• 대한지리학회지
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• 제41권6호
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• pp.701-713
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• 2006

이 연구는 개발가능성이 높은 지역이 규제지역으로 설정되어 있을 때 규제지역과 규제지역의 주변으로 규제저항이 발생할 것이라는 전제에서 출발한다. 그리고 이에 대한 분석은 GIS를 활용한 공간분석 방법으로 수행하였으며, 평창을 연구지역으로 하였다. 평창의 환경관련 규제현황을 조사하여 환경규제지도를 제작하고, 평창지역 전체의 상대적 개발 가능성 정도를 등급화 하였다. 그리고 이렇게 제작된 규제지도와 개발가능성등급도를 이용하여 상대적인 규제저항 정도를 측정하였다. 그 결과 평창의 환경관련 규제 비율은 남한강 유역권 전체의 규제 비율 보다 높게 나타났으며, 개발 가능성이 높은 지역과 환경 규제지역을 중첩하여 분석한 결과 읍면단위에서는 도암면과 진부면의 규제저항이 높을 것으로 예상되었다. 그리고 평창의 신규건물(1999년 $\sim$ 2005년) 입지와 환경규제와의 관계를 분석한 결과 개발가능성 등급이 높고 규제지역과 인접한 지역에 집중적으로 분포(신규건물의 약 66%가 규제지역으로부터 500m 이내 지역에 분포)하였다. 이러한 결과로 볼 때 지방정부와 주민에게 직접적인 이익을 제공하지 못하는 규제권역 설정 위주의 환경정책은 난 개발과 그에 따른 환경파괴라는 내재된 문제를 지니고 있음을 보여주는 것이다.

• Molecules and Cells
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• 제38권8호
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• pp.705-714
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• 2015

We investigated the role of HDAC3 in anti-cancer drug-resistance. The expression of HDAC3 was decreased in cancer cell lines resistant to anti-cancer drugs such as celastrol and taxol. HDAC3 conferred sensitivity to these anti-cancer drugs. HDAC3 activity was necessary for conferring sensitivity to these anti-cancer drugs. The down-regulation of HDAC3 increased the expression of MDR1 and conferred resistance to anti-cancer drugs. The expression of tubulin ${\beta}3$ was increased in drug-resistant cancer cell lines. ChIP assays showed the binding of HDAC3 to the promoter sequences of tubulin ${\beta}3$ and HDAC6. HDAC6 showed an interaction with tubulin ${\beta}3$. HDAC3 had a negative regulatory role in the expression of tubulin ${\beta}3$ and HDAC6. The down-regulation of HDAC6 decreased the expression of MDR1 and tubulin ${\beta}3$, but did not affect HDAC3 expression. The down-regulation of HDAC6 conferred sensitivity to taxol. The down-regulation of tubulin ${\beta}3$ did not affect the expression of HDAC6 or MDR1. The down-regulation of tubulin ${\beta}3$ conferred sensitivity to anti-cancer drugs. Our results showed that tubulin ${\beta}3$ serves as a downstream target of HDAC3 and mediates resistance to microtubule-targeting drugs. Thus, the HDAC3-HDAC6-Tubulin ${\beta}$ axis can be employed for the development of anti-cancer drugs.

• 운동영양학회지
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• 제15권4호
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• pp.153-161
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• 2011

The maintenance of skeletal muscle mass is very important for the prevention of life style-related diseases and the improvement of quality of life. It is well-known that resistance exercise and nutrition (especially amino acids) are the most effective interventions for maintaining skeletal muscle mass. It has been reported that many molecules are involved in the regulation of protein synthesis in response to resistance exercise and nutrition. Understanding the molecular mechanisms regulating muscle protein synthesis is crucial for the development of appropriate interventions. The role of intracellular signaling pathways through the mammalian target of rapamycin (mTOR), a serine/threonine protein kinase in the regulation of muscle protein synthesis, has been extensively investigated for these years. Control of protein synthesis by mTOR is mediated through phosphorylation of downstream targets that modulate translation initiation and elongation step. In contrast, upstream mediators regulating mTOR and protein synthesis in response to resistance exercise and amino acid still needed to be determined. In this brief review, we discuss the current progress of intracellular mechanisms for exercise- and amino acid-induced activation of mTOR pathways and protein synthesis in skeletal muscle.

• 한국건축시공학회지
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• 제22권6호
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• pp.673-680
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• 2022

모듈러 건축은 시공 기간의 단축, 건축비용 절감 등의 여러 가지 장점에도 불구하고 국내 건설시장에서 좀처럼 탄력을 받지 못하고 있다. 이러한 원인에는 모듈러 내화 기술 적용의 한계도 있으나 무엇보다 내화구조 제도에 대한 접근성이 쉽지 않은 것이 주요 요인으로 간주되고 있다. 따라서 모듈러 건축 활성화를 위해 주요 저해요인인 내화구조 제도 현황과 문제점에 대해 고찰하였으며, 내화구조 제도적 개선 및 연구개발 방향에 대해 제시하고자 한다.

• 대한지리학회:학술대회논문집
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• 대한지리학회 2006년도 연례 학술대회
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• pp.140-142
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• 2006

• 한국태양에너지학회 논문집
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• 제31권4호
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• pp.80-86
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• 2011

Investigation of the effective soil thermal conductivity(k) is the first step in designing the ground loop heat exchanger(borehole) of a geothermal heat pump system. Another important factor is the borehole thermal resistance($R_b$). Thermal response tests offer a good method to determine the ground thermal properties for the total heat transport in the ground. This is done by supplying a constant heat power into a borehole heat exchanger. There are two methods to supply a constant heat power. One is to employ the electricity provided by Korea Electric Power Corporation(KEPCO). The other is to use electricity generated by a generator. In this study, the power supply regulation was found to reduce when the electricity generated by the generator was used. This is because the generator evaluated with the power supply characteristically reduces the power supply regulation between an overload and a complex using. But it sometimes occurs a power supply regulation in In-situ thermal response test. In this case getting of k,$R_b$ requires delay times and restored normal state. However, the effect of the delay times and restored normal state on the soil thermal conductivity and borehole thermal resistance is very small. Therefore it is possible to use a generally accepted delay times and restored normal state in the analysis. In this work, it is also shown that an acceptable range of ${\Delta}k$, ${\Delta}R_b$ for normal state and regulation state might be approximately 0.01-0.16W/m k, and -0.004-0.007m K/W, respectively. Thus, restored normal state of power supply regulation is valuable to recommend.

• 전기학회논문지P
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• 제58권4호
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• pp.597-601
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• 2009

Green car such as a hybrid electrical vehicle and fuel cell vehicle is developed as a commercial target. UN/ECE/WP29 is developing GTR of HFCV and establishing the regulation and standard of electrical safety by ELSA. The regulation and standard about Electrical safety of vehicle are prescribed in ISO, UN/ECE, FMVSS, Japanese Attachment and so on, in case of insulation resistance is referred to keep more than 100/Vdc, 500/Vac. However, accurate method to measure insulation resistance agreeable to structure of vehicle does not exist now, it is actually that correctness of measurement drops according to the feature of battery and fuel cell stack. In this paper, the method to measure insulation resistance for protection against electrical shock by direct contact or indirect contact in Green Car will be indicated by making a comparison between the insulation measurement in standard of electrical safety and the experiment results for HEV and HFCV.

• Archives of Pharmacal Research
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• 제22권1호
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• pp.1-8
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• 1999

Transforming growth factor-$\beta$ (TGF-$\beta$) is the prototypical multifunctional cytokine, participating in the regulation of vital cellular activities such as proliferation and differentiations as well as a number of basic physiological functions. The effects of TGF-$\beta$ are critically dependent on the expression and distribution of a family of TGF-$\beta$ receptors, the TGF-$\beta$ types I, II, and III. It is now known that a wide variety of human pathology can be caused by aberrant expression and function of these receptors. the coding sequence of the type II receptor (RII) appears to render it uniquely susceptible to DNA replication errors in the course of normal cell division. By virtue of its key role in the regulation of cell proliferation, TGF-$\beta$ RII should be considered as a tumor suppressor gene. High levels of mutation in the TGF-$\beta$ RII gene have been observed in a wide range of primarily epithelial malignancies, including colon and gastric cancer. It appears likely that mutation of the TGF-$\beta$ RII gene may be a very critical step in the pathway of carcinogenesis.

• Endocrinology and Metabolism
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• 제31권1호
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• pp.1-6
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• 2016

Immoderate energy intake, a sedentary lifestyle, and aging have contributed to the increased prevalence of obesity, sarcopenia, metabolic syndrome, type 2 diabetes, and cardiovascular disease. There is an urgent need for the development of novel pharmacological interventions that can target excessive fat accumulation and decreased muscle mass and/or strength. Adipokines, bioactive molecules derived from adipose tissue, are involved in the regulation of appetite and satiety, inflammation, energy expenditure, insulin resistance and secretion, glucose and lipid metabolism, and atherosclerosis. Recently, there is emerging evidence that skeletal muscle and the liver also function as endocrine organs that secrete myokines and hepatokines, respectively. Novel discoveries and research into these organokines (adipokines, myokines, and hepatokines) may lead to the development of promising biomarkers and therapeutics for cardiometabolic disease. In this review, I summarize recent data on these organokines and focus on the role of adipokines, myokines, and hepatokines in the regulation of insulin resistance, inflammation, and atherosclerosis.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2009년도 심포지엄 및 춘계학술발표회
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• pp.297-298
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• 2009