• International Journal of Computer Science & Network Security
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• 제21권11호
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• pp.81-88
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• 2021

The presented scientific research substantiates the principles of the mechanism of the investment resources involvement in order to introduce innovations at enterprises in the context of digitalization using a resource-functional approach. The importance of attracting investment resources, which contributes to the modernization of production systems, the creation of a stable economic field of development of economic entities, is justified. The expediency of application of the resource-functional approach on research of the mechanism of attraction of investment resources for introduction of innovations at the enterprises in the conditions of digitalization is proved. The investment process is presented in the form of a chain of interdependent processes which include: attraction of investment resources, investments, increase of investment value, profit. It is proved that the mechanism of attracting investment resources for the introduction of innovations in enterprises in the context of digitalization cannot be considered in isolation from the process, due to the fact that the mechanism is aimed at performing specific functions. The functions of the mechanism include management, complex, coordination, monitoring, performance and control functions. Functions of the mechanism of attraction of investment resources for introduction of innovations at the enterprises in the conditions of digitalization are caused by the purposes of attraction of investment resources for innovative development; the presence of an objective nature; relative independence and homogeneity; implementation of functions in the process of investing in innovative activities of the enterprise.

• BMB Reports
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• 제42권6호
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• pp.315-323
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• 2009

In order to elucidate ultimate biological function of the genome, the model animal system carrying mutations is indispensable. Recently, large-scale mutagenesis projects have been launched in various species. Especially, the mouse is considered to be an ideal model to human because it is a mammalian species accompanied with well-established genetic as well as embryonic technologies. In 1990', large-scale mouse mutagenesis projects firstly initiated with a potent chemical mutagen, N-ethyl-N-nitrosourea (ENU) by the phenotype-driven approach or forward genetics. The knockout mouse mutagenesis projects with trapping/conditional mutagenesis have then followed as Phase II since 2006 by the gene-driven approach or reverse genetics. Recently, the next-generation gene targeting system has also become available to the research community, which allows us to establish and analyze mutant mice carrying an allelic series of base substitutions in target genes as another reverse genetics. Overall trends in the large-scale mouse mutagenesis will be reviewed in this article particularly focusing on the new advancement of the next-generation gene targeting system. The drastic expansion of the mutant mouse resources altogether will enhance the systematic understanding of the life. The construction of the mutant mouse resources developed by the forward and reverse genetic mutagenesis is just the beginning of the annotation of mammalian genome. They provide basic infrastructure to understand the molecular mechanism of the gene and genome and will contribute to not only basic researches but also applied sciences such as human disease modelling, genomic medicine and personalized medicine.

• 디지털융복합연구
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• 제11권2호
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• pp.205-214
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• 2013

애자일 개발방법론 기반의 소프트웨어 개발 프로젝트에서도 각광받고 있는 팀의 공동작업이 일반화되고 있다. 효율적인 팀워크는 보다 효과적인 팀 관리운영과 프로젝트의 성과 측면에서 매우 중요하다. 기존의 소프트웨어 개발 인력배치는 휴리스틱 방법을 사용하였지만 이를 보완하기 위한 알고리즘적 접근법도 필요하다. 본 논문에서는 팀워크 기반의 소프트웨어 개발 프로젝트에서 개발자의 인력 배치를 위한 수학적 접근 방안을 제안하였다. 제안한 방안은 6개의 프로세스로 구성되며, 각 프로세서에서의 활동을 수학적으로 정의하였고, 기능배치매트릭스를 사용하였다. 본 논문에서 제시한 접근방법의 유용성을 증명하기 위하여 사례 연구를 제시하였다. 본 논문은 그동안 직관적이나 경험적 방법으로 팀을 구성하는 방식에서 벗어나, 계량적인 논리에 의해 인적자원을 할당하는 수학적 접근방법을 개발하였다는데 큰 의의가 있다.

• 한국ITS학회 논문지
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• 제7권3호
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• pp.95-99
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• 2008

본 논문은 저 전력 설계 자동화를 위한 새로운 최소 자원 상위 레벨 합성 알고리즘을 제안한다. 제안된 알고리즘은 상위 레벨 합성 동안에 기능 연산자의 소비 전력 최소화를 위해 효율적인 접근 방식을 실행한다. 본 논문에서는 CDFG의 스위칭 활동을 감소시키기 위해 모든 제어 스텝을 하나씩 차례로 방문한다. 레지스터 공유 알고리즘은 모든 변수들의 생명 주기를 분석 한 후, 최소의 레지스터들을 결정한다. 또한 기능 단위의 입력 신호의 특성에 따라 모든 제어 스텝을 하나씩 차례로 방문하고, 갈망 방법에 따라 각 제어 스텝의 소비 전력을 최소화하여 자원 할당을 수행한다. 제안된 저 전력설계 자동화를 위한 최소 자원 상위 레벨 합성 알고리즘은 다양한 벤치마크들의 예를 통해 효율성을 입증한다.

• 한국컴퓨터정보학회논문지
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• 제11권2호
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• pp.7-13
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• 2006

시멘틱 웹의 대두로 인해 웹 상에서 데이터를 접근 할 수 있는 방법도 다양화 되었다. 이에 현재 진행되고 있는 웹 온톨로지 뿐만 아니라 기존에 구축된 지식베이스 시스템에 접근하여 데이터를 핸들링 할 수 있는 모델이 필요하다. 웹 온톨로지를 표현하기 위한 언어로 RDF(Resource Description Framework), DAML-OIL, OWL(Web Ontology Language)등이 사용되고 있다. 본 논문은 웹 온톨로지와 기존의 구축된 지식 베이스의 데이터를 접근, 표현 및 처리할 수 있는 온톨로지 객체 모델의 생성과 그 방법에 관한 것이다. 웹 온톨로지에 대한 접근 방법으로 각각의 언어에 맞는 파서(Parser)를 이용하여 메모리 상에 모델을 생성하여 접근하게 되어 있는 기존의 방법과는 다르게 본 논문에서는 웹 온톨로지를 표현하기 위한 모델을 계층별로 구별하여 프레임 기반의 상위 온톨로지(frame-based ontology layer), 다른 도메인에서도 사용이 가능한 공통된 어휘(vocabulary)를 표현한 핵심 온톨로지(generic ontology layer)와 각각의 온톨로지 언어에 의존적인 어휘를 표현한 기능 온톨로지(functional ontology layer)로 구성한다. 이는 표현의 중복을 없애고 재 사용성을 높이기 위한 모델을 제공함으로써, 외부 어플리케이션(온톨로지 추론, 온톨로지 병합, 온톨로지 저작 도구 등)에서의 온톨로지에 대한 쉬운 지식 표현과 접근 및 핸들링을 제공할 수 있다.

• The Plant Pathology Journal
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• 제35권6호
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• pp.575-584
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• 2019

Colletotrichum acutatum is a species complex responsible for anthracnose disease in a wide range of host plants. Strain C. acutatum KC05, which was previously isolated from an infected pepper in Gangwon Province of South Korea, was reidentified as C. scovillei using combined sequence analyses of multiple genes. As a prerequisite for understanding the pathogenic development of the pepper anthracnose pathogen, we optimized the transformation system of C. scovillei KC05. Protoplast generation from young hyphae of KC05 was optimal in an enzymatic digestion using a combined treatment of 2% lysing enzyme and 0.8% driselase in 1 M NH₄Cl for 3 h incubation. Prolonged incubation for more than 3 h decreased protoplast yields. Protoplast growth of KC05 was completely inhibited for 4 days on regeneration media containing 200 ㎍/ml hygromycin B, indicating the viability of this antibiotic as a selection marker. To evaluate transformation efficiency, we tested polyethylene glycol-mediated protoplast transformation of KC05 using 19 different loci found throughout 10 (of 27) scaffolds, covering approximately 84.1% of the entire genome. PCR screening showed that the average transformation efficiency was about 17.1% per 100 colonies. Southern blot analyses revealed that at least one transformant per locus had single copy integration of PCR-screened positive transformants. Our results provide valuable information for a functional genomics approach to the pepper anthracnose pathogen C. scovillei.

• 아태비즈니스연구
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• 제12권2호
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• pp.25-37
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• 2021

Purpose - This study analyzes the situational relationship between the components of job crafting and innovation performance, and based on this, suggests practical alternatives to the effect of the control variables of organizational support. Design/methodology/approach - For this survey, 350 questionnaires were distributed to Korean SME workers from October 5, 2020 to March 20, 2021, and 230 questionnaires were collected. In order to check the validity of the questionnaire, the questionnaire judged to be inappropriate in response was excluded. The recovery rate was 65.7%, and the effectiveness of the questionnaire was 82%. Structural equation model and hierarchical regression analysis are used to analyze those data. Findings - First, job enhancement through job redesign as well as organizational support is a key task in order to expect innovative results from field members. Innovative performance is not created by individual jobs, but is created between jobs and jobs, tasks and tasks, teams and teams, and departments and departments. This is why it is worth paying attention not to the functional approach, but to the interconnection structure of the process. Research implications or Originality - In this study, it was analyzed that structural job resource increase and social job resource increase, which are components of job crafting, had a positive effect on innovation performance, and that challenging job will had no significant effect. Challenging work will itself does not negatively affect innovation performance. Combining the survey and interview, field members who make up the majority of respondents say that they do not lack the will to work. They claim that there is no channel or opportunity to express or practice a challenging will.

• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.622-627
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• 2009

Business process engineering (BPE) is a top-down management approach for increasing efficiency and productivity through radical and fundamental changes to the business processes of the organization. BPE requires firms to initially develop a model of the existing business processes of the firm to distinguish functional tasks from processes used for coordinating inputs, activities and outputs. The model is used for understanding the business processes in the organization and to simulate the effect of changes to the processes. The model can also be used to justify business processes, which involves assessing whether the business process provides value to the customer in its current configuration. Justification requires a careful examination of the key business processes used by the firm to identify systemic shortcomings in the process and to create a new business process to produce greater efficiency. BPE also considers automating as many business processes as possible to increase operational efficiency and the integration of business process tasks. The construction industry has been slow to adopt BPE because of its project approach in which a major firm contracts with various functional service providers and regards each project as unique. The industry focuses on functional task efficiency rather than business process efficiency. There is no formal methodology or criteria for determining whether a business process is effective for a construction firm in its current configuration. The use of performance measures such as costs, task duration times or other metrics can be useful in evaluating the effectiveness of an existing business process and for modeling the possible outcome of a fundamental and radical change to the process.

• 한국도서관정보학회지
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• 제48권4호
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• pp.129-151
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• 2017

현재 디지털 아카이빙에 널리 적용되고 있는 정보 모델링에서는 기술사항 생성을 위한 개념적인 프로세스만을 정의하고 있으며, 이를 정보자원의 보존 혹은 보존을 위한 메타데이터의 생성에 실제적으로 적용하는데 있어서는 한계를보이고 있다. 이에 본 연구에서는 디지털 아카이빙에서의 정보 개체를 효율적으로 기술하기 위해 정보자원 클러스터의 개념을 제안하고, 이를 실제적으로 구현하기 위해 XML 구문에 기반한 RDF를 적용하여 보존 기술항목 프레임워크를 구축하였다. 이는 OAIS 참조모델과 FRBR의 개념적인 구조를 결합하여 보존의 대상이 되는 정보자원을 보다 효과적으로 기술하고 보존 메타데이터를 생성할 수 있는 대안적인 접근방법으로 활용될 수 있을 것으로 기대된다.

• Genomics & Informatics
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• 제8권3호
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• pp.131-137
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• 2010

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.