• The Journal of Korean Medicine
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• v.26 no.2 s.62
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• pp.1-12
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• 2005

Objectives: Malignant gliomas are often treated with cisplatin (cis-diamminedichloroplatinum(II), CDDP) and radiation but results remain unsatisfactory. Since malignant glioma displays moderate resistance to conventional therapy, a new treatment modality is needed to improve the outcome of patients with these tumors. The aim of this study was to investigate the effects of the combined use of Jongjihwan(JJH) and cisplatin(CDDP) on cultured malignant glioma cells, A172. Methodss & Results: The combined use of cisplatin and Jeongjihwan had synergistic effects on Al72 cells during 24 hr-incubation, This treatment resulted in a decrease of cell viability, Which was revealed as apoptosis Characterized by activation of caspase-3 protease as well as cleavage of poly ADP-ribose polymerase (PARP) with change of mitochondria membrane potential transition. The expression of members of the Bcl-2 protein family was modulated during co-treatment with Jeongjihwan and cisplatin. Activation of caspase-3 and mitochondrial alterations were central to co-treatment with Jeongjihwan and cisplatin-induced apoptosis. Conclusions: We conclude that co-treatment with Jeongjihwan and cisplatin-induced activation of the mitochondrial pathway enables cell death. Also, we suggest the combined theory of JJH and cisplatin could be a useful method for glioblastoma.

• Journal of the Korean Society for Advanced Composite Structures
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• v.1 no.3
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• pp.10-16
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• 2010

In construction industries, new construction materials are needed to overcome some problems associated with the use of conventional construction materials due to the change of environmental and social requirements. Accordingly, the requirements to be satisfied in the design of civil engineering structures are diversified. As a new construction material in the civil engineering industries, fiber reinforced polymeric plastic (FRP) has a superior corrosion resistance, high specific strength/stiffness, etc. Therefore, such properties can be used to mitigate the problems associated with the use of conventional construction materials. Nowadays, new types of bridge piers and marine piles are being studied for new construction. They are usually made of concrete filled fiber reinforced polymeric plastic tubes (CFFT). In this paper, a new type of FRP-concrete composite pile which is composed of reinforced concrete filled FRP tube (RCFFT) is proposed to improve compressive strength as well as flexural strength. The load carrying capacity of proposed RCFFT compression member is discussed based on the result of experimental and analytical investigations.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.1232_1233
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• 2009

Paraquat is well-known to cause hepatotoxic responses in human and other mammal species. In solution, it forms free radicals and charge-transfer complex of which formation plays an important role in determination of its biological activity in the presence of various anions. The HepG2 cells were cultured onto a quartz crystal sensor which is possible to detect the density and a viscosity changes using the resonance frequency (F) and the resonance resistance (R). The plot of F-R diagram is able to explain the rheological change of cells onto the surface of the quartz crystal sensor. In this paper, we investigated the physical properties of the HepG2 cells cultured onto a ITO electrode of the quartz crystal sensor according to the paraquat injection at various concentrations (100 mM, 10 mM, 1 mM). We also observed the morphological changes with a micro CCD camera, simultaneously. The HepG2 cells were cultured onto the ITO electrode surface of the quartz crystal modified a collagen film in $CO_2$ incubator. After the paraquat injection, we observed the changes of the morphologies by the micro CCD camera depending on time and analyzed the physical changes of cells on the electrode surface of quartz crystal using F-R diagram. From all results, we proved the effect of paraquat at various concentrations which is led to an apoptosis such as weakening and death of the cells by oxidation and reduction reaction that were produced the superoxide anions and other free radicals.

• Tribology and Lubricants
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• v.33 no.4
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• pp.134-140
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• 2017

With the increase in adoption of tilting pad journal bearings (TPJBs), various failure mechanisms related to TPJBs have been reported, of which pad wear is a frequently reported one. Pad wear causes change in geometry of the bearing, which can sometimes result in the failure of the entire system. The objective of this research is to investigate the influence of pad wear on the pad temperature, which is one of the widely used condition monitoring methods for TPJBs. For the theoretical investigation, thermohydrodynamic (THD) analysis was conducted by solving the generalized Reynolds equation and the 3D energy equation. The results of the analysis show that the temperature of the loaded pad increases while that of the unloaded pad decreases, when there is wear on the loaded pads. In addition, the minimum film thickness decreases with an increase in the wear depth. A validation test was conducted with a test rig, which mimics the axial turbine when a test rotor is supported by two TPJBs. The test bearing consists of five pads with a diameter of 60 mm, and a resistance temperature detector (RTD) is installed in the pad for temperature monitoring. The test was performed by replacing the two loaded pads with the worn pad. The test result for the TPJB with wear depth of $30{\mu}m$ show that the temperatures of the loaded pads are $8^{\circ}C$ higher and that of the unloaded pad is $2.5^{\circ}C$ lower than that of the normal TPJB. In addition, the predicted pad temperature shows good agreement with the measured pad temperatures.

• Journal of Microbiology and Biotechnology
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• v.30 no.2
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• pp.187-195
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• 2020

To understand the molecular mechanism involved in the survivability of cold-tolerant lactic acid bacteria was of great significance in food processing, since these bacteria play a key role in a variety of low-temperature fermented foods. In this study, the cold-stress response of probiotic Lactobacillus plantarum K25 isolated from Tibetan kefir grains was analyzed by iTRAQ proteomic method. By comparing differentially expressed (DE) protein profiles of the strain incubated at 10℃ and 37℃, 506 DE proteins were identified. The DE proteins involved in carbohydrate, amino acid and fatty acid biosynthesis and metabolism were significantly down-regulated, leading to a specific energy conservation survival mode. The DE proteins related to DNA repair, transcription and translation were up-regulated, implicating change of gene expression and more protein biosynthesis needed in response to cold stress. In addition, two-component system, quorum sensing and ABC (ATP-binding cassette) transporters also participated in cell cold-adaptation process. These findings provide novel insight into the cold-resistance mechanism in L. plantarum with potential application in low temperature fermented or preserved foods.

• Journal of Electrical Engineering and Technology
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• v.10 no.5
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• pp.2070-2076
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• 2015

Nano composite materials were multi-constituent combinations of nano dimensional phases with distinct differences in structure, chemistry and properties. Nano particles were less likely to create large stress concentrations and thereby can avoid the compromise of the material ductility while improve other mechanical properties. Corona discharge was an electrical discharge. The ionization of a fluid surrounding a conductor was electrically energized. This discharge would occur when the strength of the electric field around the conductor was high enough to form a conductive region, but not high enough to cause electrical breakdown or arcing to nearby objects. This paper shows all the studies done on the preparation of nano fillers. Special attention has given to the ACSR transmission line conductor, TiO₂ nano fillers and also to the evaluation of corona resistance on dielectric materials discussed in detail. The measurement of the dielectric properties of the nano fillers and the parameters influencing them were also discussed in the paper. Corona discharge test reveals that in 0%N ACSR sample corona loss was directly proportional to the applied line voltage. No significant change in corona loss between 0%N and 1%N. When TiO₂ nano filler concentration was increased up to 10%N fine decrement in corona loss was found when compared to base ACSR conductor, corona loss was decreased by 40.67% in 10%N ACSR sample. It was also found from the surface conditions test that inorganic TiO₂ nano filler increases the key parameters like tensile strength and erosion depth.

• Journal of Microbiology and Biotechnology
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• v.15 no.5
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• pp.1073-1079
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• 2005

To investigate plant protection, pathogenesis-related (PR) proteins and plant defense enzymes related to cell wall lignification were studied in pepper plants inoculated with antagonistic Bacillus subtilis HJ927 and pathogenic strain Phytophthora capsici. Phytophthora blight disease was reduced by $53\%$ in pepper roots when preinoculated with B. subtilis HJ927 against P. capsici. The activities of PR proteins (chitinase and ${\beta}$-1,3,-glucanase) and defense-related enzymes (peroxidase, polyphenoloxidase, and phenylalanine ammonia lyase) decreased in roots of B. subtilis+P capsid-treated plants, but increased in leaves with time. The decrease and increase were much greater in P. capsici-treated plants than in B. subtilis HJ927+P capsici-treated plants, although P. capsici-treated plants had more severe damage. Therefore, changes of enzyme activities do not seem to be directly related to plant protection. We suggest that the change of these enzymes in pathogen-treated plants may be related to plant response rather than to resistance against pathogen attacks.

• Structural Engineering and Mechanics
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• v.65 no.6
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• pp.679-687
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• 2018

In composite materials technology, the fiber-reinforced polymers (FRP) have opened up new horizons in infrastructural engineering field for strengthening existing structures and components of structure. The Carbon fiber reinforced polymer (CFRP) sheets are well suited for RC columns to this application because of their high strength to weight ratio, good fatigue properties and excellent resistance to corrosion. The main focus of present experimental work is to investigate effect of shapes on axial behavior of CFRP wrapped RC columns having same cross-sectional area and slenderness ratio. The CFRP volumetric ratio and percentage of steel are also adopted constant for all the test specimens. A total of 18 RC columns with slenderness ratio four were cast. Nine columns were control and the rest of nine columns were strengthened with one layer of CFRP wrap having 35 mm of corner radius. Columns confined with CFRP wrap were designed using IS: 456:2000 and ACI 440.2R.08 provisions. All the test specimens were loaded for axial compression up to failure and failure pattern for each shaped column was investigated. All the experimental results were compared with analytical values calculated as per the ACI-440.2R-08 code. The test results clearly demonstrated that the axial behavior of CFRP confined RC columns is affected with the change in shapes. The axial deformation is higher in CFRP wrapped RC circular column as compared to square and rectangular columns. Stress-strain behaviour revealed that the yield strength gained from CFRP confinement was significant for circular columns as compare to square and rectangular columns. This behaviour may be credited due to effect of shape on lateral deformation in case of CFRP wrapped circular columns at effective confinement action.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.2
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• pp.405-421
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• 2018

In most of cases, the wall friction coefficients applied for local tunnel design are quoted directly from foreign data or local design guideline. In the previous studies, the wall friction coefficient was estimated using the velocity decay method. However, it is difficult to estimate the wall friction coefficient when the convergence wind velocity in the tunnel is negative (-) or if there is a change in the natural wind. Therefore, in this study, the wall friction coefficient is estimated by applying the dynamic simulation technique in addition to the conventional the velocity decay method. As a result of the analysis, the coefficient of wall friction in the tunnels for the total of 9 tunnels (18 tubes both directions) was 0.011~0.025, and the mean value was estimated to be 0.020. In addition, the wall friction coefficient obtained quantitatively through this study was compared with the current design criteria.

• Structural Monitoring and Maintenance
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• v.7 no.3
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• pp.215-231
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• 2020

In a reinforced concrete building different shapes of column are adopted depending on the structural orientation and the architectural aspect. When there is an increase in loading due to changes in usage or revision in the design codes these columns need to be strengthened for enhanced performance during their service life. Strengthening materials such as carbon fiber and glass fiber polymer has been successfully used however, due to high cost application other alternative materials need to be explore. Galvanized steel wire mesh (GSWM) is one of the suitable materials locally available. High tensile strength, low weight, corrosion resistance, easy installation, minimum change in dimensions of the sections and cost effectives are the advantages of GSWM. Therefore, in this paper, four different shapes of column such as circular, square, rectangular and L were wrapped with different layers GSWM and jacketed with mortar. All the specimens were tested under axial compression. The objective of the study is to investigate the effectiveness of GSWM as a confining material for strengthening of column having varying shape. Test results shows that the axial strength enhanced with wrapping of GSWM jacket and a circular column presented the highest load carrying capacity and ductility as compared to the others. From the study of 22 column specimens, it is found that axial load is increased upto 20% and 19% when circular and square column are strengthened with one wrap of GSWM respectively, while a rectangular and L column required a wraps of two and three layers respectively in order to achieved the same load capacity as that of a circular column. Based on the present study, it is concluded that GSWM can be effectively used for strengthening of different shapes of concrete columns economically.