• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3921-3924
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• 2013

Background: To investigate the role of surgical treatment for locally advanced esophageal cancer, we compared the outcomes of chemoradiotheroy alone (CRT) to postoperative chemoradiotherapy (S/CRT), using, Regional Radiotherapy Center, database. Materials and Methods: This retrospective study was conducted in North-West of Iran, included of 255 consecutive patients with esophageal cancer. Eligible operable and non-operable, were treated with S/CRT and CRT respectively. Radiotherapy (RT) was delivered at 1.8-2 Gy/day for five consecutive days in a given week. Chemotherapy (CT) consisted of cisplatin and 5-fluorouracil. Results: From March 2006 to March 2011 255 patients: male/female 129/96, median age 68 (35-90), squamous/adeno 213/12, received CRT/S+CRT 166/59, median radiation dose $45{\pm}13.6Gy$, Median survival 13.5 (11-15), overall survival (OS) One/Two/Three 57/21/16%, Died/alive 158/97, Univariate analysis prognostic factors: age/stag/differentiation/dose of RT/fraction/treatment, Multivariate analysis predictor factor: dose of RT/fraction. Conclusions: Although this treatment offers some possibility for improvement of patients with esophageal cancer, there remains a significant need for development of new drug and new therapeutic approaches that can substantially impact survival.

• 한국지리정보학회지
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• 제20권3호
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• pp.42-51
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• 2017

대설은 우리나라의 법적 자연재해 중 하나이다. 최근 기상현상에 의한 사회경제적 영향력을 함께 예보하는 영향예보가 부각되고 있으며, 이를 위해서는 먼저 각 지역의 기후적 특징을 분석할 필요가 있다. 본 연구에서는 영향예보의 기반마련을 위해 자기조직화지도를 활용하여 적설동질지역을 구분하여 지역별 적설 특징을 분석했다. 연구결과 적설동질지역은 7개 군집으로 나타났으며, 강설량 및 관측일수, 최대강설량을 이용하여 각 그룹의 특징을 구분했다. 대관령, 강릉시, 정읍시는 강설량이 많은 지역으로, 경상도는 강설량이 적은 지역으로 구분되었다. 선행연구와 비교결과 대표적인 지역이 잘 구분되었으나 강설의 특징은 차이가 있는 것으로 나타났다. 본 연구의 결과는 각 지역의 영향예보를 위한 정책결정에 기초자료로 활용될 수 있다.

• 동의신경정신과학회지
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• 제8권2호
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• pp.85-95
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• 1997

After performing the auricular acupuncture therapy for the functional headache, we came to gain the following therapy effects. 1. In the whole of the patients of the functional headache, housewives of forties were most of all. 2. In the classification of mordern medicine on the patients of the functional headache, muscular contractional headache was most of all and in the classification of oriental differentiation of symtoms and signs(辨證), headache due to deficiency of blood(血虛頭痛) was most of all. 3. In the regional auricular acupuncture therapy for the functonal headache, Taiyang of auricular point(太陽點) had an effect on the lateral headache around the area of Taiyang of auricular point(太陽點) though the actions of sedation, analgesia, Neck of auricular point(頸點) had an effect on the muscular contractional headache of the occipital region, and Stomach of auricular point(胃點) had an effect on the headache of stagnation of phlegm(痰濁頭痛) of anterior region with a chronic digestive disease. 4. The average treatment times of the auricular acupuncture therapy in the patients of the functional headache was 4.08 times, if we have them take auricular acupuncture therapy about 4 times it could be thought to take excellent effect of treatment. 5. The effect of auricular acupuncture therapy for functional headache was turned out to be effective in the following orders ; lateral region(Group A), occipital region(Group B), anterior region(group C). Through the clinical consequences of therapy mentioned above, we came to confirm regular therapeuric effects and hereafter, it is considered that a clinical comparative study on oriental cure and auricular acupuncture therapy for headache has to be more progressed than now.

• 한국경제지리학회지
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• 제14권2호
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• pp.129-142
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• 2011

본 연구는 우리나라 광역대도시를 대상으로 노동시장의 양극화 패턴을 고찰하고, 양극화의 구조화 과정 속에서 나타나는 지역노동시장의 특성과 역할을 분석하였다. 노동시장의 양극화는 무엇보다도 저임금 일자리의 확대와 근로빈곤층의 양산에 기여함으로써 지역 내 사회적 배제의 심화를 창출하는 중요한 기제로 작용하고 있다. 노동시장 양극화가 갖는 역동성을 이해하는 중요한 수단으로서 지역노동시장에 기초한 공간적인 접근의 중요성이 강조되어야 한다. 본 연구는 우리나라 광역대도시 노동시장의 양극화 요인에 대한 분석결과를 토대로 보다 차별적이고 체계적인 정책적 접근이 필요하다고 주장한다. 노동시장 역동성의 공간적 차별성에 대한 이해는 광역대도시 노동시장 내 빈곤과 사회적 배제의 구조화를 이해하는데 중요한 단초를 제공하기 때문이다.

• 한국콘텐츠학회논문지
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• 제11권6호
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• pp.127-134
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• 2011

지방자치단체의 경영개념이 도입되면서 지역경제 활성화와 도시마케팅수단으로서의 지역 문화축제의 개최는 이제 각 지역마다 필수적인 수단이 되었다. 각 지자체마다 각 지역의 특성을 살린 차별화된 축제의 기획으로 단기간 최대의 효과를 얻으려고 노력하고 있다. 하지만, 많은 축제들이 비슷한 프로그램 기획으로 차이점을 보이지 않고 특성화를 꾀하지 못하고 있다. 아산시에서는 매년 4월 이순신 장군의 탄생일을 시작으로 '성웅 이순신 축제'를 개최하고 있다. 다른 축제와 차별화를 꾀하고 다양한 계층을 유입하기 위해 아산시는 호서대학교 게임공학과와 '충무공 해상대전' 온라인 게임을 만들어 이를 소재로 e-sports대회를 개최하였다. 그 결과 기존 축제와 e-sports대회의 결함이란 새로운 시도라는 평가와 함께 축제의 소외계층이었던 청소년들을 대거 축제 안으로 끌어들일 수 있었으며 축제의 다양성과 흥행에 이바지 할 수 있었다.

• 자원ㆍ환경경제연구
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• 제25권3호
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• pp.351-376
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• 2016

본 논문은 공기업과 사기업이 혼재된 혼합복점시장을 대상으로 환경오염을 고려한 최적 오염세와 후생효과를 분석하였다. 상품차별화된 시장에서 두 기업이 생산량 경쟁과 가격 경쟁을 동시 게임과 순차 게임으로 진행하는 경우를 각각 분석한 결과는 다음과 같다. 첫째, 생산량 경쟁이나 가격 경쟁 또는 동시 게임이나 순차 게임에 관계없이 최적 오염세는 항상 한계오염비용보다 작다. 둘째, 최적 오염세의 크기를 비교하면 생산량 경쟁에서는 사기업 선도모형에서 가장 높고, 가격 경쟁에서는 공기업 선도모형에서 가장 높다. 셋째, 동시 게임과 사기업 선도 모형에서 생산량 경쟁이 가격 경쟁보다 환경을 악화시키는 반면, 공기업 선도모형은 가격 경쟁이 생산량 경쟁보다 환경을 악화시킨다. 마지막으로 동시 게임이나 공기업 선도모형에서 가격 경쟁이 생산량 경쟁보다 후생을 높이는 반면, 사기업 선도모형은 생산량 경쟁이 가격 경쟁보다 후생을 높인다.

• 대한한방소아과학회지
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• 제18권2호
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• pp.127-142
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• 2004

Objective : To evaluate the effect of Oriental medical treatment on a patient with Ramsay Hunt syndrome with poor prognosis on EMG. Methods : We applied various methods of Oriental Medical treatment including Acupuncture, Electroacupuncture, Herb medicine, Vesiculation therapy using Mylabris and Crontonis Fructus, Massage, Self-excercise of face muscles. Results : 1. Herb medicine was applied on the basis of Differentiation of Syndromes(辨證): We tried Herb medicine to improve the function of Digestive System. The patient's stool condition, subjective sensation related with abdominal pain and general condition improved. 2. We used the Vesiculation therapy using Mylabris which was used traditionally to treat Facial Palsy. We powdered Mylabris and mixed it with Crontonis Fructus to make a paste. We put it on Ye-poong(?風), Nae-gwan(內關) at left side. It induced vesicles at the applied area, but it disappeared in 48 hours without any scar. 3. We applied acupuncture, electroacupunture, massage and self-excercise of face muscles. On gross scale assessment, there was some improvement. And assessment with regional scale also showed changes. The patient and the guardian were satisfied with the result. Conclusion : We experienced a case of Ramsay Hunt syndrome with poor prognosis on EMG. She also showed poor response to conservative treatment. Through various modalities of Oriental medical treatment, we attained some clinical improvement.

• Molecules and Cells
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• 제28권6호
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• pp.565-573
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• 2009

The pig could be a useful model to characterize molecular aspects determining several delicate phenotypes because they have been bred for those characteristics. The Korean native pig (KNP) is a regional breed in Korea that was characterized by relatively high intramuscular fat content and reddish meat color compared to other western breeds such as Yorkshire (YS). YS grew faster and contained more lean muscle than KNP. We compared the KNP to Yorksire to find molecular clues determining muscle characteristics. The comparison of skeletal gene expression profiles between these two breeds showed molecular differences in muscle. We found 82 differentially expressed genes (DEGs) defined by fold change (more than 1.5 fold difference) and statistical significance (within 5% of false discovery rate). Functional analyses of these DEGs indicated up-regulation of most genes involved in cell cycle arrest, down-regulation of most genes involved in cellular differentiation and its inhibition, down-regulation of most genes encoding component of muscular-structural system, and up-regulation of most genes involved in diverse metabolism in KNP. Especially, DEGs in above-mentioned categories included a large number of genes encoding proteins directly or indirectly involved in p53 pathway. Our results indicated a possible role of p53 to determine muscle characteristics between these two breeds.

• Journal of Preventive Medicine and Public Health
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• 제25권4호
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• pp.333-342
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• 1992

The purpose of this study is to estimate the minimum optimal scale(MOS) of the self-employed health insurance associations. Considering the high proportion of operating expenses, the author have selected 254 regional health insurance associations eon the 1990 Finance Report of the self-employed health insurance programs. Both a quadratic function and a hyperbolic function were chosen for the analysis. The dependent variables are the average maintenance cost per insured person and per household, and the independent variables are the number of insured members and of household The minimum optimal scale was obtained from the differentiation of the quadratic function. Major findings are summarized as follows: 1. The M.O.S. was calculated as 166,174 members (27,442 households) for the rural self-employed health insurance associations and 258,462 members (75,446 households) for the urban. Providing that both the rural and urban health insurance associations would be integrated, the M.O.S. be found to become 231,687 members (68,101 households) 2. Compared with the optimal minimum scale, the magnitude of the current health insurance association found to be much smaller, less than half of the optimal scale. 3. In order to reduce the operating cost, it is necessary to enlarge the operational scale of self-employed health insurance associations.

• Animal Systematics, Evolution and Diversity
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• 제28권4호
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• pp.279-290
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• 2012

Plecoglossus altivelis (ayu) is an amphidromous fish widely distributed in Northeastern Asia from the East China Sea to the northern Japanese coastal waters, encompassing the Korean Peninsula within its range. The shore lines of northeastern region in Asia have severely fluctuated following glaciations in the Quaternary. In the present study, we investigate the population genetic structure and historical demographic change of P. altivelis at a population level in East Asia. Analysis of molecular variance (AMOVA) based on 244 mitochondrial control region DNA sequences clearly showed that as the sampling scope extended to a larger geographic area, genetic differentiation began to become significant, particularly among Northeastern populations. A series of hierarchical AMOVA could detect the genetic relationship of three closely located islands between Korea and Japan that might have been tightly connected by the regional Tsushima current. Neutrality and mismatch distribution analyses revealed a strong signature of a recent population expansion of P. altivelis in East Asia, estimated at 126 to 391 thousand years ago during the late Pleistocene. Therefore it suggests that the present population of P. altivelis traces back to its approximate demographic change long before the last glacial maximum. This contrasts our a priori expectation that the most recent glacial event might have the most crucial effect on the present day demography of marine organisms through bottleneck and subsequent increase of effective population size in this region.