• Title/Summary/Keyword: reliability and safety

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Intake Pattern and Needs Assessment for the Development of Web-Contents on Health Functional Foods according to Age of Adults (성인의 연령에 따른 건강기능식품 섭취실태와 정보 요구도 분석)

  • Ohn, Jeong;Kim, Jung-Hee
    • Korean Journal of Community Nutrition
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    • v.17 no.1
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    • pp.26-37
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    • 2012
  • This study was done to analyze the consumption patterns of health functional food (HFF) as well as to perform needs assessment for the development of web-contents on HFF according to age of adults. The subjects were 238 male and female adults, divided into 4 groups by their age. This study collected all information by self-administrated questionnaires. The awareness on HFF was high in the older adults. The younger adults showed more negative responses to reliability and safety on HFF. The main reason for the consumption of HFF was to supplement nutrients and to prevent diseases. The main types of HFF consumed by adults were nutritional supplementary food, red ginseng products, and glucosamine products. There was higher consumption of nutritional supplementary food in the younger adults and glucosamine products in the older adults. Internet users had low level of satisfaction, with tendency to complain poor contents, reliability, difficulties in searching as problems of the pre-existing HFF websites. As useful methods for provision of information on HFF, most adults wanted general information, articles written by experts and videos. They also wanted to know the safety and side effects of HFF. Requirement of contents composition were various in-depth information, clear indication of citation, fresh updated data while that of display composition was easily-findable, uncomplicated, allowing mutual exchange of communication through bulletin board. These results can be used as basic data that reflect the consumer's needs for developing HFF web-contents according to age of adults.

Expression of Codon Optimized β2-Adrenergic Receptor in Sf9 Insect Cells for Multianalyte Detection of β-Agonist Residues in Pork

  • Liu, Yuan;Wang, Jian;Liu, Yang;Yang, Liting;Zhu, Xuran;Wang, Wei;Zhang, Jiaxiao;Wei, Dong
    • Journal of Microbiology and Biotechnology
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    • v.29 no.9
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    • pp.1470-1477
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    • 2019
  • ${\beta}_2$-adrenergic receptor (${\beta}_2-AR$) was expressed efficiently using Bac-to-Bac Baculovirus Expression System in Sf9 cells as a bio-recognition element for multianalyte screening of ${\beta}$-agonist residues in pork. Sf9 cells were selected as the expression system, and codon optimization of wild-type nucleic acid sequence and time-dependent screening of expression conditions were then carried out for enhancing expression level and biological activity. Under optimum conditions of multiplicity of infection (MOI) = 5 and 48 h post transfection, the protein yield was up to 1.23 mg/ml. After purification by chromatographic techniques, the purified recombinant protein was applied to develop a direct competitive enzyme-linked receptor assay (ELRA) and the efficiency and reliability of the assay was determined. The IC50 values of clenbuterol, salbutamol, and ractopamine were 28.36, 50.70, and $59.57{\mu}g/l$, and clenbuterol showed 47.61% and 55.94% cross-reactivities with ractopamine and salbutamol, respectively. The limit of detection (LOD) was $3.2{\mu}g/l$ and the relevant recoveries in pork samples were in the range of 73.0-91.2%, 69.4-84.6%, and 63.7-80.2%, respectively. The results showed that it had better performance compared with other present nonradioactive receptorbased assays, indicating that the genetically modified ${\beta}_2-AR$ would have great application potential in detection of ${\beta}$-agonist residues.

The Development of Third-Rail System Applied to Turn-out Section for Urban Maglev (도시형 자기부상열차 분기기 구간의 제3궤조 전차선 시스템 개발)

  • Min, Byong-Chan;Heo, Young-Tae;Hong, Du-Young;Lee, Won-Joo;Jo, Su-Yeon;Jeong, Nam-Cheol
    • Proceedings of the KSR Conference
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    • 2011.10a
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    • pp.3046-3051
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    • 2011
  • The third-rail system is an important device supplying power directly to the Maglev train through physical contact with the collecting shoe. It is directly related to safety and reliability for the running of Maglev. However, most the third-rail system used in Korea depend on foreign product or technologies, Korea Urban Maglev in the development of appropriate power feeding is urgent. In particular, the turnout section is the weakness point in the system because bending force by turnout section movement and fatigue caused by repetitive motion as well as the expansion by temperature, the forces by Maglev collecting shoe is added th the third-rail. Therefore, this paper proposes the third-rail system appropriate for Korean Urban Maglev of turnout section. To verify the structural stability of POSCO ICT third-rail system, the finite element analysis and physical testing was performed. The third-rail is fixed on each side of the turn-out section steel structure by epoxy insulation supporter and the integral behaviors are occurred. Therefore, the maximum horizontal displacements of each support are investigated and then, it is applied to finite element model of the third-rail to investigate the moments and stress. Also, the bending test about one million times and Expansion Joint for the third-rail was performed. The third-rail system safety and reliability was identified by test line on Korea Institute of Machinery & Materials in Deajeon for under the actual usage environment such as the Maglev and turn-out operation.

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Rating and Lifetime Prediction of a Bridge with Maintenance (유지관리보수가 된 교량의 내하력평가 및 잔존수명 예측)

  • Seung-Ie Yang;Han-Jung Kim
    • Journal of the Korean Society of Safety
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    • v.18 no.1
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    • pp.108-115
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    • 2003
  • Bridges are rated at two levels by either Load Factor Design (LFD) or Allowable Stress Design (ASD). The lower level rating is called Inventory Rating and the upper level rating is called Operating Rating. To maintain bridges effectively, there is an urgent need to assess actual bridge loading carrying capacity and to predict their remaining life from a system reliability viewpoint. The lifetime functions are introduced and explained to predict the time-dependent failure probability. The bridge studied in this paper was built 30 years ago in rural area. For this bridge, the load test and rehabilitation were conducted. The time-dependent system failure probability is predicted with or without rehabilitation. As a case study, an optional rehabilitation is suggested, and fir this rehabilitation, load rating is computed and the time-dependent system failure probability is predicted. Based on rehabilitation costs and extended service lifes, the optimal rehabilitation is suggested.

A Study on the Development of PD Simulation Pulse Generator for Evaluation of GIS Diagnosis System (GIS 진단시스템의 평가를 위한 PD 모의 펄스발생기 개발에 관한 연구)

  • Kim, Sungju;Chang, Sughun;Cho, Kook-hee
    • Journal of the Korean Society of Safety
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    • v.33 no.2
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    • pp.21-27
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    • 2018
  • The expansion and stable operation of electric power facilities are important factors with development of industrial facilities in modern society. In high-voltage equipment such as GIS, the insulation characteristics may be deterioated by environment-friendly gas adaption and miniaturization. There is also the possibility of accidents due to insulation breakdown due to the deterioration of power facilities. Therefore, it is necessary to extend the diagnosis system to continuously monitor the danger signals of these power equipment and to prevent accidents. Most of the internal defects in the GIS system are conductive particles, floating electrode defects, protrusion defects, and the like. In this case, a partial discharge phenomenon is accompanied. These partial discharge signals occur irregularly and various noise signals are included in the field, so it is difficult to evaluate the reliability in the development of the diagnostic system. In this paper, a study was made on equipment capable of generating a partial discharge simulated signal that can be adjusted in size and frequency to be applied to a diagnostic device by electromagnetic wave detection method. The PD simulated pulse generator consists of a user interface module, a high-voltage charging module, a pulse forming circuit, a voltage sensor and an embedded controller. In order to simulate the partial discharge phenomenon similar to the actual GIS, a discharge cell was designed and fabricated. The application of the prototype pulse generator to the commercialized PD diagnosis module confirmed that it can be used to evaluate the performance of the diagnostic device. It can be used for the development of GIS diagnosis system and performance verification for reliability evaluation.

Validation Method of ARINC 661 UA Definition File and CDS Configuration File for DO-330 Tool Qualification (DO-330 도구 자격인증을 고려한 ARINC 661 UA 정의 파일과 CDS 설정 파일의 유효성 확인 방법)

  • Younggon Kim
    • Journal of Platform Technology
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    • v.10 no.4
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    • pp.11-24
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    • 2022
  • The tool for developing airborne software requires the same level of safety as airborne software because the tool whose output is part of the airborne software and thus could insert an error into the airborne software. This paper describes how to ensure the reliability of the tool output that becomes a part of the airborne software by validating of the input and output files of the tool when generating the ARINC 661 standard UA definition file and the CDS configuration file through the A661UAGEN tool of Hanwha Systems. We present the method to validate XML data structure and contents with an XML schema definition, which is an input of the A661UAGEN tool. And the method to validate the output binary data by using mask data for the corresponding data structure and valid value, which is the output of the A661UAGEN tool, was presented. As such, validation of the input and output of the tool improves the reliability of binary DFs and CDs integrated into the airborne software, allowing airborne software developers to utilize the tool to ensure safety in developing the OFP.

Existing test data for the Act on Registration & Evaluation, etc. of Chemical Substances

  • Choi, Bong-In;Ryu, Byung-Taek;Na, Suk-Hyun;Chung, Seon-Yong
    • Environmental Analysis Health and Toxicology
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    • v.30
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    • pp.17.1-17.6
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    • 2015
  • Objectives In this study, the possibility of using existing test data provided in Korea and elsewhere for the registration of chemical substances was examined. Data on 510 chemical substances that are among the first subject to registration under the "Act on the Registration and Evaluation, etc. of Chemical Substances (K-REACH)" were analyzed. Methods The possibility of using existing data from 16 reference databases was examined for 510 chemical substances notified in July 2015 as being subject to registration. Results Test data with the reliability required for the registration of chemical substances under the K-REACH constituted 48.4% of the required physicochemical characteristics, 6.5% of the required health hazards, and 9.4% of the required environmental hazards. Conclusions Some existing test data were not within the scope of this research, including data used for registration in the European Union (EU). Thus, considering that 350 of these 510 species are registered in EU Registration, Evaluation, Authorisation & Restriction of Chemicals, more test data may exist that can be utilized in addition to the data identified in this study. Furthermore, the K-REACH states that non-testing data (test results predicted through Read Across, Quantitative Structure-Activity Relationships) and the weight of evidence (test results predicted based on test data with low reliability) can also be utilized for registration data. Therefore, if methods for using such data were actively reviewed, it would be possible to reduce the cost of securing test data required for the registration of chemical substances.

A Study on Construction of POP System with Reliable Acquisition of Production Data (생산실적의 신뢰성 향상을 위한 POP시스템 구축에 관한 연구)

  • Park, Je-Won;Lee, Chang-Ho
    • Journal of the Korea Safety Management & Science
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    • v.8 no.6
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    • pp.79-90
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    • 2006
  • Recently the construction of the ERP(Enterprise Resource Planning) system becomes accomplished actively from the many enterprises. But the many problems occur in acquisition of production data which is a fundamental data of system. Also to delay the acquisition of the production result is fatal in the efficient business operation. The construction of the POP(Point of Production) system which acquires production data at real time is become accomplished widely, In the POP system it is most important to acquire the production data which is accurate. But the many enterprises drop the competitive power with acquisition of the data which could not be trusted. In this paper, we analyze these causes and present the method which it can improve the reliability of production data. Also we introduce a real application case.

Modified Offset Method for Determination of Stable Crack Onset Point on R Curve (R 곡선상의 안정균열개시점 결정을 위한 수정옾셋방법)

  • 안광주;최재강;박준수
    • Journal of the Korean Society of Safety
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    • v.14 no.3
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    • pp.18-24
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    • 1999
  • This paper were performed to evaluate the elastic-plastic fracture toughness $J_IC$ by the unloading compliance method for 1/2 CT specimen of A5083-H112 aluminum alloy. A modified offset method for negative crack growth effect is presented and compared with Voss offset method. We found that the modified offset method presented can be used efficiently for a determination of the stable crack onset. The $J_IC$ by Voss offset method can be overestimated, but the suggested offset method showed a high reliability within 5% of tolerence from the results by the multi-specimen method.

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A Research on the Process Analysis Technique under Non-Normal Distribution (비정규분포하에서의 공정분석기술에 관한 조사연구)

  • Kim, Jong-Gurl;Um, Sang-Joon;Kim, Young-Sub
    • Proceedings of the Safety Management and Science Conference
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    • 2009.04a
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    • pp.393-400
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    • 2009
  • 품질향상을 위한 효과적인 공정관리체계는 기업의 생존에 있어서 매우 중요하다. 최근에는 제품의 수명과 관련된 신뢰성이 강조되면서, 신뢰성분포로 불리는 비정규분포하에서의 공정관리가 핵심과제로 여겨지고 있다. 특히 품질특성치가 비정규분포를 따를때, 정규가설에 기초한 공정관리기술을 사용한다면 심각한 오류가 초래될 수 있기 때문에, 비정규분포에서의 관리도와 신뢰성샘플링계획에 대한 중요성이 강조되고 있다. 본 연구의 목적은 비정규분포에서의 관리도와 신뢰성샘플링계획에 대한 최근연구를 조사하고, 보다 합리적이고 신뢰도 높은 공정분석에 대한 연구동향을 소개함으로써, 비정규분포하에서의 공정관리에 대한 발전적인 연구방향을 제시하는 것이다.

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