• 한국CDE학회논문집
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• 제6권4호
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• pp.215-221
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• 2001

In the zigzag milling of a pocket having islands, tool retraction is one of the primary factors that decrease productivity. Therefore, tool path with minimum number of tool retraction has been needed. Most researches about this topic have been concentrated on obtaining the optimum solution formulated through the geometric reasoning off pocket. Recently, several attempts were made to simplify this problem into region partitioning in order to get the numerically expressed minimum solution. In this research, a method reducing the number of tool retractions extended from existing region partitioning is provided. Applying the segment that is normal to the reference direction of zigzag milling, region partitioning is carried out and structural elements of the region are searched via graphs of islands and characteristic points. Through the processes presented, the number of region partitioned is less than that of existing processes.

• 대한족부족관절학회지
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• 제24권4호
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• pp.173-173
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• 2020

• Journal of Applied Biological Chemistry
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• 제63권4호
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• pp.339-345
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• 2020

Euchrestaflavanone A (EFA) is a flavonoid found in the root bark of Cudrania tricuspidata. C. tricuspidata extract, widely used throughout Asia in traditional medicine, has been investigated phytochemically and biologically and is known to have anti-obesity, anti-inflammatory, and anti-tumor effects. It has been reported that C. tricuspidata extract also possesses anti-platelet effects; however, the mechanism of its anti-platelet and anti-thrombotic activities is yet to be elucidated. In this study, we investigated the effects of EFA on the modulation of platelet function using collagen-induced human platelets. Our results showed that EFA markedly inhibited platelet aggregation. Furthermore, it downregulated glycoprotein IIb/IIIa (αIIb/β3)-mediated signaling events, including platelet adhesion, granule secretion, thromboxane A2 production, and clot retraction, but upregulated the cyclic adenosine monophosphate-dependent pathway. Taken together, EFA possesses strong anti-platelet and anti-thrombotic properties and is a potential therapeutic drug candidate to prevent platelet-related thrombosis and cardiovascular disease.

• 생약학회지
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• 제51권4호
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• pp.231-237
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• 2020

Euchrestaflavanone B (EFB) is a flavonoid that can be found in root bark, particularly in Cudrania tricuspidata (C. tricuspidata). The extract of C. tricuspidata is widespread throughout Asia and used in traditional medicine. In a previous study, we found anti-platelet effects of substances isolated from C. tricuspidata on collagen-induced human platelets. However, the C. tricuspidata still contains numerous substances, thus, we have searched new candidate, EFB isolated from C. tricuspidata for anti-platelet effect. Our results showed that EFA inhibited collagen-induced platelet aggregation and glycoprotein IIb/IIIa (αIIb/β3)-mediated signaling events, including platelet adhesion, granule secretion, thromboxane A2 production and clot retraction. These results suggest that EFA has inhibitory effects on human platelet activities and thrombus formation and has potential value as a natural substance for preventing platelet-induced thrombosis.

• East Asian mathematical journal
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• 제25권4호
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• pp.527-532
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• 2009

In this paper, we study the following extended generalized variational inequality problem, introduced by Noor (for short, EGVI) : Given a closed convex subset K in q-uniformly smooth Banach space B, three nonlinear mappings T : $K\;{\rightarrow}\;B^*$, g : $K\;{\rightarrow}\;K$, h : $K\;{\rightarrow}\;K$ and a vector ${\xi}\;{\in}\;B^*$, find $x\;{\in}\;K$, $h(x)\;{\in}\;K$ such that $\xi$, g(y)-h(x)> $\geq$ 0, for all $y\;{\in}\;K$, $g(y)\;{\in}\;K$. [see [2]: M. Aslam Noor, Extended general variational inequalities, Appl. Math. Lett. 22 (2009) 182-186.] By using sunny nonexpansive retraction $Q_K$ and the well-known Banach's fixed point principle, we prove existence results for solutions of (EGVI). Our results extend some recent results from the literature.

• 한국식품저장유통학회지
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• 제31권1호
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• pp.197-198
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• 2024

• Journal of Applied Biological Chemistry
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• 제66권
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• pp.455-461
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• 2023

Glycyrrhiza glabra is a well-known medicinal herb that grows in various parts of the world and glabridin is a major chemical compound that is found in the root extract of Glycyrrhiza glabra. Glabridin is a natural compound known to have antioxidant, anti-inflammatory, anti-atherogenic, anti-osteoporotic and skin-whitening. In this study, we investigated if glabridin inhibited platelet aggregation and thrombus formation. We observed that glabridin inhibited collagen-induced platelet aggregation and suppressed signal transduction molecules such as phosphatidylinositol-3 kinase (PI₃K), Akt, glycogen synthase kinase-3α/β (GSK-3α/β), SYK, cytosolic phospholipase A₂, and p38 expression. In addition, glabridin suppressed thromboxane A₂ generation and thrombin-induced clot retraction. Taken together, glabridin showed strong antiplatelet effects and may be used to block thrombosis- and platelet-mediated cardiovascular diseases.

• The Korean Journal of Physiology and Pharmacology
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• 제21권2호
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• pp.277-277
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• 2017

• 원예과학기술지
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• 제32권2호
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• pp.277-277
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• 2014

• Journal of the Optical Society of Korea
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• 제19권1호
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• pp.112-112
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• 2015