• The Korean Journal of Nuclear Medicine Technology
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• v.27 no.2
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• pp.111-127
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• 2023

Purpose: Gallium-68 (⁶⁸Ga) is increasingly used in nuclear medicine imaging for various conditions such as lymphoma and neuroendocrine tumors by labeling tracers like Prostate Specific Membrane Antigen (PSMA) and DOTA-TOC. However, compared to Fluorine-18 (¹⁸F) used in conventional nuclear medicine imaging, ⁶⁸Ga has lower spatial resolution and relatively higher Signal to Background Ratio (SBR). Therefore, this study aimed to investigate the optimized parameters and reconstruction methods for PET/CT imaging using the ⁶⁸Ga radiotracer through model-based image evaluation. Materials and Methods: Based on clinical images of ⁶⁸Ga-PSMA PET/CT, a NEMA/IEC 2008 PET phantom model was prepared with a Hot vs Background (H/B) ratio of 10:1. Images were acquired for 9 minutes in list mode using DMIDR (GE, Milwaukee WI, USA). Subsequently, reconstructions were performed for 1 to 8 minutes using OS-EM (Ordered Subset Expectation Maximization) + TOF (Time of Flight) + Sharp IR (VPFX-S), and BSREM (Block Sequential Regularized Expectation Maximization) + TOF + Sharp IR (QCFX-S-400), followed by comparative evaluation. Based on the previous experimental results, images were reconstructed for BSREM + TOF + Sharp IR / 2 minutes (QCFX-S-2min) with varying β-strength values from 100 to 700. The image quality was evaluated using AMIDE (freeware, Ver.1.0.1) and Advanced Workstation (GE, USA). Results: Images reconstructed with QCFX-S-400 showed relatively higher values for SNR (Signal to Noise Ratio), CNR (Contrast to Noise Ratio), count, RC (Recovery Coefficient), and SUV (Standardized Uptake Value) compared to VPFX-S. SNR, CNR, and SUV exhibited the highest values at 2 minutes/bed acquisition time. RC showed the highest values for a 10 mm sphere at 2 minutes/bed acquisition time. For small spheres of 10 mm and 13 mm, an inverse relationship between β-strength increase and count was observed. SNR and CNR peaked at β-strength 400 and then decreased, while SUV and RC exhibited a normal distribution based on sphere size for β-strength values of 400 and above. Conclusion: Based on the experiments, PET/CT imaging using the ⁶⁸Ga radiotracer yielded the most favorable quantitative and qualitative results with a 2 minutes/bed acquisition time and BSREM reconstruction, particularly when applying β-strength 400. The application of BSREM can enhance accurate quantification and image quality in ⁶⁸Ga PET/CT imaging, and an optimization process tailored to each institution's imaging objectives appears necessary.

• Journal of the Korean Solar Energy Society
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• v.25 no.1
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• pp.87-96
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• 2005

본 논문은 압력차로 인한 유체의 유동장에서 서스펜션의 입자 밀도를 분포 규명하기 위해 적용할 수 있는 Electric Impedance Tomography (EIT)의 새로운 기법에 대한 효율성을 다루고 있다. Regularized Newton-Raphson iterative method를 근간으로 inverse problem의 해를 구하는데, 이는 곧 목적 함수(object function)를 몇 가지의 제한조건(constraints) 하에서 최소화시키는 과정이라 할 수 있다. 한편, 관련 forward problem은 유한요소법(FEM)을 이용하여 해결하며, 기존의 연구와는 달리 선형 형상 함수(linear shape function)를 이용하여 전도도가 연속적인 물성치로 유동장에 분포되어 있는 것으로 가정하였다. 여러 경우의 test run에 대한 결과는 본 논문에서 적용한 방법론의 타당성을 보여 주고 있다. 태양에너지의 추출을 위해 직접촉식 열교환기가 종종 이용되고 있는데, 본 연구는 열교환기 내부의 분산 유체에 대한 해석에 일조를 할 수 있을 것으로 기대된다.

• Proceedings of the IEEK Conference
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• 2000.11d
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• pp.155-158
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• 2000

In this paper, the quantization noise in block-based video coding is analyzed, and a post-processing method based on the analysis is presented for reducing the quantization noise by using a wavelet transform(WT). In the proposed method, the quantization noise is considered as the sum of a blocking noise expressed as a deterministic profile and the random remainder noise. Each noise is removed in a viewpoint of image restoration using a 1-D WT, which yields a regularized differentiation. The blocking noise first is reduced by weakening the strength of each blocking noise component that appears as an impulse in the first scale wavelet domain. The impulse strength estimation is performed using median filter, quantization parameter(QP), and local activity. The remainder noise, which is considered as a white noise at non-edge pixels, then is reduced by soft-thresholding. The experimental results show that the proposed method yields better performance in terms if subjective quality as well as PSNR performance over VM post-filter in MPEG-4 for all test sequences of various compression ratios. We also present a fast post-processing in spatial domain equivalent to that in wavelet domain for real-time application.

• Proceedings of the IEEK Conference
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• 2001.09a
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• pp.283-286
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• 2001

In this paper, we present a robust region segmentation method based on the watershed transformation of a pseudo-distance map (PDM). A usual approach for the segmentation of a gray-scale image with the watershed algorithm is to apply it to a gradient magnitude image or the Euclidean distance map (EDM) of an edge image. However, it is well known that this approach suffers from the oversegmentation of the given image due to noisy gradients or spurious edges caused by a thresholding operation. In this paper we show thor applying the watershed algorithm to the EDM, which is a regularized version of the EDM and is directly computed form the edgestrength function (ESF) of the input image, significantly reduces the oversegmentation, and the final segmentation results obtained by a simple region-merging process are more reliable and less noisy than those of the gradient-or EDM-based methods. We also propose a simple and efficient region-merging criterion considering both boundary strengths and inner intensities of regions to be merged. The robustness of our method is proven by testing it with a variety of synthetic and real images.

• 한국경영정보학회:학술대회논문집
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• 2007.06a
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• pp.608-613
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• 2007

Prediction of corporate bankruptcies has long been an important topic and has been studied extensively in the finance and management literature because it is an essential basis for the risk management of financial institutions. Recently, support vector machines (SVMs) are becoming popular as a tool for bankruptcy prediction because they use a risk function consisting of the empirical error and a regularized term which is derived from the structural risk minimization principle. In addition, they don't require huge training samples and have little possibility of overfitting. However. in order to Use SVM, a user should determine several factors such as the parameters ofa kernel function, appropriate feature subset, and proper instance subset by heuristics, which hinders accurate prediction results when using SVM In this study, we propose a novel hybrid SVM classifier with simultaneous optimization of feature subsets, instance subsets, and kernel parameters. This study introduces genetic algorithms (GAs) to optimize the feature selection, instance selection, and kernel parameters simultaneously. Our study applies the proposed model to the real-world case for bankruptcy prediction. Experimental results show that the prediction accuracy of conventional SVM may be improved significantly by using our model.

• Journal of Electrical Engineering and Technology
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• v.10 no.2
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• pp.670-675
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• 2015

Medical imaging is one of the most powerful tools for gaining information about internal organs and tissues. It is a challenging task to develop sophisticated image analysis methods in order to improve the accuracy of diagnosis. The objective of this paper is to develop a Computer Aided Diagnostics (CAD) scheme for Brain Tumour detection from Magnetic Resonance Image (MRI) using active contour models and to investigate with several approaches for improving CAD performances. The problem in clinical medicine is the automatic detection of brain Tumours with maximum accuracy and in less time. This work involves the following steps: i) Segmentation performed by Fuzzy Clustering with Level Set Method (FCMLSM) and performance is compared with snake models based on Balloon force and Gradient Vector Force (GVF), Distance Regularized Level Set Method (DRLSE). ii) Feature extraction done by Shape and Texture based features. iii) Brain Tumour detection performed by various tree classifiers. Based on investigation FCMLSM is well suited segmentation method and Random Forest is the most optimum classifier for this problem. This method gives accuracy of 97% and with minimum classification error. The time taken to detect Tumour is approximately 2 mins for an examination (30 slices).

• Development and Reproduction
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• v.1 no.1
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• pp.9-24
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• 1997

To investigate the process of spermiogenesis of the Korean eastern Daubenton's bat, Myotis daubentonii ussuriensis, the testis obtained from mature male bats was studied by transmission electron microscope and were based on the variety and diagnostic characters of cell organells. The results obtained from the present study are as follows. According to the differentiation of the cell organells, the spermiogenesis of the Korean eastern Daubenton's bat, M. d. ussuriensis, was divided into Golg, cap, acrosome, maturation and spermiation phases. Besides, these Golgi, cap, acrosome, and maturation phase were subdivided into the steps of early and late phases repectively and matruation phase was subdivided into step of early, mid and late phases. Therfore, the spermiogenesisof M. d. ussuriensis has been divided into a total of 11 phases. The chromatin granules began to condense at the early cap phase, regularized at the acrosome phase, and a perfect nucleus of sperm was formed at the maturation phase. The chromatoid body was occurred in the upper cytoplasm of nucleus at the early Golgi phase, and it was accurred the posterior cytoplasm of the nucleus at the early maturatio phase. The formation of sperm tail began to be develop in the early golgi phase, and completed at the spermiation phase. The fiber structure of middle piece was consisted of nine outer doublets and two central singlet microtubules and Nos. 1, 5, 6 and 9 in the outer dense were larger than the others(2, 3, 4, 7, 8).

• Journal of the Korean Graphic Arts Communication Society
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• v.25 no.1
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• pp.121-133
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• 2007

The CMS(color management system) software was to enable consistent color reproduction from original to reproduction. The CMS was to create RGB monitor and printer characterization profiles and then use the profiles for device independent color transformation. The implemented CMM(color management module) used the CIELAB color space for the profile connection. Various monitor characterization model was evaluated for proper color transformation. To construct output device profile, SLI(sequential linear interpolation) method was used for the color conversion from CMYK device color to device independent CIELAB color space and tetrahedral interpolation method was used for backward transformation. UCR(under color removal) based black generation algorithm was used to construct CIELAB to CMYK LUT(lookup table). When transforming the CIE Lab colour space to CMYK, it was possible to involve the gray revision method regularized in the brightness into colour transformation process and optimize the colour transformation by black generation method based on UCR technique. For soft copy colour proofing, evaluating several monitor specialism methods showed that LUT algorithm was useful. And it was possible to simplify colour gamut mapping by constructing both the look-up table and the colour gamut mapping algorithm to a reference table.

• Journal of KIISE
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• v.43 no.11
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• pp.1270-1274
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• 2016

Logistic regression is widely used for predicting and estimating the relationship among variables. We propose a new logistic regression model, the value weighted logistic regression, which comprises of a fine-grained weighting method, and assigns adapted weights to each feature value. This gradient approach obtains the optimal weights of feature values. Experiments were conducted on several data sets from the UCI machine learning repository, and the results revealed that the proposed method achieves meaningful improvement in the prediction accuracy.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2000.11b
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• pp.63-67
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• 2000

디지털 영상 저장 과정에서 일어나는 문제점은 영상 저장부 센서계의 한계로 나타낼 수 있다. 센서계의 충분하지 못한 집적도는 물리적으로 피할 수 없는 현상이다. 이러한 현상을 디지털 신호처리 기술을 적용하여 극복할 수 있다. 센서계의 한계로 인한 문제는 디지털 영상의 가장 큰 문제중의 하나이며, 이러한 한계를 극복하는 고해상도 영상 복원 방법들은 많은 학자들에 의해 제안되어 왔다. 본 논문에서는, 기존의 고해상도 영상 복원 방법들과는 달리 원영상의 공간적 고주파 성분의 특성을 분석과, 주어진 저해상도 영상들의 부화소 단위 움직임 추정 오류에 대한 분석을 통해 영상 복원과정에 이러한 분석들의 결과를 반영한다. 위에서 언급한 추정 오류는 우리에게 하나의 잡음 형태로 나타날 수 있다. 이 잡음은 추정이 이루어지는 축에 따라 그 양이 다르게 나타나게 되고, 이러한 현상은 목적이 되는 영상의 공간적 고주파 성분의 분포와 밀접한 관련이 있다. 우리는 복원 과정에 기존의 영상복원 방법중의 하나인 정규화 방법을 도입한다. 위에서 분석된 현상을 이 복원 과정에 반영하여 기존의 고해상도 영상 복원 방법보다 향상된 결과를 얻을 수 있었다. 결론적으로, 제안하는 알고리즘은 부화소 단위 움직임 추정 오류의 분석 결과를 반영하므로 이러한 추정 오류에 강한 알고리즘이다.