• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 1999년도 춘계학술대회
• /
• pp.33-46
• /
• 1999

• 한국식품영양과학회지
• /
• 제28권6호
• /
• pp.1220-1225
• /
• 1999

Differences in carotenoid composition in the integument of Korean bittering, Cheilognathus signifer and bride bittering, Rhodeus ukekii which are Korean native fresh water fish were compared. Total ca rotenoid contents in the integument of wild Korean bittering was 2.11mg% and composed of 42.6% zeaxanthin, 12.1% diatoxanthin and 12.1% lutein epoxide which are predominant carotenoids and 10.3% cynthiaxanthin, 8.3% zeaxanthin epoxide, 6.4% lutein and 1.5% cryptoxanthin which are minor carotenoids. Total ca rotenoid contents in the integument of wild bride bittering was 4.99mg% during a spawning period but after the spawning period it was decreased to 4.17mg% and carotenoid composition of bride bittering during the spawning period was 46.7% zeaxanthin, 26.5% diatoxanthin and 12.3% lutein which are predominant carotenoids, and 6.2% zeaxanthin epoxide, 3.1% cynthiaxanthin, 2.9% cryptoxanthin and 0.7% canthax anthin which are minor carotenoids. These results indicated that the carotenoid composition of bride bittering during spawning period was very similar to that of Korean bittering and carotenoid composition of bride bittering after the spawning period was 30.5% diatoxanthin, 21.5% cynthiaxanthin and 16.8% zeaxanthin which are predominant carotenoids and 14.0% cryptoxanthin, 11.3% lutein and 3.4% can thaxanthin which are minor carotenoids, indicating that after the spawning period, the content of zeaxanthin was decreased while that of cryptoxanthin and cynthiaxanthin was increased as compared to that of the spawning period. Total carotenoid contents in Korean bittering and bride bittering was relatively higher than that in other species of cyprinidae whereas composition of the carotenoid was similar.

• BMB Reports
• /
• 제56권10호
• /
• pp.545-550
• /
• 2023

Osteoporosis is a major public health concern, which requires novel therapeutic strategies to prevent or mitigate bone loss. Natural compounds have attracted attention as potential therapeutic agents due to their safety and efficacy. In this study, we investigated the regulatory activities of boeravinone B (BOB), a natural rotenoid isolated from the medicinal plant Boerhavia diffusa, on the differentiation of osteoclasts and mesenchymal stem cells (MSCs), the two main cell components responsible for bone remodeling. We found that BOB inhibited osteoclast differentiation and function, as determined by TRAP staining and pit formation assay, with no significant cytotoxicity. Furthermore, our results showing that BOB ameliorates ovariectomy-induced bone loss demonstrated that BOB is also effective in vivo. BOB exerted its inhibitory effects on osteoclastogenesis by downregulating the RANKL/RANK signaling pathways, including NF-κB, MAPK, and PI3K/Akt, resulting in the suppression of osteoclast-specific gene expression. Further experiments revealed that, at least phenomenologically, BOB promotes osteoblast differentiation of bone marrow-derived MSCs but inhibits their differentiation into adipocytes. In conclusion, our study demonstrates that BOB inhibits osteoclastogenesis and promotes osteoblastogenesis in vitro by regulating various signaling pathways. These findings suggest that BOB has potential value as a novel therapeutic agent for the prevention and treatment of osteoporosis.

• 농약과학회지
• /
• 제20권3호
• /
• pp.197-202
• /
• 2016

계피 추출물의 지표성분으로 알려진 cinnamaldehyde와 cinnamyl alcohol, 데리스 추출물의 지표성분인 deguelin과 rotenone을 대상으로 유기농업자재 제품 중 안정성을 평가하였다. 시험은 $4^{\circ}C$, $23^{\circ}C$, $35^{\circ}C$, $45^{\circ}C$, $54^{\circ}C$에서 각각 진행하였으며, 계피 추출물을 주성분으로 하는 유기농업자재 중 고상제품(Biopesticide A, B)의 유효성분 반감기가 15.1-46.2 days로 액상제품(Biopesticide C, D)에 비해 보관 중 안정성이 높게 나타났다. 또한, 동일 제품 내에서는 cinnamaldehyde의 안정성이 cinnamyl alcohol보다 높은 것으로 나타났다. 데리스 추출물을 사용한 제품(Biopesticide E, F, G)의 rotenoid계 유효성분 반감기는 1.5-173 days로 제품별 보관온도에 따른 지표성분 안정성이 큰 차이를 나타내었으며, 동일 제품에서 deguelin과 rotenone의 안정성은 큰 차이를 나타내지 않았다.