• Archives of Pharmacal Research
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• 제29권11호
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• pp.1018-1023
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• 2006

Chemoresistance remains the major obstacle to successful therapy of cancer. In order to understand the mechanism of multidrug resistance (MDR) that is frequently observed in lung cancer patients, here we studied the contribution of MDR-related proteins by establishing lung cancer cell lines with acquired resistance against etoposide. We found that human H460 lung cancer cells responded to etoposide more sensitively than A549 cells. Among MDR-related proteins, the expression of p-glycoprotein (Pgp) and lung resistance protein (LRP) were much higher in A549 cells compared with that in H460 cells. When we established H460-R1 and -R2 cell lines by progressive exposure of H460 cells to increasing doses of etoposide, the response against etopbside as well as doxorubicin was greatly reduced in R1 and R2 cells, suggesting MDR induction. Induction of MDR was not accompanied by a decrease in the intracellular accumulation of etoposide and the expression of MDR-related proteins that function as drug efflux pumps such as Pgp and MRP1 was not changed. We found that the acquired resistance paralleled an increased expression of LRP in H460 cells. Taken together, our data suggest the implicative role of LRP in mediating MDR in lung cancer.

• Corrosion Science and Technology
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• 제6권3호
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• pp.96-102
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• 2007

The resistance of the linepipe steel to hydrogen-induced cracking (HIC) and sulfide stress cracking (SSC) is very important for steel to be used in sour oil/gas environments. Welding of steels is necessary to the construction of pipe-line transporting oil/gas. In this study, HIC and SSC resistance of an electric resistance welded (ERW) steel plate which belongs to API X70 grade was evaluated by using NACE TM0284-96A and NACE TM0177-96A methods. HIC and SSC fracturing behavior was investigated by observing fractured surfaces using optical microscopy (OM) and scanning electron microscopy (SEM). It was discussed in terms of metallurgical parameters such as the distribution of primary microstructure, second phases and inclusions. Results showed that the weld joint of ERW steel is more sensitive than base metal to HIC and SSC. This is due to difference in the contribution of metallurgical parameters to HIC and SSC nucleation and propagation.

• Steel and Composite Structures
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• 제50권5호
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• pp.531-548
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• 2024

This paper presents an experimental investigation into the progressive collapse behavior of composite steel-concrete frames under various column removal scenarios. This study involves testing two two-bay, two-story composite frames featuring CFST columns and profiled steel decking composite slabs. Two removal scenarios, involving the corner column and middle column, are examined. The paper reports on the overall and local failure modes, vertical force-deformation responses, and strain development observed during testing. Findings indicate that structural failure initiates due to fracture and local buckling of the steel beam. Moreover, the collapse resistance and ductility of the middle column removal scenario surpass those of the corner column removal scenario. Subsequent numerical analysis reveals the significant contribution of the composite slab to collapse resistance and capacity. Additionally, it is found that horizontal boundary conditions notably influence the collapse resistance in the middle column removal scenario only. Finally, the paper proposes a simplified calculation method for collapse resistance, which yields satisfactory predictions.

• Geomechanics and Engineering
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• 제15권3호
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• pp.879-888
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• 2018

Probability-based design codes have been developed to sufficiently confirm the safety level of structures. One of the most acceptable probability-based approaches is Load Resistance Factor Design (LRFD), which measures the safety level of the structures in terms of the reliability index. The main contribution of this paper is to calibrate the load and resistance factors of the design code for tunnels. The load and resistance factors are calculated using the available statistical models and probability-based procedures. The major steps include selection of representative structures, consideration of the limit state functions, calculation of reliability for the selected structures, selection of the target reliability index and calculation of load factors and resistance factors. The load and resistance models are reviewed. Statistical models of resistance (load carrying capacity) are summarized for strength limit state in bending, shear and compression. The reliability indices are calculated for several segments of a selected circular tunnel designed according to the tunnel manual report (Tunnel Manual). The novelty of this paper is the selection of the target reliability. In doing so, the uniform spectrum of reliability indices is proposed based on the probability paper. The final recommendation is proposed based on the closeness to the target reliability index.

• 한국마이크로전자및패키징학회:학술대회논문집
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• 한국마이크로전자및패키징학회 2003년도 International Symposium
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• pp.261-278
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• 2003

Concepts.Wafer-Level Chip-Scale Concept with Handling Substrate.Low Accuracy Placement Layout with Isolation Trench.Possible Pitch of Interconnections down to $10{\mu}{\textrm}{m}$ (Sn-Grains).Wafer-to-Wafer Equipment Adjustment Accuracy meets this Request of Alignment Accuracy (+/-1.5 ${\mu}{\textrm}{m}$).Adjustment Accuracy of High-Speed Chip-to-Wafer Placement Equipment starts to meet this request.Face-to-Face Modular / SLID with Flipped Device Orientation.interchip Via / SLID with Non-Flipped Orientation SLID Technology Features.Demonstration with Copper / Tin-Alloy (SLID) and W-InterChip Vias (ICV).Combination of reliable processes for advanced concept - Filling of vias with W as standard wafer process sequence.No plug filling on stack level necessary.Simultanious formation of electrical and mechanical connection.No need for underfiller: large area contacts replace underfiller.Cu / Sn SLID layers $\leq$ $10{\mu}{\textrm}{m}$ in total are possible Electrical Results.Measurements of Three Layer Stacks on Daisy Chains with 240 Elements.2.5 Ohms per Chain Element.Contribution of Soldering Metal only in the Range of Milliohms.Soldering Contact Resistance ($0.43\Omega$) dominated by Contact Resistance of Barrier and Seed Layer.Tungsten Pin Contribution in the Range of 1 Ohm

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.93-93
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• 2017

To develop rice cultivars with increased biomass and grain yield, superior lodging resistance is an essential trait. The new breeding approach can be adopted for the improvement of stem lodging resistance by enhancing culm strength. The resistance to breaking type lodging is attributed to bending moment of basal culm (M), which is composed of the section modulus (SM) and bending stress (BS). The resistance to the bending type lodging is attributed to flexural rigidity (FR) of stem, which is composed of the secondary moment of inertia (SMI) and Young's modulus (YM). Starch and cell wall components such as cellulose, hemicellulose and lignin also play a significant role in physical strength of culm, and thus affect lodging. Leaf Star has a superior lodging resistance due to its thick and stiff culm because of its high M and FR compared with Koshihikari. Furthermore, Leaf Star contains high densities of hemicellulose, cellulose and low lignin density in culm compared with Koshihikari. In this study, we performed QTL analysis for these traits associated with culm strength, using 94 recombinant inbred lines (RILs, $F_8$), derived from a cross between Leaf Star and Koshihikari. The SM in the RILs showed a continuous distribution. QTLs for SM were detected on chrs.2, 3 and 10. Leaf Star alleles increased SM on chrs. 2 and 3, but Koshihikari allele increased on chr.10. These QTLs overlapped with those QTLs identified using backcrossed inbred line derived from a cross between Chugoku 117 and Koshihikari, the parents of Leaf Star. The FR in Leaf Star was higher than that in Koshihikari due to the larger SMI and YM. 3 QTLs for SMI were detected on chrs.2, 3 and 10. Leaf Star alleles increased SMI on chrs.2 and 3, and Koshihikari alleles increased on chr.10. One QTL on chr.3 and two QTLs on chr.5 for hollocelulose content were detected with Leaf Star alleles contribution. Moreover, two QTLs were detected for hemicellulose density on chrs.3 and 5. Leaf Star allele increased hemicellulose density on chr.5, and Koshihikari allele increased on chr.3. Furthermore, two QTLs for cellulose density were detected on chr.5, and one QTL on chr.2. For starch content, one QTL on chr.3 and two QTLs on chr.5 with Leaf Star alleles contribution were detected. TULK-6 carrying a chromosome segment of Leaf Star on chr.5 in the Koshihikari genetic background showed higher densities of starch and hemicellulose than those in Koshihikari. These results suggest that the detected QTLs for culm strength could be utilized for the improvement of lodging resistance in rice by marker-assisted selection.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1999년도 봄 학술발표회 논문집
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• pp.249-258
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• 1999

Dynamic load and static load tests are performed on steel pipe piles and concrete piles at five construction sites in highway to compare the difference of load bearing mechanisms. At each site, one steel pile is instrumented with electric strain gages and dynamic tests are performed on the pile during installation. Damages of strain gages due to the installation are checked and static test is performed upon the same pile after two or seven days as well. It shows that load transfer from side friction to base resistance behaves somewhat differently according to the results of load-settlement analysis obtained from PDA and static load test. Initial elastic stage of load settlement curves of two load tests is almost similar. But after the yielding point, dynamic resistance of pile behaves more stiffer than static resistance, thus, dynamic load test result might overestimate the real pile capacity compared with static result. Analysis of gage readings shows that unit skin friction increases exponentially with depth. The skin friction is mobilized at the 1∼2m above the pile tip and contributes to the considerable side resistance. Comparison of side and base resistances between the measured value and the calculated value by Meyerhof's bearing capacity equation using SPT N value shows that the calculated base resistance is higher than the measured. Therefore, contribution of side resistance to total capacity shouldn't be ignored or underestimated. Finally, based upon the overall test results, a construction control procedure is suggested.

• 콘크리트학회논문집
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• 제18권6호
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• pp.819-825
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• 2006

본 연구의 목적은 휨과 전단에 지배받는 철근콘크리트 보에서 아치작용에 의한 전단기여성분을 평가하기 위한 새로운 해석 모델의 적용성을 검증하기 위한 것이다. 새로운 모델은 전단력은 휨모멘트의 변화율이라는 관계식을 기초로, 분산트러스 이상화 기법을 이용하여 횡단면에서 베르누이(Bernoulli) 휨 평면으로부터 전단변형적합조건을 새롭게 유도하였으며, MCFT와 분산트러스 이상화를 통해 전단흐름에 의한 복부전단요소의 전단곡률을 일치시키는 전단변형적합조건을 수립하였다. 전단변형적합조건을 이용하면, 보 전단거동은 타이드아치작용과 보작용의 두 성분으로 수치적 분해 될 수 있다. 이러한 분리 접근법의 유효성은 기존 문헌에 수록된 활용 가능한 실험 자료를 통해 검증하였다. 수행 결과 실제 측정 전단강도와 비교하였을 때 복부가 분담하는 전단강도는 훨씬 일정하며, 역학적 복부철근비와 훌륭한 선형 상관관계에 있는 것으로 나타났다. 새로운 해석 모델은 철근콘크리트 부재의 전단 거동에 영향을 미치는 각 변수나 메커니즘을 합리적으로 설명할 수 있는 모델이라고 할 수 있겠다.

• Journal of Power Electronics
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• 제12권1호
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• pp.164-171
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• 2012

Variable step size maximum power point trackers (MPPTs) are widely used in photovoltaic (PV) systems to extract the peak array power which depends on solar irradiation and array temperature. One essential factor which judges system dynamics and steady state performances is the scaling factor (N), which is used to update the controlling equation in the tracking algorithm to determine a new duty cycle. This paper proposes a novel stability study of variable step size incremental resistance maximum power point tracking (INR MPPT). The main contribution of this analysis appears when developing the overall small signal model of the PV system. Therefore, by using linear control theory, the boundary value of the scaling factor can be determined. The theoretical analysis and the design principle of the proposed stability analysis have been validated using MATLAB simulations, and experimentally using a fixed point digital signal processor (TMS320F2808).

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 추계학술대회 논문집 전기물성,응용부문
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• pp.13-15
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• 2002

The trench MOSFET structure is characterized by reduced on-resistance due to elimination of $R_{JFET}$ and high packing density. An analytical calculation of Ron as the sum of $R_{ch}$ and $R_{epi}$ has been reported previously for the trench MOSFET structure. However, the accumulation layer resistance may not be neglected for Trench MOSFET especially for a relatively large value of the cell spacing, where a major contribution to Ron comes from Ra as the simulation results in this paper shows.