• Title/Summary/Keyword: sTg

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Folic acid supplementation prevents high fructose-induced non-alcoholic fatty liver disease by activating the AMPK and LKB1 signaling pathways

  • Kim, Hyewon;Min, Hyesun
    • Nutrition Research and Practice
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    • v.14 no.4
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    • pp.309-321
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    • 2020
  • BACKGROUND/OBJECTIVES: The present study aimed to evaluate the effects of folic acid supplementation in high-fructose-induced hepatic steatosis and clarify the underlying mechanism of folic acid supplementation. MATERIALS/METHODS: Male SD rats were fed control, 64% high-fructose diet, or 64% high-fructose diet with folic acid for eight weeks. Plasma glutamate-pyruvate transaminase, glutamate-oxaloacetate transaminase, lipid profiles, hepatic lipid content, S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH) were measured. RESULTS: The HF diet significantly increased hepatic total lipid and triglyceride (TG) and decreased hepatic SAM, SAH, and SAM:SAH ratio. In rats fed a high fructose diet, folic acid supplementation significantly reduced hepatic TG, increased hepatic SAM, and alleviated hepatic steatosis. Moreover, folic acid supplementation in rats fed high fructose enhanced the levels of phosphorylated AMP-activated protein kinase (AMPK) and liver kinase B (LKB1) and inhibited phosphorylation of acetyl coenzyme A carboxylase (ACC) in the liver. CONCLUSIONS: These results suggest that the protective effect of folic acid supplementation in rats fed high fructose may include the activation of LKB1/AMPK/ACC and increased SAM in the liver, which inhibit hepatic lipogenesis, thus ameliorating hepatic steatosis. The present study may provide evidence for the beneficial effects of folic acid supplementation in the treatment of non-alcoholic fatty liver disease.

t10,c12 Conjugated Linoleic Acid Upregulates Hepatic De Novo Lipogenesis and Triglyceride Synthesis via mTOR Pathway Activation

  • Go, Gwang-Woong;Oh, Sangnam;Park, Miri;Gang, Gyoungok;McLean, Danielle;Yang, Han-Sul;Song, Min-Ho;Kim, Younghoon
    • Journal of Microbiology and Biotechnology
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    • v.23 no.11
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    • pp.1569-1576
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    • 2013
  • In mice, supplementation of t10,c12 conjugated linoleic acid (CLA) increases liver mass and hepatic steatosis via increasing uptake of fatty acids released from adipose tissues. However, the effects of t10,c12 CLA on hepatic lipid synthesis and the associated mechanisms are largely unknown. Thus, we tested the hypothesis that gut microbiota-producing t10,c12 CLA would induce de novo lipogenesis and triglyceride (TG) synthesis in HepG2 cells, promoting lipid accumulation. It was found that treatment with t10,c12 CLA ($100{\mu}M$) for 72 h increased neutral lipid accumulation via enhanced incorporation of acetate, palmitate, oleate, and 2-deoxyglucose into TG. Furthermore, treatment with t10,c12 CLA led to increased mRNA expression and protein levels of lipogenic genes including SREBP1, ACC1, FASN, ELOVL6, GPAT1, and DGAT1, presenting potential mechanisms by which CLA may increase lipid deposition. Most strikingly, t10,c12 CLA treatment for 3 h increased phosphorylation of mTOR, S6K, and S6. Taken together, gut microbiota-producing t10,c12 CLA activates hepatic de novo lipogenesis and TG synthesis through activation of the mTOR/SREBP1 pathway, with consequent lipid accumulation in HepG2 cells.

Channel Estimation Method Using Packet Synchronization Sequence for MB-OFDM System (MB-OFDM 시스템에서 Packet Synchronization Sequence를 사용한 채널추정 방식)

  • Shon Soung-Hwan;Lee Kyung-Tak;Kim Jae-Moung
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.30 no.12A
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    • pp.1174-1182
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    • 2005
  • This paper, we propose a new channel Estimation method for MB-OFDM(Multi-Band OFDM) system that is suggested as one of standards in IEEE 802.15 TG3a for high data rate(110Mbps${\~}$480Mbps) WPAN system. The proposed method uses correlation characteristic of the PS(Packet Synchronization) sequence for timing synchronization. It can reduce the influence of noise compared with the conventional algorithm which based on LS(Least square) algorithm is redundancy without using the CE(Channel Estimation) Sequence for channel Estimation. We simulate both conventional method and proposed method for performance analysis in S-V channel environment which proposed by IEEE 802.15.3a. Simulation results show the proposed algorithm outperforms conventional algorithm about 1${\~}$1.5dB of Eb/NO.

Effect of Mixing Ratio of Amphoteric and Anionic Latices on Print Quality of Coated Papers (라텍스의 혼합비율이 도공지 품질에 미치는 영향)

  • 강태근;박규재;이용규
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.31 no.1
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    • pp.72-79
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    • 1999
  • The binder plays important roles in determining the quality of pigment coating. In addition to its primary role of binding the pigment to the base paper, the binder performs several other important functions. The binder, also referred to as the adhesive, is the dominant in the aqueous phase of the formulation. Thus it plays a major role in determining viscosity, rheology, water release, and setting time for the coating. Latices based on styrene-butadiene dominate the market for synthetic paper coating binders. Consumption is high and is expected to increase further due to the present tendeyncy toward high-solids coating. The purpose of this study is understanding the impact of various parameters of latex(i.e. Tg, Particle size) affecting prontabilities and optical properties of the coated papers, as well as providing basic information on the use of amphoteric latex for improving print qualities of coated papers. Recently, amphoteric latices, Which are cationic at low pH's but turn anionic at high pH's have attracted interests of paper scientists and engineers. Therefore we investigated the effect of the Tg(glass transition temperature) and particle size of amphoteric latex on the coating qualities. We also studied the effect of mixing ratios (Amphoteric / Anionic)of latex on the coating qualities. Our results showed that Tg and particle size of amphoteric latex have to be controlled for optimizing coated paper qualities. The formulation consisting of 10 parts of amphoteric latex and 5 parts of anionic latex gave best results in ink receptivity, smoothness, air permeability, opacity and sheet gloss. If the results hold for the industrial paper coatings, the amount of expensive amphoteric latex can be reduced while achieving best available printing quality.

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Two-color Transient Grating Spectroscopy of a Two-level System

  • Kwak, Kyoung-Won;Cho, Min-Haeng;Fleming, Graham R.;Agarwal, Ritesh;Prall, Bradley S.
    • Bulletin of the Korean Chemical Society
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    • v.24 no.8
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    • pp.1069-1074
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    • 2003
  • A theoretical description and experimental demonstration of homodyne-detected two-color transient grating (2-C TG) signal are presented. By treating the coupled bath degrees of freedom as a collection of harmonic oscillators and using a short-time expansion method, approximated nonlinear response functions were obtained. An analytic expression for the two-color transient grating signal was obtained by carrying out relevant Gaussian integrals. The initial rising and decaying parts of the 2-C TG signal is shown to be critically dependent on the ultrafast inertial component of the solvation correlation function. The experimental results confirm the predictions of the theoretical model.

Analyses of glycerides in Gingko biloba pancreatic lipase (Pancreatic lipase에 의한 은행(銀杏) glycerides의 분석(分析))

  • Han, Jae-Sook;Park, Jyung-Rewng
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.3 no.1
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    • pp.23-28
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    • 1974
  • Fatty acids of Gingko biloba lipid and its binding position were determined by using pancreatic lipase. Optimum conditions for hydrolysis of glyceride were found as 9mg of lipase and 5 min reaction time for 50 mg of TG. The results showed that oleic acid and linoleic acid were presented about 40% and 29.7%, respectively, but linoleic acid was very small comparing with other seeds. It was found that both saturated and unsaturated fatty acids were almost equally distributed at ${\beta}\;and\;{\alpha}{\cdot}{\alpha}'-position$ of TG.

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Estimation of carbon sequestration in natural forests - A Geospatial Approach - (자연 삼림의 탄소 분리 추정에 관한 연구)

  • Ramachandran, Ramachandran;Jayakumar, S.;Heo, Joon;Kim, Woo-Sun
    • 한국공간정보시스템학회:학술대회논문집
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    • 2007.06a
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    • pp.359-362
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    • 2007
  • Estimation of carbon in the natural forest regions is a pre-requisite for carbon management. In the light of increasing carbon dioxide concentration in the atmosphere, the amount of carbon present in the plants and soils are very much needed to estimate the sequestered carbons stock of any region. Carbon stock estimation studies are limited in India, especially in the natural forest regions of Eastern ghats of Tamil Nadu. Remote sensing, Geographical Information System (GIS) and global positioning system (GPS) were used along with extensive field and laboratory works to estimate the carbon stock in the living biomass and soil. About five forest types were identified and mapped using satellite data. The total biomass carbon including above and below ground were 2.74 Tg and the total soil organic carbon was 3.48 Tg. This study has yielded significant information about the carbon stock in a natural forest region and it could be used for future comparative studies.

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Effectso f Dehulled Defatted Soy Flour on Postprandial Lipid Profile and Enzyme and Hormone Levels in Rats (탈피 탈지 대두분 식이가 흰쥐에서 식후 Lipid Profile과 효소, 호르몬 농도에 미치는영향)

  • 한정희
    • Journal of Nutrition and Health
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    • v.31 no.2
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    • pp.135-142
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    • 1998
  • This study was undertaken to determine whether dehulled defatted flour has an effect on postprandial plasma lipoprotein composition, hepatic lipid composition, enzyme and hormone levels in rats. Control(casein) and experimental (dehulled defatted soy flour)diets were fed to rats for 7 weeks. all animals (S. D. rats, male) were sacrificed 2 hrs after the feeding of 5g of each diet. Defatted soy flour feeding significantly lowered postprandial plasma total cholesterol, chylomicron/VLDL-cholesterol, hepatic cholesterol and triglyceride(TG) as compared with casein feeding, whereas no significant effect on plasma TG was observed. Intestinal kipase activity was elevated , whereas trypsin activity was suppressed in the dehulled defatted soy flour group. Plasma glucagon, thyroid hormone and hepatic HMG-coA reductase levels were not affected by diet treatment. These results hypothesize that dehulled defatted soy flour affects cholesterol digestion and absorption in guts, thus delaying the appearance of chylomicron cholesterol in plasma or affecting the disappearance of chylomicron remnant to high-density-lipoprotein(HDL).

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Properties of Polymer-Modified Mortars Using VAE Redispersible Powders

  • Joseph Ango, Aaron;Yang-Seob, Soh
    • Proceedings of the Korea Concrete Institute Conference
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    • 2003.11a
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    • pp.252-255
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    • 2003
  • Recently, there is a growing trend in the United States toward replacing latex additives in polymer-modified cement mortars with redispersible polymer powders. This movement is relatively new in the U.S. but is further advanced in Europe due to the more extensive use of cement and concrete in residential construction. Hitherto, in Korea - there is a very diminutive movement towards this growing trend. Thus, there is limited availability of data on redispersible polymer powders. This study investigates the effectiveness of redispersible polymer powder on improvement of the mechanical properties of modified mortar. It was concluded from the results of the experiments that the size of the dispersed polymer particles, variations in glass transition points (Tg), and variations in minimum film formation temperature (MFT) influenced the strength development of the modified mortars, and optimum strength in modified mortars using redispersible powders can be achieved when the Tg which accounts for the degree of powder flexibility is considered.

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Standardization Activities on Wireless Sensor Network Transmission Technologies (무선 센서네트워크 전송기술 표준화 동향)

  • Jeong, W.C.;Park, T.J.;Shin, C.S.
    • Electronics and Telecommunications Trends
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    • v.25 no.4
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    • pp.27-37
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    • 2010
  • 최근 들어 무선 센서네트워크는 온/습도 관리와 같은 단순한 기능의 저전력 모니터링 서비스에서 시의성과 무선 전송의 신뢰성을 요구하는 산업 자동화 서비스 및 스마트 그리드와 같이 통신 거리를 확장한 옥외 서비스를 위한 기술로 서비스 영역을 넓혀가고 있다. 무선 센서네트워크 기술은 자원의 제약에 기인한 고유의 특성을 갖는다. 특히 전송 계층 기술은 이러한 제약 사항을 고려하여 설계되어야 하며, 상위 계층 기술의 성능은 전송기술에 대한 성능적 의존성을 가질 수 밖에 없다. 본 고에서는 최근 무선센서 네트워크 서비스 확대를 위한 시장의 요구사항을 반영하여 표준화가 진행되고 있는 시의성/신뢰성 향상을 위한 IEEE 802 WG15의 TG4e MAC 기술과 스마트 유틸리티 네트워크를 위한 TG4g SUN PHY 기술에 대한 표준화 활동을 중심으로 표준 기술 동향을 소개하고 이에 대한 표준 전략을 분석한다.