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Discriminatian of Cnidium Rhizame using PCR-mediated RFLP

  • Cho, So-Yean;Ze, Keum-Ryon;Seong, Rack-Seon;Lee, Jong-Pill;Ju, Young-Park;Park, Sang-Yong;Jung, Young-Ja;Cho, Chang-Hee;Ha, Kwang-Won;Suh, Young-Bae
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.367.2-367.2
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    • 2002
  • Cnidium Rhizome is a frequently prescribed herbal medicine in Korea, Japan as well as China, which has been successfully used in these countries for the treatment of diseases related to. gynecology, blood circulations and dental troublers in the name of 천궁. And it is circulated as the same chinese character, which is 천궁, although original plants are different as Cnidium officinale in pharmacopoeia of Korea or Japan and Ligusticum chuanxiong Hort. In that of China. (omitted)

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Synthesis of N,N',N"-Trisubstituted Thiourea Derivatives and their Antagonistic Effect on the Vanilloid Receptor

  • Park, Hyeung-Geun;Park, Mi-Kyung;Choi, Ji-Yeon;Choi, Sea-Hoon;Lee, Ji-Hye;Suh, Young-Ger;Cho, Ha-Won;Oh, Uh-Taek;Lee, Jee-Woo
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.253.1-253.1
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    • 2003
  • Twenty-seven N,N',N"-trisubstituted thiourea derivatives were prepared. Among them, 1- [3-(4'-hydroxy-3'-methoxy-phenyl)-propyl] -1,3-diphenethyl-thiourea (81, IC$\sub$50/= 0,32 $\mu\textrm{m}$), showed 2-fold higher antagonistic activity than that of capsazepine (3, IC$\sub$50/= 0,65 $\mu\textrm{m}$) against the vanilloid receptor in a Ca$\^$2+/ -influx assay.

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The Study on the drug pharmacokinetics according to the progression of liver disease

  • Sohn, Soo-Jung;Choi, Hong-Serck;Ahn, Mee-Ryung;Chung, Hye-Joo;Yoo, Tae-Moo;Lee, Min-Ho;Park, Moon-Seung;Shin, In-Chul;Kim, Ju-ll
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.308.1-308.1
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    • 2003
  • We underwent this study to know correlation between the amount of portosysternic shunt/hepatic fibrosis and bioavailability parameters such as AUC, Cmax, Tmax and t1 /2 of high extraction ratio drug, propranolol, in CCl4-induced liver cirrhosis model of rats. This study describes the bioavaility study of propranolol(5 mg/kg), Shunt Index using thallium-201 per rectum scintigraphy to to measure the amount of portosystemic shunt indirectly and intrahepatic hydroxyproline content performed in the CCl4-induced liver cirrhosis model of rats. (omitted)

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Cascode Low Noise Amplifiers with Coplanar Waveguide Structure for Wireless LAN Application

  • Kim, Jong-Ho;Kim, Ki-Byoung;Lee, Jong-Chul;Kim, Jong-Heon;Lee, Byungje;Kim, Nam-Young
    • Journal of electromagnetic engineering and science
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    • v.3 no.1
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    • pp.12-16
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    • 2003
  • In this paper, low noise amplifiers with coplanar waveguide structure are presented for Wireless LAN data communication application. For comparison of microwave performance, LNAs of cascode type and balanced type using cascode cell with the same substrate and same bias conditions are designed and implemented. A cascode type of LNA shows the gain of 12.45 ㏈, input return loss of 11.63 ㏈, and noise figure of 1.52㏈. A balanced type of LNA using cascode cell shows the gain of 6.58 ㏈, input return loss of 16.6 ㏈, and noise figure of 1.18 ㏈.

Cloning of a novel ion channel candidate by in silico gene mining

  • Shim, Won-Sik;Kim, Man-Su;Yang, Young-Duk;Park, Seung-Pyo;Kim, Byung-Moon;Oh, Uh-Taek
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.192.2-193
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    • 2003
  • Capsaicin, a pungent ingredient in chili pepper, is known to excite sensory neurons that mediate pain sensation. This effect of capsaicin is determined by unique receptors and the capsaicin receptor (transient receptor potential subfamily V, member 1 (TRPV1)) was cloned recently. TRPV1 contains six transmembrane domains and three ankyrin repeats at N-terminal. This characteristic architecture is common in other ion channel in TRPV families. (omitted)

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