• IMMUNE NETWORK
• /
• v.15 no.2
• /
• pp.100-109
• /
• 2015

Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and circumventing diseases caused by Th1/Th2 imbalance. Interleukin 4 (IL-4) is a Th2-type cytokine and often associated with hypersensitivity-related diseases such as atopic dermatitis and allergies when overexpressed. In this study, we have tried to elucidate the function of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) as an essential modulator of Th1/Th2 balance. EC-18 has showed an inhibitory effect on the production of IL-4 in a dose-dependent manner. RT-PCR analysis has proved EC-18 affect the transcription of IL-4. By analyzing the phosphorylation status of Signal transducer and activator of transcription 6 (STAT6), which is a transcriptional activator of IL-4 expression, we discovered that EC-18 induced the decrease of STAT6 activity in several stimulated cell lines, which was also showed in STAT6 reporter analysis. Co-treatment of EC-18 significantly weakened atopy-like phenotypes in mice treated with an allergen. Collectively, our results suggest that EC-18 is a potent Th2 modulating factor by regulating the transcription of IL-4 via STAT6 modulation, and could be developed for immune-modulatory therapeutics.

• Journal of Fashion Business
• /
• v.18 no.6
• /
• pp.57-66
• /
• 2014

The purpose of this study is to design appropriate digital tools for the production of makeup designs. In this study, we used a three-dimensional facial avatar simulation program developed by the Electronics and Telecommunications Research. This study is based on the creation of three-dimensional CG digital art of facial avatar makeup, produced by using simulation technology. First, the actual application and the tools for digital-optimization and media features were created, leading to the research and cleanup. Second, the theoretical background was applied to the formative elements of oriental colors in the designing process. Makeup design elements include point, line, surface, color, and texture. In this study, effective makeup design was interpreted to be based on the representation of particular elements, notably the design principles of balance, proportion, rhythm, repetition, emphasis, contrast, harmony, and unity. In Asia, design is based on the visibility of red, blue, black, yellow, and white-the colors of the five elements-and the use of points, lines, and shapes. This study was recently under scrutiny in relations to digital simulation and various three-dimensional designs, in terms of how to take advantage of a wide range of applications, and how to apply the findings through media and the dissemination of basic research. This study applies the characteristics of the limited existing stereoscopic three-dimensional and digital simulation programs in order to take advantage of the empirical research, providing a basis to implement this research in a meaningful way. A follow-up study is needed to extend these findings and theoretical foundation through continuous observation and in-depth technical development and research.

• Journal of Biomedical Engineering Research
• /
• v.24 no.5
• /
• pp.465-471
• /
• 2003

The purpose of this research was to evaluate chronic stress using physiological parameters. Wistar rats were exposed to the sound stress for 14 days. Biosignals were acquired hourly. To develop a fuzzy inference system which can integrate physiological parameters. the parameters of the system were adjusted by the adaptive neuro-fuzzy inference system. Of the training dataset, input dataset was the physiological parameters from the biosignals and output dataset was the target values from the cortisol production. Physiological parameters were integrated using the fuzzy inference system. then 24-hour results were analyzed by the Cosinor method. Chronic stress was evaluated from the degree of circadian rhythm disturbance. Suppose that the degree of stress for initial rest period is 1. Then. the degree of stress after 14-day sound stress increased to 1.37, and increased to 1.47 after the 7-day recovery period. That is, the rat was exposed to 37%-increased amount of stress by the 14-day sound and did not recover after the 7-day recovery period.

• Journal of Digital Convergence
• /
• v.11 no.3
• /
• pp.95-100
• /
• 2013

K-POP is getting population at the all over the world. K-POP is based on the hook song that made using repetitive lyrics and melody. The characteristics of the music is a bit simple and cheerful rhythm and melody easy to sing along, interesting lyrics and great dance skills. K-POP is spreading to various countries via various social networking services such as YouTube, Facebook, Twitter. K-POP dominated by the digital music market, showed a growing tendency to shorten the length of music, to create a music that can give a strong impression. And 60 second pre-listening function increased music used the chorus in the first part. But it was generated the result that made obscures the configuration of the music and the meaning of the lyrics. In this paper, we study the characteristics of K-POP music and will present three directions of the hook song music production. Finally, we compared to Kangnamstyle of Psy using the proposed three standards.

• Journal of the Korea Society of Computer and Information
• /
• v.19 no.2
• /
• pp.57-65
• /
• 2014

The role of sound in producing 3D animation clip is one of the important factor to maximize the immersive effects of the scene. Especially interaction between video and sound makes the scene expressions more apparent, which is diversely applied in video production. One of these interaction techniques, the out-focussing technique is frequently used in both real video and 3D animation field. But in 3D animation, out-focussing is not easily implemented as in music videos or explosion scenes in real video shots. This paper analyzes the sound data to synchronize the depth of field with it. The novel out-focussing technique is proposed, where the object's field of depth is controlled by beat rhythm in the sound data.

• Journal of agriculture & life science
• /
• v.44 no.1
• /
• pp.43-49
• /
• 2010

Life history of Gampsocleis sedakovi abscura Walker, an amenity sound producing insect, was investigated in Jinju, Korea from 2005 to 2007. G. sedakovi abscura had a generation per year and could be seen in the field from early March to late September. The peak emergence period of adults was early July. Developmental period from egg to adult was 357 days in average of three years in the field. Egg and nymphal periods, and adult longevity were 269, 88, and 357 days in average, respectively. The average ovipositional period was 63 days, and an adult laid 94 eggs in average throughout her life. The average longevity of adult was 90 days for female and 82 days for male. The sex ratio was 52%. G. sedakovi abscura over-wintered as egg stage in the soil. Circadian rhythm of the adult emergence showed that more than 70% of the adults emerged in the morning.

• The Journal of the Convergence on Culture Technology
• /
• v.8 no.5
• /
• pp.603-611
• /
• 2022

As the era of metaverse approaches, there are challenges that need to be solved. Among them, 'cyber motion sickness' is a representative problem from 2016;when VR technology began to attract attention. According to the theory of sensory conflict, motion sickness is caused when the perceived direction of motion information and the expected value are not the same. The paper was written to theoretically explore the relationship between brain cognition and cyber motion sickness, and to prove the effect of user immersion on motion sickness symptoms based on this. Through the SSQ experiment, it was found that the rotation value of the camera aggravates the symptoms of cyber motion sickness and can alleviate cyber motion sickness by increasing the immersion of the game by giving the viewer visual and shift missions to solve. This study was conducted to solve the problem of cyber motion sickness during the process of developing the VR rhythm game "beatale", and it is expected to be the basis for improving cyber motion sickness not only in the development of the project but also in the production of VR contents in the future.

• Journal of Music and Human Behavior
• /
• v.19 no.2
• /
• pp.1-26
• /
• 2022

This review was conducted to identify the research trends in music intervention studies with elderly patients with dementia. Korean- and English-written studies on music intervention for this population were searched and analyzed. Seventeen studies were included in the final analysis. The results showed that behavioral and psychological symptoms were the main dependent variables. In terms of the type of music intervention employed, interventions requiring the patient's active participation in producing music were more common than interventions that required the patient to only listen to music. The majority of studies provided live music, selected music that was familiar to and preferred by the patient, and utilized rhythm-based performance activities. In the studies using active music production as the intervention, the participants were asked to express the emotions evoked by group instrument playing or singing along with music, which doesn't reflect the functional limitations (e.g., cognitive impairment) of elderly patients with moderate to severe dementia. The results of this review point to the need in the field to develop music intervention programs for the elderly with moderate to severe dementia that meaningfully engage these patients in music-related behaviors that target their specific symptomology.

• The Journal of the Korea Contents Association
• /
• v.22 no.6
• /
• pp.261-272
• /
• 2022

During the China's long history, many ethnic groups have developed their own traditions of local music which is an important part of their precious cultures. Meanwhile, each ethnic group developed its own worldview and music culture according to its unique living environment, special lifestyle and mode of production. The clarinet is a Western instrument, and has been influenced to some extent by Chinese minority culture while being introduced to China. Therefore, musicians tried to find ways of using Western musical instruments to express various elements of Chinese minority music. Focusing on two clarinet works 'The Song of Grazing Horses' by Wang Yan and 'The Sound of Pamir Clarinet Concerto' by Hu Bijing, this paper aims to analyze the musical characteristics of minority groups expressed by the clarinet in two aspects: the formation of the music style, the artistic characteristics conveyed through the works. Specifically, it consists of five parts: ethnic mode and tonality, rhythm, time signature, melody making, and imitation of animals. It also analyzes the cultural characteristics of Tajik and Mongolian music reflected in the two works in combination with living environment, mode of production, life style, and ethnic emotions. This study aims to provide a theoretical basis for composers and performers who want to understand and acquire the musical style of modern Chinese clarinet works. It also helps to find a better way to play traditional Chinese music with Western instruments.

• ALGAE
• /
• v.22 no.4
• /
• pp.287-295
• /
• 2007

Infection of free-living dinoflagellates by endoparasitic dinoflagellates of the genus Amoebophrya are thought to have significant impacts on host population dynamics and have long been proposed to be a potential biological agent for controlling harmful algal bloom (HAB). To understand the impact of Amoebophrya on particular host species, however, it is necessary to quantify aspects the parasites life cycle. Here we used cultures of Amoebophryahost systems from Jinhae Bay, Korea to determine, parasite generation time, and dinospore survival and infectivity. The proportion of host cells infected by Amoebophrya sp. changed sharply from 5% to 87% with increasing dinospore:host inoculation ratios. In the absence of H. triquetra, most free-living dinospores died within 72 hours and their ability to infect host cells decreased remarkably in a day. The relatively short free-living phase of Amoebophrya suggests that the spread of infections is most likely to occur during seasons of high host abundance, as that is when dinospores have the greatest chance of encountering host cells. Infection of host cells inoculated with dinospores during the day was higher than when inoculated during the night, suggesting that infection rates might be related to environmental light conditions and/or diurnal biological rhythm of host species. Total generation times of parasite strains from a thecate dinoflagellate Heterocapsa triquetra were nearly the same regardless of dinospore:host inoculation ratios, representing 54 ± 0.5 h in a 1:1 ratio and 55 ± 1.2 h in a 20:1 ratio. Dinospore production of Amoebophrya sp. infecting Heterocapsa triquetra was estimated to be 125 dinospores per a strain of Amoebophrya sp. There is a growing need to maintain a variety of host-parasite systems in culture and to examine their autecology under various environmental conditions. Such studies would be very helpful in understanding ecological role of these parasites, their overlooked importance in the flow of material and energy in marine ecosystem, and their practical use as biological control agents applied directly to areas affected by HAB.