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Complete Assignment of $^1H-$ and $^{13}C-NMR$ Signals for (20S)- and (20R)-ginsenoside $Rh_2$ by 2D-NMR Techniques (2D-NMR 기법을 이용한 (20S)-와 (20R)-ginsenoside $Rh_2$$^1H-$$^{13}C-NMR$ Signals의 완전 동정)

  • Kim, Dong-Seon;Lee, You-Hui;Park, Jong-Dae;Jeong, So-Young;Lee, Chun-Bae;Kim, Shin-Il;Baek, Nam-In
    • Applied Biological Chemistry
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    • v.38 no.2
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    • pp.184-189
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    • 1995
  • (20S)- and (20R)-Ginsenoside $Rh_2$ were prepared from crude ginseng saponin by chemical treatments. The $^1H-$ and $^{13}C-NMR$ signals of these compounds were fully assigned by various NMR techniques such as DEPT, $^1H-^1H$ COSY, HMQC, HMBC and NOESY.

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High-resolution optical and near-infrared spectroscopic study of 2MASS J06593158-0405277

  • Park, Sunkyung;Lee, Jeong-Eun;Pyo, Tae-Soo;Sung, Hyun-Il;Lee, Sang-Gak;Kang, Wonseok;Oh, Hyung-Il;Yoon, Tae Seog;Mace, Gregory N.;Jaffe, Daniel T.;Yoon, Sung-Yong;Green, Joel D.
    • The Bulletin of The Korean Astronomical Society
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    • v.44 no.2
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    • pp.50.2-50.2
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    • 2019
  • We present the results of high-resolution (R ≥ 30,000) optical and near-infrared spectroscopic monitoring observations of a FU Orionis-type object, 2MASS J06593158-0405277. We have monitored 2MASS J06593158-0405277 with the Bohyunsan Optical Echelle Spectrograph (BOES) and the Immersion GRating INfrared Spectrograph (IGRINS) since December 2014. Various features produced by wind, disk, and outflow/jet were detected. The wind features varied over time and disappeared about a year after the outburst occurred. The double-peaked line profiles were detected in the optical and near-infrared, and the line widths decrease with increasing wavelength. The disk features in the optical spectra are fit well with G2-type or G5-type stellar spectra convolved with a disk rotational profile of about 45 km s-1, which corresponds to a disk radius of about 71 Rfor a central mass of 0.75 M. Disk features in near-infrared spectra are fit well with a K1-type stellar spectrum convolved with a disk rotational profile of about 35 km s-1, which corresponds to a disk radius of about 117 R for a central mass of 0.75 M. We also detected [S II] and H2 emission lines, which are rarely found in FUors but are usually found in the earlier stage of young stellar objects. Therefore, we suggest that 2MASS J06593158-0405277 is in the relatively earlier part of Class II stage.

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Low Voltage Program/Erase Characteristics of Si Nanocrystal Memory with Damascene Gate FinFET on Bulk Si Wafer

  • Choe, Jeong-Dong;Yeo, Kyoung-Hwan;Ahn, Young-Joon;Lee, Jong-Jin;Lee, Se-Hoon;Choi, Byung-Yong;Sung, Suk-Kang;Cho, Eun-Suk;Lee, Choong-Ho;Kim, Dong-Won;Chung, Il-Sub;Park, Dong-Gun;Ryu, Byung-Il
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.6 no.2
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    • pp.68-73
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    • 2006
  • We propose a damascene gate FinFET with Si nanocrystals implemented on bulk silicon wafer for low voltage flash memory device. The use of optimized SRON (Silicon-Rich Oxynitride) process allows a high degree of control of the Si excess in the oxide. The FinFET with Si nanocrystals shows high program/erase (P/E) speed, large $V_{TH}$ shifts over 2.5V at 12V/$10{\mu}s$ for program and -12V/1ms for erase, good retention time, and acceptable endurance characteristics. Si nanocrystal memory with damascene gate FinFET is a solution of gate stack and voltage scaling for future generations of flash memory device. Index Terms-FinFET, Si-nanocrystal, SRON(Si-Rich Oxynitride), flash memory device.

Inhibitive Effect of KH against Toxicity Induced by 5-Flurouracil(FU) (화학요법제 5-flurouracil의 조혈 및 면역독성 억제를 위한 조성물 개발 연구)

  • Yang, Dong-Sik;Hong, Min-Young;Sung, Hyun-Jea;Yoon, Yoo-Sik
    • Korean Journal of Oriental Medicine
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    • v.8 no.2 s.9
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    • pp.109-119
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    • 2002
  • The objective on this study was to investigate effect of KH, which was composed of 9 kinds of oriental herbs tonifing the blood, against toxicity of 5-flurouracil(FU) through animal study. Reduction of WBC and platelet after treating S-FU was significantly recovered by KH. KH also rehabilitated immune gene expression of interleukin-2(IL2) and $Interferon-{\gamma}\;(IFN-{\gamma})$ by RT-PCR. In addition, in situ hybridization of spleen showed that KH treatment increased mRNA expression of IL2. In addition to the immune action, antitumor activity on 5-FU was not affected by KH treatment. In conclusion, our study demonstrated that KH alleviated damage of hematopoiesis system induced by f-FU without toss of antitumor activity.

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Analysis of Foot Type in Korean Young Adults Based on Normalized Arch Height (한국 젊은 성인의 정규화된 아치 높이에 따른 발 유형 분석)

  • Jung, Do-young
    • Physical Therapy Korea
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    • v.27 no.3
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    • pp.199-205
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    • 2020
  • Background: The classification of foot type can be commonly determined by the height of the media longitudinal arch. The normalized arch height (NAH) is defined as the ratio of navicular or instep heights to the foot length or instep length. Objects: This study investigated the relationships among foot characteristics, such as foot length (FL), instep length (IL), navicular height (NH), and instep height (IH), in Korean young adults. Also, the distribution of foot type based on calculated NAH was assessed. Methods: Three-dimensional foot scanning data of young adults aged 20 to 39 years (total: 1,978; 974 male, 1,004 female) were obtained from the Korea Technology Standards Institute, and used for analyses. NAH was calculated as the following: NH/FL, IH/FL, IH/IL, NH/IL. Spearman's rank order correlation was used to identify correlations among variables. The Mann-Whitney U-test and chi-square test were used to compare the sex differences in foot characteristics and distribution of foot type. Results: FL and IL showed a very high correlation (r = 0.94). The correlations between FL or IL and IH (r = 0.50-0.57) were greater than those between FL or IL and NH (r = 0.23-0.72). Males had significantly larger values than females (p < 0.001), and the frequency of pes planus was significantly higher in females than in males (χ2 = 50.09, p < 0.001). Based on the IH/IL index, the neutral foot, pes planus and pes cavus distributed by 16%, 78%, and 6% respectively. Conclusion: Our results on foot arch distribution could be used as basic data in clinical or footwear fields, and our data on differences in arch structure according to sex may facilitate understanding of why injury to the lower limbs differs between males and females.

The Analysis of S&T Policy Changes and Investment Direction of National R&D (과학기술 정책기조 변화 분석과 국가 연구개발 투자방향 연구)

  • Choe, Jong-Il;Kim, Jeong-Eon
    • Journal of Digital Convergence
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    • v.10 no.2
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    • pp.11-23
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    • 2012
  • This study makes an attempt to understand the changes in the National R&D policy by the comparative analysis in terms of R&D policy regime. We characterize the related issues on the National R&D policy, and analyze the direction of science and technology(S&T) policy using the method of scientometrics. The result shows that the policy regime can be categorized into three groups with respect to the R&D efficiency and the keywords; Regime 1: National S&T Innovation 5-year Plan(1999-2002) and National S&T Master plan of the previous adminstration(2003-2007), Regime 2: National S&T Master Plan(2002-2006) and National S&T Master Plan of the previous administration(2003-2007), Regime 3: National S&T Master Plan of the current administration (2008-present).

Characteristics and Antimicrobial Effects of Novel Burkholderia cepacia No. 15-2 Isolated from Compost (퇴비로부터 분리된 Burkholderia cepacia No.15-2의 특성과 항균 효과)

  • Yun, Soon-Il
    • Microbiology and Biotechnology Letters
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    • v.31 no.4
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    • pp.421-428
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    • 2003
  • To develop the functional-compost containing antifungal substance by using antagonistic microorganisms, Spinacia oleracea L and Rhizoctonia solani Kuhn O-28 were used as a model plant and phytopathogen, respectively. Total 80 strains were isolated from the compost of various waste foods mixture processed for a year. Among them, No.15-2 strain was selected due to its highest antifungal activity against R. solani Kuhn O-28 and was identified phyno- and phylogenotypically as Burkholderia cepacia genomovar V. which is rare probability in pathogen, by 16S rDNA sequencing and specific primer pair PCR method. B. cepacia No.15-2 preferentially dominated during the compost and its cell numbers were maintained almost $${\times}$10^{13}$ cuf/g for 15 days. The morbidity caused by R. solani Kuhn O-28 in S. oleracea L cultivation was reduced to 40% by addition of B. cepacia No.15-2. In conclusion, the antifungal compost using B. cepacia No.15-2 could be applied to biocontrol of various crops blights caused by fungal pathogen.

Characteristics of R-22 and R-134a Two-Phase Flow Vaporization in Horizontal Small Tubes

  • Choi, Kwang-Il;Pamitran, A.S.;Rifaldi, M.;Mun, Je-Cheol;Oh, Jong-Taek
    • Proceedings of the SAREK Conference
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    • 2009.06a
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    • pp.1528-1535
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    • 2009
  • Characteristics of R-22 and R-134a two-phase vaporization in horizontal small tubes were investigated experimentally. In order to obtain the local heat transfer coefficients, the test was ran under heat flux range of 10 to $40\;kW/m^2$, mass flux range of 200 to $600\;kg/m^2s$, saturation temperature range of 5 to $10^{\circ}C$, and quality up to 1.0. The test section, which was made of stainless steel tube and heated uniformly by applying an electric current to the tube directly, have inner tube diameters of 0.5, 1.5 and 3.0 mm, and lengths of 0.33 and 2.0 m. The effects on heat transfer coefficient of mass flux, heat flux and inner tube diameter were presented. The experimental heat transfer coefficients were compared with the predictions using existing heat transfer coefficient correlations. A new boiling heat transfer coefficient correlation based on the superposition model, with considering the laminar flow, was developed.

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Experimental Investigation of Flow Boiling Heat Transfer of R-410A and R-134a in Horizontal Small Tubes

  • Pamitran, A.S.;Choi, Kwang-Il;Oh, Jong-Taek;Hrnjak, Pega
    • Proceedings of the SAREK Conference
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    • 2009.06a
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    • pp.1141-1146
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    • 2009
  • Experimental investigation on two-phase flow boiling heat transfer of R-410A and R-134a in horizontal small tubes is reported. The pressure drop and local heat transfer coefficients were obtained over heat flux range of 5 to $40\;kW/m^2$, mass flux range of 70 to $600\;kg/m^2s$, saturation temperature range of 2 to $12^{\circ}C$, and quality up to 1.0 in test section with inner tube diameters of 3.0 and 0.5 mm, and lengths of 2000 and 330 mm, respectively. The section was heated uniformly by applying a direct electric current to the tubes. The effects of mass flux, heat flux, and inner tube diameter, on pressure drop and heat transfer coefficient are presented. The experimental results are compared against several existing correlations. A new boiling heat transfer coefficient correlation based on the superposition model for refrigerants in small tubes is developed.

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Immunoregulatory Effects of Saengshik on DSS-Induced Inflammatory Bowel Disease in Mouse Model System (DSS로 유도된 염증성 장 질환 마우스 동물모델에서 생식이 장관 임파조직내 면역조절 기능에 미치는 영향)

  • Lim, Beong-Ou;Jeong, Yong-Jun;Park, Mi-Hyoun;Kim, Jong-Dai;Hwang, Sung-Joo;Yu, Byung-Pal
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.36 no.1
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    • pp.32-42
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    • 2007
  • This study was conducted on the immunoregulatory effect of Saengshik on gut-associated lymphoid tissue with inflammatory bowel disease. Although the contents of IgA increased in mesenteric lymph node, IgE content was suppressed by Saengshik. The same results were found in spleen, but IgA and IgE responses were very weak. Concentration of fecal IgA was high from the first day through the third day in Saengshik group. In DSS + Saengshik group, concentration of IgA was high till the 2nd day and it maintained the highest level among the test groups on 5th day. Concentration of IFN-gamma and IL-2 was the highest in the Saengshik group, but the concentration of TNF-alpha was lower in DSS + Saengshik compared to DSS. The expressions of STAT1 in Saengshik group were high, while those of STAT6 were low According to these findings, Saengshik exhibited effectiveness via increasing the IgA production, suppressing the IgE production, followed by inhibiting the production of IL-4 and IL-10. Saengshik also strengthened the immune system and alleviated injury in DSS -induced inflammation.