• Journal of Microbiology and Biotechnology
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• 제23권12호
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• pp.1757-1764
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• 2013

Trichoderma harzianum ZF-2 producing laccase was isolated from decaying samples from Shandong, China, and showed dye decolorization activities. The objective of this study was to optimize its culture conditions using a statistical analysis of its laccase production. The interactions between different fermentation parameters for laccase production were characterized using a Plackett-Burman design and the response surface methodology. The different media components were initially optimized using the conventional one-factor-at-a-time method and an orthogonal test design, and a Plackett-Burman experiment was then performed to evaluate the effects on laccase production. Wheat straw powder, soybean meal, and $CuSO_4$ were all found to have a significant influence on laccase production, and the optimal concentrations of these three factors were then sequentially investigated using the response surface methodology with a central composite design. The resulting optimal medium components for laccase production were determined as follows: wheat straw powder 7.63 g/l, soybean meal 23.07 g/l, $(NH_4)_2SO_4$ 1 g/l, $CuSO_4$ 0.51 g/l, Tween-20 1 g/l, $MgSO_4$ 1 g/l, and $KH_2PO_4$ 0.6 g/l. Using this optimized fermentation method, the yield of laccase was increased 59.68 times to 67.258 U/ml compared with the laccase production with an unoptimized medium. This is the first report on the statistical optimization of laccase production by Trichoderma harzianum ZF-2.

• 한국생산제조학회지
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• 제21권3호
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• pp.387-393
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• 2012

It is very difficult to determine suitable cutting conditions in order to obtain accurate cutting profiles because machining errors caused by tool deflection depend upon cutting conditions. In this study the relationship between real cutting profiles (inclined shapes and machining errors) and cutting conditions was modeled in order to fabricate draft angle on micro molds. CCD (Central Composite Design) of DOE (Design Of Experiment) and RSM (Response Surface Method) were applied in order to model the relationship between cutting conditions and machining errors. In order to use CCD the range of radial depth of cut was chosen by $10-90{\mu}m$ and the range of feedrate was chosen by 200-300mm/min, and 9 points of cutting conditions were chosen inside determined ranges. Then, actual cutting processes were carried out as respect to 9 points of cutting conditions, draft angles and real cutting profiles were measured on cutting profiles, each response surface function was determined by conducting response surface analysis and the functions were represented by 3-dimensional graphs, contour lines and $101{\times}101$ matrices. Consequently it is possible to determine suitable cutting conditions in order to obtain arbitrary given draft angles and cutting profiles by using modeling. To validate proposed approach in this study suitable cutting conditions were determined by modeling in order to obtain arbitrary given draft angle and cutting profile, and actual cutting processes were carried out. About 95% of good agreement between predicted and measured values was obtained.

• 셀메드
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• 제11권3호
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• pp.15.1-15.9
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• 2021

The chemical constitution of a drug has been accepted as an important basis for pharmacological action in Unani medicine. Various dosage forms have been developed on this concept, such as decoctions (Joshanda), infusions (Khesanda), extract (Rub / Usara), and syrup. Zarawand Mudaharaj (ZM.) / Aristolochia rotunda L. root was subjected to extraction process using Soxhlet's apparatus by using Response Surface Methodology (RSM) to design the number of random runs of the extracts with variation in the factors of temperature, the concentration of ethanol in water, time for extraction, for optimizing and maximizing the yield concentration. The data obtained, was analyzed with regression equation and ANOVA two-way summary to interpret the interaction of the factors for yield maximization. Minitab version 18 was used to design and analyze data. Validation of the optimum conditions for maximum yield of the whole extract of ZM. Root was carried out by re-run of the extract using the optimized conditions. The maximum yield percentage thus obtained using RSM was 20.87% whereas using these optimum conditions 21.35 % yield was obtained thereby validating the method. The association between the response functions and the process variables was identified by a three-factor recorded Box-Behnken design. In the present study RSM is used because itis a cheap and affordable method to optimize maximum yield percentage which may be reliably used by researchers. The study set in the surface conditions for ZM. root extraction by the Soxhlet apparatus for maximizing the yield percentage.

• Journal of Electrical Engineering and Technology
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• 제6권2호
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• pp.202-207
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• 2011

Numerous methodologies have been developed in an effort to reduce cogging torque. However, most of these methodologies have side effects that limit their applications. One approach is the optimization methodology that determines an optimized design variable within confined conditions. The response surface methodology (RSM) and the genetic algorithm (GA) are powerful instruments for such optimizations and are matters of common interest. However, they have some weaknesses. Generally, the RSM cannot accurately describe an object function, whereas the GA is time consuming. The current paper describes a novel GA and RSM hybrid algorithm that overcomes these limitations. The validity of the proposed algorithm was verified by three test functions. Its application was performed on a surface-mounted permanent magnet.

• 한국소음진동공학회논문집
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• 제18권11호
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• pp.1097-1104
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• 2008

Working condition is one of the most important factors in precision working. In this study, we optimized the vibration acceleration of working progress direction using RSM(response surface methodology) by table of orthogonal array. RSM was well adapted to make analytic model for minimizing vibration acceleration, created the objective function and saved a great deal of computational time. Therefore, it is expected that the proposed optimization procedure using RSM can be easily utilized to solve the optimization problem of working condition. The experimental results of the surface roughness and vibration acceleration showed the validity of the proposed working condition of side wall end-milling as it can be observed.

• Journal of Electrical Engineering and Technology
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• 제11권6호
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• pp.1628-1633
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• 2016

This paper derives an effective shape of the ferromagnetic pole pieces (low-speed rotor) for the reduction of transmission torque ripple in a magnetic-geared machine based on a Box-Behnken design (BBD). In particular, using a non-linear finite element method (FEM) based on 2-D numerical analysis, we conduct a numerical investigation and analysis between independent variables (selected by the BBD) and reaction variables. In addition, we derive a regression equation for reaction variables according to the independent variables by using multiple regression analysis and analysis of variance (ANOVA). We assess the validity of the optimized design by comparing characteristics of the optimized model derived from a response surface analysis and an initial model.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2001년도 추계학술대회 논문집
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• pp.35-43
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• 2001

As the demands for lightweight construction and precision grow, there is an increasing interest on hydroforming technology. This paper deals with designing automobile subframe for applying welded blanks hydroforming. In applying welded blanks hydroforming to automobile subframe, it is a serious problem that blanks wrinkle in deformed shape. To suppress wrinklings in blanks, the sections of the die where blanks wrinkled is modified. In addition to this, it is intended that the sum of thickness variation about wrinkling regions be minimized. For this purpose, parameters for influencing formability are selected and evaluated using orthogonal array. Among these parameters, parameters having a major effect on formability are selected again. Using CCD(central composite design) with the selected parameters, response surface is build up and optimal design is performed.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.852-857
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• 2004

A new and efficient method for estimating the statistical moments of a system performance function has been developed. The method consists of two steps: (1) An approximate response surface is generated by a quadratic regression model, and (2) the statistical moments of the regression model are then calculated by experimental design techniques proposed by Seo and $Kwak^{(4)}$. In this approach, the size of experimental region affects the accuracy of the statistical moments. Therefore, the region size should be selected suitably. The D-optimal design and the central composite design are adopted over the selected experimental region for the regression model. Finally, the Pearson system is adopted to decide the distribution type of the system performance function and to analyze structural reliability.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2011년도 제42회 하계학술대회
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• pp.1055-1056
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• 2011

This paper deals with optimum design criteria for maximum torque density & minimum current density of a single phase line-start permanent-magnet motor (LSPMM) using RSM (Response Surface Methodology) & FEM (Finite Element Method). The focus of this paper is to find a design solution through the comparison of torque density and minimum current density resulting from rotor shape variations. And then, a central composite design (CCD) mixed resolution is introduced, and analysis of variance (ANOVA) is conducted to determine the significance of the fitted regression model.

• Journal of Electrical Engineering and Technology
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• 제12권6호
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• pp.2307-2316
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• 2017

The aim of this paper is to provide an optimal design of in-wheel motor for an electric scooter (E-scooter) considering economical production. The preliminary development in-wheel motor, which has a direct-driven outer rotor type attached to the E-scooter's rear wheel without any gear, is introduced first. The objective of the optimal design of this in-wheel motor is to improve the output characteristics of the motor and to have a stator form to facilitate automatic winding. Response surface methodology was used for the optimal design and 2-dimensional finite element method was used for electro-magnetic field analysis. Experimental results showed that the designed and fabricated in-wheel motor could satisfy the required specifications in terms of speed, power, efficiency, and cogging torque.