Journal of Gastric Cancer
- Volume 3 Issue 3
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- Pages.145-150
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- 2003
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- 2093-582X(pISSN)
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- 2093-5641(eISSN)
Comparative Study of p53 Mutation and Oncoprotein Expression in Gastric Adenocarcinoma
미세절편으로 얻은 위암 조직세포에서 p53 유전자의 돌연변이와 종양단백 발현에 관한 연구
- Kim Chul (Division of Gastroenterologic Surgery, Departments of Surgery Chonnam National University Medical School) ;
- Joo Jai Kyun (Division of Gastroenterologic Surgery, Departments of Surgery Chonnam National University Medical School) ;
- Choi Chan (Division of Gastroenterologic Surgery, Pathology, Chonnam National University Medical School) ;
- Kim Young Jin (Division of Gastroenterologic Surgery, Departments of Surgery Chonnam National University Medical School)
- 김철 (전남대학교 의과대학 외과학교실 위장관외과) ;
- 주재균 (전남대학교 의과대학 외과학교실, 위장관외과) ;
- 최찬 (전남대학교 의과대학 외과학교실, 병리학교실) ;
- 김영진 (전남대학교 의과대학 외과학교실, 위장관외과)
- Published : 2003.09.01
Abstract
Purpose: The p53 tumor suppressor gene is believed to play a pivotal role in preventing the uncontrolled cellular growth characteristic of cancer. Mutation of the p53 gene represent one of the most common genetic alterations in human cancers, and the acquisition of such defects is strongly associated with tumor progression and metastasis. The aim of this study was to evaluate the relation between p53 immunoreactivity and the mutation of p53 gene in gastric adenocarcinoma obtained by laser capture microscope. Materials and Methods: Formalin fixed paraffin embedded tissue specimens were obtained from 20 patients who underwent surgery for gastric cancer. According to UICC TNM system, 3 of the cases were Ia, 2 cases II, 4 cases IIIa, 5 cases IIIb, and 6 cases IV. Results: Immunohistochemical staining revealed eight cases as negative (less than