucidate effects of environmental factors on change of community structure in an intertidal flat, Hakseong-ri, Boryeong, Korea. Field surveys were seasonally conducted to collect samples of sediment and macrobenthos using can core in triplicate at nine stations in 2016 and 2017. Our results showed that sediment had high mud content (above 60%) in most samples and mean content of loss on ignition was 2.3% in 2016. A total of 79 species was collected in the study site during the study period. Mean density and biomass were 611 ind./m² and 64.1 gWWt/m², respectively. Heteromastus filiformis was the dominant species (48.6%, 297 ind./m²) followed by Macrophthalmus japonicus (10.1%, 62 ind./m²) and Upogebia major (6.9%, 42 ind./m²). Three assembly groups resulted from cluster analysis were more distinguished by interaction between organisms and frequency of dominant species than by physical and chemical environment characteristics. In addition, macrobenthic community in the Hakseong intertidal flat showed seasonal changes based on non metric multidimensional scaling using species abundance.

• Korean Journal of Ecology and Environment
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• v.54 no.2
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• pp.87-95
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• 2021

Macroinvertebrates in forest streams affect the overall health of other streams in the same water system. In this study, we compared differences in the benthic macroinvertebrate community at two headwater streams located at different latitudes in the southern and northern parts of South Korea. We calculated the community temperature index (CTI), which represents the thermal preferences of the benthic communities. Hierarchical cluster analyses (HCA) were conducted to compare the similarities among sampling sites. In addition, we analyzed the relationship between community composition and environmental and community characteristics using non-metric multidimensional scaling (NMDS). Our results showed that CTI was significantly different between the two regions, indicating that these benthic macroinvertebrate communities have different thermal preferences. These two regions were clearly distinguished from each other in the HCA; furthermore, seasonal differences in benthic community composition were observed within each region. The functional feeding groups present in the benthic macroinvertebrate communities were different even though their habitat was similar.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.3
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• pp.121-143
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• 2021

As the social economy emerges as one of the alternatives for solving social problems, interest and experiments on social franchise, a methodology for scaling the social economy, continue to increase. The success or failure of social franchise has a huge impact on franchisors, members of franchisees, as well as beneficiaries, local residents, and stakeholders in the region, but research on ways to increase their chances of success is still insufficient. Based on previous studies, this study tried to derive success factors by analyzing the effects of social franchise characteristics on business performance, and to understand the mediating effect of franchise autonomy, which is the differentiation point of social franchises, between characteristic factors and business performance. Social value orientation, social economy experience, local network utilization, and customer orientation were derived as characteristic factors affecting business performance, and franchise autonomy was set as a mediating variable, and a survey was conducted for franchisee members and their influence was analyzed. Through this study, it was found that social economy experience and local network utilization had a positive (+) effect on economic performance, and social value orientation, local network utilization, and customer orientation had a positive (+) effect on social performance. Also, the results of franchise autonomy playing a mediating role between social economy experience, local network utilization and economic performance, and a mediating role between local network utilization and social performance were presented. This study has significance as the first study to conduct a full-scale empirical study on social franchises. It is hoped that theoretical research on social franchises will be more active in the future and will be used as a useful reference for performance creation for organizations that seek or already operate social franchises.

• The Journal of the Acoustical Society of Korea
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• v.41 no.1
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• pp.64-69
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• 2022

Background music is presented simultaneously with target messages. The main content should be kept intact for some time to aid decision making process. The maintenance of this information requires auditory working memory. The temporal compression of background music may often adopted due to the limitation of the presentation time. In this study, auditory working memory and decision making proces were analyzed in terms of temporal compression ratios of the background music. A total of 37 subjects of early twenties joined the study. Selected products were categorized based on eigen values of multi-dimensional scaling. Four presentation conditions were cases with no background music, background music with no compression, background music with low compression, and background music high compression. Matched reponses were analyzed through repeated ANOVA. Results showed that the high involvement product required more working memory resources. However, the increased level of usage did not always lead to the corresponding changes in decision making process. This approach may be useful in analyzing the role of time compression and working memory in consumer behaviors.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.32 no.5
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• pp.1019-1034
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• 2022

Malware attacks become more prevalent in the hyper-connected society of the 4th industrial revolution. To respond to such malware, automation of malware detection using artificial intelligence technology is attracting attention as a new alternative. However, using artificial intelligence without collateral for its reliability poses greater risks and side effects. The EU and the United States are seeking ways to secure the reliability of artificial intelligence, and the government announced a reliable strategy for realizing artificial intelligence in 2021. The government's AI reliability has five attributes: Safety, Explainability, Transparency, Robustness and Fairness. We develop four elements of safety, explainable, transparent, and fairness, excluding robustness in the malware detection model. In particular, we demonstrated stable generalization performance, which is model accuracy, through the verification of external agencies, and developed focusing on explainability including transparency. The artificial intelligence model, of which learning is determined by changing data, requires life cycle management. As a result, demand for the MLops framework is increasing, which integrates data, model development, and service operations. EXE-executable malware and documented malware response services become data collector as well as service operation at the same time, and connect with data pipelines which obtain information for labeling and purification through external APIs. We have facilitated other security service associations or infrastructure scaling using cloud SaaS and standard APIs.

• The Journal of Engineering Geology
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• v.33 no.2
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• pp.257-273
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• 2023

Hydrochemical characteristics and microbial communities of spring (Samtong), surface water, and groundwater in Cheorwon, Korea, were analyzed. Field surveys and water quality analyses were undertaken at 10 sampling points for five spring, two surface, and three groundwater samples on 15 December 2022. Hydrochemical analysis revealed that most water samples were Ca-HCO₃ type and that water-rock interactions were the predominant mineral source. Radon concentrations were <1 kBq m^-3 for surface water, 1~10 kBq m^-3 for spring water, and 1~1,000 kq m^-3 for groundwater. Microbial cluster analysis showed that the main phyla were Proteobacteria, Planctomyceta, Verrucomicrobia, Acidobacteria, and Actinomycetota.Non-metric multidimensional scaling (NMDS) analysis indicated that water temperature, pH, and Si content were closely related to microorganism content. NMDS and canonical correspondence analysis results revealed that environmental factors affecting spring water were temperature, and Mg and Si concentrations, particularly for Acidobacteria and Proteobacteria, and Pseudomonas brenneri. Both hydrochemical and microbial community analyses yielded similar results at some spring and groundwater sampling points, likely due to the effects of a basalt aquifer.

• Journal of Korea Water Resources Association
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• v.57 no.6
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• pp.409-419
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• 2024

Climate change is already impacting sustainable water resource management. The influence of climate change on water supply from reservoirs has been generally assessed using climate change scenarios generated based on global climate models. However, inherent uncertainties exist due to the limitations of estimating climate change by assuming IPCC carbon emission scenarios. The decision scaling approach was applied to mitigate these issues in this study focusing on four reservoir watersheds: Chungju, Yongdam, Hapcheon, and Seomjingang reservoirs. The reservoir water supply reliablity was analyzed by combining the rainfall-runoff model (IHACRES) and the reservoir operation model based on HEC-ResSim. Water supply reliability analysis was aimed at ensuring the stable operation of dams, and its results ccould be utilized to develop either structural or non-structural water supply plans. Therefore, in this study, we aimed to assess potential risks that might arise during the operation of reserviors under various climate conditions. Using observed precipitation and temperature from 1995 to 2014, 49 climate stress scenarios were developed (7 precipitation scenarios based on quantiles and 7 temperature scenarios ranging from 0℃ to 6℃ at 1℃ intervals). Our study demonstrated that despite an increase in flood season precipitation leading to an increase in reservoir discharge, it had a greater impact on sustainable water management compared to the increase in non-flood season precipitation. Furthermore, in scenarios combining rainfall and temperature, the reliability of reservoir water supply showed greater variations than the sum of individual reliability changes in rainfall and temperature scenarios. This difference was attributed to the opposing effects of decreased and increased precipitation, each causing limitations in water and energy-limited evapotranspiration. These results were expected to enhance the efficiency of reservoir operation.

• Journal of Periodontal and Implant Science
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• v.24 no.2
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• pp.219-237
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• 1994

The ultimate goal of clinical periodontal therapy is to achieve regeneration of a healthy connective tissue reattachment. Conventional therapy including scaling, root planing, gingival curettage, gingivectomy and flap procedures of various types results primarily in repair rather than regeneration of the periodontium. In order for periodontal regeneration to occur, progenitor periodontal ligament cells must migrate to the denuded root surface, attach to it, proliferate and mature into an organized and functional fibrous attachment apparatus. Polypeptide growth factors belong to a class of potent biologic mediators which regulate cell differentiation, proliferation, migration and metabolism. Insulin-like growth factor-I (IGF- I ) of these factors appear to have an important role in periodontal wound healing and bone formation. The purpose of this study is to evaluate the effects of IGF- I on the periodontal ligament cells to use as a regeneration promoting agent of periodontal tissue. Human periodontal ligament cells were obtained from periodontal tissue explants culture of the first premolar tooth extracted for the orthodontic treatment. Cells were cultured in Dulbecco's modified Eagle medium(DMEM) with 10% fetal bovine serum. Fourth to seventh passage cells were plated in 24 well tissue culture plates and medium changed to serum-free medium prior to addition of growth factors. Cell proliferation was measured by the incorporation of $[^3H]-thymidine$ into DNA, Protein synthesis was determined by measurement of $[^3H]-proline$ incorporation into collagenase-digestible protein(CDP) and noncollagenous protein(NCP) according to the method of Peterkofsky and Diegelmann (1971), And alkaline phosphatase activity was measured as one parameter of osteoblastic differentiation. The results were as follows : The DNA synthetic activity was increased in a dose-dependent manner with IGF- I except for 0.1ng/ml concentration of IGF- I At the concentration of 10, 100ng/ml, IGF- I significantly increased the DNA synthetic activity(P<0.05) The total protein, collagen and noncollagen synthesis was increased in a dose-dependent manner with IGF- I except for 0.1ng/ml concentration of IGF- I. At the concentration of 1, 10, 100ng/ml, IGF- I significantly increased the total protein, collagen and noncollagen synthesis activity(P<0.95, P<0.001). The % of collagen was not effected according to the concentration of IGF- I. The alkaline phosphatase activity was increased in a dose-, time-dependent manner with IGF- I (10, 100ng/ml). In conclusions, the present study shows that IGF- I has a potentiality to enhance the DNA synthesis of periodontal ligament cells with including the increase of the total protein and collagen synthetic activity. The use of IGF- I to mediate biological stimulation of periodontal ligament cells shows promise for future therapeutic applications.