• Archives of Pharmacal Research
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• v.25 no.4
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• pp.541-545
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• 2002

Pharmacokinetic characteristics of Acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of acebutolol were significantly increased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. The ratio of the diacetolol to total acebutolol in plasma (i.e., metabolite percentage rate) was significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of acebutolol were significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Slope of terminal phase ($\beta$) of acebutolol was significantly decreased in hepatic failure rabbits. These findings suggest that the $V_{d},{\;}CL_{t}$ and $\beta$ of acebutolol were significantly decreased as a result of inhibition of the hepatic metabolism in moderate to severe hepatic failure rabbits. Therefore, dose adjustment may be necessary for acebutolol in hypertensive patients with hepatic damage.

• Journal of Chest Surgery
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• v.57 no.3
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• pp.319-322
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• 2024

Venovenous extracorporeal membrane oxygenation (VV ECMO) is often used in cases of severe respiratory failure, especially in patients considered for lung transplantation. However, because many lung diseases can ultimately result in right heart failure, the treatment of secondary right heart failure can present a challenge when the patient is already under VV ECMO support. In such cases, an oxygenated-right ventricular assist device (OxyRVAD) can be used. OxyRVAD is designed to maintain anterograde blood flow and prevent right ventricular distension. Moreover, the pulmonary arterial cannula can be inserted percutaneously. We report a case in which percutaneous OxyRVAD was successfully implemented to manage right heart failure in a patient with respiratory failure who was on VV ECMO.

• Journal of Applied Reliability
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• v.16 no.2
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• pp.125-133
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• 2016

Purpose: The purpose of this study is to evaluate durability of platform safety step system in railway. Method: We performed finite element analysis & durability analysis of platform safety step system with VPD (Virtual Product Development) techniques and examined the durability standard & qualification life through the rig test during no failure test time in reliability qualification test. We continued to test 1 million cycles in KRS (Korea Railway Standard) for system's robust design performance. Result: FEM analysis results are 14.9MPa & 14.7MPa of pin-joint, pivot and durability analysis result is above 1 million cycles. we calculated theoretically no failure test time 855,000 cycles and through the 1 million cycles durability rig test in KRS standard we confirmed product quality. Conclusion: This platform safety step system was designed very safe in terms of a mechanical strength & durability.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2003.11a
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• pp.140-144
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• 2003

To investigate failure analysis of surface acoustic wave (SAW) filter for radio frequency, high temperature storage test was carried out. The failure criteria were insertion loss at passband and rejection level at stopband. As a result, the insertion loss at passband increase about 4 dB was due to damages of interdigital transducer (IDT). That is caused by poor adhesion between metal electrode(AI) and piezoelectric substrate and defects on a manufacturing process. This result indicates that good adhesion between electrode and ceramic substrate is important factor And also we investigated the demage factors of electrode. Screen possible of saw filter using high temperature storage test(HTOL) in the manufacturing phase be presented.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.4
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• pp.11-17
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• 1996

In the case of redundancy control performed by a netowrk management system, it can not be ignored some delay of control time and break of control by failure of the system. This paper proposed a new method to improve the performacne of a redundancy control system interfaced to the network management system. At first, it produced the modelling of the total system and analyzed the functional relation of reliability and failure rate for a transmission system having an one-to-one active redundancy structure controlled by itself. After describing the loss rate of transmission data and the time required for the redundancy control process of the network management system when a failure is occurred, it proposed the new redundancy method of complex system control mode as an effective redundancy control method to improve reliability of a redundancy control system. Finally, it proved the effect by comparing the new result to the previous result.

• Journal of Applied Reliability
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• v.2 no.1
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• pp.15-22
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• 2002

This paper is concerned about an Accelerated Life Test for Micro Display Device which is being used in a Projection TV, in order to find a failure mode occurred in field in a short time, to identify a major factor to affect a life, and to estimate a mean life. For this purpose, we selected a temperature as a accelerated factor to perform a test and measured degradation of display device using visual inspection and chromaticity table. In the result of Accelerated Life Test, it is confirmed that failure mode is equal to the degradation of display device by vendor and the Temperature is a major factor to affect a failure. Besides, according as the display device is turned to green as degraded, it is identified that the change of the chromaticity value is one method to measure the degree of the degradation . So, we applied the optimal condition, which consider a cost and life to lower the Temperature which is a major factor acquired by the result of ALT, to PTV design

• Journal of Korean Institute of Industrial Engineers
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• v.40 no.4
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• pp.366-374
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• 2014

This study assessed and analysed a result of a product design experiment through Product Data Analytics (PDA), to find reasons for failure of some projects in the experiment. PDA is a computer-based data analysis that uses Product Data Management (PDM) databases as its operational databases. The study examines 20 product design projects in the experiment, which are prepared to follow same product development process by using an identical PDM system. The design result in the PDM database is assessed and analysed by On-Line Analytical Processing (OLAP) and data mining tools in PDA. The assesment and analysis reveals the lateness in creation of 3D CAD models as the main reason of the failure.

• Journal of Applied Reliability
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• v.17 no.4
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• pp.316-324
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• 2017

Purpose: The purpose of this study is to determine the replacement cycle applied age replacement policy by reliability analysis based on railway vehicle contactor's failure history data. Method: We performed reliability analysis based on railway vehicle contactor's failure history data. We found a suitable distribution by goodness of fit test and predicted the reliability through estimation of scale & shape parameter. Considering cost information we determined the replacement cycle that minimize the opportunity cost. Result: Suitable distribution was the Weibull and scale parameter & shape parameter are estimated by reliability analysis. The replacement cycle was predicted and MTTF, $B_6$ percentile life were suggested additionally. Conclusion: We confirmed that failure rate type of railway vehicle contactor is degradation model having a time dependent characteristic and examined the replacement cycle in our country's operating environment. We expect that this study result contribute to railway operation agency for maintenance policy decision.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 1997.04a
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• pp.269-279
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• 1997

An investigation was peformed to study the predicting the joint strength of mechanical fasteners. Bearing failure is most important failure mode for designing joint. So in this study, the prediction method in consideration with bearing failure was chosen. In the proposed method, the characteristic length is combined with the Yamada-Sun failure criterion, Tsai-Hill failure criterion and characteristic length for Tension and Compression is determined from investigation. Especially the length of compression is determined from the "bearing failure test" that newly conceived to take bearing failure into consideration. The proposed prediction method was applied to quasi-isotropic carbon/epoxy joint showing net-tension and bearing failure experimentally. Good agreement was found between the predicted and experimental result for each joint geometry.

• Journal of the Korean GEO-environmental Society
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• v.10 no.7
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• pp.167-177
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• 2009

This study investigates a failure mechanism of a tunnel shotcrete lining with respect to a concentrated load due to blocky rock mass. First of all, it is carried out to survey relevant researches to shotcrete failures by literature reviews and to numerically re-investigate the failure modes of shotcrete lining given by previous researches. Through this study, the failure modes are relocated with the conditions which induce each failure mode newly proposed by this study. In addition to this, the arching shape of tunnel lining, which has not been considered in the previous research despite of inherent geometrical characteristics in tunnels, is taken into consideration in numerical investigation on lining failure in this study. As a result, it is shown that more simplified failure modes can be found on the tunnel boundary condition and the corresponding failure condition to each mode can be different from ones of the previous study due to a tunnel arching effect.