• 융합보안논문지
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• 제10권1호
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• pp.55-61
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• 2010

소프트웨어 제품을 개발하여 테스팅을 거친 후 사용자에게 인도하는 시기를 결정하는 일은 아주 실제적이고 흥미 있는 일이 된다. 이러한 문제를 소프트웨어 최적 방출시기라고 한다. 본 연구에서는 소프트웨어의 결함을 제거하거나 수정 작업 중에도 새로운 결함이 발생될 가능성이 있는 무한고장수를 가진 비동질적인 포아송 과정에 기초하고 고장간격 수명 시간의 형태에 따른 방출시간의 비교에 대하여 연구되었다. 소프트웨어 요구 신뢰도를 만족시키고 소프트웨어 개발및 유지 총비용을 최소화시키는 최적 소프트웨어 방출 정책이 된다. 본 논문의 수치적인 예에서는 모의실험 자료 즉, 강도함수가 일정한 경우, 증가하는 경우, 감소하는 경우를 적용하여 최적 방출시기를 추정하고 그 결과를 나열 하였다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권6호
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• pp.526-529
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• 2006

The aim of this study was to prepare cyclosporin A-loaded liposome (CyA-Lip) as an oral delivery carrier, with their encapsulation into microspheres based on alginate or extracellular polysaccharide (EPS) p-m10356. The main advantage of liposomes in the microspheres (LIMs) is to improve the restricted drug release property from liposomes and their stability in the stomach environment. Alginate microspheres containing CyA-Lip were prepared with a spray nozzle; CyA-Liploaded EPS microspheres were also prepared using a w/o emulsion method. The shape of the LIMs was spherical and uniform, and the particle size of the alginate-LIMs ranged from 5 to $10\;{\mu}m$, and that of the EPS-LIMs was about $100\;{\mu}m$. In a release test, release rate of CyA in simulated intestinal fluid (SIF) from the LIMs was significantly enhanced compared to that in simulated gastric fluid (SGF). In addition, the CyA release rates were slower from formulations containing the liposomes compared to the microspheres without the liposome. Therefore, alginate-and EPS-LIMs have the potential for the controlled release of CyA and as an oral delivery system.

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 2008년도 춘계학술논문발표회 논문집
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• pp.44-47
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• 2008

This paper evaluated the fire characteristics by using furniture calorimeter. Fire property assessment using the furniture calorimeter showed that the heat release rate is maximum 1,600 kW, maximum CO is 0.261%, maximum CO2 is 2.597%, while for the sofa for one person, the maximum heat release rate is approx. 531.5 kW, max. CO is 0.102%, and max. CO2 is 1.011%.

• 전자공학회논문지
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• 제52권1호
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• pp.24-31
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• 2015

코드워드의 인자로 M진 위상 편이 방식(M-ary phase shift keying, M-PSK)를 사용하는 차분 코드북은 Long term Evolution (LTE), LTE-Advanced (LTE-A) 그리고 WiMax 시스템 등에 제안된다. 인접하는 무선 채널의 시간 상관 특성에 의해 연속된 선부호화 행렬 내 양자화된 채널 정보는 천천히 변화된다. 이는 전체 무선 채널 공간을 양자화 하지 않고, 시간 상관 특성에 따른 채널 공간 내 일부분만을 양자화하여 피드백하기 때문에 기존과 동일한 크기의 코드북을 구성해도 가상적으로 보다 정확한 채널정보를 양자화할 수 있어 채널 용량이 증가하는 효과를 갖는다. 제안하는 코드북은 constant modulus, complexity reduction, 그리고 nested property와 같은 LTE release-8 코드북 특성을 갖는다. 또한 동 이즉 전송 특성을 갖기 때문에 상대적으로 저렴한 비선형 증폭기를 사용할 수 있어 가격의 제한을 받는 단말기 설계에도 이점을 갖는다. 컴퓨터 시뮬레이션을 통해 제안하는 차분 동 이득 전송 기술은 동일한 피드백 비트 수를 갖는 기존의 LTE-8 코드북보다 향상된 성능을 보인다.

• Journal of Pharmaceutical Investigation
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• 제41권3호
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• pp.179-184
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• 2011

This study aimed to confirm the effect of molecular weight (MW) in solid dispersion of carvedilol with poly-vinylpyrrolidone (PVP) of various MW. Solid dispersion of carvedilol with PVP was prepared by spray-drying method. Scanning electron microscopy (SEM) was used to analyze the surface of solid dispersion samples. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystalline of solid dispersion. Fourier transform infrared spectroscopy (FT-IR) was used to analyze the change of chemical structure characteristic of solid dispersion. DSC and XRD show that drug crystalline was changed. FT-IR revealed that chemical structure of solid dispersion comparing the chemical structure of drug was changed. The dissolution studies of solid dispersion presented at simulated gastric juice (pH 1.2). The dissolution rate of solid dispersion was dramatically enhanced than pure drug and the MW of PVP has an effect on the release property of carvedilol in solid dispersion. In conclusion, the present study has confirmed the effect of MW of PVP on release property of solid dispersion formulation of carvedilol with PVP.

• Biomolecules & Therapeutics
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• 제29권6호
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• pp.630-636
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• 2021

Eupafolin, a constituent of the aerial parts of Phyla nodiflora, has neuroprotective property. Because reducing the synaptic release of glutamate is crucial to achieving pharmacotherapeutic effects of neuroprotectants, we investigated the effect of eupafolin on glutamate release in rat cerebrocortical synaptosomes and explored the possible mechanism. We discovered that eupafolin depressed 4-aminopyridine (4-AP)-induced glutamate release, and this phenomenon was prevented in the absence of extracellular calcium. Eupafolin inhibition of glutamate release from synaptic vesicles was confirmed through measurement of the release of the fluorescent dye FM 1-43. Eupafolin decreased 4-AP-induced [Ca²⁺]_i elevation and had no effect on synaptosomal membrane potential. The inhibition of P/Q-type Ca²⁺ channels reduced the decrease in glutamate release that was caused by eupafolin, and docking data revealed that eupafolin interacted with P/Q-type Ca²⁺ channels. Additionally, the inhibition of calcium/calmodulin-dependent protein kinase II (CaMKII) prevented the effect of eupafolin on evoked glutamate release. Eupafolin also reduced the 4-AP-induced activation of CaMK II and the subsequent phosphorylation of synapsin I, which is the main presynaptic target of CaMKII. Therefore, eupafolin suppresses P/Q-type Ca²⁺ channels and thereby inhibits CaMKII/synapsin I pathways and the release of glutamate from rat cerebrocortical synaptosomes.

• Carbon letters
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• 제11권2호
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• pp.122-126
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• 2010

The alginate-based hydrogel was prepared as a pH-sensitive drug delivery system. To enhance the drug loading capacity, activated carbon was introduced as a drug absorbent. The iron oxide was incorporated into the alginate matrix for the magnetic transferring to the target organ. The activated carbon and iron-oxide were dispersed uniformly in the alginate hydrogel. The drug release from the alginate/activated carbon composite hydrogel was carried out in various pH conditions with vitamin B12 and Lactobacillus lamnosers as model drugs. The fast and sustainable release of drug was observed in the basic condition due to the pH-sensitive solubility of alginate. The novel drug delivery system having pH-sensitive release property and magnetic movement to target place was developed by using the alginate/activated carbon composite magnetic hydrogels.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2009년도 춘계학술대회 논문집
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• pp.206-212
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• 2009

Chemical behaviors of each surface material for interior facilities affect to fire initiation and growth in general fire situation. These chemical behaviors were characterized by thermal properties (Heat release rate, Pyrolysis rate, specific heat, etc) which could be derived from experimental test. Especially, Heat release rate which indicates aspect of fire size is one of the most important property to asses fire hazard and protection needs. The cone calorimeter test (ISO 5660) has recently assumed to a dominant role in bench scale fire testing to obtain the Heat release rate of materials. This value could be calculated by the 'Oxygen Consumption Method' under various producing irradiances to each surface of materials. In this study, Process of the cone calorimeter test was simulated by Pyrolysis model of FDS (Fire Dynamics Simulator by NIST) base on the ISO 5660 international standard. Then, we could estimate the simulation method of FDS in case of single materials through the comparative study with test results.

• Journal of Advanced Marine Engineering and Technology
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• 제22권4호
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• pp.490-497
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• 1998

An elast-biscoplastic finite element analysis is performed to investigate detailed growth behavior of creep cracks and the numerical results are compared with experimental results. The results of mesh translation method are compared with those of node release method. Load line displancement curve obtained from the crack growth analysis by mesh translation shows the improved results than that obtained from the crack growth by node release method when the secondary creep rate is only used as creep material property. The results of accounting for primary creep rate and instantaneous plasticity shows a good agreement with the experimental result.

• Journal of Pharmaceutical Investigation
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• 제33권3호
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• pp.179-185
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• 2003

Melatonin (MT) is an indole amide pineal hormone. It has not only very short half-life but also pH-sensitive property. The sustained release dosage form which delivers MT in a circadian fashion over 8 h is clinical value. The purpose of this study is to prepare sugar beads using multiple coating methods and enteric-coated in a sustained release to evaluate in vitro release characteristics in simulated gastric and intestinal fluids. The $Eudragit^{\circledR}$ as a polymer, sustained release membrane, and triethylcitrate (TEC) as a plasticzer were used. Multi-coated melatonin delivery system was composed of sugar, various excipients, $Eudragit^{\circledR}$ and enteric materials (e.g. hydroxy propyl methyl cellulose phthalate, HPMCP), and prepared by fluid bed coater. The dissolution test was carried out using the basket method at a stirring speed of 100 rpm at $37^{\circ}C$ in simulated gastric (pH 1.2) and intestinal fluid (pH 7.4). The released amount of MT was determined by High performance liquid chromatography method. The morhologies of surface and cross section of multi-coated beads were observed by scanning electron microscope. Size of multi-coated sugar beads was ranged over $1000{\sim}1300\;{\mu}m$. The release rate of MT from coated beads was limited in simulated gastric fluid (pH 1.2), but it was sustained in intestinal fluid (pH 7.4) during $3{\sim}8$ hours. The MT beads may provide small-intestine-targeted device for oral delivery. Studies on animal and relative experiment are in process.