• Genomics & Informatics
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• 제6권2호
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• pp.72-76
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• 2008

Hypoxia-inducible factor $1{\alpha}\;(HIF1{\alpha})$ is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation (ODD) domain of $HIF1{\alpha}$ is responsible for the negative regulation of $HIF1{\alpha}$ in normoxia. The interactions of the $HIF1{\alpha}$ ODD domain with partner proteins such as von Hippel-Lindau tumor suppressor (pVHL) and p53 are mediated by two sequence motifs, the N- and C-terminal ODD(NODD and CODD). Multiple sequence alignment with $HIF1{\alpha}$ homologs from human, monkey, pig, rat, mouse, chicken, frog, and zebrafish has demonstrated that the NODD and CODD motifs have noticeably high conservation of the primary sequence across different species and isoforms. In this study, we carried out molecular dynamics simulation of the structure of the $HIF1{\alpha}$ CODD motif in complex with the p53 DNA-binding domain (DBD). The structure reveals specific functional roles of highly conserved residues in the CODD sequence motif of $HIF1{\alpha}$ for the recognition of p53.

• BMB Reports
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• 제53권4호
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• pp.173-180
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• 2020

Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic biomarker of various diseases, including heart disease, kidney disease, and cancer. Galectin-3 exists as a cytosol, is secreted in extracellular spaces on cells, and is also detected in nuclei. It has been found that galectin-3 has different functions in cellular localization: (i) Extracellular galectin-3 mediates cell attachment and detachment. (ii) cytosolic galectin-3 regulates cell survival by blocking the intrinsic apoptotic pathway, and (iii) nuclear galectin-3 supports the ability of the transcriptional factor for target gene expression. In this review, we focused on the role of galectin-3 on translocation from cytosol to nucleus, because it happens in a way independent of carbohydrate recognition and accelerates cancer progression. We also suggested here that intracellular galecin-3 could be a potent therapeutic target in cancer therapy.

• 한국수학교육학회지시리즈A:수학교육
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• 제53권1호
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• pp.93-110
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• 2014

Algebra deals with so general properties about number system that it is called as 'generalized arithmetic'. Observing students' activities in algebra classes, however, we can discover that recognition of the generality in algebraic proofs is not so easy. One of these difficulties seems to be caused by variables which play an important role in algebraic proofs. Many studies show that students have experienced some difficulties in recognizing the meaning and the role of variables in algebraic proofs. For example, the confusion between 2m+2n=2(m+n) and 2n+2n=4n means that students misunderstand independent/dependent variation of variables. This misunderstanding naturally has effects on understanding of the meaning of proofs. Furthermore, students also have a difficulty in making a transition from algebraic proof to numerical cases which have the same structure as the proof. This study investigates whether middle school students can recognize dependent generality and make a transition from proofs to numerical cases. The result shows that the participants of this study have a difficulty in both of them. Based on the result, this study also includes didactical implications for teaching the generality of algebraic proofs.

• 한국간호교육학회지
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• 제4권2호
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• pp.131-146
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• 1998

The study was attempted and executed to reach the following conclusions. The period was May 1st through June 15th, 1998 and the subjects were 302 teachers consisting of School Nurses and general teachers in Pusan city. 1) The degrees of recognition of sexual roles by the subjects were compared as follows : The average point as to the recognition of sexual roles in the occupational functions by the school nurses was 2.41, higher than that of the general teachers. The average points as to the recognition of sexual roles in the attitudes by the school nurses was 2.28, higher than that of the general teachers. The average points as to the recognition of sexual roles in the abilitis was 2.26, higher than that of the general teachers. These ascertain that school nurses recognize the man has higher superities in the occupational functions, the attitudes and the abilities than the woman. 2) The degrees of demand of sexual education by the subjects were compared as follows : As to the degrees of demand of sexual education, the school nurses showed higher demand than the general teachers in the concepts such as 'the society and sexualities, physiology and actual education'. 3) The levels of the consciousness of sexual education by the subjects were compared as follows : the general teachers showed the more strict attitudes than the school nurses against the lascivious sex objects and wanted the punishment against the related students and the general teachers have myth. They claimed that their family have no relation with the sexual violence or pornography. As to the masturbation, the general teachers showed the more conservative attitudes. 4) The opinions by the subjects as to the well-qualified person in charge of sexual education in school were compared as follows : 77.3% of the school nurses, and 36.1% of the general teachers supported the school nurses.

• 인지과학
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• 제20권3호
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• pp.357-381
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• 2009

이전의 연구들이 외부 피드백 정보에 대한 반응민감도에 성격특성적 개인차가 반영된다는 사실을 밝힌바 있지만, 재인기억과 관련한 의사결정에서 이러한 기질 혹은 특성적 개인차가 어떻게 관여하는지는 아직 알려진 바가 없다. 본 연구는 재인기억 과제에서 피드백에 근거한 의사결정 준거의 순응적 변화정도와 피드백에 대한 일반적 반응민감도의 개인차간 관계를 살펴보았다. 통제 조건인 실험 1에서는 올바른 피드백 조건이 의사결정 준거의 유동성에 영향을 미치지 않음을 보인 반면 피드백 조작이 이루어진 실험 2에서는 확신도가 높은 오기억 반응에만 선택적으로 편향된 피드백이 주어졌음에도 전반적인 Old/New 반응 범주의 결정준거 또한 순응적으로 이동함이 나타났다. 보다 중요하게 이 피드백에 근거한 의사결정 준거 학습에 나타나는 개별 피험자들의 반응민감도 차이가 강화 추구 혹은 불안 회피와 밀접하게 관련된 안정적 성격(Behavioral Activation System-BAS 혹은Behavioral Inhibition System-BIS)의 개인차에 의해 유의미하게 예측될 수 있음이 나타났다. 이러한 결과는 그동안 외현적인 재인 기억 의사 결정에 있어서 중요하게 여기지 않았던 점증적 강화학습 기제가 결정 준거의 설정에 관여할 수 있음을 보여준다는 데에서 중요한 의미를 찾을 수 있다.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제20권11호
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• pp.579-585
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• 2014

음소는 음성을 구성하는 최소 단위로서 음성을 인식하는데 있어 매우 중요한 역할을 한다. 본 논문은 음소 기반 한국어 음성 인식의 일부로서, 한국어 음소 중 'ㅅ', 'ㅈ', 'ㅊ'에 대한 새로운 인식 방안을 제안한다. 제안하는 방식은 입력 음성 신호를 구성하는 각각의 블록에 대해 계산되는 변동성 지표와 전환점 지표에 기반한다. 변동성 지표는 블록 내의 인접한 샘플 값들의 차이의 총합이며, 전환점 지표는 블록 내에서 샘플 값의 증가와 감소의 방향이 전환되는 극점의 총수이다. 두 지표를 결합하여 음소 인식을 수행하는 인식 알고리즘은 두 지표와 관련하여 최적화된 임계치들을 활용하여 목표로 하는 세 가지 음소가 인식된 위치를 최종적으로 결정한다. 실험 결과를 통해, 제안하는 방식을 사용함으로써 기존의 방식들에 비해 FRR과 FAR의 관점에서 모두 오류율을 현저히 감소시킬 수 있음을 확인하였다.

• 한국ITS학회 논문지
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• 제18권6호
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• pp.241-250
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• 2019

도로표지는 도로 이용자를 위한 시설물로서 관리 및 유지보수의 편의성 증진을 위해 국토교통부에서는 관리시스템을 구축하여 운영 중에 있다. 향후 자율주행 시대에 도로표지의 역할은 감소하겠지만 그 필요성은 지속되고 있다. 이에 도로표지에 표기된 안내지명의 정확한 기계적 판독을 위해 도로표지 자동인식 장비를 개발하여 영상 기반의 문자 인식 기술을 적용하고 있지만 불규칙적인 규격과 수작업 제조, 조도, 빛반사, 강우 등 외부환경에 의해 오인식되는 경우가 다수 발생하고 있다. 본 연구에서는 영상 분석 등으로 극복할 수 없는 오인식 결과를 개선하기 위해 위치기반의 안내지명 후보를 도출하여 기준으로 하고, 오인식된 지명의 음소 분리를 통한 레벤슈타인 문자 유사도 검증 방법을 이용해 도로표지 안내지명 자동인식율을 개선하고자 하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권4호
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• pp.1904-1926
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• 2016

Iris recognition for biometric personnel identification has gained much interest owing to the increasing concern with security today. The image quality plays a major role in the performance of iris recognition systems. When capturing an iris image under uncontrolled conditions and dealing with non-cooperative people, the chance of getting non-ideal images is very high owing to poor focus, off-angle, noise, motion blur, occlusion of eyelashes and eyelids, and wearing glasses. In order to improve the accuracy of iris recognition while dealing with non-ideal iris images, we propose a novel algorithm that improves the quality of degraded iris images. First, the iris image is localized properly to obtain accurate iris boundary detection, and then the iris image is normalized to obtain a fixed size. Second, the valid region (iris region) is extracted from the segmented iris image to obtain only the iris region. Third, to get a well-distributed texture image, bilinear interpolation is used on the segmented valid iris gray image. Using contrast-limited adaptive histogram equalization (CLAHE) enhances the low contrast of the resulting interpolated image. The results of CLAHE are further improved by stretching the maximum and minimum values to 0-255 by using histogram-stretching technique. The gray texture information is extracted by 1D Gabor filters while the Hamming distance technique is chosen as a metric for recognition. The NICE-II training dataset taken from UBRIS.v2 was used for the experiment. Results of the proposed method outperformed other methods in terms of equal error rate (EER).

• The Journal of Korean Physical Therapy
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• 제33권6호
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• pp.307-313
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• 2021

Purpose: This study was to the investigate recognition of physical activity between physical therapy students (PTS) and non-physical therapy students (NPTS) by measuring the level of physical activity using International Physical Activity Questionnaires (IPAQ). Methods: A cross-sectional survey was completed by 191 university students. The IPAQ with an additional question (Is physical activity necessary for your future job?) was used to evaluate the recognition and the amount of physical activity. The collected data were calculated as MET-minutes scores and were classified as walking, moderate, and vigorous level of physical activity. The students were analyzed by dividing them into those who had a part-time employment (16 PTS and 12 NPTS) and those who did not have a part-time employment (80 PTS and 83 NPTS). Results: In students with a part-time employment, no significances were observed between the PTS and NPTS, in terms of MET, frequency and time of physical activity, and sitting time (p>0.05). In students without a part-time employment, the NPTS was significantly higher than the PTS for the MET and frequency of physical activity in a vigorous level (p<0.05), and there were no significant differences in other levels of physical activity (p>0.05). In the additional question, the PTS showed a slightly higher than the NPTS (p<0.05). Conclusion: The physical therapy students did not remarkable barrier to recognition of physical activity, but there was a difference in their recognition of the vigorous level of physical activity. Therefore, the understanding of physical activity for PTS would play an important role in the recognition of how physical activity can be promoted.

• 한국콘텐츠학회논문지
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• 제11권12호
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• pp.774-784
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• 2011

본 연구는 학교폭력 및 학교안전을 위한 학교보안관 제도 활성화 방안 모색을 위해 제도에 대한 초등학교 학부모들의 인식을 조사하고 개선방안을 제시하고자 하는데 목적을 두고 있다. 이를 위하여 이 연구에서는 서울시 소재 학교보안관이 배치되어 근무하고 있는 초등학교 학생을 자녀로 둔 학부모를 연구대상으로 선정한 후 집락무선표집법을 이용하여 200명의 표본을 추출하여 최종분석에는 189명을 분석하였다. 설문지의 타당도는 전문가회의와 요인분석, 신뢰도는 신뢰도 분석을 통하여 검증하였다. 통계처리는 카이스퀘어 검정과 t검정, F검정 등의 방법을 활용하였다. 결론은 다음과 같다. 첫째, 개인적 특성에 따라 학교보안관 제도의 필요성은 차이가 있다. 둘째, 개인적 특성에 따라 학교보안관 제도에 대한 인식은 차이가 있다. 셋째, 개인적 특성에 따라 학교보안관의 역할 인식은 차이가 있다. 넷째, 학교보안관의 역할 활동인식은 차이가 있다. 다섯째, 개인적 특성에 따라 학교생활안전에 도움정도는 차이가 있다. 여섯째, 개인적 특성에 따라 학교보안관 만족은 차이가 있다.