• Transactions of the Korean Society of Mechanical Engineers
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• v.13 no.2
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• pp.307-315
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• 1989

In recent years, the fatigue design method by analysis for the mechanical components and the welded structures has much increased, instead of the fatigue design method by rule that has been widely used from the past days. When a fatigue design is conducted by that method, the basic informations, fatigue life curves are mainly obtained from the results of the strain controlled low cycle fatigue test. From these point of views, the low cycle fatigue test is coming to be given a much importance lately. In this paper, the strain controlled low cycle fatigue properties at room temperature in air environment were investigated for the low carbon forged steel, SF45A, and the rolled steel for the welded structure, SM 41B. Throughout the test, strain ratio, R, was maintained constant with the fully reversed condition, -1. As the experimental results, the cyclic stress-strain behaviours of the test materials were different each other, but the low cycle fatigue life-time of them appeared to show little difference in the region of this test conditions.

• Journal of the Korea Concrete Institute
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• v.22 no.2
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• pp.263-271
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• 2010

The purposes of this study is to verify the fracture characteristic of steel which is manufactured in Korea, subjected to cyclic loading. This investigation deals with the low cycle fatigue behavior of longitudinal reinforcement in reinforced concrete bridge substructure (piles and columns of piers). Eighty-one specimens of longitudinal reinforcement were tested under axial strain controlled reversed cyclic tests with strain amplitudes. The selected test variables are ratio of tension strain to compression strain, yield stress of longitudinal reinforcement, ratio of diameter of longitudinal steel to clear length of longitudinal steel, size of longitudinal steel and strain amplitudes. Low cycle fatigue behavior and low-cycle fatigue life are investigated and discussed in this paper.

• Steel and Composite Structures
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• v.19 no.3
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• pp.585-599
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• 2015

This paper presents the experimental work on fatigue life and specific fatigue strength of circular hollow sectioned steel tube and wood filled circular hollow section steel tube. Burning effect was observed in the case of circular hollow sectioned steel tube when it is subjected to Maximum bending moment of 19613.30 N-mm at 4200 rpm, but this did not happen in the case of wood filled hollow section. Statistical analysis was done based on the experimental data and relations have been built to predict the number of cycles for the applied stress or vice versa. The relations built in this paper can safely be applied for design of the fatigue life or fatigue strength of circular hollow sections and wood filled hollow sections. Results were validated by static specific bending strengths determined by ANSYS using a known applied load.

• Proceedings of the Korea Concrete Institute Conference
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• 2005.05a
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• pp.239-242
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• 2005

The purpose of this research was focused on substantiating an effects of tendon-layouts and compressed stress($=f_{pc}$) induced by post-tensioning on seismic performance of post-tensioned flat plate slab-column connection designed as non-participating system. To accomplish this purpose, an experimental research of flat plate exterior slab-column connections subjected to gravity load and reversed lateral displacement history are presented. As a result, tendon-layout is a main variable to influence failure mechanism, dissipated energy and lateral deformation capacity. Furthermore, compressed stress ($=f_{pc}$) induced by post-tensioning enhanced the seismic performance of flat plate slab.

• Journal of the Korean Society for Railway
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• v.9 no.4 s.35
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• pp.371-378
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• 2006

This study investigates the effects of the material properties and the fatigue behaviors in the SM490A material butt weld specimens due to the heat-treatment and the grinding. In the fatigue behavior, the heat-treatment affects the fatigue life. The S-N curves of both matrix specimen and butt weld specimen are reversed at some cycle by the existence or nonexistence of heat-treatment. The grinding on the bead makes the fatigue limit decrease in the all specimens. But the reinforcement removed, the fatigue limit increases at the high cycle. Also, this study investigates the fatigue life estimation by examining butt weld bead profiles. The butt weld beads, which are welded by semi-robot method, have non-uniform bead profiles described by $\theta,\;\rho$ and h. The stress concentration factors $K_t$, are changed by each different $\theta,\;\rho$ and h from 1.395 to 2.863. Hence, the sensitivity of $K_t$ is changed by each $\theta,\;\rho$ and h. As $\theta$ becomes lower and $\rho$ and h become higher, $K_t$ increases. The fatigue life can he estimated very closely for the AAY specimens without residual stress using only butt weld bead profiles. But, fur the AAN specimens with residual stress, the fatigue life must be estimated by considering both the weld bead profiles and the residual stress data.

• Journal of Microbiology and Biotechnology
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• v.31 no.8
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• pp.1069-1078
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• 2021

Sevoflurane postconditioning (SPostC) has been proved effective in cardioprotection against myocardial ischemia/reperfusion injury. It was also reported that heat shock protein 70 (HSP70) could be induced by sevoflurane, which played a crucial role in hypoxic/reoxygenation (HR) injury of cardiomyocytes. However, the mechanism by which sevoflurane protects cardiomyocytes via HSP70 is still not understood. Here, we aimed to investigate the related mechanisms of SPostC inducing HSP70 expression to reduce the HR injury of cardiomyocytes. After the HR cardiomyocytes model was established, the cells transfected with siRNA for HSP70 (siHSP70) or not were treated with sevoflurane during reoxygenation. The lactate dehydrogenase (LDH) level was detected by colorimetry while cell viability and apoptosis were detected by MTT and flow cytometry. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blotting were used to detect HSP70, apoptosis-, cell cycle-associated factors, iNOS, and Cox-2 expressions. Enzyme-linked immuno sorbent assay (ELISA) was used to measure malondialdehyde (MDA) and superoxide dismutase (SOD). SPostC decreased apoptosis, cell injury, oxidative stress and inflammation and increased viability of HR-induced cardiomyocytes. In addition, SPostC downregulated Bax and cleaved caspase-3 levels, while SPostC upregulated Bcl-2, CDK-4, Cyclin D1, and HSP70 levels. SiHSP70 had the opposite effect that SPostC had on HR-induced cardiomyocytes. Moreover, siHSP70 further reversed the effect of SPostC on apoptosis, cell injury, oxidative stress, inflammation, viability and the expressions of HSP70, apoptosis-, and cell cycle-associated factors in HR-induced cardiomyocytes. In conclusion, this study demonstrates that SPostC can reduce the HR injury of cardiomyocytes by inducing HSP70 expression.

• Journal of Welding and Joining
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• v.13 no.2
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• pp.96-105
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• 1995

A modified method for the analysis of short fatigue crack growth has been presented, and calculations based upon the modified method are compared with experimental results for S45C carbon steel. It is also shown that the modified method is in good agreement with experimental data. The proposed equation for the fatigue crack growth rates includes a material constant which relates the threshold level to the endurance limit, a correction for elastic-plastic behaviour and a means for dealing with the effects of crack closure. In this study one of the modifications is to substitute the Forman' s elastic expression of the stress intensity factor range into the geometrical factor The other is a consideration of the bending effect which is developed from the moment caused by the eccentric cross sectional geometry as the crack grows. Thus, this method is useful for residual life prediction of the mechanical structures as well as the welding structures.

• Journal of the Ergonomics Society of Korea
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• v.26 no.4
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• pp.153-160
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• 2007

Due to the high occurrence rate of musculoskeletal disorders(MSDs), many Korean companies adopted various assessment tools to evaluate workers' musculoskeletal stress. Using the results of this evaluation, tasks were selected for improvements. However, there are still many workers who complained of musculoskeletal stress of their tasks. Their tasks usually consist of repetitive activities and a short rest cycle. This prompts a concern of reliability of the evaluation tools and especially RULA. Thus in this study, OCRA(The Occupational Repetitive Action tool) was used to check whether RULA(Rapid Upper Limb Assessment) evaluates workers' musculoskeletal stress reasonably well since OCRA has been known to be a good evaluation tool for repetitive tasks and tasks with short recovery periods. The evaluation was conducted on 142 tasks. It was found that 65 tasks showed higher action levels by OCRA than by RULA. However, 13 tasks showed the reversed result and 64 tasks showed the same level regardless of the evaluation tool. It was concluded that either RULA or OCRA alone cannot evaluate all types of tasks very well. It is suggested that OCRA needs to be used with RULA together for the evaluations of musculoskeletal stress at workplaces where repetitive activities and short recovery periods exist.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.3
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• pp.193-198
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• 2017

Alloy 617 is one of the primary candidate materials to be used in a very high temperature reactor (VHTR) system as an intermediate heat exchanger (IHX). To investigate the low cycle fatigue behavior of Alloy 617 weldments at a high temperature of $850^{\circ}C$, fully reversed strain-controlled fatigue tests were conducted with the total strain values ranging from 0.6~1.5％. The weldment specimens were machined using the weld pads fabricated with a single V-grove configuration by gas tungsten arc welding (GTAW) process. The fatigue life is reduced as the total strain range increases. For all testing conditions, the cyclic stress response behavior of the Alloy 617 weldments exhibited the initial cyclic strain hardening phenomenon during the initial small number of cycles. Furthermore, the overall fatigue cracking and the propagation or cracks showed a transgranular failure mode.

• Molecules and Cells
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• v.38 no.5
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• pp.457-465
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• 2015

The 15-kDa selenoprotein (Sep15) is a selenoprotein residing in the lumen of the endoplasmic reticulum (ER) and implicated in quality control of protein folding. Herein, we established an inducible RNAi cell line that targets Sep15 mRNA in Chang liver cells. RNAi-induced Sep15 deficiency led to inhibition of cell proliferation, whereas cell growth was resumed after removal of the knockdown inducer. Sep15-deficient cells were arrested at the G1 phase by upregulating p21 and p27, and these cells were also characterized by ER stress. In addition, Sep15 deficiency led to the relocation of focal adhesions to the periphery of the cell basement and to the decrease of the migratory and invasive ability. All these changes were reversible depending on Sep15 status. Rescuing the knockdown state by expressing a silent mutant Sep15 mRNA that is resistant to siRNA also reversed the phenotypic changes. Our results suggest that SEP15 plays important roles in the regulation of the G1 phase during the cell cycle as well as in cell motility in Chang liver cells, and that this selenoprotein offers a novel functional link between the cell cycle and cell motility.