• YAKHAK HOEJI
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• v.36 no.6
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• pp.598-603
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• 1992

The purpose of this study was to assess the effect of three formulations; product A (polyethylene glycol was used as a main dispersing agent), product B (wax mixture was used as a main dispersing agent) and product C(silicon dioxide was used as a main dispersing agent) on bioavailability of acetaminophen soft gelatin capsules(softgels) and to develop an effective acetaminophen softgel which exhibits an excellent bioavailability. Acetaminophen softgels of various formulations were prepared as 4 minim round type by rotary die method. Four softgels of the three formulation (A, B, C), each of which contained 50 mg acetaminophen, were administered orally to 12 normal healthy rabbits using a three-way cross over design. Plasma acetaminophen concentrations were measured by HPLC. The results obtained in this study were as follows: 1. The Tmax rank order of acetaminophen softgel was C$(63.75{\pm}10.62\;min)$>A$(36.25{\pm}5.37\;min)$>B$(35{\pm}6.74\;min)$. 2. The decreasing Cmax order of softgel product was A$(93.51{\pm}0.55\;{\mu}g/ml)$>B$(3.16{\pm}0.37\;{\mu}g/ml)$>C$(2.6{\pm}0.55\;{\mu}g/ml)$. 3. The $[AUC]^{\infty}_0$ rank order for three acetaminophen softgel formulations was A $(14.89{\pm}1.56\;{\mu}g/ml{\cdot}min)$ >B$(14.39{\pm}1.43\;{\mu}g/ml{\cdot}min)$>C$(11.45{\pm}1.49\;{\mu}g/ml{\cdot}min)$. 4. Pharmacokinetic parameters such as Tmax, Cmax and $[AUC]^{\infty}_0$ of product A and B did not differ significantly(p>0.05). On the other hand, those of product C were significantly different(p>0.05).

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.6
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• pp.1886-1896
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• 1991

This paper presents a method to predict the flying height of the head slider in a hard disk drive. Quantitative predicts of the flying height according to the variations of the external load and the disk velocity have been done by numerical computation. In addition, the magnitude of the external load to keep flying height constant were also suggested. The Modified Reynolds' equation driven from hydrodynamic lubrication theory under slip flow condition was used to describe air-bearing system under the slider. To solve the equation, a Finite Volume Method (FVM) has been applied. To determine the final minimum flying height and pitch angle of the head slider, the Secant iteration method is used which update initial guess of the minimum flying height and pitch angle of the slider. In this study, the model head slider has been selected from a real hard disk drive which is equipped in many commercial personal computers. As a result, as the disk velocity increases at constant external load, the minimum flying height and the pitch angle increase due to the in crease of the air-bearing force at the bottom of slider.

• Journal of Biosystems Engineering
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• v.36 no.6
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• pp.453-460
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• 2011

This study was carried out to test a red pepper tedding factors which is needed for design and development of an auto-tedding machine and a performance. According to this test, the results can be summarized as follows: The results of the tedding factors test according to shape of rotary blade, which is the 0.4 to 0.5 mm brush type, was found to be the most appropriate. As a result of tedding ratio which includes brush diameters, driving velocities and rotation velocities, there was generally no significance difference, but the red pepper tedding efficiency was found to be 39.7%. The moisture drying rate of red pepper was found to be 0.9 %w.b./h in prototype auto-tedding machine and 0.4 %w.b./h in traditional practice. The drying time was found to be 3 days in prototype auto-tedding machine and the traditional practice was 6 days. The average variable coefficient of the red pepper moisture content was found to be 16.8% in prototype auto-tedding machine in comparing with the traditional practice of 35.0%. This test showed a difference around two times, and this difference was evaluated to be the reason for irregular drying and different drying times.

• Journal of Biosystems Engineering
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• v.34 no.3
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• pp.140-146
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• 2009

The garlic, along with the red pepper, is one of the major seasoning vegetables in Korea. Garlic clove planting is one of the most laborious operations. Labor cost is the main source of high production cost of the garlic. Because of the geometrical uniqueness and irregularity of garlic cloves, mechanization of garlic clove planting is very difficult. To overcome price competition against the imported garlic, however, there has been a need of development of a clove metering device and a planting device for the garlic clove planter. Computer simulation, laboratory tests and field tests were conducted to develop a garlic clove planter. This research was conducted to drop garlic cloves into a soil holes through a drum bucket metering system and a rotary type planting system. Followings are the major achievements from this study. 1. The metering device consisted of a drum, a guide, a bucket and a bucket cover. Opening positions of the metering hopper were evaluated at different positions and trajectories of planting hoppers. The simulation showed that the optimum positions of hopper was -15${\sim}$0 mm in the x direction. 2. When the planter was tested under different soil textures and water contents, the best performances were obtained in a upland field with 29.1% water content and a paddy field with 18.3% water content where single clove metering and missing rate were 88.4% and 1.3%, and 90.7% and 2.0%, respectively.

• Korean Journal of Food Science and Technology
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• v.26 no.6
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• pp.709-712
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• 1994

The volatile components of citron juice juice extracted by three methods, which were Rotary-crushing and screening method (method I), Pressing method (method II) and Belt pressing method (method III), were analyzed with GC and GC/MS. Juice extracted by method III had more components of flavor than those by methods I and II. Also, the contents of total volatile components in method III were about 1.36 and 1.59 times than those in methods I and II, respectively. Limonene in juice extracted by method III was predominantly occupied, amount of which was 76.87%. Other important components were terpene hydrocarbons, such as ${\gamma}-terpinene$, ${\alpha}-terpinene$ and so on.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.1
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• pp.140-148
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• 2004

A novel rapid prototyping (RP) process, a full-automated transfer type variable lamination manufacturing process (Full-automated VLM-ST) has been developed. In the full-automated VLM-ST process, a vacuum chuck and a rectilinear motion system transfer the EPS foam material in the form of the plate with two pilot holes to the rotary supporting stage. The supplied material is then cut into an automated unit shape layer (AUSL) with a desired width, a desired length, a desired slope on the side surface, and a pair of reference shapes, which is called the guide shape (GS)’, including two pilot holes in accordance with CAD data through cutting in two steps using a four-axis synchronized hotwire cutter. Then, each AUSL is stacked by setting each AUSL with two pilot holes in the building plate with two pilot pins, and subsequently, adhesive is applied onto the top surface of the stacked AUSL by a bonding roller and pressure is simultaneously given to the bottom surface of the stacked AUSL. Finally, three-dimensional shapes are rapidly and automatically fabricated. This paper describes the method to generate guide shapes in AUSL data for the full-automated VLM-ST process. In order to examine the applicability of the method to generate guide shapes, three-dimensional shapes, such as a piston shape and a human head shape, are fabricated from the full-automated VLM-ST apparatus.

• Journal of Biosystems Engineering
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• v.35 no.1
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• pp.21-30
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• 2010

This study was performed to develop an active tire pressure control system that can adjust tire pressure to the optimum level according to traveling and working condition of agricultural tractor. For the development of active tire pressure control system, pneumatic supplier, solenoid valve block including pneumatic supply line, infinite rotation type pneumatic supplier with rotary joint unit, tire pressure transceiver module and control algorithm were developed. Also, tire simulator was developed. Using this tire simulator, the feasibility of each part constructing actual system was tested by checking the performance. The average communication success ratio was 98.3% between tire pressure transmitter and receiver module according to the various tire rotational speed and data receipt position of receiver module. The communication performance of the developed transmitter and receiver module was very stable in any condition. The tire pressure control system was accomplished by using the proportional control algorithm in this study. Also tire pressure control performance of developed control system was analyzed by using the tire simulator. As a result of control performance analysis to the developed system, the developed control system took 307 seconds to inflate agricultural tractor's tire from 50 kPa to 180 kPa. In opposite case, it took 210 seconds. Also it was able to control the tire pressure accurately under ${\pm}0.9%$ (FS) in any condition.

• The Journal of Internal Korean Medicine
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• v.25 no.2
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• pp.277-287
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• 2004

Objective : Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications showed that oxidative stress might playa major role. Therefore, many efforts have been made to regulate oxygen free radicals for treating diabetes and its complications. Because Jindangwon has been known to be effective in treatment of diabetes, the methanol extract of Jindangwon was tested for its effectiveness in reducing the oxidative stress induced by Streptozotocin. Methods : Jindangwon was washed, dried in the shade and crushed. The crushed Jindangwon was extracted 3 times, each time with 3 volumes of methyl alcohol at $60^{\circ}C$ for 24 hours. The extract was filtered and evaporated under reduced pressure using a rotary evaporator to yield 30.6 g. Jindangwon extract was oral-administered to the diabetic rats induced by streptozotocin 50 mg per 1 kg of body weight for 15 days. The efficacy of the Jindangwon extract was examined with regard to the enzymatic pathways involved in the oxygen free radical production and the glutathione balance. Results : he effects of the methanol extract of Jindangwon in streptozotocin-induced diabetics rats with regard to body weight, blood glucose level, hepatic lipid peroxide level, hepatic xanthine oxidase activity and type conversion rate, hepatic glutathione level, hepatic glutathione peroxidase activity, hepatic glutathione reductase activity, hepatic aldose reductase activity, and hepatic sorbitol dehydrogenase activity were favorable enough to suggest that it is a cure for diabetes and its complications. Conclusions :These results support Jindangwon as an effective reducing agent for oxidative stress in the tissues and organs by regulating the production of oxygen free radicals. Jindangwon, in particular, shows promising results for its use as a cure, or preventative medicine for diabetes and its complications by reducing oxidative stress in beta-cells of the pancreas.

• Journal of Biosystems Engineering
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• v.17 no.3
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• pp.229-236
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• 1992

In an effort to localize the spray-dryer which is markedly used for drying food materials, a experiment was carried out with a wheel type atomizer locally designed and manufactured to evaluate the effect of rotational speed, feed rate and physical properties of liquid food material on the droplet size, and to develop a model to predict the droplet size sprayed at various operational conditions. The result are summarized as follows. 1. The frequency of droplet size sprayed from the atomizer at every treatment were similar to normal distributions. 2. Under the test conditions adopted in this study, that is, rotational speed of the atomizer ranging from 15,000 to 20,000 rpm (55.0 m/sec - 73.3 m/sec), feed rate from 14 to 37 kg/hr and viscosity of the material from 1.14 to 350 cP, the mean volume-surface dia. of droplets was decreased as increase in rotational speed and was not affected significantly by the feed rate and viscosity. 3. Through the dimensional analysis, a prediction model was developed as follows : $$\frac{Dvs}{r}=K[\frac{Q}{{\mu}r}]^a[\frac{rN^2}{g}]^b[\frac{{\rho}^2r^3g}{{\mu}^2}]^c[\frac{L}{r}]^d$$ and it was proved that the above model was better in degree of fitness than other models reported. 4. A prediction equation for the droplet size sprayed from the atomizer under the test was expressed as follows : $$\frac{Dvs}{r}=0.0215[\frac{Q}{{\mu}r}]^{0.06}[\frac{rN^2}{g}]^{0.3314}[\frac{{\mu}^2}{{\rho}^2r^3g}]^{0.0158}$$.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.3
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• pp.639-646
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• 2016

In this study, the contactless measurement method with a optical displacement sensor(ODS, ADNS 9500) was proposed to overcome flaws in a rotary encoder based measurement under particular circumstances, such as a slippage and a case of little rotational inertia. The performance tests of the optical displacement sensor using data acquisition board and National Instruments's LabVIEW program were performed to accomplish accurate displacement measurements and the performance characteristics according to measurement direction, speed, acceleration, height and surface types were discovered through the repetitive tests. The experimental results indicate that, in order to get an accurate in-plane motion, the height(distance between the ODS and the target surface) has to be maintained at the range of 2.4 mm to 3.2 mm and the sensitivity(resolution) should be modified and applied to the formulae for displacement calculation, considering its measurement direction, speed and surface type.