• Biomolecules & Therapeutics
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• v.28 no.1
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• pp.83-91
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• 2020

Tryptamines are monoamine alkaloids with hallucinogenic properties and are widely abused worldwide. To hasten the regulations of novel substances and predict their abuse potential, we designed and synthesized four novel synthetic tryptamine analogs: Pyrrolidino tryptamine hydrochloride (PYT HCl), Piperidino tryptamine hydrochloride (PIT HCl), N,N-dibutyl tryptamine hydrochloride (DBT HCl), and 2-Methyl tryptamine hydrochloride (2-MT HCl). Then, we evaluated their rewarding and reinforcing effects using the conditioned place preference (CPP) and self-administration (SA) paradigms. We conducted an open field test (OFT) to determine the effects of the novel compounds on locomotor activity. A head-twitch response (HTR) was also performed to characterize their hallucinogenic properties. Lastly, we examined the effects of the compounds on 5-HTR1a and 5-HTR2a in the prefrontal cortex using a quantitative real-time polymerase chain reaction (qRT-PCR) assay. None of the compounds induced CPP in mice or initiated SA in rats. PYT HCl and PIT HCl reduced the locomotor activity and elevated the 5-HTR1a mRNA levels in mice. Acute and repeated treatment with the novel tryptamines elicited HTR in mice. Furthermore, a drug challenge involving a 7-day abstinence from drug use produced higher HTR than acute and repeated treatments. Both the acute treatment and drug challenge increased the 5-HTR2a mRNA levels. Ketanserin blocked the induced HTR. Taken together, the findings suggest that PYT HCl, PIT HCl, DBT HCl, and 2-MT HCl produce hallucinogenic effects via 5-HTR2a stimulation, but may have low abuse potential.

• Korean Journal of Childcare and Education
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• v.8 no.2
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• pp.139-155
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• 2012

This study aimed to glean lessons for desirable early childhood physical education programs by contouring the current paradigms on body or physical activities in the area of early education for young children. It also aimed to analyze their postures while participating in daily activities. The research method for analysis of children's postures while doing daily activities was OWAS(Ovako Working Posture Analysing System) which has been extensively used in ergonomics. Components of data analysis have been redesigned on the basis of information gathered from OWAS with the help of ergonomic experts. The results showed different percentages of children's movements according to activities such as whole class meeting, small group activity and outdoor activity. Small group and outdoor activities can be considered the most desirable physical activities not only for cognitive and social development but also for physical development. And it is recommended to reconstruct the quality and nature of whole class meetings in order to coordinate the physical nature of young children.

• Journal of Digital Contents Society
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• v.12 no.4
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• pp.511-518
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• 2011

One of the most important paradigms in society has recently been a set of efforts to prepare for the future and to protect the environment by saving carbon that occurs in everyday life as well as in the industry. In order to successfully deal with this new paradigm, Korean government has adopted and implemented various policies including the green certification, the development of green technologies and green growth. Many agencies and organizations in both public and private sectors have established plans about the carbon savings and performed a lot of research using IT technology. For example, attempts have been made in Korea to use as electronic documents instead of paper documents using these green IT and mobile devices. This paper proposes a 'Paperless' waiting order count system using QR code and mobile phone as an example of green IT for 'Low carbon and Green growth'.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.4
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• pp.1721-1737
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• 2020

Human apparent age estimation has become a popular research topic and attracted great attention in recent years due to its wide applications, such as personal security and law enforcement. To achieve the goal of age estimation, a large number of methods have been pro-posed, where the models derived through the cumulative attribute coding achieve promised performance by preserving the neighbor-similarity of ages. However, these methods afore-mentioned ignore the geometric structure of extracted facial features. Indeed, the geometric structure of data greatly affects the accuracy of prediction. To this end, we propose an age estimation algorithm through joint feature selection and manifold learning paradigms, so-called Feature-selected and Geometry-preserved Least Square Regression (FGLSR). Based on this, our proposed method, compared with the others, not only preserves the geometry structures within facial representations, but also selects the discriminative features. Moreover, a deep learning extension based FGLSR is proposed later, namely Feature selected and Geometry preserved Neural Network (FGNN). Finally, related experiments are conducted on Morph2 and FG-Net datasets for FGLSR and on Morph2 datasets for FGNN. Experimental results testify our method achieve the best performances.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2000.11c
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• pp.623-631
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• 2000

Advanced Life Support Systems (ALSS) are being studied to support human life during long-duration space missions. ALSS can be categorized into four subsystems: Crew, Biomass Production, Food Processing and Nutrition, Waste Processing and Resource Recovery. The System Studies and Modeling (SSM) team of New Jersey-NASA Specialized Center of Research and Training (NJ-NSCORT) has facilitated and conducted analyses of ALSS to address systems level issues. The underlying concept of the SSM work is to enable the effective utilization of information to aid in planning, analysis, design, management, and operation of ALSS and their components. Analytical tools and computer models for ALSS analyses have been developed and implemented for value-added information processing. The results of analyses have been delivered through the Internet for effective communication within the advanced life support (ALS) community. Several modeling paradigms have been explored by developing tools for use in systems analysis. They include object-oriented approach for top-level models, procedural approach for process-level models, and application of commercially available modeling tools such as MATLAB$\^$(R)//Simulink$\^$(R)/. Every paradigm has its particular applicability for the purpose of modeling work. An overview is presented of the systems studies and modeling work conducted by the NJ-NSCORT SSM team in its efforts to provide systems analysis capabilities to the ALS community. The experience gained and the analytical tools developed from this work can be extended to solving problems encountered in general agriculture.

• Journal of the Korean Society for information Management
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• v.28 no.2
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• pp.135-158
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• 2011

The ability of the searcher to express their information problem to an information retrieval system is fundamental to the retrieval process. Query by visual example is the principal query paradigm for expressing queries in a content-based image retrieval environment yet there is little empirical evidence to support its efficacy in facilitating query formulation. The aim of this research was to investigate the usability of the query by colour method in supporting a range of information problems in order to contribute to the gap in knowledge regarding the relationship between searchers' information problems and the query methods required to support efficient and effective visual query formulation. The results strongly suggest that the query method does not support visual query formulation and that there is a significant mismatch between the searchers information problems and the expressive power of the retrieval paradigm.

• Journal of the Korean Society for Library and Information Science
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• v.38 no.3
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• pp.85-101
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• 2004

The revolution of information in information society innovates a lot of business processes. and the renewed processes contribute new paradigms of the 21th century. As one of the revolutions, ISO 9000 becomes a standard for developing efficient quality management systems which provide any-time and any-where environments satisfying customer needs. Thus, it becomes important to research on quality management systems for improving quality in information flowing and service domain. In this paper, we describe the applicable direction and the case study of ISO 9001 : 2000 which establishes quality management systems in the domain and hope to help for the Quality enhancement.

• The Korean Journal of Applied Statistics
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• v.28 no.6
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• pp.1075-1091
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• 2015

This paper reviews the developments of econometric analysis and seeks a statistical applicability to current economic phenomena. During the last half century, economic analysis has progressed continuously, analyzing and predicting a broad variety of economic phenomena. In the center of this progress lies the remarkable contribution of econometrics and mathematical statistics. New economic research environment has been recently created via developments of IT and the spread of internet and SNSs. Economic phenomena has become increasingly complicated along with more volatile and sophisticated economic analysis. In that context, it can be suggested that there is a need to move beyond current economic paradigms and adapt new approaches such as complex theory and econophysics, all of which posits as a challenge for econometrics and statistics.

• Korean Institute of Interior Design Journal
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• v.22 no.3
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• pp.100-107
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• 2013

In smart era, concept of User experience has been an important issue both in academic and practical areas in recent years. Interactive space became one of the major design paradigms. For elevating the interactive effect, we need user?centered design methodology which uses the influential factors on the interactivity. As, well developed information technology made a lot of changes to various fields of our society, interactive space with the concept of HCI became a big issue in environmental design field. In this interactive space, various types of informative factors of the given space are sent using sensor and computer networking technology to the main system. So, a user's movement in the space in more than just a movement itself-user's movement now forms a important spatial structure that leads the narrative of the space. in this research, I will come up with the problems that the interactive space has right now, and analyze what the public space must have, and combine them with interactive space by HCI theory. architecture space is not the old space adapting digital technology. In order to take the role as new space paradigm. environment and technology, it has to develop technology continuously and experimental space at the same time. It must have co-evolution of architecture space field and others through organic network. by that, the evolution of space will be in the way that combines space which is responded to human emotion and user centric human friendly.

• Agricultural and Biosystems Engineering
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• v.2 no.2
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• pp.41-49
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• 2001

Advanced Life Support Systems(ALSS) are being studied to support human life during long-duration space missions. ALSS can be categorized into four subsystems: Crew, Biomass Production, Food Processing and Nutrition, Waste Processing and Resource Recovery. The System Studies and Modeling (SSM) team of New Jersey-NASA Specialized Center of Research and Training (NJ-NSCORT) has facilitated and conducted analyses of ALSS to address systems level issues. The underlying concept of the SSM work is to enable the effective utilization of information to aid in planning, analysis, design, management, and operation of ALSS and their components. Analytical tools and computer models for ALSS analyses have been developed and implemented for value-added information processing. The results of analyses heave been delivered through the internet for effective communication within the advanced life support (ALS) community. Several modeling paradigms have been explored by developing tools for use in systems analysis. they include objected-oriented approach for top-level models, procedureal approach for process-level models, and application of commercially available modeling tools such as $MATLAB^{R}$/$Simulink^{R}$. Every paradigm has its particular applicability for the purpose of modeling work. an overview is presented of the systems studies and modeling work conducted by the NJ-NSCORT SSM team in its efforts to provide systems analysis capabilities to the ALS community. The experience gained and the analytical tools developed from this work can be extended to solving problems encountered in general agriculture.