• Korean Journal of Plant Resources
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• v.16 no.3
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• pp.212-217
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• 2003

This study was conducted to search for possible cultivation area of Rhodiola sachalinensis as well as to obtain the basic information of growth characteristics. One­year old nursery plants of Rhodiola sachalinensis were collected from Yonbyeon Hongkyungcheon development society in China This expriment was evaluted in three areas according to sea level such as plain region in Cheongwon(50m at sea level), mid­mountainous region in Jecheon(350m at sea level) mountainous region in Banyans(650m at sea level). The growth status Rhodiola sachalinensis showed wide range of variation in there areas. Plant height showed from 8.1cm to 15.8cm, number of branch showed from 3.1 eachs to 4.6 eachs and rate of withering showed from 76％ to 94％, respectively. It was increased rapidly at the early August caused by summer depression. Flowering period of Rhodiola sachalinensis was shown at around middle and late June, total duration of flowering showed from 12 to 13 days and flower colors were various as brown, dark purple, yellow green and brown red color.

• Korean Journal of Medicinal Crop Science
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• v.16 no.6
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• pp.383-389
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• 2008

This study was performed to compare effect of immune activities of Rhodiola sachalinensis by various extraction process with different temperature and extraction solvents. Experiments were performed for investigate the immune activities on human B and T cell growth and secretion of their cytokines. Also, antibodies in serum were investigated in female ICR mouse by feeding the extracts of R. sachalinensis at doses of 40, 120 and 360 mg/kg orally for 15 days. The immune cell growth and secretion of cytokines (IL-6, TNF-$\alpha$) on human B and T cells were increased by adding R. sachalinensis extracts compare to the control. Also, total serum IgG levels increased by feeding R. sachalinensis extracts. It can be conclude that optimum condition for efficient extraction of R. sachalinensis as functional material is slovent extraction process using water with ultrasonification at below $100^{\circ}C$ than typical process.

• Journal of Applied Biological Chemistry
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• v.56 no.1
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• pp.1-3
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• 2013

Rhodiola sachalinensis A. Bor is a plant naturally grows in a high mountain areas. Aim of this study was to evaluate the effects of R.sachalinensis A. Bor extract against excessive exercise induced stress. R.sachalinensis A. Bor extract significantly inhibited L6 muscle cell death and ATP reduction caused by $H_2O_2$ damage. In addition, the oral administration of R. sachalinensis A. Bor extract in mice improved the 43.9% of treadmill running time and blood profiles of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase, creatinine, lactate when compared to distilled water. These results suggested that R. sachalinensis A. Bor can attenuate excessive exercise induced damage.

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.115-116
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• 2007

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.117-118
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• 2007

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.111-112
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• 2007

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.109-110
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• 2007

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.113-114
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• 2007

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2002.04b
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• pp.131-131
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• 2002

• The Korean Journal of Food And Nutrition
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• v.26 no.3
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• pp.485-491
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• 2013

Rhodiola spp. and red ginseng have been used for food and medicinal applications in disease chemoprevention in many Asian countries. Increased oxidative stress by reactive oxygen species (ROS) has been proposed to be a major cause of muscle fatigue. The present study was designed to investigate the protective effects of a fermented hot-water extract mixture from Rhodiola sachalinensis and red ginseng (MFR) on cell damage and the antioxidant enzyme system in $H_2O_2$-induced oxidative stress in skeletal muscle cells. C2C12 myoblasts were treated with various concentrations of NFR (non-fermented Rhodiola sachalinensis extract), FR (fermented hot-water extract from Rhodiola sachalinensis) and MFR for up to 5 days after the standard induction of differentiation, followed by semi-quantitative RT-PCR. MFR treatment dose-dependently protected oxidative damage of C2C12 cells. The treatment with MFR also enhanced mRNA expressions of MyoD, Cu/Zn SOD, Mn-SOD and GPX up to 16%. These results indicate that MFR exerts an anti-oxidative effect through a mechanism (s) that may involve the up-regulation of antioxidant enzymes, which may be important for the cellular redox environment in muscle cells.