• IMMUNE NETWORK
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• 제14권3호
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.

• 한국사회복지학
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• 제57권4호
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• pp.91-118
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• 2005

본 연구는 OECD 14개 회원국을 대상으로 복지체제와 생산체제의 조정전략과 이들 사이의 제도적 상보성이 소득 불평등에 미치는 영향을 분석하는 것이 목적이다. 분석에 포함된 기간은 1980년에서 1997년이며, 분석방법은 벡과 카츠(Beck and Katz, 1995)가 제안한 PCSE(Panel Corrected Standard Errors) 방법이 사용되었다. 제도적 상보성은 분배조정과 생산조정 변수의 상호작용 항으로 분석된다. 본 연구의 결과 제도적 상보성 수준이 높을 경우가 그렇지 않을 경우보다 소득불평등 수준을 낮추는 것으로 분석되었다. 또한, 조정전략의 관점에서 볼 때, 분배조정 영역과 생산조정 영역이 모두 전략적 조정을 지향하도록 제도가 구성될 때 소득 불평등 정도를 더 낮추는 것으로 분석되었다. 즉, 복지체제 영역에서 전략적 조정을 지향하는 정책 변화는 생산체제 영역에서 전략적 조정을 증가시키는 정책 변화가 같이 진행될 때 소득 불평등 수준을 더 낮출 수 있다는 것을 확인하였다.

• 한국임상수의학회지
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• 제34권2호
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• pp.146-151
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• 2017

Six major outbreaks of highly pathogenic avian influenza (HPAI) occurred from 2003 to 2016 in Korea. Epidemiological investigations of each outbreak revealed that migratory birds were the primary source of the HPAI virus. During the last five years, the geographic transmission pattern of domestic HPAI seems to have extended from local to nationwide; therefore, it is necessary to identify specific locations in which poultry farms are at elevated risk for HPAI outbreak to enable targeted surveillance and other mitigation strategies. Here, a geographical information system (GIS)-based analysis was used to identify geographic areas at high risk for future HPAI incidents in Korea based on historical outbreak data collected between December 2003 and April 2016. To accomplish this, seven criteria were used to identify areas at high-risk for HPAI occurrence. The first three criteria were based on defined spatial criteria buffering of 200 bird migration sites to some defined extents and the historical incidence of HPAI outbreaks at the buffering sites. The remaining criteria were based on combined attribute information such as number of birds or farms at district levels. Based on the criteria established for this study, the most-likely areas at higher risk for HPAI outbreak were located in Chungcheong, Jeolla, Gyeonggi, and Gyeongnam provinces, which are densely populated poultry regions considered major poultry-production areas that are located along bird migration sites. The proportion of areas at risk for HPAI occurrence ranged from 4.5% to 64.9%. For the worst criteria, all nine provinces, including Jeju Island, were found to be at risk of HPAI. The results of this study indicate that the number of poultry farms at risk for HPAI outbreaks is largely underestimated by current regulatory risk assessment procedures conducted for biosecurity authorization. The HPAI risk map generated in this study will enable easy use of information by policy makers to identify surveillance zones and employ targeted surveillance to reduce the impact of HPAI transmission.

• International Journal of Computer Science & Network Security
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• 제21권9호
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• pp.118-124
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• 2021

The article examines the formation of a competitive paradigm of economic security of industrial enterprises in the formation of a circular economy. The basic laws of industrial enterprises are formed, which determined the characteristics of competitive positions and threats. The basic competitive concepts and their application at maintenance of economic safety of the industrial enterprises in the conditions of formation of circular economy are described. Thus, the technological approach to the formation of a competitive paradigm is based on production technologies, opportunities for technological modernization and development of infrastructure and intellectual competencies. The institutional concept reveals the regulatory mechanisms for ensuring competitiveness through the protectionism of national industrial enterprises, standardization and regulation of market imbalances. The innovation-investment approach within the competitive paradigm is also manifested in the creation of competitive advantages due to the presence of active innovative developments and their commercialization, knowledge and competencies of staff, capitalization of intelligence and communications, constant updating of infrastructure and technologies. Collectively, innovation and investment effects on the level of economic security allow industrial enterprises to ensure resilience to increasing competition, the emergence of new market challenges in the formation of a circular economy. A strategic approach to the application of a competitive paradigm to ensure the economic security of industrial enterprises allows you to justify the prospects for development and design behavioral models to predict and assess potential threats. The concept of system management is based on the complexity of threat analysis, the integrity of the economic security system, system-forming functions and patterns of implementation of industrial development tasks in the formation of a circular economy. The application of the described concepts is formalized by the authors through the definition of the basic patterns, directions and characteristics of their impact on the elements of the security system of industrial enterprises in the formation of a circular economy.

• 한국빅데이터학회지
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• 제5권2호
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• pp.111-120
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• 2020

최근 코로나 19 사태로 인한 경기 위축에도 불구하고, 재택근무 증가로 집에 거주하는 시간이 늘어나면서 주거환경에 관한 관심이 커지고 있으며, 이에 따라 리모델링에 대한 수요가 증가하고 있다. 또한, 정부의 부동산 정책 또한 규제 정책에서 주택공급 확대 방향으로 전환하면서 이에 따른 인테리어, 가구업계의 매출에도 가시적인 영향이 있을 것으로 예상한다. 정확한 수요예측은 재고 관리와 직결되는 문제로 정확한 수요예측은 불필요한 재고를 보유할 필요가 없어 과잉생산으로 인한 물류, 재고 비용을 줄여줄 수 있다. 하지만 정확한 수요를 예측하기 위해서는 지속적으로 변화하는 경제동향, 시장동향, 사회적 이슈등 외부요인을 모두 고려하여 분석해야 하기 때문에 어려운 문제이다. 본연구에서는 가구 부자재를 생산하고 있는 제조업체에 대하여 신뢰성 있는 결과 도출을 위해 인공지능기반 시계열 분석 방법으로, LSTM 모형, 1D-CNN 모형을 비교 분석하였다.

• Genomics & Informatics
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• 제21권2호
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• 한국미생물·생명공학회지
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• 제51권4호
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• pp.432-440
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• 2023

Irrational and injudicious use of antibiotics, easy availability of them as over-the-counter drugs in economically developing countries, and unavailability of regulatory policies governing antimicrobial use in agriculture, animals, and humans, has led to the development of multi-drug resistance (MDR) bacteria. The use of medicinal plants can be considered as an alternative, with a consequent impact on microbial resistance. We tested extracts of Piper longum fruits as new natural products as agents for reversing the resistance to antibiotics. Six crude extracts of P. longum fruits were utilized against a clinical isolate of multidrug-resistant Staphylococcus aureus.The antibiotic susceptibility testing disc method was used in the antibiotic resistance reversal analysis. Apart from cefoxitin and erythromycin, all other antibiotics used (lincosamides [clindamycin], quinolones [levofloxacin and ciprofloxacin], and aminoglycosides [amikacin and gentamicin]) were enhanced by P. longum extracts. The extracts that showed the greatest synergy with the antibiotics were EAPL (ethyl acetate [extract of] P. longum), n-BPL (n-butanol [extract of] P. longum), and MPL (methanolic [extract of] P. longum The results of this study suggest that P. longum extracts have the ability to increase the effectiveness of different classes of antibiotics and reverse their resistance. However, future studies are needed to elucidate the molecular mechanisms behind the synergy between antibiotic and phytocompound(s) and identify the active biomolecules of P. longum responsible for the synergy in S. aureus.

• 융합경영연구
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• 제12권5호
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• pp.21-30
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• 2024

Purpose: As competition in the online platform market heats up due to the growing online presence, there is a growing interest in consumer protection legislation to protect consumers. The current online platform law has been criticized for its limitations in regulating the rapidly evolving platform economy. In particular, there is an ongoing need to regulate 'dark patterns' that deceive and mislead consumers. Research Design and Methods: This trend has been recognized not only in Korea, but also in Europe and the United States, which have enacted related regulatory bills, making some types of dark patterns illegal. It is necessary to protect consumers from dark patterns. However, there are some opinions that legal regulations do not protect consumers, but reduce consumer choice, as there is no specific definition of 'dark patterns' or analysis of the damage status. It has also been argued that extensive regulations could shrink the online platform market. Results: Therefore, it is necessary to clarify the areas that can resolve consumers' complaints about dark patterns before the revised law is implemented. In addition, it should be a rational and efficient system so that the continuously growing online platform market does not shrink due to excessive regulations and can develop healthily through the prevention of dark patterns. Conclusions: Here, it is also extremely important to specifically present the scope and standards of regulations and reduce the scope for unnecessary legal interpretation. It can also be a good idea to strengthen the education of consumers and businesses on dark pattern problems and their solutions, and to create a foundation that allows them to solve problems autonomously.

• 한국산학기술학회논문지
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• 제22권6호
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• pp.441-452
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• 2021

본 연구는 잡크래프팅이 혁신행동을 통해 조직헌신에 미치는 영향에 대해 검증하고, 잡크래프팅과 혁신행동을 촉진하는 요인으로 구성원의 지식공유를 설정하여 조절효과를 분석하였다. 또한 잡크래프팅이 혁신행동을 통하여 구성원의 조직헌신에 이르는 간접효과가 지식공유의 수준에 따라 다를 것으로 예상하고 조절된 매개효과를 분석하였다. 분석을 위해 전국의 스타트업 및 중소기업, 공공기관, 대기업 종사자 등 463명을 대상으로 설문조사를 진행하였고, SPSS 18.0과 SPSS Process Macro 분석을 통해 가설을 검증하였다. 분석결과 첫째. 잡크래프팅이 구성원의 혁신행동에 긍정적인 영향을 미치며, 둘째, 지식공유 수준이 높을수록 구성원의 혁신행동에 긍정적인 영향을 미치는 것으로 나타났다. 셋째, 혁신행동은 구성원의 조직헌신에 긍정적인 영향을 미치며, 넷째, 잡크래프팅과 조직헌신 간의 관계에서 혁신행동의 매개효과가 나타났다. 마지막으로 잡프래프팅이 혁신행동을 통해 조직헌신에 영향을 미치는 간접효과에 대한 지식공유의 조절된 매개효과는 유의미하지 않은 것으로 나타났다. 이러한 가설검증 결과를 토대로 본 연구의 이론 및 실무적 시사점을 제시하였다.

• 한국경제지리학회지
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• 제14권3호
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• pp.286-306
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• 2011

본 연구는 2008년 국가경쟁력강화위원회의 발표를 필두로 현 정부가 추진하고 있는 수도권정책의 변화의 방향과 그 영향을 고찰하기 위하여 수도권정책의 변화에 민감하게 반응하는 기업의 공간수요 변화를 분석하였다. 연구내용은 수도권 정책이 기업의 입지에 미치는 영향을 살펴보고 현 정부의 수도권 규제완화 정책에 따른 기업들의 입지행태 변화 및 공간수요의 변화방향을 분석한다. 연구방법은 실증분석과 설문분석을 활용하였다. 실증분석은 1980년대 이후 통계자료를 활용하여 제조업체의 공간수요 변화추이를 분석하였다. 설문분석은 외생적 충격인 수도권 정책 변화가 기업체의 의사결정에 미치는 영향을 고찰하여 향후 기업들의 제조업용지 수요방향을 도출하였다. 연구결과 기업체들은 그동안 수도권정책으로 인하여 기업입지 결정이나 공장규모결정에 영향을 많이 받았으며 가장 큰 규제정책은 수도권정비계획법상의 권역규제와 공장총량제인 것으로 조사된다. 현 정부의 수도권규제완화로 인하여 제조업용지 수요증가가 예상된다. 특히 수도권과 충청권을 중심으로 제조업용지 수요가 증가될 것이며 강원도는 수요감소가 전망된다. 이는 수도권지역이 우리나라 중에서 가장 교통 물류 조건과 시장조건이 양호한 지역이므로 이 지역에 대한 기업선호도가 높은 까닭이다. 그러나 독자적인 경제권을 형성하고 있는 동남권이나 대경권의 경우 수도권 정책변화로 인한 영향력이 적다. 수도권지역 경우도 전체 지역에서 수요가 증가하는 것이 아니라 성장관리권역에서의 수요증가가 예상된다.