• International Journal of Reliability and Applications
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• 제2권1호
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• pp.1-26
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• 2001

The purpose of this paper is to introduce a proportional reversed hazard rate model, in contrast to the celebrated proportional hazard model, and study some of its structural properties. Some criteria of ageing are presented and the inheritance of the ageing notions (of the base line distribution) by the proposed model are studied. Two important data sets are analyzed: one uncensored and the other having some censored observations. In both cases, the confidence bands for the failure rate and survival function are investigated. In one case the failure rate is bathtub shaped and in the other it is upside bath tub shaped and thus the failure rates are non-monotonic even though the baseline failure rate is monotonic. In addition, the estimates of the turning points of the failure rates are provided.

• International Journal of Reliability and Applications
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• 제14권1호
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• pp.27-39
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• 2013

In this article, a new model based on the Rayleigh distribution is introduced. This model is useful and practical in physics, reliability, and life testing. The statistical and reliability properties of this model are presented, including moments, the hazard rate, the reversed hazard rate, and mean residual life functions, among others. In addition, it is shown that the distributions of the new model are ordered regarding the strongest likelihood ratio ordering. Four estimating methods, namely, method of moment, maximum likelihood method, Bayes estimation, and uniformly minimum variance unbiased, are used to estimate the parameters of this model. Simulation is used to calculate the estimates and to study their properties. Finally, the appropriateness of this model for real data sets is shown by using the chi-square goodness of fit test and the Kolmogorov-Smirnov statistic.

• Communications for Statistical Applications and Methods
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• 제22권5호
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• pp.487-494
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• 2015

A calculation of the Kullback-Leibler information of consecutive order statistics is complicated because it depends on a multi-dimensional integral. Park (2014) discussed a representation of the Kullback-Leibler information of the first r order statistics in terms of the hazard function and simplified the r-fold integral to a single integral. In this paper, we first express the Kullback-Leibler information in terms of the reversed hazard function. Then we establish a generalized result of Park (2014) to an arbitrary consecutive order statistics. We derive a single integral form of the Kullback-Leibler information of an arbitrary block of order statistics; in addition, its relation to the Fisher information of order statistics is discussed with numerical examples provided.

• Communications for Statistical Applications and Methods
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• 제18권6호
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• pp.787-798
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• 2011

In this paper, we develop some characterization results in terms of survival entropy of the first order statistic. In addition, we generalize the cumulative entropy recently proposed by Di Crescenzo and Logobardi (2009) to a new measure of information (called the failure entropy) and study some properties of it and its dynamic version. Furthermore, power distribution is characterized based on dynamic failure entropy.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5883-5890
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• 2013

Previously, we demonstrated overexpression of semaphorin4D (SEMA4D, CD100) to be closely related to tumor angiogenesis in epithelial ovarian cancers (EOCs). However, the function and expression of SEMA4D in the EOC microenvironment has yet to be clarified in detail. In this study, we confirmed that overexpression of SEMA4D in primary tumors and ascites was related to low differentiation, platinum resistance and a refractory status (P<0.05), while high M2 macrophage count and percentage were evident in EOC patients with advanced FIGO stage and platinum resistance (P<0.05), using immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and fluorescence-activated cell sorting (FACS), respectively. The data showed correlations of SEMA4D expression and M2 macrophage counts in primary tumors and M2 macrophage percentage in ascites (r=0.281 and 0.355, each P<0.05). In the Cox proportional hazard mode, SEMA4D expression was an independent indicator of overall survival (OS) and progression-free survival (PFS) for EOC patients. Furthermore, higher expression of SEMA4D in ovarian cancer cell lines (SKOV3, A2780, and SW626) and their supernatants were found than that in a human primary cultured ovarian cell and its supernatant by reversed transcript PCR (RT-PCR), Western blotting and ELISA, respectively. Interestingly, peripheral blood monocytes (MOs) tended towards the M2-polarized macrophage phenotype ($CD163^{high}$) in vitro after human recombined soluble SEMA4D protein stimulation. These findings suggest that SEMA4D might possibly serve as a reliable tool for early and accurate prediction of EOC poor prognosis and could playan important role in promoting tumor dissemination and metastasis in the EOC microenvironment. Thus SEMA4D and its role in macrophage polarization in EOC warrants further study.