• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.958-960
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• 2015

Sickle cells possess a unique combination of traits that may enable their use as models for novel synthetic tumor targeting controlled release drug carriers with the ability to treat disseminated tumors in advanced metastatic disease. In this study, we assess the ability of light-activated release sickle cells to enhance tumor delivery of the fluorescent dye calcein by delayed photolysis controlled release compared to free systemic administration of calcein. Sickle cells from mouse models of the disease were shown to preferentially accumulate in tumors compared to adjacent tissue, in 4T1 tumors in mice on a time scale about 12 hours. Sickle cells photosensitized with protoporphyrin IX achieved delayed release of 50% of contents 8-16 hours after photoactivation, which was deemed useful for in vivo delivery of cargo to tumors given the tumor accumulation time of the sickle cells. Sickle cells may be useful as a model for new synthetic drug carrier particles with delayed photolysis controlled release properties.

• Nuclear Engineering and Technology
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• v.41 no.7
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• pp.945-952
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• 2009

The Three Mile Island Unit 2 (TMI-2) accident provides unique full scale data, thus providing opportunities to check the capability of codes to model overall plant behavior and to perform a spectrum of sensitivity and uncertainty calculations. As part of the TMI-2 analysis benchmark exercise sponsored by the Organization for Economic Cooperation and Development Nuclear Energy Agency (OECD NEA), several member countries are continuing to improve their system analysis codes using the TMI-2 data. The Republic of Korea joined this benchmark exercise in November 2005. Seoul National University has analyzed the TMI-2 accident as well as the currently proposed alternative scenario along with a sensitivity study using the Modular Accident Analysis Program Version 4.03 (MAAP4.03) code in collaboration with the Korea Hydro and Nuclear Power Company. Two input files are required to simulate the TMI-2 accident with MAAP4: the parameter file and an input deck. The user inputs various parameters, such as volumes or masses, for each component. The parameter file contains the information on TMI-2 relevant to the plant geometry, system performance, controls, and initial conditions used to perform these benchmark calculations. The input deck defines the operator actions and boundary conditions during the course of the accident. The TMI-2 accident analysis provided good estimates of the accident output data compared with the OECD TMI-2 standard reference. The alternative scenario has proposed the initial event as a loss of main feed water and a small break on the hot leg. Analysis is in progress along with a sensitivity study concerning the break size and elevation.

• Journal of Korean Medicine for Obesity Research
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• v.4 no.1
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• pp.161-183
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• 2004

Context : Oriental medicine deals with mind cardinally and effectiveness of CBT on weight control is well-known. but there is no well-structured psychotherapy for weight control like CBT in Oriental medicine so far. Therefore It is necessary to develop new cognitive program based on the theory of Oriental medical. Objective: This study examined whether Yangsung program based on new cognitive weight regulation model is effective on weight loss, self esteem and self control. Design and setting: 44 women were assigned randomly to 2 groups; experimental group(n=24) and control group(n=10). experimental group had 11 sessions consisted of cognitive therapy, meditation, general diet and exercise education. Control group had personal interview with general diet and exercise education and ear acupuncture once a week for two months. All subjects were weighed and evaluated with Rosenberg self esteem scale, and three factor eating questionnaires at the beginning of the program and at the end of the program. Result: Experimental group reported significant changes of weight, self esteem, restraint eating, disinhibition and hunger(p<0.01). Compared with control group, more significant(p<0.05) Weight reduction and self-esteem enhancement were reported in experimental group than control group. There is no significant difference between two groups in changes of restraint eating, disinhibition and hunger.

• Journal of the Society of Naval Architects of Korea
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• v.51 no.5
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• pp.409-418
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• 2014

Simulation of flow past a complex marine structure requires a fine resolution in the vicinity of the structure, whereas a coarse resolution is enough far away from it. Therefore, a lot of grid cells may be wasted, when a simple Cartesian grid system is used for an Immersed Boundary Method (IBM). To alleviate this problems while maintaining the Cartesian frame work, we adopted an Adaptive Mesh Refinement (AMR) scheme where the grid system dynamically and locally refines as needed. In this study, We implemented a moving IBM and an AMR technique in our basic 3D incompressible Navier-Stokes solver. A Volume Of Fluid (VOF) method was used to effectively treat the free surface, and a recently developed Lagrangian Dynamic Subgrid-scale Model (LDSM) was incorporated in the code for accurate turbulence modeling. To capture vortex induced vibration accurately, the equation for the structure movement and the governing equations for fluid flow were solved at the same time implicitly. Also, We have developed an interface by using AutoLISP, which can properly distribute marker particles for IBM, compute the geometrical information of the object, and transfer it to the solver for the main simulation. To verify our numerical methodology, our results were compared with other authors' numerical and experimental results for the benchmark problems, revealing excellent agreement. Using the verified code, we investigated the following cases. (1) simulating flow around a floating sphere. (2) simulating flow past a marine structure.

• Transactions of Materials Processing
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• v.20 no.4
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• pp.316-323
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• 2011

The hot curvature-forming of large aluminum thick plate using a grid-typed hybrid die is a process for the production of a spherical LNG tank. Many variables such as the initial die surface quality, grid size, grid thickness, size of blank plate and cooling line design, control the success of the process. In addition, the plate used in this process is generally larger than $10{\times}10m$ in size. Thus, it is very difficult to predict the surface characteristics of the plate during forming and to measure the different parameters due to the high cost of the experiments. In order to optimize the process design for the grid-type die, the development of an analytical method to predict the surface characteristics of the final product in hot curvature-forming is needed. This paper described the development of the method and procedures for FE simulations of the hot curvature-forming process, including hot forming, air flow, cooling, and thermal deformation analyses. An experiment for a small scale model of the process was conducted to check the validity of the numerical method. The results showed that the curvature of the plate in the analysis agrees well with that of the experiment within 0.037 and 0.016% tolerance margins for its side and corner, respectively.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.12
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• pp.3276-3286
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• 1994

In most direct contact liquid-liquid heat exchangers, oil or hydrocarbon with a density less than water is normally used as dispersed working fluid. The main difficulty that arises with this arrangement lies in the control of the interface at the top of the column. When it is connected with a solar collector which uses water as its working fluid, the main difficulties arise from the fact that the water can be frozen during winter time. In order to solve these problems and to demonstrate the technical feasibility of a direct contact liquid-liquid heat exchanger, liquids heavier than water with low freezing temperature has been utilized as dispersed phase liquids in a small laboratory scale model made of pyrex glass. In the present investigation, dimethyl phthalate(C/sub 6/H/sub 4/)COOCH/sub 3/)/sub 2/) and diethyl phthalate (C/sub 6/H/sub 4/(CO/sub 2/C/sub 2/H/sub 5/)/sub 2/) are utilized as heavy dispersed phase working fluids. The results of the present investigation the technical in the utilization of heavier dispersed working liquid in the spray-column liquid-liquid heat exchanger for a solar system. The overall average temperature difference along the column is found to be almost half of the initial temperature difference between the dispersed and the continuous phase. Despite the fact that the two phthalates tested in the experiment differ significantly in some of their physical properties, the volumetric heat transfer coefficients in terms of dispersed fluid superficial velocities were found to be similar for both phthalates tested.

• The Transactions of the Korea Information Processing Society
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• v.4 no.5
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• pp.1221-1230
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• 1997

In this study, the performance of a parallel file system(N-PFS), which is inplemented using conventional disks as disk arrays on a Workstation Cluster, is analyzed by using analytical method and adtual values in experiments.N-PFS can be used as high-performance file sever in small-scale server systems and effciently pro-cess massive data I/Os such as multimedia and scientifid data. In this paper, an analytical model was suggested and the correctness of the suggested was verified by analyzing the experimental values on a system.The result of the appropriate stping unit for processing massive data of the Workstation Cluster with 8 disks is 64-128Kbytes and the maximum throughput on it is 15.8 Mbytes/ses.In addition, the performance of parallel file system on massive data is bounded by the time required to copy data between buffers.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.690-693
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• 2008

Recently, the trend has been for buildings to become larger and more sophisticated, and this has created safety issues. Because the buildings are big it takes lots of time to check building codes related to anti-disaster and safety manually, and there is the high possibility of making mistakes. Due to these problems, according to a study, 83% of architecture and construction workers believe that an automated code-checking system is needed. This study researches past automated code checking systems and research activity, and using Building Information Model (BIM) technology, determines the feasibility of developing a system to automatically check domestic codes related to egress and anti-disaster. This paper describes the necessity of an automated building code checking system and expected effects. It then reports whether the methods used in previous studies can be deployed in domestic building code checking and discusses problems and limitations. It also suggests an alternative approach. Although this study covers limited codes related to egress, we need to find out what is needed for automatic general code checking system and do further studies for that.

• Journal of Korean Society for Geospatial Information Science
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• v.1 no.1 s.1
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• pp.171-180
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• 1993

Concern about nonpoint source pollution associated with urban storm water has led to the development of new tools for better water quality planning. This paper presents an application of a geographic information system (GIS) for urban water quality study. The GIS was used to manage land use data for nonpoint source pollution modeling and to aggregate pollutant loadings within various types of geographic units. An empirical water quality model was used to estimate pollutant loadings based primarily on land use. A land use coverage was created by updating an old coverage through interpretation of recent photography. This land use coverage was also used to record all pollutant loadings for each land use polygon. Storm sewer maps were digitized and interpreted to create a coverage of storm sewer basins and sub-basins. By overlaying pollutant loadings with the sewer sub-basin layer, aggregated pollutant loadings for major sewer outfalls were calculated. Based on the loading information, critical areas of excessive pollutant loadings were located and the effectiveness of Best Management Practices (BMPs) to control pollutant loadings were evaluated.

• Journal of Korean Society for Geospatial Information Science
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• v.11 no.1 s.24
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• pp.3-12
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• 2003

The main objective of this study is to extract the hydro-Parameter of the Tamjin River basin. A CIS is capable of extracting various hydrological factors from DEM. One of important tasks for hydrological analysis is the division of watershed. In this study, watershed itself and other geometric factors of watershed are extracted from DEM by using a CIS technique. The data of topographical map with scale of 1:25,000 and 1:250,000 in the Tamjin River basin is used for this study and it is converted to DEM date. Various forms of representation of spatial data are handled in main modules and a CRID module of ArcView. A GRID module is used on a stream in order to define watershed boundary. Based on the spatial analysis using those GIS technique, it would be possible to obtain the reasonable results of watershed characteristics. Also, the results show not only that GIS can aid watershed management, research and surveillance, but also that the geometric characteristics as parameters of watershed can be quantified more accurately and easily than conventional graphic methods. From the equations($Y=14632.87{\cdot}X^{-0.542444},\;Y=37014.1{\cdot}X^{-1.058808}$), it can be concluded that the optimal count of flow accumulation is 468 and cell size is 42m for spatial analysis by using GIS technique in Tamjin River basin.