• Journal of Oriental Neuropsychiatry
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• v.30 no.3
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• pp.209-220
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• 2019

Objectives: As a general emotion, everyone can temporarily experience depression, but depressive disorder is a disease that excessively affects daily life. Among the various causes of depression, the deficiency of monoamine-based neurotransmitters such as serotonin and epinephrine are considered significant. Thus, antidepressants that target monoamines are used frequently. However, side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction are observed. Thus, it is necessary to develop a new therapeutic agent with fewer side effects. In this study, we investigated the antidepressant effect of JG02, used to treat depression by normalizing the flow of qi (氣) in Korean medicine. Methods: C57BL/6 mice were selected and randomly divided into six groups: normal, control, amitriptyline, and JG02 (50, 125, 250 mg/kg), respectively. Except for normal, depression was induced by applying restraint stress at the same time for six hours daily for 14 consecutive days. Saline, amitriptyline or JG02 samples were orally administered two hours before applying the stress. After that, a forced swimming test and an open field test were performed. Additionally, serum corticosterone, serotonin mRNA, BDNF mRNA, and protein in the hippocampal region were measured and compared. Results: JG02 decreased immobility time rate in the FST and increased the zone transition number and travel distance in the OFT. Also, JG02 inhibited the release of serum corticosterone, and increased serotonin, BDNF gene expression, and BDNF protein in the hippocampus. Conclusions: In this study, JG02 showed significant antidepressant effects on the chronic restraint stress mice model. When further research is performed based on JG02, the development of a new antidepressant is considered highly possible.

• Structural Engineering and Mechanics
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• v.52 no.1
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• pp.75-87
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• 2014

To analyze the tension performance of laminated rubber bearings under tensile loading, a theoretical tension model for analyzing the rubber bearings is proposed based on the theory of elasticity. Applying the boundary restraint condition and the assumption of incompressibility of the rubber (Poisson's ratio of the rubber material is about 0.5 according the existing research results), the stress and deformation expressions for the tensile rubber layer are derived. Based on the derived expressions, the stress distribution and deformation pattern especially for the deformation shapers of the free edges of the rubber layer are analyzed and validated with the numerical results, and the theory of cracking energy is applied to analyze the distributions of prediction cracking energy density and gradient direction. The prediction of crack initiation and crack propagation direction of the rubber layers is investigated. The analysis results show that the stress and deformation expressions can be used to simulate the stress distribution and deformation pattern of the rubber layer for laminated rubber bearings in the elastic range, and the crack energy method of predicting failure mechanism are feasible according to the experimental phenomenon.

• Korean Journal of Health Education and Promotion
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• v.22 no.4
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• pp.73-90
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• 2005

Objectives: Smokers who had failed to quit smoking were frequently reported that life stress mostly interrupted their abstention. Stress vulnerability model for smoking cessation has been considered, and most of contemporary smoking cessation programs help smokers develop coping strategies for stressful situations. This study aims to investigate the appropriate coping styles for stress of abstention from smoking. The result of investigating the relationship between abstention following smoking cessation program and coping styles would suggest useful information for those who want to stop smoking and health practitioners who help them. Methods: Participants were 69 smokers (62 males, 7 females) participated in a hospitalized smoking cessation program, whose mean age was 44.89 (SD=9.61). Participants took medical test and completed questionnaires and psychological tests including: Fagerstrom Test for Nicotine Dependence and Multidimensional Coping Scale. To identify participants' abstention, researchers followed them for 2 years. To identify whether abstained or not and encourage them to abstain, researchers called them on the telephone once a week for 3 months. After 3 months, they were contacted every other week till 6 months passed since they left smoking cessation program. And they were contacted once a month for other 18months. Researchers also contacted their family to identify their abstention. Data Mining Decision Tree was performed with 37 variables (13 variables for the coping styles and 24 smoking-related variables) by Answer Tree 3.0v Results: Forty four (63.8%) out of sixty nine for 2 weeks, 34 (49.3%) for 6 months, 25 (36.2%) abstained for 1 year, and 22 (31.9%) abstained for 2 years. Participants of this study abstained average of 286.77 days from smoking. Included variables of a Decision Tree model for this study were positive interpretation, emotional expression, self-criticism, restraint and emotional social support seeking. Decision Tree model showed that those (n=9) who did not interpret positively (<=7.5) and criticized themselves (>6.5) abstained 23 days only, while those (n=9) who interpreted positively (>7.5), expressed their emotion freely (>6.5), and sought social support actively (>11.5) abstained 730 days, till last day of the investigation. Conclusion: The results of this study showed that certain coping styles such as positive interpretation, emotional expression, self-criticism, restraint and emotional social support seeking were important factors for long-term abstention from smoking. These findings reiterate the role of stress for abstention from smoking and suggest a model of coping styles for successful abstention from smoking. Despite of limitation of this study, it might help smokers who want to stop smoking and health practitioners who help them.

• Journal of Digital Convergence
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• v.20 no.1
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• pp.399-414
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• 2022

The purpose of this study was to test the structural model for the effect on abnormal eating behavior targeting 493 nurses. Results, The direct effects of variables affecting abnormal eating behavior were in the order of eating abstinence and socially imposed perfectionism, and these variables explained 85% of abnormal eating behavior. Explicit narcissism had a significant effect on abnormal eating behavior through socially imposed perfectionism and eating restraint, and sociocultural attitude toward appearance through eating restraint. In the multi-group moderating effect, the path coefficients between job stress and abnormal eating behavior, socially imposed perfectionism and abnormal eating behavior were different between groups. Therefore, it is necessary to find a way to lower the socially-imposed perfectionism and nursing intervention that can escape excessive eating abstinence.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.11a
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• pp.604-607
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• 2003

Recently, hybrid concrete structures such as a concrete-filled steel tubular(CFT), a steel reinforced concrete(SRC) and a composite material are popular in structure applications. They also have merit of high strength, high ductility, and large energy absorption capacity. But the analysis of hybrid concrete structures is very difficult owing to the complex behavior of concrete under passive confinement. This paper has analyzed CFT, which receives passive confinement using Tri-Surface concrete model for three dimension finite element analysis. By the result of that, the proposed model was properly forecasted a concrete behavior that receives passive restraint as well as non-linear analysis of concrete which receive uniaxial stress and high active confinement of 400Mpa. If the model through the steady study is set up especially on the factor of concrete under passive confinement, the proposed concrete model will be surely useful for analysis of the hybrid concrete structures.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.3
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• pp.755-761
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• 2014

Internal or external restraint of concrete strain due to drying shrinkage and creep in concrete structures causes mechanical strain and becomes a source of persistent change in creep-causing stress conditions. Mathematical modeling to incorporate the persistent change of creep-inducing stress is generally achieved with consideration of the ages of concrete and concrete properties at the times of loadings, and stress history. This paper presents an incremental format of creep model based on parallel creep concept to depict the creep under time-varying stress history in developing creep strain. Laboratory experiments are carried out to validate the performance of the presented creep model. Typical creep phenomena are addressed through the comparisons between the measured and predicted creep strains.

• Earthquakes and Structures
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• v.22 no.1
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• pp.39-51
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• 2022

The axial compression behavior of nine self-compacting concrete columns confined with CFRP-PVC spirals was studied. Three parameters of spiral reinforcement spacing, spiral reinforcement diameter and height diameter ratio were studied. The test results show that the CFRP strip and PVC tube are destroyed first, and the spiral reinforcement and longitudinal reinforcement yield. The results show that with the increase of spiral reinforcement spacing, the peak bearing capacity decreases, but the ductility increases; with the increase of spiral reinforcement diameter, the peak bearing capacity increases, but has little effect on ductility, and the specimen with the ratio of height to diameter of 7.5 has the best mechanical properties. According to the reasonable constitutive relation of material, the finite element model of axial compression is established. Based on the verified finite element model, the stress mechanism is revealed. Finally, the composite constraint model and bearing capacity calculation method are proposed.

• Journal of the Korea Concrete Institute
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• v.14 no.3
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• pp.331-340
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• 2002

In this paper, finite element analysis is applied for simulation of cracks due to restraining autogenous and drying shrinkage at early-age concrete. A micro-level heat hydration model and a shrinkage prediction model along with a moisture diffusion model are adopted for the finite element analysis. Then, an axial restraint test is carried out for concrete specimens containing different amounts of chloride ions to evaluate stress development and cracking due to the restraining shrinkages at early ages. Test results show that the increase of contents of chloride ions increases restrained stress, but does not increase strength. By this increase of shrinkage strain at early-age, time to occur the crack is accelerated. Finally, stress development and cracking of concrete specimens containing different amount of chloride ions we simulated using the finite element analysis. Results of the analysis using the Proposed model are verified by comparison with test results.

• Journal of Korean Tunnelling and Underground Space Association
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• v.10 no.3
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• pp.303-312
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• 2008

Multi-axial compression tests have been frequently adopted for the evaluation of material properties of rock cores and rock fracture model tests. Special care has to be applied on the boundary condition between the specimen and loading platen to draw the precise test results of the multi-axial compression tests. With the use of dry steel platen, the stress rotation will occur, due to the frictional restraint from the boundary between the specimen and loading platen. The restraint will deviate the expected test results under the conditions of the given external pressures. Various methods have been applied to reduce the side restraint along the specimen/loading platen interface. The steel brush type loading platen is one example of the attempts. In this paper, a new type of loading platen is introduced to overcome the limitation caused by the use of the brush type loading platen, which requires some internal space for the installation of the brushes. The new type of loading platen, roller supported steel piston type loading platen. is constituted of shot steel pistons which have sufficient stiffness to deliver the external pressure and the shaft type roller installed at the rear of the pistons. The pistons are designed to follow the local deformation of the specimens. In this paper, structural details of the loading platen are presented and frictional and biaxial compression tests results are shown to verify the required functions of the loading platen. Furthermore, calibration process is followed by a comparison between the test results and numerical analyses.

• Journal of the East Asian Society of Dietary Life
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• v.8 no.2
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• pp.126-136
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• 1998

This study was designed to determine the effects of linoleic acid contents and $\omega$ 6/$\omega$3 ratios on the induction of gastric ulcer by water immersion and restraint stress. Sprague-Dawley rats were fed 5diets containing 7% fat(w/w) for 6weeks. These diet groups were Lh, Mh, Hh, Mm, Ml, : 3 different linoleic acid levels(0.3% of energy(L). 3.5(M), 10(H) and 3 different $\omega$6/$\omega$3 ratios (11(1), 33(m), 100(h) with beef tallow, sunflower or fish oil. The Lh group showed a significantly higher ulcer index (UI) than the Mh and Hh groups(p<0.05). At the same linoleic levels, the UI had no significant difference within the $\omega$6/$\omega$3 ratios. The Mh group showed significantly higher (p<0.05) PGE2 and TBX2 content than any other group. Pearson's correlation coeffcients between UI and PGE2 and TBX2 had a negatively significant correlation(p<0.05). Linoleic acid of gastric mucosal phospholipids was reflected by the diet, but was not significantly different. The most significant finding of this study is that not only the absolute amount of linoleic acid, but also the $\omega$6/$\omega$3 ratios are important factors for the prevention of gastric ulcer.