• 한국과학교육학회지
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• 제12권3호
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• pp.49-59
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• 1992

New-Piagetian theory has proposed that mental capacity and mental demand do a critical role in human cognitive processes. In this study, the students' mental capacity and the mental demand of the given problems were examined. The principal findings of the study are as follows; (1) There was no significant difference among achievement scores of subjects (3rd grade students of middle school, 2nd grade students of high school, 3rd grade students of high school) in the items of balance that needed specific content knowledge. But, in the Newton's 2nd law items that needed specific content knowledge, there was significant difference be ween3rd grade students of middle school and high school students(2nd, 3rd). According to increase of mental demand, middle school students' achievement score appeared to decrease linearly. However high school students' achievement score didn't change untill they faced the items of critical mental demand. When mental demand was beyond critical mental demand,their score was decreased rapidly. (2) According to hierchical analysis of items, the more mental demand an item needed, the higher or at least the same hierachical item was. These results showed that mental demand was the main factor which decided diffculties of problem solving (3) It was possible for students to solve the newton's 2nd law item that had one or two more mental demand relative to balance beam item. Although the item needed the same mental demand.students recognized that the Newton's 2nd law items were easier than the balance beam items.

• 보건교육건강증진학회지
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• 제22권2호
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• pp.173-193
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• 2005

Objectives: The purpose of this study is to analyze the peer group factor related to adolescent smoking in the social structure(network) of adolescent groups, by applying the theory of social network. Methods: The data was collected from boy students of one high school located in Gun-Po city of Kyonggi Province. The total number of the sample was 605(223 first grade, 198 second grade, 184 third grade). The survey using the questionnaire was carried out in April 2005. Social position is finally classified as clique member, liaison, isolate group by using the NetMiner II 2.5 version. Results: The current smoking rate was 15.0%, and the life-time smoking rate was 34.9%. The smoking rate increased significantly, as the grade went up. And it was significantly high among the group having smoking friends. The logistic regression analysis showed that the odds ratio of the smoking friends group was about 4 times higher than the no smoking friends group in experience of smoking. But the smoking rate was higher significantly in the isolate group within the network composed of 2. person's social-link. The odds ratio of the isolate group was about 4.5 times higher than the clique member. However, this pattern was not found in the network composed of 3 person's social-link. Therefore, the hypothesis that clique member would have a correlation with smoking was rejected. In reality, the isolate group had a tendency of smoking more frequently. Conclusions: The result of this study suggests that the role of the peer group in smoking is to be considered in the prevention program. More attentions should be paid for the isolate group.

• Nutrition Research and Practice
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• 제4권4호
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• pp.259-269
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• 2010

Resistance training (RT) is associated with reduced risk of low grade inflammation related diseases, such as cardiovascular disease and type 2 diabetes. The majority of the data studying cytokines and exercise comes from endurance exercise. In contrast, evidence establishing a relationship between RT and inflammation is more limited. This review focuses on the cytokine responses both following an acute bout, and after chronic RT. In addition, the effect of RT on low grade systemic inflammation such as individuals at risk for type 2 diabetes is reviewed. Cytokines are secreted proteins that influence the survival, proliferation, and differentiation of immune cells and other organ systems. Cytokines function as intracellular signals and almost all cells in the body either secrete them or have cytokine receptors. Thus, understanding cytokine role in a specific physiological situation such as a bout of RT can be exceedingly complex. The overall effect of long term RT appears to ameliorate inflammation, but the specific effects on the inflammatory cytokine, tumor necrosis factor alpha are not clear, requiring further research. Furthermore, it is critical to differentiate between chronically and acute Interleukin-6 levels and its sources. The intensity of the RT and the characteristics of the training protocol may exert singular cytokine responses and as a result different adaptations to exercise. More research is needed in the area of RT in healthy populations, specifically sorting out gender and age RT acute responses. More importantly, studies are needed in obese individuals who are at high risk of developing low grade systemic inflammatory related diseases. Assuring adherence to the RT program is essential to get the benefits after overcoming the first acute RT responses. Hence RT could be an effective way to prevent, and delay low grade systemic inflammatory related diseases.

• 한국생활과학회지
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• 제9권1호
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• pp.85-95
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• 2000

This study is about psychological growth environment and style of loving among 88 men and 128 women in university students. The results of this study are following. First, the result of psychological growth environment and style of loving among university students show that men have expectation for the achievement and encouragement more than women as they are moved up the higher grade. Largely when they are moved up the higher grade, they respect individual opinion and have responsibility for their behaviors. Also they tend to have the cooperation in their home. So as they are moved up the higher grade, they have the independent spirit from their parents and are prepared to adaptability for social life. Second, the result of the style of loving show that men tend to fall in love easily and also pursuit altruistic and romantic love. According to being moved up the higher grade, they have the actual attitude in the intercourse with the other sex. Third, the result of psychological growth environment show that persons who want to come true their desire more need the friendly love, altruistic love and love for amusement. Contrarily, when they don't communicate each other in their home, they tend to pursuit love for amusement. When they have the higher level of communication and cooperation in their psychological environment, they tend to pursuit for logical love. When they have expectation of mutual role, mutual intimacy, love and respect, they pursuit friendly love. Also through they are adapt for style of social behaviors in each other, they acpuire the love and respect between family members. And they pursuit friendly love through it.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1077-1082
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• 2016

Background: The three standard biomarkers used in breast cancer are the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). The Ki-67 index, a proliferative marker, has been shown to be associated with a poorer outcome, and despite absence of standardization of pathological assessment, is widely used for therapy decision making. We aim to study the role of the Ki-67 index in a group of Asian women with breast cancer. Materials and Methods: A total of 450 women newly diagnosed with Stage 1 to 3 invasive breast cancer in a single centre from July 2013 to Dec 2014 were included in this study. Univariable and multivariable logistic regression was used to determine the association between Ki-67 (positive defined as 14% and above) and age, ethnicity, grade, mitotic index, ER, PR, HER2, lymph node status and size. All analyses were performed using SPSS Version 22. Results: In univariable analysis, Ki -67 index was associated with younger age, higher grade, ER and PR negativity, HER2 positivity, high mitotic index and positive lymph nodes. However on multivariable analysis only tumour size, grade, PR and HER2 remained significant. Out of 102 stage 1 patients who had ER positive/PR positive/HER2 negative tumours and non-grade 3, only 5 (4.9%) had a positive Ki-67 index and may have been offered chemotherapy. However, it is interesting to note that none of these patients received chemotherapy. Conclusions: Information on Ki67 would have potentially changed management in an insignificant proportion of patients with stage 1 breast cancer.

• 대한지구과학교육학회지
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• 제6권3호
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• pp.196-206
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• 2013

The purpose of this study was to analyze perfectism, interpersonal characteristic between the gifted & talented students and the general. The subject of this study were 112 the gifted students and 120 the general. They answered the questions about perfectism and interpersonal characteristic. To compare the gifted and general students' tendency, collected data was classified by their gender and grade. And correlation analysis was done in oder to analyze the relation between the gifted students' perfectism and interpersonal characteristic. The important results of this study were as follows. First, the grade gap of perfectism was not meaningful in both groups. Otherwise, the gender gap of perfectism was meaningful in both groups. Female's perfectism was higher than male's. And the gifted students' perfectism was higher than the general students'. Second, Differently, the gender gap of interpersonal characteristic was meaningful in the same group. Female had higher positive social-relationship, expression tendency than male. But female had lower competition-aggressiveness propensity than male. In the general group, the 6th grade students showed more positive role, social-relationship than 5th grade. And male showed more competition-aggressiveness propensity than female. Comparing the gifted and the general, the gifted had more dominant-superior, exhibitionistic-narcissistic propensity. It could be a reason of the gifted students' social problem. Third, among self-oriented perfectism and dominant-superior, independent-responsible propensity had meaningful correlation. Also socially-prescribed perfectism had influenced on dominant-superior, sociability-friendliness, exhibitionistic-narcissistic propensity.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4859-4864
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• 2013

Background: The purpose of this study was to assess the effectiveness of a recombinant human epidermal growth factor (EGF)-based cream for the prevention of acute radiation dermatitis in breast cancer patients receiving radiotherapy (RT). Materials and Methods: Between December 2012 and April 2013, 40 breast cancer patients who received postoperative RT were prospectively enrolled in this study and randomly assigned to receive human recombinant EGF-based cream (intervention group) or general supportive skin care (control group). The grade of radiation dermatitis and pain score were examined at weekly intervals during RT and 6 weeks after RT completion. Results: All patients completed the planned RT and complied well with instructions for applying the study cream and general supportive skin care. In the intervention group, radiation dermatitis of maximum grade 3, 2, and 1 developed in 3 (15%), 11 (55%), and 6 patients (30%), respectively. In comparison, in the control group, radiation dermatitis of maximum grade 3, 2, and 1 developed in 8 (40%), 10 (50%), and 2 patients (10%), respectively. The intervention group showed lower incidence of grade 3 radiation dermatitis than the control group (p=0.068 in univariate analysis and p=0.035 in multivariate analysis). There was no statistically significant difference in the maximal pain score between the two groups (p=0.934). Conclusions: This single-blind randomized preliminary study showed that recombinant human EGF-based cream can have a beneficial role in preventing or minimizing radiation dermatitis in breast cancer patients. To confirm the results of our study, additional studies with a large sample size are required.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3355-3360
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• 2015

Background: Zinc transporters have been considered as essential regulators in many cancers; however, their mechanisms remain unknown, especially in gliomas. Isocitrate dehydrogenase 1(IDH1) mutation is crucial to glioma. This study aimed to investigate whether zinc transporters are correlated with glioma grade and IDH1 mutation status. Materials and Methods: IDH1 mutation status and mRNA expression of four zinc transporters (ZIP4, ZIP9, ZIP11, and ZnT9) were determined by subjecting a panel of 74 glioma tissue samples to quantitative real-time PCR and pyrosequencing. The correlations between the expression levels of these zinc transporter genes and the grade of glioma, as well as IDH1 mutation status, were investigated. Results: Among the four zinc transporter genes, high ZIP4 expression and low ZIP11 expression were significantly associated with higher grade (grades III and IV) tumors compared with lower grade (grades I and II) counterparts (p<0.0001). However, only ZIP11 exhibited weak correlation with IDH1 mutation status (p=0.045). Samples with mutations in IDH1 displayed higher ZIP11 expression than those without IDH1 mutations. Conclusions: This finding indicated that zinc transporters may interact with IDH1 mutation by direct modulation or action in some shared pathways or genes to promote the development of glioma. Zinc transporters may play an important role in glioma. ZIP4 and ZIP11 are promising molecular diagnostic markers and novel therapeutic targets. Nevertheless, the detailed biological function of zinc transporters and the mechanism of the potential interaction between ZIP11 and IDH1 mutation in gliomagenesis should be further investigated.

• Human Ecology Research
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• 제56권5호
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• pp.435-446
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• 2018

This study investigated relationships between primary caregivers' life satisfaction and abuse mediated by children's life satisfaction. We included term panel data for 3 years (2013-2015) from the 4th year to the 6th year of 2,067 children in the first grade of elementary school of the Korean Youth and Youth Panel(KCYPS)(2015); in addition, three years' longitudinal panel data (2013-2015) were analyzed utilizing SPSS 18.0 and AMOS 22.0 to measure Latent Growth Model(LGM) term relationships between variables. Analysis results were as follows. First, the life satisfaction of the primary caregiver, the life satisfaction of the child, and abuse gradually decreased from the fourth grade to the sixth grade. Second, the initial status of primary caregivers' life satisfaction influenced the initial status of the children's life satisfaction, and the initial status and change in the abuse rate. Third, the rate of change of life satisfaction of the primary caregiver did not have a significant effect on the change in the abuse rate and the rate of change of life satisfaction of the child. The initial value of the life satisfaction of the child played a partial mediating role in the relationship between the initial value of the life satisfaction of the primary caregiver, initial value of the abuse, and abuse change rate. The results suggest that a program to improve the life satisfaction of the 4th grade elementary school should be developed and applied.

• Archives of Plastic Surgery
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• 제32권5호
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• pp.619-624
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• 2005

Patency of the radial artery plays an important role in the survival of radial forearm fasciocutaneous free flap and artery conduit of coronary artery bypass graft procedure. Even though Allens' test has been used for evaluating the patency of radial artery, the studies on the correlations between risk factors for atherosclerosis and histopathologic findings of radial arteries are rare, until now. Therefore, the authors investigated the correlations between these two factors, and tried to estimate the feasibility of the radial artery in high-risk groups for artherosclerosis. The risk factors for atherosclerosis and lipid profiles were investigated in 38 patients by history taking, physical examinations and blood analysis. And 38 cases of segments of vessel were harvested during the elevation of the flap. The degrees of vessel medial sclerosis were estimated by R values(by Kobayashi and colleagues) that is the median value between the thickness of the intima and that of the media. The measured mean R value was $0.210{\pm}0.05$. Thirty one cases belonged to Grade I(R<0.25), 7 cases belong to Grade II(0.25