• Journal of the Korea Society for Simulation
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• v.18 no.3
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• pp.103-112
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• 2009

In a nuclear power plant (NPP), periodic sensor calibrations are required to assure sensors are operating correctly. However, only a few faulty sensors are found to be calibrated. For the safe operation of an NPP and the reduction of unnecessary calibration, on-line calibration monitoring is needed. In this paper, principal component-based Auto-Associative support vector regression (PCSVR) was proposed for the sensor signal validation of the NPP. It utilizes the attractive merits of principal component analysis (PCA) for extracting predominant feature vectors and AASVR because it easily represents complicated processes that are difficult to model with analytical and mechanistic models. With the use of real plant startup data from the Kori Nuclear Power Plant Unit 3, SVR hyperparameters were optimized by the response surface methodology (RSM). Moreover the statistical techniques are integrated with PCSVR for the failure detection. The residuals between the estimated signals and the measured signals are tested by the Shewhart Control Chart, Exponentially Weighted Moving Average (EWMA), Cumulative Sum (CUSUM) and generalized likelihood ratio test (GLRT) to detect whether the sensors are failed or not. This study shows the GLRT can be a candidate for the detection of sensor drift.

• Applied Chemistry for Engineering
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• v.34 no.2
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• pp.137-143
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• 2023

In this study, natural surfactants were extracted from Medicago sativa L. The O/W emulsification processes with the extracted natural surfactants were optimized using central composite design model-response surface methodology (CCD-RSM) and a 95% confidence interval was used to confirm the reasonableness of the optimization. Herein, independent parameters were the ratio of saponins to total surfactant (P), amount of surfactant (W), and emulsification speed (R), whereas the reaction parameters were the emulsion stability index (ESI), mean droplet size (MDS), and viscosity (V). Using the multiple reaction, the optimal conditions for the ratio of saponins to total surfactant, amount of surfactant, and emulsification speed for O/W emulsification were 49.5%, 9.1 wt%, and 6559.5 rpm, respectively. Under these optimal conditions, the expected values of ESI, MDS, and V as the reaction parameters were 89.9%, 1058.4 nm, and 1522.5 cP, respectively. The values of ESI, MDS, and V from these expected values were 88.7%, 1026.4 nm, and 1486.5 cP, respectively, and the average experimental error for validating the accuracy was about 2.3 (± 0.4)%. Therefore, it was possible to design an optimization process for evaluating the O/W emulsion process with Medicago sativa L. using CCD-RSM.

• Journal of the Korean Geotechnical Society
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• v.25 no.1
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• pp.5-19
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• 2009

Most of earthquake-induced geotechnical hazards have been caused by the site effects relating to the amplification of ground motion, which is strongly influenced by the local geologic conditions such as soil thickness or bedrock depth and soil stiffness. In this study, an integrated GIS-based information system for geotechnical data, called geotechnical information system (GTIS), was constructed to establish a regional counterplan against earthquake-induced hazards at an urban area of Daejeon, which is represented as a hub of research and development in Korea. To build the GTIS for the area concerned, pre-existing geotechnical data collections were performed across the extended area including the study area and site visits were additionally carried out to acquire surface geo-knowledge data. For practical application of the GTIS used to estimate the site effects at the area concerned, seismic zoning map of the site period was created and presented as regional synthetic strategy for earthquake-induced hazards prediction. In addition, seismic zonation for site classification according to the spatial distribution of the site period was also performed to determine the site amplification coefficients for seismic design and seismic performance evaluation at any site in the study area. Based on this case study on seismic zonations in Daejeon, it was verified that the GIS-based GTIS was very useful for the regional prediction of seismic hazards and also the decision support for seismic hazard mitigation.

• Journal of the Korean GEO-environmental Society
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• v.24 no.8
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• pp.5-11
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• 2023

Due to frequent occurrences of concentrated heavy rainfall caused by abnormal climate conditions in recent years, collapses of steep slopes have been occurring frequently due to surface erosion and increased pore water pressure. Various methods are being applied to prevent slope collapses, such as increasing the resistance to movement and reducing pore water pressure. Research on these methods has been consistently conducted as they provide an efficient response to slope collapses by satisfying both the conditions of resistance to movement and pore water pressure simultaneously. Therefore, in this study, we propose an upward slope reinforcement method by burying drainage materials with an upward slope inclination, instead of the conventional horizontal application. This approach aims to satisfy both slope reinforcement and drainage functions effectively, offering a comprehensive solution for slope stabilization. Furthermore, to determine the optimal burial angle that exhibits the most effective reinforcement and drainage effects of the proposed method, we investigated the reinforcement and drainage effects under conditions where the horizontal drainage materials were set at angles ranging from 0° to 60° in increments of 10° on a representative cross-section. Additionally, indoor model experiments were conducted under the conditions of 40°, which showed the most outstanding drainage effect, and 20°, which exhibited the highest safety factor, to validate the numerical analysis results. The results showed that the burial angle of 40° exhibits a relatively higher drainage effect as with the numerical analysis results, while the angle of 20° results in inadequate drainage and observed slope collapse.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.1C
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• pp.65-76
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• 2010

Recent earthquake events revealed that severe seismic damages were concentrated mostly at sites composed of soil sediments rather than firm rock. This indicates that the site effects inducing the amplification of earthquake ground motion are associated mainly with the spatial distribution and dynamic properties of the soils overlying bedrock. In this study, an integrated GIS-based information system for geotechnical data was constructed to establish a regional counterplan against ground motions at a representative metropolitan area, Seoul, in Korea. To implement the GIS-based geotechnical information system for the Seoul area, existing geotechnical investigation data were collected in and around the study area and additionally a walkover site survey was carried out to acquire surface geo-knowledge data. For practical application of the geotechnical information system used to estimate the site effects at the area of interest, seismic zoning maps of geotechnical earthquake engineering parameters, such as the depth to bedrock and the site period, were created and presented as regional synthetic strategy for earthquake-induced hazards prediction. In addition, seismic zonation of site classification was also performed to determine the site amplification coefficients for seismic design at any site and administrative sub-unit in the Seoul area. Based on the case study on seismic zonations for Seoul, it was verified that the GIS-based geotechnical information system was very useful for the regional prediction of seismic hazards and also the decision support for seismic hazard mitigation particularly at the metropolitan area.

• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.4
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• pp.332-337
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• 2023

Korea is not only surrounded by the sea on three sides, but also has national and local rivers extending 26,843 km, so it has a geographical feature in which abundant sea and inland water surface coexist. As the number of ships operating in the inland waters is continuously increasing due to the improvement of national income, the risk of ship accidents and human casualties in the inland waters is also increasing. In this study, a macroscopic plan for the safety management of inland water ships was presented through investigation of inland water related laws and operation status analysis. As an improvement plan, as a hardware infrastructure it is proposed to secure sufficient inland water fire-boats to secure the golden time for early response to accidents and lifesaving, and to operate an institution specializing in the prevention of inland water ships accidents. And as a software infrastructure, establish departure control standards for inland water ships and the safety diagnosis system currently applied only to sea going ships, the introduction of a system tailored to the characteristics of inland water ships. The proposed inland water safety management policy is expected to contribute to the preparation of prompt and systematic countermeasures in the event of an inland water ship accident, and it is hoped that it will serve as an opportunity to continue to pay attention to safety-related research on inland water ships, which was briefly activated after the sinking of M/V Sewol.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.37-37
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• 2021

Calystegia soldanella L. is a perennial herbaceous halophyte belonging to the convolvulaceae family, which mainly grows in coastal sand dunes in Korea. Shoots and rhizomes are edible, and roots called 'Hyoseon Chogeun' are known to have medicinal effects such as antipyretic, sterilization, and diuretic. In addition, physiological activities of antioxidant, anti-inflammatory, antiviral, antifungal and PTP-1B (protein tyrosine phosphate-1B) inhibition have been reported. In this study, in vitro induction cell lines of C. soldanella L. collected from the coastal sand dunes in Jeju island was redifferentiated into adventitious roots that can be used as medicinal resources. Also the biomass of mass-proliferated adventitious roots using a bioreactor were evaluated. Plants of C. soldanella L. were collected from the crevice of the seashore in the coastal area of Taeheung 2-ri, Namwon-eup, Seogwipo-si. Then, it was separated into leaves, stems, rhizomes, and roots, and surface sterilized with 70% ethyl alcohol and 2% NaOCl (sodium hypochlorite). After washing with sterilized water, each organ section was cultured in Hormone-free MS medium (Murashige & Skoog Medium). As a result, the induction response rates were evaluated at 85% and 55%, respectively, in terms of callus formation and shoot generation in the rhizome segment. In the case of the adventitious roots morphological characteristics induced by single-use treatment of auxin-based plant growth regulators IBA and NAA from redifferentiated shoots were compared. Most efficient adventitious root culture method as a rooting rate, number, length, and biomass proliferation in the bioreactor system was confirmed when treated by culturing in MS salts, Sucrose 30 g·L^-1, and IBA 1mg·L^-1 for 4 weeks. In this study, the medium composition and culture period were confirmed using a bioreactor system to mass-proliferate adventitious roots derived from C. soldanella L. in Jeju island. Also this adventitious root line developed a new medicinal material could increase value of the bio-industry ingredient through quantitative and qualitative screening of phyto-bioactive compounds.

• Journal of Life Science
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• v.34 no.6
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• pp.418-425
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• 2024

Solid tumors are heterogeneous populations of multiple cell types. While the majority of the cells that comprise cancer are unable to divide, cancer stem cells have self-renewal and differentiation properties. Normal stem cell pathways that control self-renewal are overactivated in cancer stem cells, making cancer stem cells important for cancer cell expansion and progression. Dick first proposed the definition of cancer stem cells in acute myeloid leukemia, according to which cancer stem cells can be classified based on the expression of cell surface markers. Cancer stem cells maintain their potential in the tumor microenvironment. Multiple cell types in the tumor microenvironment maintain quiescent cancer stem cells and serve as regulators of cancer growth. Since current cancer treatments target proliferative cells, quiescent state cancer stem cells that are resistant to treatment increase the risk of recurrence or metastasis. Various signals of the tumor microenvironment induce changes to become a tumor-supportive environment by remodeling the vasculature and extracellular matrix. To effectively treat cancer, cancer stem cells and the tumor microenvironment must be targeted. Therefore, it is important to understand how the tumor microenvironment induces reprogramming of the immune response to promote cancer growth, immune resistance, and metastasis. In this review, we discuss the cellular and molecular mechanisms that can enhance immunosuppression in the tumor microenvironment.

• The Korean Journal of Quaternary Research
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• v.34 no.1
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• pp.41-51
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• 2024

The Sincheon wetland shows a remarkable diversity of fluvial landforms, such as river islands, anastomosing channels, braided channels, and sand-gravel bars, which contribute to its rich ecological habitat. The wetland area is characterized by a ecological diversity of herbaceous and woody plants. Significant changes in land cover within the wetlands were observed from 2008 to 2020. Notably, there was a rapid decrease in agricultural area from 18% to 0.04%, while the vegetation area expanded from 45% to 54%. Concurrently, the water area also experienced a notable increase from 34% to 41%. The surface sediment composition in the studied area displays sandy loam characteristics and exhibits acidic soil properties. Sediment acidity tends to increase downstream and in the central part of channels. Variations in acidity are also observed at nearby collection sites due to the tributaries and local discharge. The presence of dense vegetation in river islands and bars has led to a significant transformation of sediments into soil, with this change being more pronounced downstream, particularly near the weirs. The installation of a weir in Sincheon wetland is believed to have a significant impact on altering flow velocities between upstream and downstream sections, as well as influencing erosion and sediment deposition patterns. However, given the formation of landforms in response to weirs, effective administration and management are essential to address potential risks of catastrophic environmental disruptions, such as the removal of weirs and/or the maintenance of river channels.

• Food Science and Preservation
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• v.30 no.1
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• pp.122-131
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• 2023

Persimmon peels are mostly discared as a by-product of dried persimmon manufacturing, but effective use is required as it contains various functional constituents. This study covers the preparation of carotenoid-enriched oil by ultrasound treatment of persimmon peel in soybean oil solvent, and the investigation of its physicochemical characteristics. Using the Box-Behnken design and response surface methodology, the optimal extraction conditions (temperature, 62℃; time, 32 min; and persimmon peel to oil ratio, 1:3.1) were determined based on the carotenoid concentration of the extract. The physicochemical characteristics of the extract obtained under optimal conditions and the untreated soybean oil (control) were compared. The total carotenoid content of the extract increased. The carotenoid-enriched soybean oils had a lighter color than the controls, but with high redness and yellowness values. The effect of sonication and a component of the persimmon peel on the oxidation and heating stability of soybean oil was weak. The viscosity and activation energy of carotenoid-enriched soybean oil were slightly higher than those of the control. Thus, it was possible to prepare yellow-red carotenoid-enriched soybean oil by applying ultrasonic-soybean oil solvent extraction to persimmon peel. The oil is expected to be useful as an additive as well as a substitute for general edible oils.