• 한국의류학회지
• /
• 제34권7호
• /
• pp.1087-1099
• /
• 2010

This study explores the retail environment factors of the changes mentioned in the "Factors and Directions of the Change of the Apparel Retail Structure in Korea" (Part I) to understand the changes in apparel retail institutions. This study was done through a literature research method and the results are as follows. First, changing consumer needs and trends require extensive new products, a method to manufacture diverse products according to the market demand, and the necessity to manufacture based on trends in demand. This limits the role of mass production, which brought about more flexible manufacturing modes, scaled down manufacturing factories, promoted more cooperative subcontract relationships, and increased global sourcing which uses other companies at the most appropriate global venue. How to organize and use cooperative networks that benefit companies is the key to global competitiveness in the new era and the information technology developed around retail shops plays a key role. Consequently, the management of consumers and their information becomes critical and retail distribution functions become a key corporate function. In addition, it is difficult for small shops to introduce effective new technologies that encourage the growth of large companies. Second, apparel companies that use to benefit from scale merits based on the previous mass production system are now becoming effective by using economies of scale through mass retailing while shops are enlarging their sizes as a way to survive. On the other hand, inexpensive clothes become even more inexpensive while expensive ones become even more expensive, promoting polarization and diverse price ranges that widen consumer options.

• 한국재료학회지
• /
• 제20권5호
• /
• pp.257-261
• /
• 2010

A non-volatile resistive random access memory (RRAM) device with a Cr-doped $SrZrO_3/SrRuO_3$ bottom electrode heterostructure was fabricated on $SrTiO_3$ substrates using pulsed laser deposition. During the deposition process, the substrate temperature was $650^{\circ}C$ and the variable ambient oxygen pressure had a range of 50-250 mTorr. The sensitive dependences of the film structure on the processing oxygen pressure are important in controlling the bistable resistive switching of the Cr-doped $SrZrO_3$ film. Therefore, oxygen pressure plays a crucial role in determining electrical properties and film growth characteristics such as various microstructural defects and crystallization. Inside, the microstructure and crystallinity of the Cr-doped $SrZrO_3$ film by oxygen pressure were strong effects on the set, reset switching voltage of the Cr-doped $SrZrO_3$. The bistable switching is related to the defects and controls their number and structure. Therefore, the relation of defects generated and resistive switching behavior by oxygen pressure change will be discussed. We found that deposition conditions and ambient oxygen pressure highly affect the switching behavior. It is suggested that the interface between the top electrode and Cr-doped $SrZrO_3$ perovskite plays an important role in the resistive switching behavior. From I-V characteristics, a typical ON state resistance of $100-200\;{\Omega}$ and a typical OFF state resistance of $1-2\;k{\Omega}$, were observed. These transition metal-doped perovskite thin films can be used for memory device applications due to their high ON/OFF ratio, simple device structure, and non-volatility.

• 한국추진공학회지
• /
• 제15권4호
• /
• pp.26-34
• /
• 2011

스월러를 가진 천연가스 연료분사기가 장착된 희박 예혼합 연소기에서 화염구조의 일부분인 재순환 영역의 형성이 연소불안정에 미치는 영향에 대하여 실험적으로 연구를 진행하였다. PIV 계측기법으로 연소장에서의 화염의 안정화 그리고 불안정한 영역에서 유동장을 확인해본 결과 스월러에 의한 재순환 영역은 화염의 안정화 및 난류의 강도뿐만 아니라 재순환영역 형성의 크기에 따른 화염 재점화에도 영향을 미쳐 연소불안정 발생의 원인이 되는 열방출 섭동과 매우 밀접한 관계가 있음을 확인하였다.

• Molecules and Cells
• /
• 제39권3호
• /
• pp.211-216
• /
• 2016

CYP107W1 from Streptomyces avermitilis is a cytochrome P450 enzyme involved in the biosynthesis of macrolide oligomycin A. A previous study reported that CYP107W1 regioselectively hydroxylated C12 of oligomycin C to produce oligomycin A, and the crystal structure of ligand free CYP107W1 was determined. Here, we analyzed the structural properties of the CYP107W1-oligomycin A complex and characterized the functional role of the Trp178 residue in CYP107W1. The crystal structure of the CYP107W1 complex with oligomycin A was determined at a resolution of $2.6{\AA}$. Oligomycin A is bound in the substrate access channel on the upper side of the prosthetic heme mainly by hydrophobic interactions. In particular, the Trp178 residue in the active site intercalates into the large macrolide ring, thereby guiding the substrate into the correct binding orientation for a productive P450 reaction. A Trp178 to Gly mutation resulted in the distortion of binding titration spectra with oligomycin A, whereas binding spectra with azoles were not affected. The Gly178 mutant's catalytic turnover number for the 12-hydroxylation reaction of oligomycin C was highly reduced. These results indicate that Trp178, located in the open pocket of the active site, may be a critical residue for the productive binding conformation of large macrolide substrates.

• 디지털융복합연구
• /
• 제13권1호
• /
• pp.481-486
• /
• 2015

이 연구는 SBS 수목드라마에서 나타난 등장인물의 행위들에서 만들어 내는 다양한 관계들이 어떻게 소통되고 있는지를 그레마스 행위소 모델을 통해 의미를 분석하고자 하였다. 주체와 대상의 관계에서 주체가 가지고 있는 결핍구조를 분석하여 이러한 관계에서 발생하는 문제들을 살펴본다면 서로 다른 장르에서 나타나는 드라마 속의 등장인물 관계를 종합적으로 분석할 수 있다. 이를 해석해보면 같은 사건에서 시작된 발신된 주체와 대상의 결핍 구조는 다르게 나타난 반면, 우연한 사건으로 인한 주체와 대상은 같은 결핍구조를 가지고 있었다. 주체와 발신자의 관계에서는 주체보다 나약하고 보호 받아야하는 불쌍한 인물들로 설정되었을 때는 극중 역할이 제한적이지만 발신자가 주체에게 적대자로써의 역할을 같이하는 구조에서는 주체보다 권위적이었다. 세 작품 속에서 나타난 반대자들은 결국 주체와 대상에게 또 다른 협력자들로 변절하며 사건 해결에 도움을 주며, 불행해지기보다는 한결 더 성숙해지는 경향이 있었다.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2011년도 제36회 춘계학술대회논문집
• /
• pp.445-452
• /
• 2011

스월러를 가진 천연가스 연료분사기가 장착된 희박 예혼합 연소기에서 화염구조의 일부분인 재순환 영역의 형성이 연소불안정에 미치는 영향에 대하여 실험적으로 연구를 진행하였다. PIV 계측기법으로 연소장에서의 화염의 안정화 그리고 불안정한 영역에서 유동장을 확인해본 결과 스월러에 의한 재순환영역은 화염의 안정화 및 난류의 강도뿐만 아니라 재순환영혁 형성의 크기에 따른 화염 재점화에도 영향을 미쳐 연소불안정 발생의 원인이 되는 열방출 섭동과 매우 밀접한 관계가 있음을 확인하였다.

• Biomolecules & Therapeutics
• /
• 제31권1호
• /
• pp.108-115
• /
• 2023

Numerous psychotropic and addictive substances possess structural features similar to those of β-phenethylamine (β-PEA). In this study, we selected 29 β-PEA derivatives and determined their structure-activity relationship (SAR) to their ability to inhibit dopamine (DA) reuptake; conducted docking simulation for two selected compounds; and identified their potential functionals. The compounds were subdivided into arylethylamines, 2-(alkyl amino)-1-arylalkan-1-one derivatives and alkyl 2-phenyl-2-(piperidin-2-yl)acetate derivatives. An aromatic group, alkyl group, and alkylamine derivative were attached to the arylethylamine and 2-(alkyl amino)-1-arylalkan-1-one derivatives. The inhibitory effect of the compounds on dopamine reuptake increased in the order of the compounds substituted with phenyl, thiophenyl, and substituted phenyl groups in the aromatic position; compounds with longer alkyl groups and smaller ring-sized compounds at the alkylamine position showed stronger inhibitory activities. Docking simulation conducted for two compounds, 9 and 28, showed that the (S)-form of compound 9 was more stable than the (R)-form, with a good fit into the binding site covered by helices 1, 3, and 6 of human dopamine transporter (hDAT). In contrast, the (R, S)-configuration of compound 28 was more stable than that of other isomers and was firmly placed in the binding pocket of DAT bound to DA. DA-induced endocytosis of dopamine D₂ receptors was inhibited when they were co-expressed with DAT, which lowered extracellular DA levels, and uninhibited when they were pretreated with compound 9 or 28. In summary, this study revealed critical structural features responsible for the inhibition of DA reuptake and the functional role of DA reuptake inhibitors in regulating D₂ receptor function.

• Molecules and Cells
• /
• 제43권11호
• /
• pp.935-944
• /
• 2020

Aryl hydrocarbon receptor nuclear translocator (ARNT) plays an essential role in maintaining cellular homeostasis in response to environmental stress. Under conditions of hypoxia or xenobiotic exposure, ARNT regulates the subset of genes involved in adaptive responses, by forming heterodimers with hypoxia-inducible transcription factors (HIF1α and HIF2α) or aryl hydrocarbon receptor (AhR). Here, we have shown that ARNT interacts with DDB1 and CUL4-associated factor 15 (DCAF15), and the aryl sulfonamides, indisulam and E7820, induce its proteasomal degradation through Cullin-RING finger ligase 4 containing DCAF15 (CRL4^DCAF15) E3 ligase. Moreover, the two known neo-substrates of aryl sulfonamide, RNA-binding motif protein 39 (RBM39) and RNA-binding motif protein 23 (RBM23), are not required for ARNT degradation. In line with this finding, aryl sulfonamides inhibited the transcriptional activities of HIFs and AhR associated with ARNT. Our results collectively support novel regulatory roles of aryl sulfonamides in both hypoxic and xenobiotic responses.

• Journal of Astronomy and Space Sciences
• /
• 제25권4호
• /
• pp.335-346
• /
• 2008

Using the global total electron contents (TEC) measured by the TOPEX satellite from Aug. 1992 to Oct. 2005, we investigate the variations of the longitudinal wavenumber-4 (LW-4) structure in the equatorial anomaly (EA) crests with season, local time, and solar activity. Our study shows that the LW-4 structure in the EA crests ($5{\sim}20^{\circ}$ MLAT in both hemispheres) has clear four peaks at fixed longitude sectors during the daytime for both equinoxes and June solstice. In spite of being called a wavelike structure, however, the magnitudes and spatial intervals of the four peaks are far from being the same or regular. After sunset, the four-peak structure begins to move eastward with gradual weakening in its amplitude during equinoxes and this weakening proceeds much faster during June solstice. Interestingly, the longitudinal variations during December solstice do not show clear four-peak structure. All these features of the LW-4 structure are almost the same for both low and high solar activity conditions although the ion densities are greatly enhanced from low to high solar activities. With the irrelevancy of the magnetic activity in the LW-4, this implies that the large changes of the upper atmospheric ion densities, one of the important factors for ion-neutral interactions, have little effect on the formation of the LW-4 structure. On the other hand, we found that the monthly variation of the LW-4 is remarkably similar to that of the zonal component of wavenumber-3 diurnal tides at low latitudes, which implies that the lower atmospheric tidal forcing, transferred to the upper atmosphere, seems to have a dominant role in producing the LW-4 structure in the EA crests via the E-region dynamo.

• 한국문헌정보학회지
• /
• 제43권3호
• /
• pp.417-439
• /
• 2009

본 연구는 논문제목의 구문 및 의미구조를 기반으로 국내 기록관리학 분야의 연구영역의 특성을 분석하였다. 이를 위해 1999년부터 2008년까지 국내 기록관리학 분야 전문 학술지 3종으로부터 핵심 연구논문 344개를 선정하였다. 해당 연구논문의 제목을 대상으로 구문 및 의미 구조를 분석하여 논문제목에 포함된 키워드들의 역할개념으로 '연구도메인', '연구대상', '연구초점'을 추출하였다. 추출된 3개의 역할개념별로 키워드들을 배정하여 군집화 하였다. 군집화 결과를 통해 최종적으로 국내 기록관리학 분야에서 어떤 연구대상이 핵심 연구대상이며 핵심 연구대상은 어느 연구도메인에서 어떤 연구초점에 관심을 두고 있는지를 분석하였다.