• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.365-374
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• 2019

Unlike benign tumors, malignant tumors are capable of metastasis, easy to relapse, poor survival, and low quality of life. In Korea, here is a tendency to treat the tumors collectively according to the General Principles of Cancer Chemotherapy(GPCC) of the Health Insurance Review & Assessment Service (HIRA). But recently, companion diagnostics(CDx) is recommended rather than unilateral medication because biomarker-based molecular diagnostics is possible to predict the drug response of patients before drug treatment. Not only domestic but also overseas Food and Drug Administratio (FDA) recommends the development of the CDx system at the stage of drug development to ensure the responsiveness and safety of medicines. In this study, I focused on the necessity of CDx development direction as well as CDx development status through literature review. Furthermore I also discussed CDx types according to the molecular diagnostic technology such as immunohistochemistry (IHC), polymerase chain reaction (PCR), in situ hybridization (ISH), and next-generation sequencing (NGS) not only in the approved CDx but also in the developing one by US FDA. And I suggested the technology issue of CDx development process such as a selection of molecular diagnostics at the time of release, a clear understanding of the CDx mechanism, and a convergence of drug with CDx development. The necessity of social insurance system also was proposed for CDx development.

• The Korean Society of Law and Medicine
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• v.23 no.1
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• pp.149-176
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• 2022

South Korean law strictly prohibits engagement in medical activities by non-medical practitioners. In the country, tattooing is classified as a medical practice, and non-medical practitioners who engage in it are penalized because they are unauthorized to carry out this procedure. In reality, however, people rarely seek tattooing services from medical personnel. Arguing that their freedom of job selection is violated, non-medical personnel who make a living as tattoo artists reject the characterization of the procedure as a form of medical treatment and demand the decriminalization of tattooing by non-medical practitioners. Nevertheless, tattooing can cause health- and hygiene-related dangers when it is not performed by medical professionals because it involves penetration into the skin using needles. Hence, stringent management is necessary for infection prevention. The gap between reality and the law gives rise to the need for proactive thinking about the institutionalization of tattoo practice by non-medical personnel. Policymakers should reflect on the fact that only minimal tattooing services are currently performed by medical staff while also accounting for health and safety. On this basis, this study examined tattoo-related legislation in South Korea to determine whether the procedure corresponds to medical practice and identify ways to solve problems that occur from the perspective of health care. As a response that promotes safety and reflects reality, this research proposed a three-phase approach.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.28 no.4
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• pp.425-430
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• 1983

Rice (Oryza sativa L.) anthers collected from different genotypes were cultured to investigate the priority to increase callus production rate among several factors affecting on callus formation. Rice varieties, F$_1$ hybrids and F$_2$ plants differed greatly in their abilities to produce callus from anthers, and it was confirmed that the culturability of rice anther was a heritable characteristic. Cold shock treatment before plating anthers promoted callus formation rate, but combined effect with genotype having high culturability was more significant. The response to sucrose concentration in culture medium in callus induction rate was different between rice genotypes, but combined effect with genotype was not significant. Single supplement of NAA to R$_2$ medium increased callus production rate remarkably only in rice genotype having high culturability. Conclusively selection of genotypes is most important to increase callus initiation frequency from rice anthers.

• Journal of the Korean Institute of Landscape Architecture
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• v.51 no.5
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• pp.70-83
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• 2023

Recently, the Korea Forest Service has implemented a planning project about wind corridor forests as a response measure to climate change. Based on this, research on wind corridors has been underway. For the creation of wind corridor forests, a preliminary evaluation of the wind corridor function is necessary. However, currently, there is no evaluation index to directly evaluate and spatially distinguish the types of wind corridors, and analysis is being performed based on indirect indicators. Therefore, this study proposed a method to evaluate and classify wind corridors by utilizing heat deficit analysis as an evaluation index for cold air generation. Heat deficit was analyzed using a cold air analysis model called Kaltluftabflussmodell_21 (KLAM_21). According to the results of the simulation analysis, the wind path was functionally classified. The top 5% were classified as cold-air generating Areas (CGA), and the bottom 5% as cold-air vulnerable Areas (CVA). In addition, the cold-air flowing Areas (CFA) were classified by identifying the flow of cold air moving from the cold air generation area. It is expected that the methodology of this study can be utilized as an evaluation method for the effectiveness of wind corridors. It is also anticipated to be used as an evaluation index to be presented in the selection of wind corridor forest sites.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.35 no.1
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• pp.169-192
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• 2024

This study was conducted with the aim of providing a foundation for high-quality national place name authority data by developing Korean-specific guidelines for place name authority data in response to the need for systematic construction and standardization of authority databases. To this end, a survey of domestic and international trends and cases related to place name authority data was conducted, and the rules and guidelines of each country for establishing place name authority data were analyzed. Based on these surveys and rule analyses, the scope of concepts and terminology required to build a place name authority database were defined and the direction for the development of place name authority data guidelines was set. The analysis also determined the scope and framework of the guidelines, and how they should be referenced to existing rules. The structure of the guidelines proposed in this study is based on the original RDA and NCR. Based on the implications derived from the analysis process, the guidelines were organized and presented in terms of scope of construction, selection and recording of preferred place names, recording of variant place names, and attributes of place names to propose a technical guideline for place name authority data that fits the Korean situation. Future discussions were revealed accordingly.

• Journal of Soil and Groundwater Environment
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• v.12 no.1
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• pp.73-86
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• 2007

Risk-based remediation strategy (RBRS) is a consistent decision-making process for the assessment and response to chemical release based on protecting human health and the environment. The decision-making process described integrates exposure and risk assessment practices with site assessment activities and remedial action selection to ensure that the chosen actions are protective of human health and the environment. The general sequences of events in Tier 1 is as follows: initial site assessment, development of conceptual site model with all exposure pathways, data collection on pollutants and receptors, and identification of risk-based screening level (RBSL). If site conditions do not meet RBSL, it needs further site-specific tier evaluation, Tier 2. In most cases, only limited number of exposure pathways, exposure scenarios, and chemicals of concern are considered the Tier 2 evaluation since many are eliminated from consideration during the Tier 1 evaluation. In spite of uncertainties due to the conservatism applied to risk calculations, limitation in site-specific data collections, and variables affecting the selection of target risk levels and exposure factors, RBRS provides us time- and cost-effectiveness of the remedial action. To ensure reliance of the results, the development team should consider land and resource use, cumulative risks, and additive effects. In addition, it is necessary to develop appropriate site assessment guideline and reliable toxicity assessment method, and to study on site-specific parameters and exposure parameters in Korea.

• Journal of Biosystems Engineering
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• v.30 no.1 s.108
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• pp.45-55
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• 2005

Knowledge of the relationship between crop yield and yield-limiting factors is essential for precision farming. However, developing this knowledge is not easy because these yield-limiting factors are interrelated and affect crop yield in different ways. In this study, data for grain yield and yield-limiting factors, including crop chlorophyll content, soil chemical properties, and topography were collected for a small (0.3 ha) rice paddy field in Korea and a large (36 ha) upland corn field in the USA, and relationships were investigated with path analysis. Using this approach, the effects of limiting factors on crop yield could be separated into direct effects and indirect effects acting through other factors. Path analysis provided more insight into these complex relationships than did simple correlation or multiple linear regression analysis. Results of correlation analysis for the rice paddy field showed that EC, Ca, and $SiO_2$ had significant (P<0.1) correlations with rice yield, while pH, Ca, Mg, Na, $SiO_2,\;and\;P_2O_5$ had significant correlations with the SPAD chlorophyll reading. Path analysis provided additional information about the importance and contribution paths of soil variables to rice yield and growth. Ca had the highest direct effect (0.52) and indirect effect via Mg (-0.37) on rice yield. The indirect effect of Mg through Ca (0.51) was higher than the direct effect (-0.38). Path analysis also enabled more appropriate selection of important factors limiting crop yield by considering cause-and-effect relationships among predictor and response variables. For example, although pH showed a positive correlation (r=0.35) with SPAD readings, the correlation was mainly due to the indirect positive effects acting through Mg and $SiO_2$, while pH not only showed negative direct effects, but also negatively impacted indirect effects of other variables on SPAD readings. For the large upland Missouri corn field, two topographic factors, elevation and slope, had significant (P<0.1) direct effects on yield and highly significant (P<0.01) correlations with other limiting factors. Based on the correlation analysis alone, P and K were determined to be nutrients that would increase corn yield for this field. With the help of path analysis, however, increases in Mg could also be expected to increase corn yield in this case. In general, path analysis results were consistent with published optimum ranges of nutrients for rice and com production. We conclude that path analysis can be a useful tool to investigate interrelationships between crop yield and yield limiting factors on a site-specific basis.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.780-803
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• 2003

Exposure of skin cells, particularly keratinocytes to various nuclear factor-kappaB ($\textrm{NF}_{-{\kappa}}\textrm{B}$) activators [e.g. tumor necrosis factor-$\alpha$, interleukin-1, lipopolysaccharides, and ultraviolet light] leads to phosphorylation and degradation of the inhibitory protein, $\textrm{I}_{{\kappa}}\textrm{B}$. Liberated $\textrm{NF}_{-{\kappa}}\textrm{B}$ is translocated into the nucleus where it can change or alter expression of target genes, resulting in the secretion of extracellular signaling molecules including melanotrophic factors affecting melanocyte. In order to demonstrate the possible role of $\textrm{NF}_{-{\kappa}}\textrm{B}$ activation on the synthesis of melanotrophic factors from the keratinocytes, the activities of $\textrm{NF}_{-{\kappa}}\textrm{B}$ induced by melanogenic inhibitors (MIs) were determined in human HaCaT keratinocytes transfected with $\textrm{pNF}_{-{\kappa}}\textrm{B}$-SEAP-NPT plasmid. Transfectant cells released the secretory alkaline phosphatase (SEAP) as a transcription reporter in response to the $\textrm{NF}_{-{\kappa}}\textrm{B}$ activity and contain the neomycin phosphotransferase (NPT) gene for the dominant selection marker for geneticin resistance. MIs such as niacinamide, kojic acid, hydroquinone, resorcinol, arbutin, and glycolic acid were preincubated with transfectant HaCaT cells for 3 h and then ultraviolet B (UVB) was irradiated. $\textrm{NF}_{-{\kappa}}\textrm{B}$ activation was measured with the SEAP reporter gene assay using a fluorescence detection method. Of the Mis tested, kojic acid ($IC_{50}$/ = 60 $\mu$M) was found to be the most potent inhibitor of UVB-upregulating $\textrm{NF}_{-{\kappa}}\textrm{B}$ activation in transfectant HaCaT cells, which is followed by niacinamide ($IC_{50}$/= 540 $\mu$M). Pretreatment of the transfectant HaCaT cells with the Mis, especially kojic acid and niacinamide, effectively lowered $\textrm{NF}_{-{\kappa}}\textrm{B}$ binding measured by electrophoretic mobility shift assay. Furthermore, these two inhibitors remarkably reduced the secretion level of IL-6, one of melanotrophic factors, triggered by UV-radiation of the HaCaT cells. These observations suggest that Mis working at the in vivo level might act partially through the modulation of the synthesis of melanotrophic factors in keratinocyte.

• Ecology and Resilient Infrastructure
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• v.7 no.2
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• pp.97-113
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• 2020

Soil is the foundation of human life and the basis for food security. Considering this it is prioritized in the UN's Sustainable Development Goals (SDG). Therefore, research on soil resilience in the agricultural environment is crucial for sound and sustainable soil management, especially in highly uncertain and unpredictable conditions. Soil resilience is defined in different ways by several researchers; however, its definition typically includes the concepts of recovery and resistance to stress. The physical, chemical, and biological characteristics of soils that are used to assess the soil resilience, i.e., the response of soil to various types of stress are summarized in this study. In addition, various statistical processing techniques and quantification methods are summarized considering the wide spatial and temporal scope of soil resilience research. Several soil resilience studies typically conduct the following five steps: (1) soil and site selection (2) stress (independent variable) setting (3) soil characteristics and indicator (dependent variable) setting (4) performing various spatiotemporal scale experiments (5) statistical analysis. The previous and present studies present a general introduction of soil resilience, based on which, further practical research considering domestic agricultural environment should be conducted. The extensive range of soil resilience measurements will require collaboration between researchers in various fields.

• Science of Emotion and Sensibility
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• v.22 no.4
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• pp.31-44
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• 2019

This study intended to investigate the effects of the subtitle location on the decreased working memory abilities caused by aging. A junior group (average age: 26, SD: 3.06, N=27) and a senior group (average age: 61.69, SD=4.18, N=26) participated in this study and they all performed N-back tasks which measured the working memory ability of the participants and video subtitle recognition tasks that assessed the most effectively recognized subtitle locations in the video. The results of the N-back task revealed slower response times and low accuracy rates in the senior group in comparison to the junior group, suggesting lower working memory abilities in the senior group vis-à-vis the junior group. The deterioration of working memory due to aging also negatively influenced the 'left-bottom' subtitle location in the video subtitle recognition task and positively influenced the 'left-center' location of the screen. The deterioration of working memory ability did not affect other subtitle locations. By examining the positive or negative effects of the deterioration of working memory ability as a function of age on subtitle locations, the present study suggests that the selection of suitable subtitle locations taking into account the ages of video viewers would cause information to be more effectively displayed on screen.