• 한국도서관정보학회지
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• 제47권4호
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• pp.19-42
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• 2016

2013년 12월에 개관한 국립세종도서관의 기본적 정체성은 정책정보 중심의 특화도서관이다. 그럼에도 여전히 정체성이 자리매김하지 못하는 현실에 주목하여 이해집단(정부부처 공무원과 정부출연연구기관의 연구원, 세종시민, 국립세종도서관 직원)을 대상으로 기본적 정체성과 역할 각종 서비스의 이용률 및 만족도 정책정보 및 정책정보서비스의 필요성과 이용, 전략적 및 중점적 추진과제에 대한 인식을 조사 분석하였다. 이를 바탕으로 이해집단의 국립세종도서관 서비스 만족도 및 정책정보서비스 의존도 제고를 위한 인력확충과 조직확대, 국내외 정책정보 수집전략 국가정책정보서비스 강화방안을 제안하였다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.808-811
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• 2006

The KOMPSAT-2 was developed by KARI and it was successfully launched from Plesetsk, Russia on 28th July 2006. The Korean government decided the commercialization of the KOMPSAT-2 image data and direct reception services worldwide. SPOT Image, based in Toulouse (France) was selected by KARI through an international open bidding as a foreign company for the KOMPSAT-2 image promotion over the entire world except the territory of Republic of Korea including the North Korea, the United States of America, UAE, Saudi Arabia, Kuwait, Qatar, Oman, Yemen, Egypt, Iran, Iraq, Jordan, Lebanon, and Syria. KAI (Korea Aerospace Industry Ltd.) is an engaged Korean company for this area. KARI has responsibility to operate the satellite, data acquisition, archiving for the worldwide commercialization. For the processing and delivery of the KOMPSAT-2 image data to the users of KAI and SPOT Image, KAI has the binding contract with KARI. So KAI has the responsibility for the commercial ground station operation such as user support, data processing, and the data delivery. The KOMPSAT-2 ground station is hosted in KARI, so KARI has developed the concept of KOCUST (KOMPSAT-2 Commercial User Support Team) jointly with KAI to support the data processing and delivery as KOMPSAT-2 developer and satellite operator. The main purpose of the KOCUST is to support the operational activities to provide the data and service quality to satisfy customers. KOCUST will be organized by the members of KARI and KAI together. KARI members will mainly take the role of KOCUST coordination, data processing and user support in a public sector. KAI members are going to take user desk, data validation and delivery et cetera, which are related with users. This paper describes a summarized concepts of KOCUST like organization, dedicated tasks of each part and work flow of daily operation.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume I
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• pp.90-93
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• 2006

The first Geostationary Ocean Color Imager (GOCI) onboard its Communication Ocean and Meteorological Satellite (COMS) is scheduled for launch in 2008. GOCI includes the eight visible-to-near-infrared (NIR) bands, 0.5km pixel resolution, and a coverage region of 2500 ${\times}$ 2500km centered at 36N and 130E. GOCI has had the scope of its objectives broadened to understand the role of the oceans and ocean productivity in the climate system, biogeochemical variables, geological and biological response to physical dynamics and to detect and monitor toxic algal blooms of notable extension through observations of ocean color. The special feature with GOCI is that like MODIS, MERIS and GLI, it will include the band triplets 660-680-745 for the measurements of sun-induced chlorophyll-a fluorescence signal from the ocean. The GOCI will provide SeaWiFS quality observations with frequencies of image acquisition 8 times during daytime and 2 times during nighttime. With all the above features, GOCI is considered to be a remote sensing tool with great potential to contribute to better understanding of coastal oceanic ecosystem dynamics and processes by addressing environmental features in a multidisciplinary way. To achieve the objectives of the GOCI mission, we develop the GOCI Data Processing System (GDPS) which integrates all necessary basic and advanced techniques to process the GOCI data and deliver the desired biological and geophysical products to its user community. Several useful ocean parameters estimated by in-water and other optical algorithms included in the GDPS will be used for monitoring the ocean environment of Korea and neighbouring countries and input into the models for climate change prediction.

• Journal of Gastric Cancer
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• 제3권3호
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• pp.145-150
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• 2003

Purpose: The p53 tumor suppressor gene is believed to play a pivotal role in preventing the uncontrolled cellular growth characteristic of cancer. Mutation of the p53 gene represent one of the most common genetic alterations in human cancers, and the acquisition of such defects is strongly associated with tumor progression and metastasis. The aim of this study was to evaluate the relation between p53 immunoreactivity and the mutation of p53 gene in gastric adenocarcinoma obtained by laser capture microscope. Materials and Methods: Formalin fixed paraffin embedded tissue specimens were obtained from 20 patients who underwent surgery for gastric cancer. According to UICC TNM system, 3 of the cases were Ia, 2 cases II, 4 cases IIIa, 5 cases IIIb, and 6 cases IV. Results: Immunohistochemical staining revealed eight cases as negative (less than $10\%$), twelve cases as postive (more than $10\%$). The locations of mutations were as follows; 7 cases had point mutation at exon 4, and 3 cases point mutation at exon 8. There was no mutation at exon 5, 6, 7 and 9. The mutation was observed in 1 case out of 8 p53 oncoprotein negative cases, and 7 cases out of 12 p53 positive cases. The mutation was more common in p53 positive cases (P<0.05), However, there was no significant correlation between p53 mutation observed by DNA sequencing after laser capture microdissection and expression of p53 oncoprotein. Conclusion: These result suggest that he expression of p53 oncoprotein not to be related to the mutation of p53 gene at exons 4 through 9 in gastric cancer.

• Parasites, Hosts and Diseases
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• 제32권4호
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• pp.231-242
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• 1994

자연 감염된 가재에서 폐흡충의 피낭유충을 분리하고 개에 경구 감염시켜 성충을 얻었다. 폐흡충 성충의 조효소를 ion-exchange chromatography, affinity chromatography와 gel filtration chromatoglaphy를 실시하여 cysteine proteinase를 순수 정제하였다. 이들 효소의 생화학적 특성과 분해능을 관찰하였으며. 효소면역전기영동이적법을 이용하여 순수 정제한 효소의 항원성을 관찰하였다. 정제된 효소는 저분자 합성기질인 CBZ-arg-arg-AFC 보다 CBZ-phe-arg-AFC에서 높은 활성을 보였으며. 이들 효소는 thiol-dependent이었다. 정제된 효소 및 조효소의 최적 pH는 5.5이었고. 최적 mole 농도는 0.1 M(0.1 M sodium citrate, pH 5.5)이었고, 이들 효소는 $4^{\circ}C$에서 48시간 동안 80%의 안정성을 보였다 정제된 효소의 native 분자량은 20.000 dalton이었고, SDS- PAGE상에 나타난 분자량은 17,500 dalton이었다 정제된 효소는 cysteine proteinase 특이 억제 인자인 E-64, lodoacetic acid, NEM에 의해 활성이 완전히 억제되었으며, serine proteinase, aspartic proteinase 및 metallo proteinase 특이 억제인자에 의해 활성이 억제되지 않았다. 정제된 효소는 collagen(Type I)과 hemoglobin을 분해하였고, 효소면역전기영동이적법으로 정제된 효소의 항원성을 확인하였다.

• 한국의류학회지
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• 제35권5호
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• pp.587-600
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• 2011

This study presents the strategic directions for Korean multi-brand fashion stores by running in-depth industry research and market analysis. Over 20 professionals were selected from Korean multi-brand fashion stores for this study and in-depth interviews were conducted to evaluate related subjects. The results of the study were as follows. First, Korean multi-brand fashion stores could be classified into three criteria: operating ownership, merchandise mix, and store identity. Second, operating ownership criterion was chosen for further investigations of strategies and directions of the multi-brand fashion stores. The operating ownership criterion consists of three types; department store types, specialty store types, and boutique types. Each type deploys different buying practice, organizational strategies, and distribution channels. Lastly, the suggested strategic directions for each type are summarized as follows. The 'department store type' should utilize its strong direct buying capabilities and acquisition of merchandising can be more effectively managed. The store should utilize its strong buying power as a tool to develop new private brands (PBs). For 'specialty store type', two key factors have been derived: market share expansion and positioning themselves to become a new distribution channel. To respond to these factors, the store needs to be perceived as a brand then diversify its business. Strengthening its brand will allow it to expand into a new distribution channel and also enable a strategic partnership with its competitor brands. The factors influencing 'boutique type' is personalization and uniqueness. With an emphasis on the uniqueness of products and merchandising it will be able to implement the role as a personal shopper and stylist to provide a very personalized service to its customers.

• Biomolecules & Therapeutics
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• 제19권2호
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• pp.206-210
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• 2011

Natural Killer (NK) cells are the lymphocytes that are derived from hematopoietic stem cells, developed in the bone marrow from hematopoietic stem cells (HSC) by sequential acquisition of functional surface receptors, and express the repertoire of inhibitory and activating receptors. Recently, Osteopontin (OPN) has been identified as a critical factor for differentiation of natural killer cells. However, the detailed mechanism of OPN-induced NK differentiation has been still to be elucidated. Here, we determined the signaling pathway and possible receptor for OPN in NK differentiation. OPN induced expression of Bcl-2 and activation of Erk kinase. Inhibition of Erk pathway decreased the effect of OPN on NK differentiation. In addition, the expression of integrin ${\alpha}9$ was significantly increased by OPN during NK differentiation, suggesting the possible role of a major signaling molecule for OPN- induced NK differentiation.

• 한국중재학회지:중재연구
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• 제26권2호
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• pp.67-89
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• 2016

An ADR arbitration system has a necessary value in the sports industry for settlement of disputes. Sports disputes should be resolved independently by enacting internal regulations within the basic principles of national law rather than treated as a civil action. If the dispute is not fair and transparent, it may cause distrust. Because an arbitration system has values such as speed, flexibility of economic decisions, professionalism of arbitrator and confidentiality of arbitration-related information, the efficiency of the arbitration system for conflict resolution has emerged recently. We have to assign sports experts to reactivate sports arbitration commission committees which existed from 2006 to 2009 in Korea. Many countries, such as the UK, USA, Canada, New Zealand, Hungary, the Netherlands, Poland, Germany, and Japan, which attain advancement of sports and the International Court of Arbitration establish and run their own sports arbitration agencies. However, Korea disbanded its sports arbitration commission committee for political and economic reasons. In 2012, after their disbanding, athlete Kim Yeon-kyoung came into conflict with Heungkuk Life over terms of free agent acquisition and international transfer certification. Finally they were able to settle those political conflicts. However if there had been related laws in Korea, they could have resolved those problems easily without international disputes. Practically, it would have been almost impossible for Kim Yeon-kyoung to win the dispute. But her problem became an issue after the London Olympics, so she could win. Although it is well for her to take an active role on the international stage, it left much to be desired on account of the intervention of political circles in order to resolve the conflict. If the sports arbitration commission committee in Korea had still been active, it could have come to a peaceful settlement domestically. Therefore we have to reestablish a Korean sports arbitration committee centered around experts of sports law.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3519-3524
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• 2014

Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. It has been hypothesized that Oct4 positive radioresistant stem cells may be responsible for tumor recurrence. Hence, we evaluated Oct4 expression in ESCC in pre-treatment, post neo-adjuvant residual and post-surgical recurrent tumours. Materials and Methods: Endoscopic mucosal biopsies were used to study Oct4 expression and the observations were correlated with histological tumor grades, patient data and clinical background. Results: All patients presented with dysphagia with male predominance and a wide age range. Majority of the patients had intake of mixed diet, history of alcohol and tobacco intake was documented in less than half of the patients. Oct 4 expression was significantly higher in poorly differentiated (PDSCC) and basaloid (BSCC) subtypes than the other better differentiated tumor morphology. Oct4 was also expressed by adjoining esophageal mucosa showing low grade dysplasia and basal cell hyperplasia (BCH). Biopsies in PDSCC and BSCC groups were more likely to show a positive band for Oct4 by polymerase chain reaction (PCR). Dysplasia and BCH mucosa also showed Oct4 positivity by PCR. All mucosal biopsies with normal morphology were negative for Oct4. Number of tissue samples showing Oct4 positivity by PCR was higher than that by the conventional immunohistochemistry (p>0.05). Oct4 expression pattern correlated only with tumor grading, not with other parameters including the clinical background or patient data. Conclusions: Our observations highlighted a possible role of Oct4 in identifying putative cancer stem cells in ESCC pathobiology and response to treatment. The implications are either in vivo existence of Oct4 positive putative cancer stem cells in ESCC or acquisition of cancer stem cell properties by tumor cells as a response to treatment given, resulting ultimately an uncontrolled cell proliferation and treatment failure.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4853-4858
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• 2013

Objectives: To investigate whether hypoxia has an effect on regulation of multidrug resistance (MDR) to chemotherapeutic drugs in laryngeal carcinoma cells and explore the role of hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$). Methods: Laryngeal cancer cells were cultured under normoxic and hypoxic conditions. The sensitivity of the cells to multiple drugs and levels of apoptosis induced by paclitaxel were determined by MTT assay and annexin-V/propidium iodide staining analysis, respectively. HIF-$1{\alpha}$ expression was blocked by RNA interference. The expression of HIF-$1{\alpha}$ gene was detected by real-time quantitative RT-PCR and Western blotting. The value of fluorescence intensity of intracellular adriamycin accumulation and retention in cells was evaluated by flow cytometry. Results: The sensitivity to multiple chemotherapy agents and induction of apoptosis by paclitaxel could be reduced by hypoxia (P<0.05). A the same time, the adriamycin releasing index of cells was increased (P<0.05). However, resistance acquisition subject to hypoxia in vitro was suppressed by down-regulating HIF-$1{\alpha}$ expression. Conclusion: HIF-$1{\alpha}$ could be considered as a key regulator for mediating hypoxia-induced MDR in laryngeal cancer cells via inhibition of drug-induced apoptosis and decrease in intracellular drug accumulation.