• 대한한의학방제학회지
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• 제18권1호
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• pp.121-132
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• 2010

Inflammatory reaction is characterized by over-production of inflammatory mediators due to an up-regulation of inflammatory pathways, which produce pro-inflammatory mediators, such as interleukin-1beta (IL-$1{\beta}$), IL-6, tumour necrosis factor alpha (TNF-$\alpha$), prostaglantin $E_2$ ($PGE_2$), and nitric oxide (NO) in U937 cells. We investigate the anti-inflammatory effects of water extracts from Lonicerae Flos and Scutellariae Radix in lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-$1{\beta}$, TNF-$\alpha$, and $PGE_2$) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner. These suppressive effects were synergistically increased by their combination. Their combination extract also inhibited NF-${\kappa}B$-DNA complex of NF-${\kappa}B$ binding activity and translocation of NF-${\kappa}B$ from cytosol to nucleus. These results suggest that the combination of water-extractable components of Lonicerae Flos and Scutellariae Radix may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.

• 무역상무연구
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• 제69권
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• pp.699-720
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• 2016

In the past 10 years, there have been lots of misuses of the trademark system in China. For example, some Chinese companies have registered same or similar oversea's well-known trademark as a prior rights holder, and oversea's companies lost a chance to register their own trademarks or commence cases to acquire their own trademark determination in China. So Chinese government revised Chinese Trademark Law in 2014 to remedy these mistakes. Article 30 is intended to crack down on preemptive registration and compensate for the possible unfair consequences resulted from the principle of prior registration. Under the principle of prior registration, only where the unregistered trademarks of prior use have certain influence, and where the applicant of latter applied trademark knows or should know the prior trademark and the applicant has the bad faith of obtaining unjustified interests from goodwill of such unregistered marks, it shall be curbed by Article 30. Furthermore, trademark oppositions could be filed by anybody previously. Under the revised Trademark Law Article 44, oppositions based on absolute grounds can still be filed by anyone, but oppositions based on other available grounds can only be filed by a prior rights holder or a materially-interested party with undefined but similar to the standing requirement for filing nullities under Article 41 of the old law, and likely intended to cover trademark licensees and successors.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제14권7호
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• pp.743-747
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• 2008

이질적 무선 셀들의 계층적인 오버레이는 차세대 무선망을 위해서 예상되는 구조로 여겨지고 있다. 본 논문은 그러한 특별한 형식의 구조로서 WWAN/WLAN 2-홉 무선 중계 네트워크를 고려하였다. 먼저 이러한 망의 내부에서 기존의 PF 스케줄링 기법이 일으킬 수 있는 문제점을 구성하였다. 그리고 이 문제점을 해결하기 위해서 향상된 PF 스케줄링 기법을 제시하였다. 새롭게 제시된 기법에 대한 검증을 위해서, NS-2를 사용하여 UMTS/WLAN망에서의 시뮬레이션을 진행하였고, 그것을 기반으로 성능을 평가하였다.

• Journal of Computing Science and Engineering
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• 제1권1호
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• pp.31-55
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• 2007

Contemporary end-servers and network-routers rely on traffic shaping to deal with server overload and network congestion. Although such traffic shaping provides a means to mitigate the effects of server overload and network congestion, the lack of cooperation between end-servers and network-routers results in waste of network resources. To remedy this problem, we design, implement, and evaluate NetDraino, a novel mechanism that extends the existing queue-management schemes at routers to exploit the link congestion information at downstream end-servers. Specifically, NetDraino distributes the servers' traffic-shaping rules to the congested routers. The routers can then selectively discard those packets-as early as possible-that overloaded downstream servers will eventually drop, thus saving network resources for forwarding in-transit packets destined for non-overloaded servers. The functionality necessary for servers to distribute these filtering rules to routers is implemented within the Linux iptables and iproute2 architectures. Both of our simulation and experimentation results show that NetDraino significantly improves the overall network throughput with minimal overhead.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10045-10051
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• 2015

Chemotherapy is a major therapeutic approach for malignant neoplasms; however, due to the most common adverse events of nausea and vomiting, scheduled chemotherapeutic programs may be impeded or even interrupted, which severely impairs the efficacy. Aprepitants, 5-HT3 antagonists and dexamethasone are primary drugs used to prevent chemotherapy-induced nausea and vomiting (CINV). These drugs have excellent efficacy for control of acute vomiting but are relatively ineffective for delayed vomiting. Aprepitant may remedy this deficiency. Substance P was discovered in the 1930s and its association with vomiting was confirmed in the 1950s. This was followed by a period of non-peptide neurokinin-1 (NK-1) receptor antagonist synthesis and investigation in preclinical studies and clinical trials (phases I, II and III). The FDA granted permission for the clinical chemotherapeutic use of aprepitant in 2003. At present, the combined use of aprepitant, 5-HT3 antagonists and dexamethasone satisfactorily controls vomiting but not nausea. Therefore, new therapeutic approaches and drugs are still needed.

• Journal of Microbiology and Biotechnology
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• 제16권5호
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• pp.757-763
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• 2006

Angiotensin I-converting enzyme (ACE) inhibitors have generally been very useful to remedy or prevent hypertension. This study describes the extraction and characterization of an ACE inhibitor from the fruiting body of Pholiota adiposa ASI 24012, which can be used as an antihypertensive drug. The maximal ACE inhibitory activity $(IC_{50};0.25mg)$ was obtained when the fruiting body of Pholiota adiposa ASI 24012 was extracted with distilled water at $30^{\circ}C$ for 12 h. After the purification of ACE inhibitor with ultrafiltration, Sephadex G-25 column chromatography, and reverse-phase HPLC, an active fraction with an $IC_{50}$ of 0.044 mg was obtained. The purified ACE inhibitory peptide was a novel pentapeptide, showing very little similarity to other ACE inhibitory peptide sequences. The molecular mass of the purified ACE inhibitor was estimated to be 414 daltons with a sequence of Gly-Glu-Gly-Gly-Pro, and showed a clear antihypertensive effect on spontaneously hypertensive rats (SHR) at a dosage of 1 mg/kg.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2004년도 제28회 KOSCO SYMPOSIUM 논문집
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• pp.102-111
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• 2004

Partial quenching structure of turbulent diffusion flames in a turbulent mixing layer is investigated by the method of flame hole dynamics to develope a prediction model for the turbulent lift off. The present study is specifically aimed to remedy the problem of the stiff transition of the conditioned partial burning probability across the crossover condition by adopting level-set method which describes propagating or retreating flame front with specified propagation speed. In light of the level-set simulations with two model problems for the propagation speed, the stabilizing conditions for a turbulent lifted flame are suggested. The flame hole dynamics combined with level-set method yields a temporally evolving turbulent extinction process and its partial quenching characteristics is compared with the results of the previous model employing the flame-hole random walk mapping. The probability to encounter reacting' state, conditioned with scalar dissipation rate, demonstrated that the conditional probability has a rather gradual transition across the crossover scalar dissipation rate in contrast to the stiff transition of resulted from the flame-hole random walk mapping and could be attributed to the finite response of the flame edge propagation.

• 무역상무연구
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• 제51권
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• pp.133-158
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• 2011

The purpose of this study is to analyze one of CIETEC(China International Economic and Trade Arbitration Commission) Award on the dispute arising from Cotton Sale Contact which deals with damages and reduction of the price. Especially this case focused on the effect of reduction of the price to damages. The purpose of damages is to place the aggrieved party in as good a position as if the other party had properly performed the contract. So court costs and attorney's fee should be regarded as the loss, because these are caused by consequence of the breach which is recoverable. With the same reason, overpaid taxes should also regard as the loss. It is not impossible, however, to claim both damages and reduction of the price for same loss at the same time. It means buyer could not claim damages for the same loss, once he already claimed reduction of the price. So Korean companies should consider which remedy is proper to himself under the circumstances. He should choose reduction of the price when market price is down. In case of rising market price, he should consider follows: first, it is better to choose damages based on current price(Art.76), if upswing of non-conformity price is higher then upswing of market price. Second, it is better to choose general rule for measuring damages(Art.74), if upswing of market price is higher then upswing of non-conformity price.

• 한국컴퓨터산업학회논문지
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• 제2권11호
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• pp.1453-1464
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• 2001

인터넷 사용자의 폭발적인 증가로 인해 웹 서비스는 심각한 성능상의 지연을 보이고 있다. 인기 있는 웹사이트의 입장에서는 많은 요청으로 인하여 원활한 서비스를 제공하기 어렵고, 사용자 또한 만족스러운 수준의 응답시간을 제공받지 못한다. 이에 대한 해결책으로 제시된 웹캐슁은 서버에 대한 요청을 흡수하여 전체적인 교통량을 줄이며 사용자에게는 보다 빠른 응답을 제공한다. 본 논문에서는 미국의 웹 캐쉬 프로젝트인 NLANR(National Laboratory for Applied Network Research)의 최상위 캐쉬들로부터 생성된 트레이스와 서울대에 위치한 교육망 캐쉬의 트레이스를 이용하여 웹 캐쉬 트래픽의 특성들에 관해 분석하고, 이들로부터 얻은 각종 특성 자료를 바탕으로, 미래에 필요하리라고 여겨지는 웹 오브젝트를 미리 가져오는 prefetch 방법을 제시하였으며 그로 인한 효과에 관해 분석하였다. 그 결과, l∼3% 정도 일일 평균 적중률의 향상과 최대 5% 정도의 평균 응답시간의 개선을 기대할 수 있음을 발견하였다.

• Fisheries and Aquatic Sciences
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• 제14권2호
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• pp.79-88
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• 2011

The sea tangle, Laminaria japonica has long been used in Korea as a folk remedy to promote health. Gamma-amino butyric acid-enriched (5.56% of dry weight) sea tangle was obtained by fermentation with Lactobacillus brevis BJ-20 (FLJ). A suppressive effect of FLJ on carbon tetrachloride-induced hepatotoxicity has been shown previously. Alcohol administration to Sprague-Dawley rats leads to hepatotoxicity, as demonstrated by heightened levels of hepatic marker enzymes as well as increases in both the number and volume of lipid droplets as fatty liver progresses. However, FLJ attenuated alcohol-induced hepatotoxicity and the accumulation of lipid droplets following ethanol administration. Additionally, FLJ increased the activities and transcript levels of major alcoholmetabolizing enzymes, such as alcohol dehydrogenase and aldehyde dehydrogenase, and reduced blood concentrations of alcohol and acetaldehyde. These data suggest that FLJ protects against alcohol-induced hepatotoxicity and that FLJ could be used as an ingredient in functional foods to ameliorate the effects of excessive alcohol consumption.