• Title/Summary/Keyword: responsive

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Pathogen Associated Molecular Pattern (PAMP)-Triggered Immunity Is Compromised under C-Limited Growth

  • Park, Hyeong Cheol;Lee, Shinyoung;Park, Bokyung;Choi, Wonkyun;Kim, Chanmin;Lee, Sanghun;Chung, Woo Sik;Lee, Sang Yeol;Sabir, Jamal;Bressan, Ray A.;Bohnert, Hans J.;Mengiste, Tesfaye;Yun, Dae-Jin
    • Molecules and Cells
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    • v.38 no.1
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    • pp.40-50
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    • 2015
  • In the interaction between plants and pathogens, carbon (C) resources provide energy and C skeletons to maintain, among many functions, the plant immune system. However, variations in C availability on pathogen associated molecular pattern (PAMP) triggered immunity (PTI) have not been systematically examined. Here, three types of starch mutants with enhanced susceptibility to Pseudomonas syringae pv. tomato DC3000 hrcC were examined for PTI. In a dark period-dependent manner, the mutants showed compromised induction of a PTI marker, and callose accumulation in response to the bacterial PAMP flagellin, flg22. In combination with weakened PTI responses in wild type by inhibition of the TCA cycle, the experiments determined the necessity of C-derived energy in establishing PTI. Global gene expression analyses identified flg22 responsive genes displaying C supply-dependent patterns. Nutrient recycling-related genes were regulated similarly by C-limitation and flg22, indicating re-arrangements of expression programs to redirect resources that establish or strengthen PTI. Ethylene and NAC transcription factors appear to play roles in these processes. Under C-limitation, PTI appears compromised based on suppression of genes required for continued biosynthetic capacity and defenses through flg22. Our results provide a foundation for the intuitive perception of the interplay between plant nutrition status and pathogen defense.

Quality Improvement in Patient Care Services : Obstacles and Approaches (진료의 질관리에 대한 시론 -장애와 접근-)

  • 한달선
    • Health Policy and Management
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    • v.2 no.2
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    • pp.112-130
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    • 1992
  • Patient care services are provided to individual patients in response to their health needs produced by illnesses or injuries. The services are often addressed to very serious conditions, and also they constitute the most expensive component of health care services. Therefore, the importance of quality is emphasized, but there are many indications that patient care quality is far from a satisfactory state in most of the countries. Based upon this observation, it is attempted to examine obstacles and approaches to quality improvement in patient care services. In doing so, following Taguchi's(1986) definition of product quality, quality of patient care services is conceived of as better when the less is the sociental loss attributalbe to variability of intended function and harmful side effects they emhibit after being delivered. Some distinguishing features of medical care sector pose difficulties in implementing effective quality improvement programs in patient care services. Nevertheless, newly proposed method of quality management, based on industrial quality management approach, seems to have a great deal of potential to effectively cope with such difficulties. This method, unlike the traditional approach to quality assurance, focuses on total organisational processes, not individuals, as the obproach to quality assurance, focuses on total organizational processes, not individuals, as the objects of quality improvement; variation, not comparison with standards, in quality measurement; and continuous improvement, not removing only bad quality care, as an ideal. Prerequisite to a successful use of any quality mangement method is motivating providers to improve quality. Conceivable approaches for such motivation are self-regulation, external controls and promotion of competition. Since these approaches are not mutually exclusive, they may be employed in an appropriate combination. In Korea, medical care providers are now functioning under the circumstances where they have little reason for making efforts to improve quality of their services. Once these circumstantial conditions are changed to exert pressures on providers to improve quality, the use of adequate quality management method becomes an issue. In this connection, much attention shoould be directed to the newly proposed method described above. In all these efforts for improving quality of patient care services, health insurance would be able to play a pivotal role. Poviders of medical care, buth indiciduals and organizations, are usually very responsive to the measures that affect their financing, and thus health insurance can be a strong instrument for motivationg providers to improve quality. Also, the insurance continuously acquires data on patient care, which could be processed to produce information required to effective quality control.

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Characterization of a Drought-Tolerance Gene, BrDSR, in Chinese Cabbage (배추의 건조 저항성 유전자, BrDSR의 기능 검정)

  • Yu, Jae-Gyeong;Lee, Gi-Ho;Park, Young-Doo
    • Horticultural Science & Technology
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    • v.34 no.1
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    • pp.102-111
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    • 2016
  • The goal of this study was to characterize the BrDSR (Drought Stress Resistance in B. rapa) gene and to identify the expression network of drought-inducible genes in Chinese cabbage under drought stress. Agrobacterium-mediated transformation was conducted using a B. rapa inbred line ('CT001') and the pSL100 vector containing the BrDSR full length CDS (438 bp open reading frame). Four transgenic plants were selected by PCR and the expression level of BrDSR was approximately 1.9-3.4-fold greater than that in the wild-type control under drought stress. Phenotypic characteristics showed that BrDSR over-expressing plants were resistant to drought stress and showed normal growth habit. To construct a co-expression network of drought-responsive genes, B. rapa 135K cDNA microarray data was analyzed to identify genes associated with BrDSR. BrDSR was directly linked to DARK INDUCIBLE 2 (DIN2, AT3G60140) and AUTOPHAGY 8H (ATG8H, AT3G06420) previously reported to be leaf senescence and autophagy-related genes in plants. Taken together, the results of this study indicated that BrDSR plays a significant role in enhancement of tolerance to drought conditions.

Effect of Dried Leaf Powders and Ethanol Extracts of Perilla Frutescens, Artemisia Princeps Var. Orientalis and Aster Scaber on Lipid Metabolism and Antioxidative Capacity in Rats (깻잎, 쑥, 참취의 건분 및 에탄올 추출물이 흰쥐의 지방대사와 항산화능에 미치는 영형)

  • 김주희
    • Journal of Nutrition and Health
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    • v.32 no.5
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    • pp.540-551
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    • 1999
  • This study was performed to investigate the effects of dried leaf powders and ethanol extracts of Perilla frutescens(perilla leaf), Artemisia princeps var. orientalis(mugwort) and Aster scaber(chamchui) on lipid metabolism and antioxidative capacity in rats. Forty-nine male Sprague-Dawley rats weighing 105.9$\pm$1.7g were blocked into seven groups according to body weigth and raised for four weeks with diets containing 5% dried powders of perilla leaf, mugwort and chamchui, or ethanol extracts from the same amount of each dried leaf powder. Food intake was higher in the control and chamchui powder groups than the other remaining groups. Weight gain was not significantly different among all experimental groups. Food efficiency ratio was highest in the perilla leaf powder group. Plasma total lipid and cholesterol, liver total lipid and triglyceride levels were highest in the perilla leaf powder group. In contrast, dried powders of mugwort and chamchui showed hypolipidemic effects in plasma and liver. Plasma and liver TBARS levels in both dried powder and ethanol extract groups of the three plants were lower than control. There was also no significant difference between corresponding dried powder and ethanol extract groups. Catalas and GSH-Px activities in erythrocyte and liver were not different among all the experimental groups. However, SOD activities were significantly different among the esperimental groups. In erythrocyte. SOD activiteis of all dried powder and ethanol extract groups except the perilla leaf powder group were higher than control, and the chamchui power group showed the highest activity among them. In liver, all the plant groups showed higher SOD activities than control. There was no significant difference between corresponding dried powder and ethanol extract groups. In conclusion, the dried chamchui powder and liver. All the dried plant powder and ethanol extract were effective in decreasing the TBARS levels of liver and particularly plasma. Among the antiocidative enzymes, SOD activity was most responsive to the experimental diets. All the plant groups showed increases in liver SOD activities and there were more increments in dried powder groups. Since the effects of dried powder groups on lipid metabolism were better than those of extract groups, it is plausible that the high dietary fiber level in dried powders was effective. Antioxidative effects were not significantly different between corresponding dried power and extract groups, and it was thought that ethanol extracts from three plants also had similar antioxidative effects as dried powderers.

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A Study on Low-Floor Bus Routes Selection - Focused on the Case of Jeollabuk-Do - (저상버스 노선선정 방안에 관한 연구 -전라북도 사례를 중심으로-)

  • Lee, Chang-Hyun;Kim, Sang-Youp;Kim, Jai-Sung
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.13 no.4
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    • pp.73-85
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    • 2014
  • Approaching to aging society with increasing transportation vulnerable, most developed countries has positively promote low-floor bus. Such circumstance in Korea has plan to introduce low-floor bus to intra-city bus system which accounted for 30 percent of total number of buses however there is no specific operating plan for this matter. According to the revealed preference study on bus service, the study shows that the efficiency of low-floor is relatively low than that of other buses, therefore, it is necessary to establish feasible plan for bus route selection. Thus, this study is to conduct research on analyzing trip characteristics of transportation vulnerable and establish bus route selection measures for low-floor bus. The result from the survey in Jeollabuk-do Province reveals that the trip purpose of transportation vulnerable is mainly for welfare and medical service, which was made less than 6 times a week. Futhermore, 37.6 percent of transportation vulnerable use buses, thus, it is essential to improve its service quality for enhancing user's convenience and safety. In that transportation vulnerable O-D needs to be established and forecasts future demand for selecting optimal bus route. According to the estimation, route passing through densely populated areas with transportation vulnerable should take the first priority, city circular and other route would be next. Moreover, it is economically efficient that areas populated more than 200,000 with fixed route and less than 200,000 with limited route responsive to demands would be feasible plans. This study will have greater an impact on transportation planning and further research on transportation vulnerable.

Effect of Age on Glucose Metabolism of Skeletal Muscle in Rats (흰쥐에서 연령이 골격근의 당 대사에 미치는 영향)

  • Jang, Eung-Chan;Youn, Woon-Ki;Lee, Suck-Kang
    • Journal of Yeungnam Medical Science
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    • v.18 no.1
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    • pp.94-100
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    • 2001
  • Background: It is doubtful that aging causes deteriorated glucose metabolism and insulin resistance of skeletal muscle. Some researchers had different results about it. So we have studied the mechanism responsible for the abnormal glucose tolerance associated with aging in rapidly growing and matured rats. Materials and Methods: Animals were used S.D. rats. Growing rats were 7 weeks old (BW: 160-190 gm) and matured rats were 28 weeks old (BW: 420-525 gm). Results: Fasting blood glucose and plasma insulin levels were significantly elevated in matured rat compared with growing rats. And during oral glucose tolerance test the glucose level was also significantly elevated in matured rats. These results confirmed an insulin resistant state of aging. Insulin levels at 30 minutes of oral glucose tolerance test was significantly elevated in growing rat. But at 120 minutes it was maintained at higher level in matured rats than in growing rats. It suggested the possibility of increased insulin secretion by initial stimulation of beta-cells in growing rats, and increased secretion and decreased catabolic rate of insulin in matured rats. Glucose uptake rate of soleus muscle in matured rats was lower than that of growing rats, but the difference was not statistically significant. The dose(insulin)-responsive(glucose uptake) curve of soleus muscle was only slightly deviated to the right side. Conclusion: Glucose metabolism of rat skeletal muscle was worsened by aging. The data of glucose uptake experiments suggested the possibility of insulin resistance of skeletal muscle in matured rats. but the mechanism of insulin resistance of skeletal muscle need further studies.

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Meaning and identity of social work practice by thinking through settlement house as a welfare space : Comparison of Toynbee Hall and Hull House (복지공간으로서 인보관을 통한 사회복지실천의 뜻과 정체성의 사유 : 토인비 홀과 헐 하우스의 비교)

  • Park, Sunyoung
    • Korean Journal of Social Welfare Studies
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    • v.48 no.1
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    • pp.91-111
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    • 2017
  • Purposes of this study, summoning thoughts and activities of Toynbee Hall of the UK and Hull House of the US held in between the end of 19C and the early 20C, are two folded: first, it is to examine the momentum and aims for which 'social' work was progressively established at that time; second, it is to look for implications for today's social work practice through understanding their characteristic activities and the context in which 'social' work was devised as an alternative in the two nations. The study method mainly relies on literature review, but further goes on to analyze the spirit of the age when settlement house was constructed as a welfare space and activities, leadership demonstrated in there, and to draw meanings for today, in terms of three dimensions: aim and location, professionality and education, and social action. Some of useful findings are: first, the COS and settlement house need to be considered in a continuum of socially responsive remedies against poverty and social work practice was developed in the process of 'suggestion-performance-critique-alternative suggestion-emergence of social work', rather than contrasting the two as opposite roots of social work practice. Second, settlement house was a socially constructed welfare space that contained intersectional dynamics of class, gender, personal vs. social, private vs. public, surrounding poverty issue. Third, besides differences between the two settlements, both purported for public goods and well-being and tried to realize the 'social' in that society. Lastly, this study explored historical meanings of settlement house as the welfare space with critical questions and discussed implications for social work practice today.

Health and Medical Practice Revisited with a Historical Review of Health Care Legislature and Application to Health Policy (보건의료법제의 연혁적 검토를 통해 본 건강과 의료행위 개념의 변화와 정책 적용)

  • Bae, Hyun-A;Kim, Hyo-Sin;Kang, Min-Ah
    • Journal of Legislation Research
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    • no.44
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    • pp.387-433
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    • 2013
  • Understanding the concepts of health and medical practice are significant because they are the basis of health and medical policy and law. How legislators, policy makers, and the public perceive those concepts defines the direction of legislation and policy making. This study aims to show the changes of the concepts by reviewing the history of major Statutes relating to health and medicine. Alongside medicalization of human conditions and daily activities, the concepts of health and medical practice also expanded. On the other hand, as technologies of health and medicine have specialized and segmented, the large portion of public services of the past is now provided by the private sector. We argue that the actual laws and decisions by the judiciary should be responsive to social and scientific changes, which may cause the changes of the perceptions of health and medical practice. By doing so, they not only can have actual legal force but also even initiate a movement for establishing new medical policy or law.

An Evaluation of 30-Year's Democratization in South Korea: Focus on the Evolution of South Korean Presidential System and Its Future Prospects (민주화이후 한국 대통령제의 진화과정 분석)

  • Kim, Yong-Ho
    • Korean Journal of Legislative Studies
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    • v.23 no.1
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    • pp.37-79
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    • 2017
  • The major purpose of this paper is to analyze the evolution of the presidential system in South Korea during the past three decades ever since the country's democratization in 1987 from the comparative institutional perspective. As imperial presidentialism during the so-called three Kim's era(1987-2003) disappeared right after the political retirement of the three Kims in 2003, then president-centered presidentialism emerged during the post-three Kim's era, since the country's recent three presidents possessed their relatively low-level of partisan power in terms of their control of National Assemblies and their respective presidents' parties during their presidencies. South Korea has now a strong possibility to transform the current president-centered presidentialism into the American-style separatist presidential system in the near future, since the country's National Assembly has continuously been making its efforts to function as an effective governing body being compatible with the American Congress. In addition, the country's judiciary branch has effectively been playing a political role like the US supreme court ever since the country's democratization in 1987. It is also emphasized that South Korea's civic society is currently playing as a guardian of democracy through its effective and responsive political participations in many public sectors for promoting civic liberties, public welfare, and other democratic values. South Korea now needs to carry out constitutional revisions, political reforms of legislative system, party system, and electoral system as well as correct some contradictory political understandings and habits in a way to transform the current president-centered presidentialism into American-style separatist presidential system in the near future.

Pig Manure Compost and Urea Application Effects on Chinese Cabbage in Different Soil Fertility (토양 비옥도가 상이한 조건에서 돈분 퇴비와 요소 비료의 배추에 대한 시비효과)

  • Yun, Hong-Bae;Han, Seung-Gap;Lee, Jong-Sik;Lee, Ye-Jin;Kim, Myung-Sook;Lee, Yong-Bok
    • Korean Journal of Soil Science and Fertilizer
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    • v.43 no.6
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    • pp.962-967
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    • 2010
  • The influences of the different mixture of urea fertilizer and pig manure compost as a nitrogen (N) source on Chinese cabbage yield, N uptake, and N agronomic efficiency (AE) were evaluated in two soils having different soil fertility levels. Increasing urea application level was very effective to improve yield and N uptake of Chinese cabbage, and the highest yield was obtained by urea fertilization alone in two soils. On the other hand, the lowest yield and N uptake was obtained from compost alone application in two soils. There was no significant difference in terms of the nitrogen AE between low and high fertility soils that were fully applied with urea. The AE values of Chinese cabbage applied by compost alone were significantly higher in the soil having a low fertility (28.8 g $g^{-1}$) than that in soil with high fertility (16.2 g $g^{-1}$), suggesting that N in compost was more responsive in improving the yield of Chinese cabbage in low fertility soils.