• Title/Summary/Keyword: relaxation and tension

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The Effect of Carbon Monoxide on Contraction, Cytosolic $Ca^{2+}$ Level and Ionic Currents in Guinea Pig Ileal Smooth Muscle

  • Kwon, Seong-Chun;Chung, Seung-Soo;Kim, Yun-Suk;Nam, Taick-Sang
    • The Korean Journal of Physiology and Pharmacology
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    • v.4 no.6
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    • pp.479-486
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    • 2000
  • The aim of this study was to clarify the mechanism of the inhibitory action of carbon monoxide (CO) on contraction, by measuring cytosolic $Ca^{2+}$ level $([Ca^{2+}]_i)$ and ionic currents in guinea-pig ileum. CO (10%) inhibited 40 mM KCl-induced contraction and this effect was blocked by ODQ $(1\;{\mu}M),$ a soluble guanylyl cyclase (sGC) inhibitor. CO inhibited the 40 mM KCl-induced contraction without changing $[Ca^{2+}]_i.$ Cumulative addition of KCl induced a graded increase in $[Ca^{2+}]_i$ and muscle tension. In the presence of CO, cumulative addition of KCl induced smaller contraction than in the absence of CO. On the other hand, the increase in $[Ca^{2+}]_i$ induced by cumulative addition of KCl was only slightly decreased in the presence of CO, and the $[Ca^{2+}]_i-tension$ relationship shifted downwards. Using the patch clamp technique with a holding potential of -60 mV, we found that CO had little effect on the peak Ba currents $(I_{Ba})$ when voltage was stepped from -60 mV to 0 mV. In addition, CO showed no effect on the depolarization-activated outward $K^+$ currents in the all potential ranges. We conclude that CO inhibits smooth muscle contraction mainly by decreasing the $Ca^{2+}$ sensitivity of contractile elements via a cGMP-dependent pathway, not by involving L-type $Ca^{2+}$ and outward-potassium currents in guinea-pig ileum.

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Collision Analysis of Submerged Floating Tunnel by Underwater Navigating Vessel (수중운항체에 대한 해중터널의 충돌해석)

  • Hong, Kwan-Young;Lee, Gye-Hee
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.27 no.5
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    • pp.369-377
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    • 2014
  • In this paper, to recognize the collision behavior between a submerged floating tunnel(SFT) and underwater navigation vessel(UNV), both structures are modeled and analyzed. The SFT of collision point is modeled tubular section using concrete with steel lining. The other part of SFT is modeled elastic beam elements. Mooring lines are modeled as cable elements with tension. The under water navigation vessel is assumed 1800DT submarine and its total mass at collision is obtained with hydrodynamic added mass. The buoyancy force on SFT is included in initial condition using dynamic relaxation method. The buoyancy ratio (B/W) and the collision speed are considered as the collision conditions. As results, energy dissipation is concentrated on the SFT and that of the UNV is minor. Additionally, the collision behaviors are greatly affected by B/W and the tension of mooring lines. Especially, the collision forces are shown different tendency compare to vessel collision force of current design code.

Biological Change by Forest Healing according to Sasang Constitution : preliminary study (사상체질별 숲치유의 생체학적 변화 : 예비연구)

  • Hong, Sun-Gi;Choi, Eun-Ju;Sun, Seung-Ho;Choi, Ga-Young;Lee, Sun-Ju;Han, In-Sik;Lee, Jae-Hun;Yoo, Jun-Sang
    • Journal of Sasang Constitutional Medicine
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    • v.23 no.4
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    • pp.487-502
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    • 2011
  • 1. Objective This study was performed to research the biological change of forest healing according to Sasang constitution. 2. Methods Forty seven applicants are involved in this study. They were classified into three groups(Soyangin, Taeeumin, Soeumin) by QSCC II. And then they participated in forest healing program from March 26 to March 27 in 2011. We performed before and after experiment, including vital sign, electroencephalography(EEG), heart rate variability(HRV), complete blood cell count(CBC), biochemical test(BC), and stress hormones. 3. Results Men had the relaxative effect of tension. While, the group of women and Soyangin was more sensitive to sudden environmental change than the group of men or other constitutions. The tension of women and soyangin's group increased after the forest healing program. Soeumin group showed reduced diastolic blood pressure after the forest healing program. 3. Conclusions Forest healing program has shown better efficacy in relaxation in men than women, in lowering diastolic blood pressure in Soeumin group than other constitutional groups. However a single positive result within this study should be carefully interpreted.

Effect of Temperature and Thickness on Fracture Toughness of Solid Propellant (고체추진제의 파괴인성에 대한 온도 및 두께의 영향)

  • Seo, Bo Hwi;Kim, Jae Hoon
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.37 no.11
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    • pp.1355-1360
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    • 2013
  • A cracked solid propellant would have failure or fracture of rocket because of excessive combustion according to increase of burning area, therefore it is important to evaluate the fracture toughness of solid propellant. A procedure is used to investigate the material under a range of test temperatures between -60 and $60^{\circ}C$, three kind of specimen thickness, 4, 12.5 and 24.5 mm to determine the effect of two parameters on the fracture toughness. A center cracked tension (CCT) specimen is used in these tests, which were conducted using INSTRON 5567 testing machine and environmental chamber to evaluate the fracture toughness. The experimental results show that the fracture toughness tends to decreases with an increase in the temperature, and the effect of thickness indicates that the fracture toughness is highest at 12.5 mm under various temperatures except $-60^{\circ}C$. It is found that the fracture toughness of solid propellant is changed due to glass transition behavior around $-60^{\circ}C$.

Mechanical and Rheological Properties of Rice Plant (수도(水稻)의 역학적(力學的) 및 리올러지 특성(特性)에 관(關)한 연구(硏究))

  • Huh, Yun Kun;Cha, Gyun Do
    • Korean Journal of Agricultural Science
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    • v.14 no.1
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    • pp.98-133
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    • 1987
  • The mechanical and rheological properties of agricultural materials are important for engineering design and analysis of their mechanical harvesting, handling, transporting and processing systems. Agricultural materials, which composed of structural members and fluids do not react in a purely elastic manner, and their response when subjected to stress and strain is a combination of elastic and viscous behavior so called viscoelastic behavior. Many researchers have conducted studies on the mechanical and rheological properties of the various agricultural products, but a few researcher has studied those properties of rice plant, and also those data are available only for foreign varieties of rice plant. This study are conducted to experimentally determine the mechanical and the rheological properties such as axial compressive strength, tensile strength, bending and shear strength, stress relaxation and creep behavior of rice stems, and grain detachment strength. The rheological models for the rice stem were developed from the test data. The shearing characteristics were examined at some different levels of portion, cross-sectional area, moisture content of rice stem and shearing angle. The results obtained from this study were summarized as follows 1. The mechanical properties of the stems of the J aponica types were greater than those of the Indica ${\times}$ Japonica hybrid in compression, tension, bendingand shearing. 2. The mean value of the compressive force was 80.5 N in the Japonica types and 55.5 N in the Indica ${\times}$ Japonica hybrid which was about 70 percent to that of the Japonica types, and then the value increased progressively at the lower portion of the stems generally. 3. The average tensile force was about 226.6 N in the Japonica types and 123.6 N in the Indica ${\times}$ Japonica hybrid which was about 55 percent to that of the Japonica types. 4. The bending moment was $0.19N{\cdot}m$ in the Japonica types and $0.13N{\cdot}m$ in the Indica ${\times}$ Japonica hybrid which was 68 percent to that of the Japonica types and the bending strength was 7.7 MPa in the Japonica types and 6.5 MPa in the Indica ${\times}$ Japonica hybrid respectively. 5. The shearing force was 141.1 N in Jinju, the Japonica type and 101.4 N in Taebaeg, the Indica ${\times}$ Japonica hybrid which was 72 percent to that of Jinju, and the shearing strength of Taebaeg was 63 percent to that of Jinju. 6. The shearing force and the shearing energy along the stem portion in Jinju increased progressively together at the lower portions, meanwhile in Taebaeg the shearing force showed the maximum value at the intermediate portion and the shearing energy was the greatest at the portion of 21 cm from the ground level, and also the shearing strength and the shearing energy per unit cross-sectional area of the stem were the greater values at the intermediate portion than at any other portions. 7. The shearing force and the shearing energy increased with increase of the cross-sectional area of the rice stem and with decrease of the shearing angie from $90^{\circ}$ to $50^{\circ}$. 8. The shearing forces showed the minimum values of 110 N at Jinju and of 60 N at Taebaeg, the shearing energy at the moisture content decreased about 15 percent point from initial moisture content showed value of 50 mJ in Jinju and of 30 mJ in Taebaeg, respectively. 9. The stress relaxation behavior could be described by the generalized Maxwell model and also the compression creep behavior by Burger's model, respectively in the rice stem. 10. With increase of loading rate, the stress relaxation intensity increased, meanwhile the relaxation time and residual stress decreased. 11. In the compression creep test, the logarithmic creep occured at the stress less than 2.0 MPa and the steady-state creep at the stress larger than 2.0 MPa. 12. The stress level had not a significant effect on the relaxation time, while the relaxation intensity and residual stress increased with increase of the stress level. 13. In the compression creep test of the rice stem, the instantaneous elastic modulus of Burger's model showed the range of 60 to 80 MPa and the viscosities of the free dashpot were very large numerical value which was well explained that the rice stem was viscoelastic material. 14. The tensile detachment forces were about 1.7 to 2.3 N in the Japonica types while about 1.0 to 1.3 N in Indica ${\times}$ Japonica hybrid corresponding to 58 percent of Japonica types, and the bending detachment forces were about 0.6 to 1.1 N corresponding to 30 to 50 percent of the tensile detachment forces, and the bending detachment of the Indica ${\times}$ Japonica hybrid was 0.1 to 0.3 N which was 7 to 21 percent of Japonica types. 15. The detachment force of the lower portion was little bigger than that of the upper portion in a penicle and was not significantly affected by the harvesting period from September 28 to October 20. 16. The tensile and bending detachment forces decreased with decrease of the moisture content from 23 to 13 percent (w.b.) by the natural drying, and the decreasing rate of detachment forces along the moisture content was the greater in the bending detachment force than the tensile detachment force.

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Effects of KH204 on the Relaxation Response of Rabbit Corpus Cavernosum and Reproductive Function in Male Rats (토끼 음경해면체평활근 이완 및 10주간 경구투여한 흰쥐의 생식기능에 미치는 KH204의 효과)

  • Lee, Hyun-Ji;Lee, Eun-Jeong;Kim, Hee-Seok;Kim, Si-Na;Hwang, Sung-Yeoun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.35 no.7
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    • pp.847-852
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    • 2006
  • This study was designed to investigate the effects of KH204 on the relaxation response and reproductive function in male. Strips of rabbit corpus cavernosum were prepared for mounting and isometric tension measurement in an organ bath. On cavernosal strips contracted with $1{\times}10^{-6}$ phenylephrine and KH204 was applied in increasing concentrations from 0, 61, 183 and 549 mg/L, causing dose-dependent relaxation. Male Sprague-Dawley rats were orally administered with 61, 183 and 549 mg/kg/day of KH204 for 10 weeks. We examined organ weights, testicular sperm head counts, epididymal sperm counts, motility and morphology. KH204 relaxed rabbit corpus cavernosal strip contracted by $1{\times}10^{-6}$ phenylephrine in a dose-dependent manner. In the male rat, testicular weight was increased significantly in the KH204 treated groups compared with control group. Also in the testicular sperm head counts, epididymal sperm counts were increased significantly in the KH204-treated rats. In conclusion, the data suggest that KH204 could enhance erectile and reproductive function.

Evaluation of Prestress Loss in Prestressing Reinforcing Units using Steel Bar and Pipe (강봉 및 강관을 이용한 프리스트레싱 유닛의 긴장 응력 손실 평가)

  • Sim, Jae-Il;Mun, Ju-Hyun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.25 no.4
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    • pp.75-82
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    • 2021
  • The objective of this study is to examine the loss of prestressing stress in the developed prestressing reinforcing units using steel bar and pipe (SP). The main parameters were the reinforcing bar type, the magnitude of prestressed force, and prestressing method. The test results showed that the loss of prestressing stress for SP was highest in the initial prestressing step, which was higher for the compression introduction typed specimens than tension introduction typed specimens. The loss of prestressing stress of SP made with P800 was 1.6% for the compression introduction typed specimen with 0.8fy, which was lowest than the other specimens. Meanwhile, the relaxation of SP with the respect to the time ranged between 0.4 and 1.9%, irrespective of SP material type, the magnitude of prestressed force, and prestressing method. These values were less than 2.5%, which is the maximum value for the relaxation of prestressed reinforcing steel bars in design codes. Consequently, considering the loss of stress developed in the initial prestressing step, the developed SP material type, prestressing introduction method, and magnitude are recommended to be P800, compression introduction type, and 0.8fy.

Contractile Effect of Ultraviolet Light on Isolated Thoracic Aortae of Rats (흰쥐 적출 흉부대동맥근의 자외선 수축반응에 관하여)

  • Baik, Yung-Hong;Kang, Seong-Don;Kang, Jung-Chaee
    • The Korean Journal of Pharmacology
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    • v.29 no.1
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    • pp.65-72
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    • 1993
  • Ultraviolet light radiation (UVR) did not affect resting tension of isolated thoracic aortae of rats. In aortic rings contracted with phenylephrine, however, UVR produced contractile and relaxant responses in preparations with and without endothelium, respectively. The contractile response was dependent upon the duration $(10{\sim}320\;sec)$ of irradiation, while the relaxation was not. UVR-induced contractions in endothelium-intact rings were significantly potentiated by increasing the concentrations of phenylephrine from $10^{-7}M$ to $10^{-5}M$, and also by addition of $10^{-6}M$ acetylcholine, $10^{-7}M$ isoproterenol and $3.5{\times}10^{-8}M$ nitroglycerine. However, addition of $10^{-6}M$ phentolamine, or $10^{-7}M$ to $10^{-6}M$ LY83583 inhibited the contraction or reversed the contraction to a relaxation. In endothelium-removed preparations the UVR-induced relaxation was attenuated by increasing concentractions of phenylephrine, and by addition of isoproterenol, nitroglycerin, phentolamine or LY83583. These results suggest that UVR produces contractile and relaxant responses in rat thoracic aortae with and without endothelium, respectively, and that the contractile effect results from the inhibition of endothelium-derived relaxing factor (EDRF) release by UVR the inhibition of and/or is in part re-lated to some endothelium-derived contractile factors (EDCFs).

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Seismic assessment of base-isolated nuclear power plants

  • Farmanbordar, Babak;Adnan, Azlan Bin;Tahir, Mahmood Md.;Faridmehr, Iman
    • Advances in Computational Design
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    • v.2 no.3
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    • pp.211-223
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    • 2017
  • This research presented a numerical and experimental study on the seismic performance of first-generation base-isolated and fixed-base nuclear power plants (NPP). Three types of the base isolation system were applied to rehabilitate the first-generation nuclear power plants: frictional pendulum (FP), high-damping rubber (HDR) and lead-rubber (LR) base isolation. Also, an Excel program was proposed for the design of the abovementioned base isolators in accordance with UBC 97 and the Japan Society of Base Isolation Regulation. The seismic assessment was performed using the pushover and nonlinear time history analysis methods in accordance with the FEMA 356 regulation. To validate the adequacy of the proposed design procedure, two small-scale NPPs were constructed at Universiti Teknologi Malaysia's structural laboratory and subjected to a pushover test for two different base conditions, fixed and HDR-isolated base. The results showed that base-isolated structures achieved adequate seismic performance compared with the fixed-base one, and all three isolators led to a significant reduction in the containment's tension, overturning moment and base shear.

Comparative Study on the Nonlinear Material Model of HyperElastic Material Due to Variations in the Stretch Ratio (신장률 변화에 따른 초탄성 재료의 비선형 재료모델 비교 연구)

  • Lee, Kangsu;Ki, Minsuk;Park, Byoungjae
    • Journal of Ocean Engineering and Technology
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    • v.32 no.4
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    • pp.253-260
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    • 2018
  • Recently, the application of non-steel materials in ships and offshore plants is increasing because of the development of various nonlinear materials and the improvement of performance. Especially, hyper-elastic materials, which have a nonlinear stress-strain relationship, are used mainly in marine plant structures or ships where impact relaxation, vibration suppression, and elasticity are required, while elasticity must be maintained, even under high strain conditions. In order to simulate and evaluate the behavior of the hyperelastic material, it is very important to select an appropriate material model according to the strain of the material. This study focused on the selection of material models for hyperelastic materials, such as rubber used in the marine and offshore fields. Tension and compression tests and finite element simulations were conducted to compare the accuracy of the nonlinear material models due to variations in the stretch ratio of hyper-elastic material. Material coefficients of nonlinear material models are determined based on the curve fitting of experimental data. The results of this study can be used to improve the reliability of nonlinear material models according to stretch ratio variation.