• Title/Summary/Keyword: safety examination

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Clinical Efficacy of Radiation-Sterilized Allografts for Sellar Reconstruction after Transsphenoidal Surgery

  • Kim, Se-Jin;Jeon, Chi-Man;Kong, Doo-Sik;Park, Kwan;Kim, Jong-Hyun
    • Journal of Korean Neurosurgical Society
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    • v.50 no.6
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    • pp.503-506
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    • 2011
  • Objective : The aim of this study was to assess the safety and efficacy of radiation-sterilized allografts of iliac bone and fascia lata from cadaver specimens to repair skull base defects after transsphenoidal surgery. Methods : Between May 2009 and January 2010, 31 consecutive patients underwent endonasal transsphenoidal surgery and all patients received sellar reconstruction using allografts following tumor removal. The allografts were obtained from the local tissue bank and harvested from cadaver donors. The specimens used in our approach were tensor fascia lata and the flat area of iliac bone. For preparation, allografts were treated with gamma irradiation after routine screening by culture, and then stored at $-70^{\circ}C$. Results : The mean follow-up period after surgery was 12.6 months (range, 7.4-16 months). Overall, postoperative cerebrospinal fluid (CSF) leaks occurred in three patients (9.7%) and postoperative meningitis in one patient (3.2%). There was no definitive evidence of wound infection at the routine postoperative follow-up examination or during re-do surgery in three patients. Postoperative meningitis in one patient was improved with the use of antibiotics and prolonged CSF diversion. Conclusion : We suggest that allograft materials can be a feasible alternative to autologous tissue grafts for sellar reconstruction following transsphenoidal surgery under selected circumstances such as no or little intraoperative CSF leaks.

Evaluation of the Bacteriological Safety for the Shellfish Growing Area in Hansan.Geojeman, Korea (한산.거제만해역 패류양식장에 대한 세균학적 위생안전성 평가)

  • Ha, Kwang-Soo;Shim, Kil-Bo;Yoo, Hyun-Duk;Kim, Ji-Hoe;Lee, Tae-Seek
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.42 no.5
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    • pp.449-455
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    • 2009
  • In Hansan Geojeman area, 2,050 ha of shellfish growing area has been designated as shellfish production area for export. The main shellfish species from the designated area is oysters. For the sanitary management of the designated area established in Hansan Geojeman area, bacteriological examination of sea water and shellfish at the sampling stations inside and outside of the designated area were performed from January 2006 to December 2008. The range of fecal coliform of 756 sea water samples at 21 stations located in the designated area were <1.8~>1,600 MPN/100mL. And the range of geometric mean and the estimated 90th percentile of fecal coliform were 1.8~2.9 and 2.7~15.8 MPN/100mL, respectively. Sanitary conditions of the current designated area in Hansan Geojeman meets the required standards of the Fisheries Product Quality Control and National Shellfish Sanitation Program (NSSP, USA) criteria for the approved area. Also, the sanitary status of the shellfish harvested from the designated area met the Korean Shellfish Sanitation Program (KSSP) fecal coliform criterion (<230 MPN/100g). And the human pathogen such as Salmonella spp. and Shigella spp. were not detected from the examined shellfish samples.

Evaluation of the Bacteriological Safety for the Shellfish Growing Area in Jaranman.Satyangdo Area, Korea (자란만.사량도 패류생산해역의 위생학적 안전성 평가)

  • Shim, Kil-Bo;Ha, Kwang-Soo;Yoo, Hyun-Duk;Kim, Ji-Hoe;Lee, Tae-Seek
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.42 no.5
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    • pp.442-448
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    • 2009
  • Bacteriological examination of a 12,700 ha area within Jaranman Saryangdo area, located in Jaran bay and Saryangdo island, was conducted with 35 fixed (designated areas and adjacent areas) seawater sampling stations between January 2006 and December 2008. According to results, the geometric mean range and the estimated 90th percentile range of fecal coliform counts in sea water samples collected in the designated area were <1.8-2.4 and <1.8-8.6 MPN/100mL, respectively. The estimated 90th percentile range of fecal coliform counts in sea water samples collected from 6 sampling stations in the adjacent areas were 6.1-34.6 MPN/100mL. Based on these results, bacteriological water quality of the designated areas in the Jaranman. Saryangdo area meet the NSSP (National Shellfish Sanitation Program) guidelines for approved area. The bacteriological sea water quality in Jaranman.Saryangdo area has been shown to be favorable at all investigated sampling stations except for July and August which coincided with heavy rainfall. In fact, the bacteriological water quality was not affected if rainfall was less than 30 mm rainfall. However, the degree of bacteriological contamination increased rapidly and the water quality exceeded approved NSSP guidelines set for rainfall above 60 mm.

Seismic Vulnerability Analysis of River Levee by Earthquake Return Period (지진 재현주기에 따른 하천 제방의 지진취약성 분석)

  • Kim, Kyung-Oh;Han, Heui-Soo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.5
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    • pp.679-686
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    • 2020
  • In this study, the seismic vulnerability of public river levees was analyzed quantitatively. Input seismic waves were generated in Pohang seismic waves in return periods of 200, 500, 1000, and 2400 years. The behavior of the levee was analyzed by seismic vulnerability analysis according to the return period. The displacement that occurs during an earthquake showed the same tendency as the input seismic wave and was largest in the return period of 2400 years. An analysis of the sliding stability revealed a 31.5% and 26.7% decrease in the sliding safety factor for the return period of 2400 for the landside and waterside, respectively. An examination of liquefaction by the q/p' ratio showed that the seepage line inside the embankment rises due to earthquakes. As a result, in the case of a return period of 2400 years, most embankments generate liquefaction, making them vulnerable to earthquakes. Through this research, it will be necessary to re-establish domestic seismic-design standards and establish clear standards for the results through a dynamics method.

Preparation and Evaluation of Cosmetic Tissue using W/Si/W Multiple Emulsion (실리콘 다중유제 (W/Si/W)를 이용한 화장용 티슈의 개발 및 평가)

  • Han, Sang-Chul;Park, Duck-Sang;Shin, Jae-Hong;Kim, Tae-Hyeon;Park, Jeong-Sook;Cho, Cheong-Weon;Hwang, Sung-Joo
    • Journal of Pharmaceutical Investigation
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    • v.37 no.4
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    • pp.217-222
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    • 2007
  • To develop cleansing tissue composed of silicone multiple emulsions which could easily remove make-up residues and confer skin protecting effect without damaging skin, we formulated various silicone multiple emulsions and evaluated the physicochemical properties including viscosity, cleansing effect, and safety effect. Also, cleansing tissue incorporated with silicone multiple (W/Si/W) emulsion was stored for 6 months, and judged its stability through microscopes under accelerated and long-term condition. Cleansing effect was evaluated by chromameter. Skin hydration effect was determined by corneometer and incorporation effect into non-woven fabric cotton was evaluated by volunteer survey. Low viscosity ranged from 400 centipoise (cP) to 1,000 cP was obtained from a stabilized W/Si/W emulsion containing more than 10% volatile silicone. Mean diameter of fresh W/Si/W emulsion was $20{\mu}m$, but after storage for 3 months at $45^{\circ}C$, the particle size of the W/Si/W emulsion increased up to $50{\mu}m$. Both W/Si/W emulsion-incorporated cleansing tissue and commercial product showed equally good cleansing effect. In addition, skin allergies such as erythema, edema, scaling itching, stinging, burning, tightness and prickling were not observed through macroscopic examination. From the transepidermal water loss results, the cleansing tissue consisting of W/Si/W emulsion showed superior hydration effect to commercial product. In conclusion, this study suggests cleansing tissue using W/Si/W emulsion could be used for an excellent efficacy compared with commercialized cleansing tissue.

Development of Measurement System for Welding Bead Shape using LabVIEW (LabVIEW를 이용한 용접비드 형상 계측시스템 개발)

  • Kang, Hoon-Hyo;Lee, Da-Hye;Jeon, Euy-Sik
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.8 no.2
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    • pp.189-194
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    • 2007
  • Recently, as consumer's claim fur car safety is increased, quality inspection method fur welding zone is strengthened. Therefore, from the methods that depend on welding zone bead shape size of seat frame in macrography or passive examination, the quality control by whole recording inspection is required. In this study, the system that is measuring automatically if worker checks welding bead fur quality inspection of seat frame is developed using LabVIEW. If the quality standard for the bead width and length of welding zone is inputted, the system measures automatically whether welding zone is bead length or bead width. Measured data is preserved by points and quality recording of welding zone is stored. The car seat きme welding zone is applied and experimented. The results gave good influence o9 the quality control of work efficiency.

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Clinical Application of Transcatheter Arterial Chemoembolization Combined with Synchronous C-arm Cone-Beam CT Guided Radiofrequency Ablation in treatment of Large Hepatocellular Carcinoma

  • Wang, Zhi-Jun;Wang, Mao-Qiang;Duan, Feng;Song, Peng;Liu, Feng-Yong;Wang, Yan;Yan, Jie-Yu;Li, Kai;Yuan, Kai
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.1649-1654
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    • 2013
  • Objective: This work aimed to evaluate the safety and clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with c-arm cone-beam CT guided synchronous radiofrequency ablation (RFA) in treatment of large hepatocellular carcinoma (HCC). Methods: 21 patients with large HCC were studied from January 2010 to March 2012. TACE combined with synchronous C-arm cone-beam CT guided RFA were performed on a total of 25 lesions. Conventional imaging examination (CEUS, enhanced CT or MRI) and AFP detection were regularly conducted to evaluate the technical success rate of combined treatment, complications, treatment response, time without disease recurrence and survival rate. Results: The technical success rate of combined treatment was 100%, without any significant complication. After 1 month, there were 19 cases with complete response and 2 cases with partial response, with an complete response rate of 90.4% (19/21) and a clinical effective rate of 100% (21/21). The complete response rates of single nodular lesions (100%, 17/17) was significantly higher than that of multiple nodular lesions (50%, 2/4) (P<0. 05). During 2 to 28 months of follow-up, in 19 cases with complete response, the average time without disease recurrence was $10.8{\pm}6$ months. The total survival rates of 6, 12 and 18 months in 21 patients were 100%, respectively. Conclusion: TACE combined with synchronous C-arm CT guided RFA is safe and effective for treatment of large HCC. The treatment efficacy for single nodular lesion is better than that for multiple nodular lesions.

A Study of the Neonatal Care in the hospitals located in Pusan (부산광역시 소재 병원의 신생아간호 실태조사)

  • Kim, Young-Hae;Lee, Hwa-Za;Kim, Soon-Goo
    • Korean Parent-Child Health Journal
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    • v.6 no.1
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    • pp.31-45
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    • 2003
  • This study is designed to produce basic data on the nursing intervention between infants and mothers after discharge from hospitals. This research is carried by investigating the nursing intervention during their after-delivery staying in the hospitals located in Pusan. The object of this study includes the neonatal wards of 51 hospitals. Data collection was carried from the 3rd of September, 2001 to the 4th of October in the same year. Tools for measurement using in this research is the nursing checklist designed by these researchers. The data were analyzed by using SPSS and the output was produced in frequency and percentage considering general characteristics and nursing activities. On the course of investigation, it was revealed that the average number of items checked are as follows; total beds in one hospital came up to 360.1, the beds in each newborn infant ward came up to 36.1, in each ward the numbers of incubators came up to 9.2 and intensive care unit to 1.7. In each ward 8.4 nurses and 2.9 nurse aids were working at that time. In each hospital, secure of air way, physical examination, eye care, umbilical cord care, maintenance of body temperature, identification of infant, nutritive condition, safety and danger management, infection management, mother-infantile interaction, medical assistant to doctor, medication and discharge education were comparatively well done. But, in case of emotional, social and cognitive aspect of nursing activities through interactions between newborn infants and nurses as substitutes are not reached to the adequate level. In the end, this study hereby suggests that further investigation on the device to facilitate the interaction between newborn infant and nurse as a nursing intervention of high quality.

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Image-guided navigation surgery for bilateral choanal atresia with a Tessier number 3 facial cleft in an adult

  • Sung, Ji Yoon;Cho, Kyu-Sup;Bae, Yong Chan;Bae, Seong Hwan
    • Archives of Craniofacial Surgery
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    • v.21 no.1
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    • pp.64-68
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    • 2020
  • The coexistence of craniofacial cleft and bilateral choanal atresia has only been reported in three cases in the literature, and only one of those cases involved a Tessier number 3 facial cleft. It is also rare for bilateral choanal atresia to be found in adulthood, with 10 previous cases reported in the literature. This report presents the case of a 19-year-old woman with a Tessier number 3 facial cleft who was diagnosed with bilateral choanal atresia in adulthood. At first, the diagnosis of bilateral choanal atresia was missed and septoplasty was performed. After septoplasty, the patient's symptoms did not improve, and an endoscopic examination revealed previously unnoticed bilateral choanal atresia. Computed tomography showed left membranous atresia and right bony atresia. The patient underwent an operation for opening and widening of the left choana with an image-guided navigation system (IGNS), which enabled accurate localization of the lesion while ensuring patient safety. Postoperatively, the patient became able to engage in nasal breathing and reported that it was easier for her to breathe, and there were no signs of restenosis at a 26-month follow-up. The patient was successfully treated with an IGNS.

Toxicity Evaluation of Irradiated Tarakjuk for Three Months (감마선 조사 타락죽의 3개월 반복투여 독성평가)

  • Yin, Xing Fu;Jeon, Young Eun;Kim, Tae-Keun;Shim, Jae-Hoon;Kang, Il-Jun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.11
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    • pp.1534-1539
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    • 2012
  • This study was conducted to evaluate the possible subacute toxicity of gamma-irradiated Tarakjuk. Tarakjuk was irradiated at a dose of 30 kGy at room temperature. For the animal study, AIN-93G as a control diet and 30 kGy irradiated and non-irradiated Tarakjuk diets were administered to male and female ICR mice (10 mice per group) for 3 months. During the experimental period, the group fed 30 kGy irradiated Tarakjuk did not show any changes in appearance, behavior, mortality, body weight, organ weight, or food consumption compared to control. Further, all biochemical parameters were in normal ranges. In the histopathological examination of liver and kidney tissues of ICR mice, there were no significant differences between the control and 30 kGy irradiated Tarakjuk groups. These results indicate that Tarakjuk irradiated at 30 kGy did not cause any toxic effects under these experimental conditions.