• Molecules and Cells
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• 제26권3호
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• pp.319-322
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• 2008

Little is known about the chromosomal variability and polymorphism existing in mitotic chromosomes of Citrus, mainly due to lack of reliable chromosomal markers and small chromosome size. To test the hypothesis of chromosomal polymorphism and provide the foundation of the genome organization in the Citrus cultivars, we have developed molecular cytogenetic markers for 13 Citrus species collected from Jeju island, Korea. In this study, we demonstrated that the chromosomal locations of cytogenetic markers are quite variable and extremely polymorphic, in contrast to the previous studies. The data obtained in this study will be of utmost importance in cytological systematics and karyotyping of the Citrus species.

• Journal of Astronomy and Space Sciences
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• 제36권2호
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• pp.69-74
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• 2019

Spacecraft requires sufficient power in orbit to perform its mission. So as to comply with system requirements, the sufficient power should be made by a solar cell array by photovoltaic power conversion. A life time of space program depends on its mission considering parts reliability and parts grade. Based on the mission life time, power equipment might be designed to meet specifications. In outer space, solar cell array might generate the dc power by photovoltaic conversion effects and GaInP/GaAs/Ge solar cells are used in this study. Space programs that require more than five years should select parts for high reliability applications. Therefore, reliability analysis for high reliability applications should be performed to check its fulfilment of the requirements. This program should also require more five years for its mission and we performed its analysis using parts count method (PCM) for its reliability. Finally, we performed reliability analysis and obtained quantitative figures found out 99.9%. In this study, we presented the reliability analysis of the 300 W GaInP/GaAs/Ge solar cell array.

• Journal of Yeungnam Medical Science
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• 제40권4호
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• pp.423-425
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• 2023

Porokeratosis ptychotropica is an uncommon form of porokeratosis, which was initially described in 1995. It is clinically characterized by symmetrical reddish to brown-colored hyperkeratotic, verrucous, or psoriasiform plaques on the perianal and gluteal regions. The lesions tend to integrate and expand centrally, with small peripheral satellite lesions. Early skin biopsy and appropriate diagnosis are essential because malignant change occurs in 7.5% of porokeratotic lesions. Conventional treatment options include topical steroid, retinoid, imiquimod, 5-fluorouracil, isotretinoin, excimer laser, photodynamic therapy, intralesional steroid or bleomycin injection, cryotherapy, carbon dioxide (CO₂) laser, and dermatome and excision, but none seem to achieve complete clearance. A 68-year-old woman presented with diffuse hyperkeratotic scaly lichenoid plaques on the buttocks that had persisted for several years. A skin biopsy of the buttocks revealed multiple cornoid lamellae and intense hyperkeratosis. There were some dyskeratotic cells beneath the cornoid lamellae and the granular layer was absent. Porokeratosis ptychotropica was diagnosed based on the characteristic clinical appearance and typical histopathological manifestations. She was treated with a CO₂ laser in one session and topical application of urea and imiquimod cream for 1 month. The lesions slightly improved at the 1-month follow-up. We herein present a rare case of porokeratosis ptychotropica.

• Journal of Ginseng Research
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• 제48권1호
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• pp.12-19
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• 2024

Skeletal muscle (SM) is the largest organ of the body and is largely responsible for the metabolism required to maintain body functions. Furthermore, the maintenance of SM is dependent on the activation of muscle satellite (stem) cells (MSCs) and the subsequent proliferation and fusion of differentiating myoblasts into mature myofibers (myogenesis). Natural compounds are being used as therapeutic options to promote SM regeneration during aging, muscle atrophy, sarcopenia, cachexia, or obesity. In particular, ginseng-derived compounds have been utilized in these contexts, though ginsenoside Rg1 is mostly used for SM mass management. These compounds primarily function by activating the Akt/mTOR signaling pathway, upregulating myogenin and MyoD to induce muscle hypertrophy, downregulating atrophic factors (atrogin1, muscle ring-finger protein-1, myostatin, and mitochondrial reactive oxygen species production), and suppressing the expressions of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cachexia. Ginsenoside compounds are also used for obesity management, and their anti-obesity effects are attributed to peroxisome proliferator activated receptor gamma (PPARγ) inhibition, AMPK activation, glucose transporter type 4 (GLUT4) translocation, and increased phosphorylations of insulin resistance (IR), insulin receptor substrate-1 (IRS-1), and Akt. This review was undertaken to provide an overview of the use of ginseng-related compounds for the management of SM-related disorders.

• 정보처리학회논문지B
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• 제11B권2호
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• pp.141-148
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• 2004

영상 매칭 방법을 이용하여 항공 사진 및 위성 영상으로부터 획득한 지상 위치 및 고도 정보인 수치표고모델(DEM)은 여러 환경의 영향으로 인하여 오차를 포함하고 있다. 본 연구에서는, 전문가가 이러한 오차를 수정 편집할 수 있도록 하기 위하여 기준 수치표고모델과 대상 수치 표고모델간의 유사도 값을 사용하여 수치표고모델을 평가하는 방법을 제시하고자 한다. 수치표고모델의 전 지역에 대해 수평 및 수직 오차를 구하기 위해서는 기준 수치표고모델의 격자와 대상 수치표고 모델 격자간의 유사도 값을 사용하여 각 기준 격자에 대한 정합 대상 격자를 구한다. 각 기준 격자에 대한 정합 대상 격자가 구해지면, 수평 및 수직 오차를 계산하여 전문가가 수정 편집할 영역을 판단할 수 있도록 한다. 즉, 유사도 값이 낮고, 고도의 차가 높은 경우. 그 격자는 후보 변화 또는 오류 격자로 판단된다. 이러한 후보 격자들이 영역을 이룰 경우. 수정 편집 대상인 변화 또는 오류 지역으로 판단한다. 이러한 방법을 사용함으로써, 모든 점에 대한 평가가 가능할 뿐 아니라, 수직 오차 외에도 수평 오차를 구할 수 있으므로, 보다 효과적으로 변화 또는 오류 지역을 찾을 수 있었다.

• 한국전자파학회논문지
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• 제25권3호
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• pp.348-356
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• 2014

기존의 ITU-R 모델은 강우 환경이 다른 국내 측정치와 편차가 크고, 실효 경로 길이가 주파수와 무관함에도 주파수의 함수로 되어 있으며, 강우셀의 물리적 특성이 반영되지 않은 경험 모델이라는 단점이 있다. 본 논문에서는 강우셀 개념을 이용한 실효 경로 길이 모델에 대한 이론 모델을 제안하고, 측정 데이터를 이용하여 제안 모델의 타당성을 검증하였다. 강우셀 파라미터의 통계적 특성 분석을 위하여 한국 기상청의 기상레이더 측정 데이터(CAPPI)를 분석하고, 한국전자통신연구원에서 측정한 천리안 비콘 수신 데이터를 이용하여 보정계수를 도입함으로써 측정치와 잘 일치하는 물리적 이론 모델을 도출하였다. 도출된 실효 경로 길이 모델의 검증을 위하여 국방과학연구소의 연구비 지원을 받아 충남대학교에서 측정한 무궁화 5호(Ka 대역) 위성 비콘신호 측정 데이터를 사용하여 비교하였으며, 제안한 실효 경로 길이 모델과 측정데이터가 잘 일치함을 확인하였다.

• Journal of Chest Surgery
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• 제36권10호
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• pp.711-720
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• 2003

배경: 폐암은 근치적 절제술이 가장 좋은 치료법이나 수술 후에 재발한 경우나 수술 시기가 지난 경우에는 항암 화학요법의 중요성이 강조된다. 항암 치료 전에 감수성 있는 항암 화학 치료제가 선별되어진다면 치료 효과를 극대화할 수 있다. 신피막하 분석법은 흉, 복부 종양의 생체 내 검사법으로 중요성이 인정되고 있고 항암 감수성 검사로서도 짧은 기간 내에 판별이 가능한 이점이 있다. 신장은 각종 암세포의 이식 장소로 잘 알려져 있으나 비장이나 간에서의 이식 성적을 비교한 연구는 없는 실정이다. 인체 암세포 이식의 실험방법 중에 비장과 간장에 암 세포주를 이식하였을 경우와 신장에 시행되는 신피막하 분석법에 의한 성장의 차이점 유무를 평가하였다. 대상 및 방법: 인체 폐암 세포주(SW-900 G IV)를 RPMI 1640 (Leibovitz L-15 medium)배지에서 배양하여 fibrin clot으로 만들어 $10^{8}$ 개의 암세포가 포함되도록 한 후 3${\times}$${\times}$3mm의 크기로 Spague Dawely (S.D.) 암컷 쥐의 신, 비장 및 간 피막하에 이식하였다. 이식 후 1일부터 6일간 면역억제를 위하여 cyclosporin-A (80 mg/kg)를 피하투여하였다. 이식 전후 실험동물의 체중 변화, 종양의 성장 여부 및 종양의 크기를 계측하고 병리 조직 검사와 혈청 내 암 표지자 검사를 실시하여 비교하였다. 걸과: 실험 5.D. 쥐의 체중 변화는 대조군이나 실험 군 모두에서 체중 증가가 있었다. 혈청 내 암 표지자의 정량 검사 결과 Cyfra 21-1은 검출되지 않았고, CEA및 NSE는 의미 있는 변화가 없었으며, SCC-Ag이 실험 군에서 유의한 증가가 있었다. 비장에 이식한 폐암 세포주의 성장이 신장 및 간장에 비해 더 증가된 결과를 보였다. 표면적, 두께와 용적 모두가 비장에서 유의한 증가를 나타내었다. 이식 성공률은 신장이 80%, 비장이 76.7%, 간장이 43.3%이었다. 병리학적 검사 결과 신장에는 비교적 둥글게 성장하며 크기는 제일 작았으며 성장 방향이 일정한 모양을 보이는 특징이 있으며 비장은 성장이 잘되어 제일 큰 종양을 형성하나 불규칙한 성장과 위성 종양(satellite tumor)이 빈번히 발견되었으며 현미경적으로는 혈관 신생과 함께 종양 혈전이 발견되었다. 간장은 간 내부로 침투 성장하여 이식 성공률이 가장 저조하며 현미경적 소견은 응고성 괴사와 점액양 섬유성 병변을 가지는 특징을 보였다. 걸론: 이식 성공률은 신장과 비장이 높으나, 성장이 일정하고 계측이 용이한 것은 신장이었다. 혈청 암 표지자는 SCC-Ag이 가장 조기에 반응하였으며, Cyfra 21-1은 조기에 검출되지 않았다. 이상에서 감수성 검사를 위한 종양이식 실험에 이용하기에 가장 적합한 장기는 신장을 이용한 신피막하 이식법으로 생각되며, 조기에 유용한 암표지자 검사는 SCC-Ag 정량법이라고 판단된다.

• The Korean Journal of Pain
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• 제25권4호
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• pp.213-220
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• 2012

Background: It has been demonstrated that the expression of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and apoptotic cell death in the dorsal root ganglion (DRG) following spinal nerve constriction injury play a role in the initiation and continuation of hyperalgesia and allodynia. The present study was designed to investigate the effects of ethyl pyruvate (EP) on mechanical and cold allodynia, TNF-${\alpha}$ expression, and apoptosis in DRG after spinal nerve ligation injury. Methods: Rats were divided into 3 groups: control, pre-EP, and post-EP. EP (50 mg/kg) was intraperitoneally injected 30 minutes before (pre-EP) or after (post-EP) surgery. Behavioral tests to determine mechanical and cold allodynia were conducted before surgery and 4 and 7 days after surgery. Seven days after surgery, TNF-${\alpha}$ protein levels in DRG were evaluated by enzyme-linked immunosorbent assay, and DRG apoptosis was determined by immunohistochemical detection of activated caspase-3. Results: Treatment with EP significantly reduced mechanical and cold allodynia following spinal nerve ligation injury. TNF-${\alpha}$ protein levels in the pre-EP ($4.7{\pm}1.2$ pg/200 ${\mu}g$; P < 0.001) and post-EP ($6.4{\pm}1.8$ pg/200 ${\mu}g$; P < 0.001) groups were 2-3 times lower than the control group ($14.4{\pm}1.2$ pg/200 ${\mu}g$). The percentages of neurons and satellite cells that co-localized with caspase-3 were also significantly lower in the pre-EP and post-EP groups than the control group. Conclusions: These results demonstrate that EP has a strong anti-allodynic effect that acts through the inhibition of TNF-${\alpha}$ expression and apoptosis in DRG after spinal nerve ligation injury.

• 한국패류학회지
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• 제27권3호
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• pp.273-282
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• 2011

The ultrastructural characteristics of germ cells during spermatogenesis and mature sperm morphology in male Pinctada martensii were investigated by transmission electron microscope observation. The morphologies of the sperm nucleus and the acrosome of this species are the oval shape and cone shape, respectively. Spermatozoa are approximately $47-50{\mu}m$ in length including a sperm nucleus (about $1.24{\mu}m$ in length), an acrosome (about $0.60{\mu}m$ in length), and tail flagellum (about $45-47{\mu}m$). The axoneme of the sperm tail shows a 9+2 structure. In P. martensii in Pteriidae, a special substructure showing a thick and wide triangular shape which is composed of electron-dense opaque material (occupied about 50% of all, the upper part of the acrosomal vesicle), appeared in the upper region (part) of the acrosomal vesicle, while the lower region (part) of the acrosomal vesicle is composed of electron-lucent material. Thus, this special structure, which exist in the upper part of the acrosomal vesicle in P. martensii, is somewhat different from those of other subacrosomal vesicle in other families in subacrosomal vesicles. Therefore, we assume that the existence of a special substructure showing a thick and wide triangular shape in the acrosomal vesicle of the spermatozoon can be used as a key characteristic for identification of P. martensii or other species in Pteriidae in subclass Pteriomorphia. The number of mitochondria in the midpiece of the sperm of this species are five (exceptionally sometimes four), as one of common characteristics appear the same number of mitochondria in the same families of superfamilyies. This species in Pteriidae does not contain the axial rod and satellite fibres which appear in the species in Ostreidae in subclass Pteriomorphia. These characteristics can be used for the taxonomic analysis of the family or superfamily levels as a systematic key or tools.

• 대기
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• 제26권2호
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• pp.321-336
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• 2016

Damages caused by torrential rain occur every year in Korea and summer time convection can cause strong thunderstorms to develop which bring dangerous weather such as torrential rain, gusts, and flash flooding. On 6 August 2013 a sudden torrential rain concentrated over the inland of Southern Korean Peninsula occurred. This was an event characterized as a mesoscale multicellular convection. The purpose of this study is to analyze the conditions of the multicellular convection and the synoptic and mesoscale nature of the system development. To this end, dynamical and thermodynamic analyses of surface and upper-level weather charts, satellite images, soundings, reanalysis data and WRF model simulations are performed. At the beginning stage there was a cool, dry air intrusion in the upper-level of the Korean Peninsula, and a warm humid air flow from the southwest in the lower-level creating atmospheric instability. This produced a single cell cumulonimbus cloud in the vicinity of Baengnyeongdo, and due to baroclinic instability, shear and cyclonic vorticity the cloud further developed into a multicellular convection. The cloud system moved southeast towards Seoul metropolitan area accompanied by lightning, heavy precipitation and strong wind gusts. In addition, atmospheric instability due to daytime insolation caused new convective cells to develop in the upstream part of the Sobaek Mountain which merged with existing multicellular convection creating a larger system. This case was unusual because the system was affected little by the upper-level jet stream which is typical in Korea. The development and propagation of the multicellular convection showed strong mesoscale characteristics and was not governed by large synoptic-scale dynamics. In particular, the system moved southeast crossing the Peninsula diagonally from northwest to southeast and did not follow the upper-level westerly pattern. The analysis result shows that the movement of the system can be determined by the vertical wind shear.