• Microbiology and Biotechnology Letters
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• v.41 no.4
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• pp.433-441
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• 2013

In this study, the anti-oxidative, anti-inflammatory, anti-melanogenic activities of Endlicheria anomala (Nees) Mez methanol extract (EAME) were evaluated by use of in vitro assays and cell culture model systems. The results revealed that EAME scavenges various radicals such as 1,1-diphenyl-2-picryl hydrazyl hydrogen peroxide induced reactive oxygen species, and lipopolysaccharide induced nitric oxide. Furthermore, EAME induced the expression of anti-oxidative enzymes such as heme oxygenase 1, thioredoxin reductase 1, NAD(P)H dehydrogenase 1, and their upstream transcription factor, nuclear factor-E2-related factor 2. Moreover, EAME inhibited in vitro DOPA oxidation and 3-isobutyl-1-methylxanthine induced melanogenesis in B16F10 cells. Its anti-melanogenic activity will have originated from the inhibition of tyrosinase enzyme activity and melanogenesis related protein expression. Taken together, these results provide the important new insight that E. anomala possesses various biological activities such as anti-oxidative, anti-inflammatory, and anti-melanogenic. Therefore, it might be utilized as a promising material in the fields of nutraceuticals and cosmetics.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.40 no.6
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• pp.387-393
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• 2007

We examined the conditions for separating and preserving the male and female gametophytes of Kjellmaniella crassifolia. The highest percentage of zygote germination (85%) was on semi-solid medium composed of 1.0% transfer gel agar at $15\;^{\circ}C$ and $20\;{\mu}mol/m^2/s$ after a 4-week culture. Zygote germination in PESI liquid medium was 93.5% at $20\;^{\circ}C$ and $20\;{\mu}mol/m^2/s$. The maximum zygote growth was $252{\pm}19.7\;{\mu}m$ on 1.0% transfer gel agar at $15\;^{\circ}C$ and $40\;{\mu}mol/m^2/s$ after 5-week culture, and was $76.7{\pm}2.8\;{\mu}m$ in PESI liquid medium at $20\;^{\circ}C$ and $40\;{\mu}mol/m^2/s$. The respective numbers of separated male and female gametophytes from germinated zygotes were 157 and 93 on 1.0% transfer gel agar and 14 and 28 in PESI liquid medium. The maximum growth of separated male and female gametophytes was $575{\pm}28.3\;{\mu}m$ at $5\;^{\circ}C$ and $60\;{\mu}mol/m^2/s$ and $686{\pm}35.4\;{\mu}m$ at $20\;^{\circ}C$ and $20\;{\mu}mol/m^2/s$ in PESI liquid medium after 3 weeks, respectively. The highest percentage fertilized was $93.3{\pm}5.8%$ at $15\;^{\circ}C$ and $20\;{\mu}mol/m^2/s$ in PESI liquid medium. These results show that the best conditions for the separation and preservation of gametophytes (male and female) consisted of culturing on 1.0% transfer gel agar at $15\;^{\circ}C$ and $20\;{\mu}mol/m^2/s$.

• Journal of Life Science
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• v.24 no.7
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• pp.713-720
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• 2014

In this study, the antioxidative and anti-inflammatory activities of Ardisia arborescens ethanol extract (AAEE) were evaluated using in vitro assays and a cell culture model system. AAEE exhibited potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl (DPPH), similar to ascorbic acid, which was used as a positive control. Moreover, AAEE effectively suppressed lipopolysaccharide (LPS)- and hydrogen peroxide ($H_2O_2$)-induced reactive oxygen species (ROS) in RAW 264.7 cells. Furthermore, AAEE induced the expression of antioxidative enzymes, heme oxygenase 1 (HO-1), and thioredoxin reductase 1 (TrxR1), in addition to their upstream transcription factor, nuclear factor-E2-related factor 2 (Nrf2), in a dose-dependent manner. The upstream signaling pathways of mitogen-activated protein kinases (MAPKs) might regulate the modulation of HO-1, TrxR1, and Nrf2 expression. On the other hand, AAEE inhibited LPS-induced nitric oxide (NO) formation, without cytotoxicity. Suppression of NO formation was the result of AEEE-induced down-regulation of inducible NO synthase (iNOS). The suppression of NO and iNOS by AAEE might be modulated by their upstream transcription factor, nuclear factor (NF)-${\kappa}B$, and activator protein (AP)-1 pathways. Taken together, these results provide important new insights into the antioxidative and anti-inflammatory activities of A. arborescens. AAAEE might represent a promising material in the field of nutraceuticals.

• Journal of the Korean association of regional geographers
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• v.18 no.3
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• pp.326-335
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• 2012

The purpose of this study id to identify service quality of national stone culture festival, to find relationship service quality to festival satisfaction and after behavioral intention of festival participants. To achieve the purpose of this study, 13 elements of service quality was chosen through previous literature study. And 3 factors were extracted by 1st factor analysis, these are hardware, software, and humanware factor. And second factor analysis was performed to identify validity and reliability these factors. And 5th hypothesis was established and adopted in three hypothesis. That is Hardware service quality factor have a influence to festival satisfaction of participants, festival satisfaction of participants have a influence to revisitation and recommendation intention. This paper indicates that results of this study is useful to regional festival planning to settle down as a sustainable events, necessary to retain service quality and satisfaction as a precedent condition.

• Korea Science and Art Forum
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• v.37 no.3
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• pp.365-376
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• 2019

Now, our urban space is composed of all kinds of sculptures that lost its individual charm in trend flows and street furniture standardized by the integrated design of standardized franchises and similar architectures per each region and autonomous districts. This study was to introduce the concept called the 'community furniture' in the urban environment that there is no an identity of the regional culture and a sense of place because of the mostly similar street environment. The purpose of this study is to propose the concept called the 'community furniture' referred to as public facilities that imply specific identities of some regions that have became the community art expanded into necessary facilities of urban composition as bus shelter's universal convenience and functionality have been preferentially handled and its regional identities are reflected. For doing this, this study fulfilled application alternatives of community furniture design's basic principles after examining the storytelling process of local cultural heritages and analyzing domestic and foreign cases of bus shelters. Results of this study are as follows. First, convergent synergy effects in information and culture and art sectors could be expected as bus shelters visually deliver storytelling factors that imply locally related images. Second, space and place's characteristics and sustainable design concepts embody local characteristics. They can suggest directions for vitalizing urban environment designs by being in harmony with surrounding environments. Third, it is expected that realizing distinctive places is possible as bus shelters with local communities' aesthetic consciousness and regionality are composed of new street spaces.

• International Journal of Advanced Culture Technology
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• v.9 no.1
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• pp.16-21
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• 2021

As the average age of national veterans has increased from 69 years old(2011) to 71 years old(since 2015) over the past five years, the overall medical service cost of veterans has increased by about 20%. The main cause of this phenomenon is 'ultra-aging', which accounts for 67% of veterans, while the proportion of health insurance patients aged 70 or older is 9%. Therefore, it is judged that the analysis of the trend of use of medical services at veterans hospitals in each region that is in charge of severe medical services of national veterans can serve as an opportunity to seek countermeasures for the severe medical system of national veterans. First of all, based on the details of major medical expenses (hospitalization, outpatient, pharmaceutical expenses) by region for the last 10 years(2010-2019), data significance was performed through a chi-square test, and the Central Veterans Hospital and Non-Central Veterans Hospital using EXCEL. 'Expected frequency' was calculated by year. By applying the CHITEST(observation frequency, expected frequency) function again, the p-value(p<0.05) was calculated, and the profit bias of each region's veterans hospital could be determined. The specific research method is for the last 10 years(2010-2019) for state-sponsored patients_outpatient treatment income, state-sponsored patients_hospitalization income, exempt patients_outpatients at the Central Veterans Hospital, Busan Veterans Hospital, Gwangju Veterans Hospital, Daegu Veterans Hospital, and Daejeon Veterans Hospital. A one-way analysis of variance was conducted to verify the significance of the difference between group averages on the status of 5 medical revenues of veterans hospitals in each of the 5 regions, including medical treatment income, reduced patients_hospitalization income, and reduced patients_medicine expenses. It was found to be significant(p<0.05) at all levels, including region and type. Finally, the bias in the profit structure of regional veterans hospitals was the highest in 2017(p=0.0004) and the lowest in 2013(p=0.0349). In addition, in the profit structure of the Veterans Hospital, the year in which the'regional' variable worked the most was 2019, and the year with the least affected was 2010. The order of the former is Jungang(=31,674,713), Busan(=12,314,614), Gwangju(=11,957,038), Daegu(=10,168,015), and Daejeon(=6,991,034), and the order of the latter is Jungang(=57,868,791), and Busan(=19,183,194). Gwangju(=17,904,712), Daegu(=15,656,034), and Daejeon(=14,377,395). In conclusion, the profit bias of veterans hospitals repeatedly raced the lowest(p=0.01986) and highest(p=0.03499) for the past five years(2010-2014) year by year, with the 'regional' variable being the most in the veterans hospital's profit structure It was identified as a major influence factor. On the other hand, for the last 5 years (2015-2019), the influence factors of the'regional' variable every year were in 2015(p=0.02015), 2016(p=0.01741), 2017(p=0.00045), and 2018(p=0.00394). in 2019(p=0.00227), a significant difference was confirmed at a very low level.

• Journal of the Economic Geographical Society of Korea
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• v.10 no.4
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• pp.355-376
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• 2007

The aim of this study is to examine the changes of approach methods of research framework in the history of Korean economic geography during the last fifty years($1956{\sim}2005$). The five factors that have influenced Korean economic geography are Korean geography, European, American, and Japanese geography, fundamental theories of economics and business administration, regional problems, and culture. The study of Korean economic geography can be divided into four periods: 'period of cradle of economic geography($1956{\sim}1962$)', 'period of establishment of economic geography(1963$\sim$later 1970s)', 'period of leap of economic geography(the former half of 1980s$\sim$the former half of 1990s)', and 'period of transition of economic geography (since later 1990s)'. And research framework of Korean economic geography has changed from the regional structure theory in 'period of leap' to the spatial system of economies and network theory in 'period of transition'. Spatial system of economies and network theory consists of spatial system of world economies, spatial system of national economies, spatial system of regional economies, spatial network of enterprise economies, and spatial network of information economies.

• Journal of the Korean association of regional geographers
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• v.11 no.3
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• pp.323-335
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• 2005

The aim of this study is m inquire the features of preservation and utilization of traditional buildings landscape through the effort of civics and public institution. Kawagoe is 30km from Tokyo and keeps the history and culture of Edo period. The tourism feature of the Ichibangai area which has the traditional warehouse(Kurazukuri) landscape is that the rate of old tourists from nearby regions is high and the one day trip is majority. The most tourists have visited many times, but they have spent small sum of money. The tourism activation of Ichibangai area is the result of the cooperation and effort of public institution, civic organization, and civics. The public institutions have the institutional support system has established which is including the designation of cultural assets, ordinance enactment, tax exemption, repairing charges support, public hearing, construction of tour network. The residents of the Ichibangai area have contributed to preserving the traditional landscape and activating tourism through their own organizations and meetings for a long time. And the roles of various committees which have leaded close cooperation relations between civics and public institution are activated.

• Journal of Digital Convergence
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• v.9 no.6
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• pp.231-242
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• 2011

The purpose of this study are as follows. First, to analyze relative LQ index of the No. of character company, the No. of employee and the amount of revenue. Second, to analyze the strength and weakness about technology competence, human resource competence, infra competence and network competence of regional character contents R&D. The results are as follows. The relative competitively LQ index results of company infra indicated all regional area are over 1 LQ index. But, in case of except of seoul & kyunggi, the competence LQ index of R&D which is jeju, dongnam(pusan & kyungnam) are in order. Final result suggested that the high competitiveness of regional character industry are seoul & kyunggi, jeju, dongnam area.

• Journal of the Economic Geographical Society of Korea
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• v.8 no.2
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• pp.301-314
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• 2005

The purpose of this study is to inquiry specialized development strategies to revive the declining regional tourism in Japan, through the general characteristics of tourists and the evaluation of various tourism resources. Reaching its period of maturity after the bubble economy collapse, domestic tourism in Japan requires a change in quality of the regional tourism industry. The Kakeyu spa region, which has long history and abundant cultural resources, is specializing through rehabilitation strengthening theme of 'health seeking and recuperation'. The rate of the elderly women visitors is high in the Kakeyu spa, and the visitors use public transport and make a relatively long stay, because they want to recuperate their health or to cure their disease. In the evaluation of tourism resources, the visitors showed an increasing interest in the solemn temple scenery and the tranquil stroll road which are near by their lodgings. To reflect such demand characteristics, the Kakeyu community is actively developing the business such as rehabilitation, health-food development, voluntary service, and barrier free based on spa, culture, and nature.