• 전자공학회논문지SC
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• 제45권5호
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• pp.8-12
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• 2008

본 논문에서는 미지의 외란이 존재하는 불확실한 비선형 시스템에 대한 강인 상태 관측기 설계 방법을 제안한다. 제안한 관측기는 추정 오차에 대한 외란의 영향을 원하는 수준까지 감소시킬 수 있다. 또한, 제안한 관측기의 이득행렬은 선형 행렬 부등식을 이용하여 얻을 수 있다. 제안한 설계 방법은 기존의 적응관측기에서 다룬 파라미터 불확실성 보다 더 넓은 범위의 외란을 다룰 수 있다는 장점을 가진다. 마지막으로 제안한 결과의 유효성을 증명하기 위하여 모의실험 예제를 제공한다.

• 한국식품위생안전성학회지
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• 제25권3호
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• pp.209-214
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• 2010

Metastasis is the primary cause of from breast cancer mortality. Cell migration and invasion play important roles in neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in cancer cell invasion. NF-${\kappa}B$ is transcription factor important in the regulation of MMP-9, as the promoter of MMP-9 gene contains binding sites for NF-${\kappa}B$. Brazilin, an active component of sappan wood (Caesalpinia sappan), decreases TPA-induced MMP-9 expression and invasion in MCF-7 cells. Also, brazilin suppressed NF-${\kappa}B$ activation in TPA-treated MCF-7 cells. Taken together, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by brazilin is mediated by the suppression of the NF-${\kappa}B$ pathway in MCF-7 cells. This result suggest brazilin provide a potential therapeutic app roach for the treatment of breast cancer.

• 가정과삶의질연구
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• 제4권1호
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• pp.1-13
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• 1986

The purpose of this study was to examine whether the Marital Satisfaction Scale(M.S.S) is properly applicable to Korean couples and further to be devoted to the designed of a marital satisfaction scale for Korea. The scale employed in this study was a Korean adaptation of the M.S.S., which originally included 73 items but was reduced to 48 through a study of its validity by Bowden. This scale was administered to 420 couples. One kindergarten, two elementary schools, one middle school, and four high schools, all of them located in Seoul or its satellite cities were selected for the present study. The results of the study were as follows. 1) Through item analysis, 85.4% of the total items showed a high index of discrimination, i.e, of more than +.40, which all was significant discrimination (P<0.001) excluding two items. 2)Factor analysis, which was oriented toward combining factors proper to theory, showed that the M.S.S. consisted of 6 factors and its total variance was 50.18%. The 6 factors were marital satisfaction (factor 1), marital social psychological companionship (factor 2), obstacles to marriage (factor 3), dissatisfaction of marital relationship (factor 4), attitude of the reasonable marital relationship (factor 5), and cognition of married life (factor 6), 3) internal consistency reliability of the M.S.S. was 0.951 and the reliability of the total items after excluding two through item analysis 0.956 and 0.949 respectively, which showed a high internal consistency 4) The marital satisfaction examined by the M.S.S showed significant differences according to sex, education , income, the duration of marriage, the number of children but no significant differences according to age, and family type. From these results, it will be concluded that the M.S.S is a reliable and valid psychological scale for examining marital satisfaction of Korean couples. The limitations of this study were as follows. 1) It can not be generalized to all Korean couples because the subjects was sampled from Seoul or satellite cities. 2)The factor analysis in this study was oriented toward combining factors proper to theory. However, it was very difficult to find out the factors because the components of the M.S.S. was more or less abstract. Thus, from these results some suggestions follow for developing the marital satisfaction scale proper to Korean couples systematically and scientifically. 1) The subjects must be sampled form urban as well as rural areas 2)Factor analysis in this study is oriented toward finding out factors of the M.S.S. Thus, it is needed to analyze the factor validity or construct validity by multitrait - multimethod of the scale with more theoretical conceptualization. 3) It is necessary to examine whether marital satisfaction shows difference according to couples and psychological variables besides objective demographic variables. 4) More research is needed before the M.S.S. con be adapted into a turely useful marital satisfaction scale for Korea.

• 생태와환경
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• 제45권3호
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• pp.322-328
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• 2012

금강수계 백곡천 상류에 서식하는 미호종개(국가 천연기념물)를 대상으로 형광물질 주입에 의한 다중표지-재포획법(졸리-시바모델적용)으로 개체군 크기를 추정하였다. 총 어류조사지점은 335개였고, 그 중 미호종개가 출현 지점은 217개 였다. 본 연구에서 추정한 미호종개 평균 개체군 크기는 6,143개체였다. 이는 2009년 환경부에서 수행한 미호종개 개체군 규모와 비교 했을때보다 41% 감소된 것이다. 백곡천에서 본 종의 감소는 미소서식지 훼손, 퇴적물, 서식환경의 악화 등의 영향으로 판단된다. 따라서 백곡천 본 종의 개체군 회복 미소서식지 보호를 위해 서식지복원 프로그램이 요구된다.

• 대한치과보철학회지
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• 제32권4호
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• pp.526-552
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• 1994

The extent and direction of movement of removable partial dentures during function are influenced by the nature of the supporting structures and and the design of the prosthesis. Since forces are transmitted to the abutment teeth through occlusal rests, guide planes and direct retainers during functional movements, proper design based on the avaialble research data will maintain the health of abutment teeth and their supporting structures. The purpose of this in vitro study is evaluating stress distribution clinically around the abutment teeth prepared following 4-type clasping systems for unilateral free-end removable partial dentures. Three-Dimensional Photoelastic Stress Analysis method was used because it shows a visual display of stresses of the simulated abutment teeth and residual ridges and reveals stress concentration that can be read at any given points in terms of direction and magnitude. For this study, the author fabricated 4 mandibular photoelastic epoxy models missing left 1st and End molar. Epoxy models were duplicated and 4 unilateral removable partial dentures were construe- ted in accordance with 4-type direct retainers. Unilateral free-end removable partial dentures were positioned on their own models. 6kg force was loaded on the every removable partial dentures of the epoxy model on the central fossa of mandibular left 1st molar vertically by the loading device. After the stress was frozen in a stress freezing furnace, 6 specimens of 6-mm thickness were made from every epoxy model and examined with the circular polariscope. The results were as follows : 1. Generally I-bar clasp revealed the most favorable stress distribution around the abutment teeth. 2. At the end portion of the free-end ridge, Back action clasp showed the highest stress concentration at the bucco-lingual and top portions of the residual alveolar ridge. 3. At the distal area of the abutment teeth, Akers clasp and Roach clasp showed higher stress concentration bucco-lingually and apically than the others. 4. To the abutment tooth, I-bar clasp showed the least stress distribution bucco-lingually but the others showed irregular stress distribution. 5. At the mesial area of the abutment teeth, the order of effective stress distribution was I-bar clasp, Back-action clasp, Akers clasp and Roach clasp. There was big difference of stress distribution between them. 6. At the right 2nd premolar and 1st molar, the stress concentration of Akers clasp was a little high but that of I-bar clasp was low.

• 간호행정학회지
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• 제22권5호
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• pp.480-495
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• 2016

Purpose: The purpose of the study was to identify characteristics of nursing and caring concepts measured by nursing competencies or caring behaviors tools for general nurses working in acute care hospitals. Methods: Five major nursing literature databases were used to identify the relevant tools. The study included 19 nursing competencies tools with a total of 843 measurement items and 12 caring behaviors tools with 334 items. According to the International Council of Nurses (ICN)'s Competencies Framework and 8Cs suggested by Roach (1987) and Pusari (1998), the measurement items were classified by two researchers independently first and in agreement finally. Results: Competency of 'key principles of care' including sub-areas of the ICN Framework was most commonly found: on average 49.3% of nursing competencies items and 91.9% of caring behaviors items. 97.0% of the caring behaviors items were classified into one of six Cs: competence (27.5%), confidence (21.3%), compassion (17.1%), commitment (16.5%), communication (9.9%), or conscience (4.8%). Conclusion: Nursing competencies tools were more likely to measure 'what to do' focusing on tasks, while caring behaviors tools were to measure 'how to do' focusing on nurses' attitudes or values. Nursing practices should be evaluated with both nursing competencies and caring behaviors tools, considering that nursing and caring were differently conceptualized in the quantitative tools.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2009년도 추계학술발표논문집
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• pp.358-362
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• 2009

The coastal zone is the transitional area between land and sea. It plays an important role in the land-sea ecosystem. Unfortunately, most of the world's coastal areas are polluted due to the human being activities. Pollution and development are changing coastal habitats, and feeding and nursery areas are being destroyed, reducing fish and wildlife populations. The pollution in coastal areas is becoming a global environmental problem, more and more attention has been paid to coastal areas. America passed the Coastal Zone Management Act (CZMA) in 1972, and from then, CZMA outlined and conducted the National Coastal Zone Management Program and the National Estuarine Research Reserve System which including 34 projects. And England established "the Crouch & Roach Estuary Project" in 2003, and "South East Coastal and Marine Project" was started in 2007 in responding to the non-point pollutants challenge.

• 가정과삶의질연구
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• 제11권1호
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• pp.159-175
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• 1993

The purpose of this study was to find out the psychological distance through semantic app-roach perceived by adolescent child in the subtypes of 'Extrem Family' dysfunctional families by classification of Olson and his associates ' Circrumplex Model. The subjects of this research were 1072 abolescents living in Seoul. Korea The survey methods were questionnaires including FACES II and The Psychological Distance Scale. Data were analyzed by means of the statistics of frequency percentage arithematic mean standard devia-tion crosstabs and one way-anova. The major findings are as follows: 1) The levels of family cohesion family adaptibility and the psychologival distances with father mother and siblings perceived by adolescent were high. 2) The most of subject's families belonged to 'Balanced Family' in the types of family system ' Extreme Family' type showed the lowest frequency and the main subtypes of it that had the highest frequency were 'Enmeshed Chaotic Family' ' Disengaged Rigid Family' 3) While adolescents of 'Enmeshed Chaotic Family' perceived most closely with other family members. those of 'Disengated Rigid Family' most distantly totally and in evaluation potency and activity three subfactors in psychological distance. 4) There were differences of unit points in subfactors of psychological distances with other family members perceived by adolescents according to the types of family system. While the points of 'Enmeshed Chaotic Family' were the highest those of 'Disengaged Rigid Family' were the lowest. 5) While 'Enmeshed Chaotic Family' were located most closely 'Disengaged Rigid Family' were located most distantly in the mutual distances and direct distances among family concepts on semantic space.

• Parasites, Hosts and Diseases
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• 제43권3호
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• pp.101-110
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• 2005

In this study, the trypsin gene (bgtryp-1) from the German cockroach, Blattella germanica, was cloned via the immunoscreening of patients with allergies to cockroaches. Nucleotide sequence analysis predicted an 863 bp open reading frame which encodes for 257 amino acids. The deduced amino acid sequence exhibited $42-57\%$ homology with the serine protease from dust mites, and consisted of a conserved catalytic domain (GOSGGPLV). bgtryp-1 was determined by both Northern and Southern analysis to be a 0.9 kb, single-copy gene. SDS-PAGE and Western blotting analyses of the recombinant protein (Bgtryp-1) over-expressed in Escherichia coli revealed that the molecular mass of the expressed protein was 35 kDa, and the expressed protein was capable of reacting with the sera of cock-roach allergy patients. We also discussed the possibility that trypsin excreted by the digestive system of the German cockroach not only functions as an allergen, but also may perform a vital role in the activation of PAR-2.

• BMB Reports
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• 제35권3호
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• pp.283-290
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• 2002

The glycogen-associated protein phosphatase (PP1G/$R_{GL}$) may play a central role in the hormonal control of glycogen metabolism in the skeletal muscle. Here, we investigated the in vivo epinephrine effect of glycogen metabolism in the skeletal muscle of the wild-type and $R_{GL}$ knockout mice. The administration of epinephrine increased blood glucose levels from 200±20 to 325±20 mg/dl in both wild-type and knockout mice. Epinephrine decreased the glycogen synthase -/+ G6P ratio from 0.24±0.04 to 0.10±0.02 in the wild-type, and from 0.17±0.02 to 0.06±0.01 in the knockout mice. Conversely, the glycogen phosphorylase activity ratio increased from 0.21±0.04 to 0.65±0.07 and from 0.30±0.04 to 0.81±0.06 in the epinephrine trated wild-type and knockout mice respectively. The glycogen content of the knockout mice was substantially lower (27%) than that of both wild-type mice; and epinephrine decreased glycogen content in the wild-type and knockout mice. Also, in Western blot analysis there was no compensation of the other glycogen targeting components PTG/R5 and R6 in the knockout mice compared with the wild-type. Therefore, $R_{GL}$ is not required for the epinephrine stimulation of glycogen metabolism, and rather another phosphatase and/or regulatory subunit appears to be involved.