• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.3
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• pp.110-126
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• 2005

Purpose : The Purpose of this research was to investigate the effects of antithrombotic activities of Wuslsan (WSS). Methods : Measure the effect which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD soulution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. Being classified one group of eight mice, each of them was divided into Normal, Control, and WSS. The normal group supplied a saline solution and the control group brought the dextran extravasated blood after an hour of administering the saline solution. Also WSS was dissolved in 2ml saline solution and then we dosed it to the experimental mice with Oral Zonde one day before the experiment. After that, the mice were abstained from food. And then we gave a measured amount of it before an hour. Finally, it gave rise to dextran extravasated blood in the same way as the Control group. Results : The results were obtained as follows. WSS inhibited platelet aggregation induced by ADP and epinephrine significantly as compared with the control group. WSS showed fibrinolytic activity insignificantly as compared with the control group. WSS increased blood flow rate significantly as compared with the control group in vitro. WSS inhibited pulmonary embolism induced by collagen and Epinephrine(inhibitive rate is 37.5%). WSS increased number of platelet and fibrinogen amount significantly, and shortened PT and APTT as compared with the control group in thrombus model induced by dextran. Conclusion : WSS is effective antithrombotic activity from experimental result.

• Journal of Industrial Convergence
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• v.18 no.6
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• pp.61-73
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• 2020

The purpose of this study was to categorize conflict resolution by exploring the conflict experiences of the elderly who participate in jobs for the elderly to create an elderly-friendly village. This study applied grounded theory, a qualitative research method, For data collection, a FGI was conducted by sampling 5 elderly job participants in ◯◯-dong, ◯◯-gu, Seoul. The data were analyzed according to the paradigm model of Strauss & Corbin(1998). As a result of the analysis, causal conditions were social, economic, psychological and physical motivations for participation and contextual conditions were economic difficulties, social disconnection, and differences in life experiences influenced the initiation of conflict. The core phenomena were conflict initiated by 'the difference between experience and role' and 'the difference in psychosocial relationship skills', and the intervention condition were the activation of interpersonal relationships through communication to resolve the conflict, social integration through the use of capabilities, It appeared as a regular social activities. The interaction strategy emerged as a strategy for resolving conflict for senior citizen jobs through education, mutual support for building trust, and successful senior-friendly village program operation. The consequences, it was found that job conflicts for the elderly were alleviated by finding one's life, activating community exchanges, increasing a sense of achievement, and growing a sense of community. In conclusion, the conflict resolution types for senior citizens were classified into educational solution type, mutual support solution type, and success experience solution type.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.36 no.4
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• pp.129-137
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• 2024

An analytic solution for the interaction between an array of circular piles made by joining trapezoid steel pipes (TSP) and waves was obtained using an eigenfunction expansion method. First, an analytic model for the wave scattering of multiple piles fixed at arbitrary positions was derived, and then a simplified model was obtained assuming that an infinite array of identical piles were deployed perpendicular to the propagating direc- tion of incident waves. A regular wave experiment was conducted using an experimental model with a scale ratio of 1/100 in a two-dimensional wave tank to verify the analytic solutions. The analytic results and experimental results were qualitatively consistent with each other. Using a developed analytic model, we examined the wave force on the multiple piles and the wave deformation in front of the arrayed piles. The period for the installation is greatly reduced as the TSP pile can be prefabricated in a factory. In particular, it is possible to install at the soft seabed. A seawall structure using arrayed TSP piles will be an ideal complement for a concrete seawall in future.

• Journal of the Society of Naval Architects of Korea
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• v.47 no.3
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• pp.291-305
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• 2010

A three-dimensional time-domain calculation method is of crucial importance in prediction of the motions and wave loads of a ship advancing in a severe irregular sea. The exact solution of the free surface wave-ship interaction problem is very complicated because of the essentially nonlinear boundary conditions. In this paper, an approximate body nonlinear approach based on the three-dimensional time-domain forward-speed free-surface Green function has been presented. The Froude-Krylov force and the hydrostatic restoring force are calculated over the instantaneous wetted surface of the ship while the forces due to the radiation and scattering potentials over the mean wetted surface. The time-domain radiation and scattering potentials have been obtained from a time invariant kernel of integral equations for the potentials which are discretized according to the second-order boundary element method (Hong and Hong 2008). The diffraction impulse-response functions of the Wigley seakeeping model advancing in transient head waves at various Froude numbers have been presented. A simulation of coupled heave-pitch motion of a long rectangular barge advancing in regular head waves of large amplitude has been carried out. Comparisons between the linear and the approximate body nonlinear numerical results of motions and wave loads of the barge at a nonzero Froude number have been made.

• YAKHAK HOEJI
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• v.36 no.6
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• pp.518-528
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• 1992

To determine the optimal conformation of sulfonylureas, the correlation between conformation and hypoglycemic activity of the two sulfonylureas of tolbutamide and chlorpropamide as hypoglycemic agent was studied using an empirical potential function (ECEPP/2) and the hydration shell model in the unhydrated and hydrated states. The conformational energy was minimized from several starting conformations with possible torsion angles in each molecule. The conformational entropy change of each conformation was computed using a harmonic approximation. To understand the hydration effect on the conformation of the molecules in aqueous solution, the contribution of water-accessible volume of each group or atom in the lowest-free-energy conformation was calculated and compared each other. From comparison of the computed lowest-free-energy conformations of two sulfonylureas, it could be suggested that the hydration of sulfonylurea moiety is related to increase the hypoglycemic activity. From the calculation results, it was known that the conformational entropy is the major contribution to stabilize the low-free-energy conformations of two sulfonylureas in unhydrated state. Whereas, in hydrated state, the hydration free energy largely contributes to the total free energies of low-free-energy conformations of tolbutamide and conformational entropy contributes to stabilize the low-free-energy conformations of chlorpropamide. The torsion angles from phenyl ring to urea moiety of the low-free-energy conformations of the two sulfonylureas were shown the nearly regular trend. On the basis of these results, the conformation exhibiting the optimal hypoglycemic activity of sulfonylureas and the binding direction to pancreatic receptor site A could be predicted. Also, according to the side chain lengthening of urea moiety, tolbutamide showed various conformational change. Therefore, steric effect may be important factor in the interaction between sulfonylureas and the putative pancreatic receptor.

• The Journal of Korean Academy of Prosthodontics
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• v.39 no.4
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• pp.336-350
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• 2001

The purpose of this study was to investigate corrosion tendency and to compare corrosion resistance of three dental magnetic attachments and its keeper alloy by coercive, electrochemical method. By using petentiodynamic polarization technique, magnetic elements and its keeper alloy of Magfit EX600 system(MF, MFK), Dyna ES regular system(DN, DNK) and Shiner SR magnet system(SR, SRK) were corroded electrochemically in 0.9% NaCl electrolytic solution. Open-circuit potential and anodic polarization curve was measured with Potentiostat(model 273 EG&E) and polarization curve was created by current density per square area following scanning of increased series of voltage in the rate of 1.0mV per second. Before and after electrochemical corrosion, the surface roughness test was done. Thereafter the change of mean surface roughness value(Ra) and mean peak value(Rt) of surface roughness was compared one another. In order to observe the corroded surface of each specimen, metallurgical light microscopic(${\times}37.5$) and scanning electron microscopic view(SEM ${\times}100$) was taken and compared one another. Conclusion is followings. 1. All of six covering metal of dental magnetic attachments and its keeper alloy were corroded in various degree after electrochemical corrosion. 2. The corrosion resistance of which used in this experiment is the following in high order; DNK, MFK, DN, MF, SRK and SR. 3. Especially Shiner magnet system and its keeper alloy were more severely corroded after electrochemical corrosion and the change of Ra Rt value were more increased than others. 4 Metallurgical and scanning electron microscopic view showed the pitting corrosion tendency of all experimental alloy but DNK and SR. 5. Covering metal of magnet was more corroded than its keeper alloy.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.25 no.6_1
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• pp.545-555
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• 2007

3D buildings are the most prominent feature comprising urban scene. A few of mega-cities in the globe are virtually reconstructed in photo-realistic 3D models, which becomes accessible by the public through the state-of-the-art online mapping services. A lot of research efforts have been made to develop automatic reconstruction technique of large-scale 3D building models from remotely sensed data. However, existing methods still produce irregular building polygons due to errors induced partly by uncalibrated sensor system, scene complexity and partly inappropriate sensor resolution to observed object scales. Thus, a geometric regularization technique is urgently required to rectify such irregular building polygons that are quickly captured from low sensory data. This paper aims to develop a new method for regularizing noise building outlines extracted from airborne LiDAR data, and to evaluate its performance in comparison with existing methods. These include Douglas-Peucker's polyline simplication, total least-squared adjustment, model hypothesis-verification, and rule-based rectification. Based on Minimum Description Length (MDL) principal, a new objective function, Geometric Minimum Description Length (GMDL), to regularize geometric noises is introduced to enhance the repetition of identical line directionality, regular angle transition and to minimize the number of vertices used. After generating hypothetical regularized models, a global optimum of the geometric regularity is achieved by verifying the entire solution space. A comparative evaluation of the proposed geometric regulator is conducted using both simulated and real building vectors with various levels of noise. The results show that the GMDL outperforms the selected existing algorithms at the most of noise levels.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.2
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• pp.1-17
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• 2006

Purpose : The Purpose of this research was to investigate the effects of antithrombotic activities of Haenggyonghonghwatang (HGHHT). Methods : Measured the effect which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD soulution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. Each of the groups consisted in 8 mice, was divided into Normal, Control, and HGHHT. All of these 3 group were supplied a saline solution and after an hour the control group brought the dextran extravasated blood. Also the HGHHT group was dosed to the experimental mice with Oral Zonde one day before the experiment. After that, the mice were abstained from food. And then we gave a measured amount of it before an hour. Finally, it gave rise to dextran extravasated blood as well as the Control group. Results : The results were obtained as follows. HGHHT inhibited platelet aggregation induced by ADP and epinephrine significantly as compared with the control group. HGHHT showed fibrinolytic activity insignificantly as compared with the control group. HGHHT increased blood flow rate significantly as compared with the control group in vitro, but insignificantly as compared with the control group in vivo. HGHHT inhibited pulmonary embolism induced by collagen and epinephrine(inhibitive rate 50%). HGHHT increased number of platelet, fibrinogen amount and shortened prothrombin time, activated partial thromboplastin time significantly as compared with the control group in thrombus model induced by dextran. Conclusion : HGHHT is effective antithrombotic activity from experimental result.

• Journal of Korean Elementary Science Education
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• v.22 no.2
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• pp.163-172
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• 2003

The purpose of this study was to develop the analytic framework of Creative Problem Solving(CPS) for elementary school science textbook. For this purpose, we developed the framework based on the theories of problem, definition of problem solving and various kinds of CPS model. The six elements of the framework for content analysis were extracted through theoretical examination: problem introduction, problem statement, solution thinking, formulating hypothesis, testing hypothesis, and assessment. The developed framework was applied to the extbooks for the 5th and the 6th grades 1st semester in elementary science textbook of the 7th national curriculum. The results of this study were as follows: 1. The scores of the framework for content analysis in the 5th grade were slightly higher than those of the 6th grade, but there were no significant difference. 2. The comparison of the scores between the elements of the framework was found that the scores on the elements of testing hypothesis and formulating hypothesis were higher than those of the other elements. 3. The comparison of the scores between the units was found that the scores of the framework for the 9th unit (“trip of water”) of the 5th grade were higher than those of the other units, which were presented lower level than 1.0 (50.0%) score of the framework. 4. The comparison of the scores between the intensive course and the regular coures in the 6th grade textbook was showed that the scores on the intensive course were higher than the basic course. In conclusions, it was found that the problem introduction and problem statement in the textbook should be amended, and that various information and activities should be presented in the textbook.

• Steel and Composite Structures
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• v.49 no.4
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• pp.361-380
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• 2023

A size dependent bending behavior of piezoelectrical flexoelectric layered perforated functionally graded (FG) composite nanobeam rested on an elastic foundation is investigated analytically. The composite beam is composed of regularly cutout FG core and two piezoelectric face sheets. The material characteristics is graded through the core thickness by power law function. Regular squared cutout perforation pattern is considered and closed forms of the equivalent stiffness parameters are derived. The modified nonlocal strain gradient elasticity theory is employed to incorporate the microstructure as well as nonlocality effects into governing equations. The Winkler as well as the Pasternak elastic foundation models are employed to simulate the substrate medium. The Hamiltonian approach is adopted to derive the governing equilibrium equation including piezoelectric and flexoelectric effects. Analytical solution methodology is developed to derive closed forms for the size dependent electromechanical as well as mechanical bending profiles. The model is verified by comparing the obtained results with the available corresponding results in the literature. To demonstrate the applicability of the developed procedure, parametric studies are performed to explore influences of gradation index, elastic medium parameters, flexoelectric and piezoelectric parameters, geometrical and peroration parameters, and material parameters on the size dependent bending behavior of piezoelectrically layered PFG nanobeams. Results obtained revealed the significant effects both the flexoelectric and piezoelectric parameters on the bending behavior of the piezoelectric composite nanobeams. These parameters could be controlled to improve the size dependent electromechanical as well as mechanical behaviors. The obtained results and the developed procedure are helpful for design and manufacturing of MEMS and NEMS.