Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Protective Effect of Rhodiola sachalinensis A. Bor on Excessive Exercise Stress

홍경천의 과도한 운동스트레스에 대한 방어효과

  • Received : 2012.05.17
  • Accepted : 2012.08.07
  • Published : 2013.03.31
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Abstract

Rhodiola sachalinensis A. Bor is a plant naturally grows in a high mountain areas. Aim of this study was to evaluate the effects of R.sachalinensis A. Bor extract against excessive exercise induced stress. R.sachalinensis A. Bor extract significantly inhibited L6 muscle cell death and ATP reduction caused by $H_2O_2$ damage. In addition, the oral administration of R. sachalinensis A. Bor extract in mice improved the 43.9% of treadmill running time and blood profiles of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase, creatinine, lactate when compared to distilled water. These results suggested that R. sachalinensis A. Bor can attenuate excessive exercise induced damage.

본 연구결과에서 홍경천 추출물은 L6 근육세포에서 산화적 손상으로 인한 세포사멸과 ATP 생성량 감소를 유의적으로 억제하였을 뿐만 아니라 마우스에 2주간 200 mg/kg 농도로 경구투여시 통계적으로 유의하지는 않았으나 treadmill 운동시간을 증가시켰고 glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase, creatinine, lactate 등의 혈액지표를 개선시켰다. 따라서 홍경천은 과도한 운동 스트레스로 인한 손상을 억제할 수 있는 소재로써의 큰 가능성을 가지고 있는 것으로 판단된다.

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References

  1. Bae SJ (2005) Anticarcinogenic and antioxidant effects of Rhdiola sachalinensis. J Korean Soc Food Sci Nutr 34, 1302–7. https://doi.org/10.3746/jkfn.2005.34.9.1302
  2. Bassuk SS and Manson JE (2005) Epidermiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease. J Appl Physiol 99, 1193–204. https://doi.org/10.1152/japplphysiol.00160.2005
  3. Djordjevi VB (2004) Free radicals in cell biology. Int Rev Cytol 237, 57-89. https://doi.org/10.1016/S0074-7696(04)37002-6
  4. Hyun KY (2009) An association of changed levels of inflammatory markers with hematological factors during one-time aerobic exercise in twentyaged young men. J Life Sci 19, 1658-65. https://doi.org/10.5352/JLS.2009.19.11.1658
  5. Irshad M and Chaudhuri PS (2002) Oxidant-antioxidant system: role and significance in human body. Indian J Exp Biol 40, 1233-9.
  6. Ji LL (1996) Excercise, oxidative stress, and antioxidants. American J Sports Med 42, 20-4.
  7. Jung HS, Kim EY, Shim ES, Lee HS, Moon EJ, Jin ZH et al. (2008) Effects of Rhodiola rosea (KH101) on anti-fatigue in forced swimming rats. Korean J Orient Int Med 29, 922-38.
  8. Lee EJ, Im JS, Park CK, Jeon BS, and Kyung JS (2005) Anti-hepatotoxic activity of sachalinensis Roots. Food Industry and Nutrition 10, 37-42.
  9. Lee FT, Kuo TY, Liou SY, and Chien CT (2009) Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am J Chin Med 37, 557-72. https://doi.org/10.1142/S0192415X09007053
  10. Li HB, Ge YK, Zheng XX, and Zhang L (2008) Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol 588, 165-9. https://doi.org/10.1016/j.ejphar.2008.04.036
  11. Park KU, Yoon JH, Kim JY, Jeong CH, Park CK, Song WS et al. (2005) Biological activity of the fractions extracted from Rhodiola dumulosa. Korean J Food Preserv 12, 496-500.
  12. Roberts CK and Barnard RJ (2005) Effects of exercise and diet on chronic disease. J Physiol 536, 329-37.
  13. Ryu SH, Kim SY, Jung HS, Sohn NW, and Sohn Y (2008) Effects of Rhodiola rosea on anti-fatigue and hypothalamic IEGs expressions of forced swimming rats. Korean J Herbology 23, 9-19.
  14. Urso ML and Clarkson PM (2003) Oxidative stress, exercise, and antioxidant supplementation. Toxicology 15, 41-54.

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