• 한국콘텐츠학회논문지
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• 제5권5호
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• pp.182-190
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• 2005

컴퓨터와 인터넷의 보급이 일반화되면서, 현재 인터넷으로부터 기업이나 국가 조직 내부의 정보나 자원을 보호하기 위해 여러 가지 정보보호시스템을 비롯한 보안 네트워크를 구성하여 네트워크 및 시스템을 운영하고 있다. 그러나 인터넷과 같은 개방형 네트워크 환경에서 외부의 침입에 대한 가능성은 증대되고 있다. 현재 많은 보안 시스템들이 개발되고 있지만, 대부분 커널 레벨이 아닌 응용 레벨에서 구현되고 있다. 또한 다수의 파일 보호 시스템들이 개발되어 있지만, 사용상의 불편함 등으로 인해 널리 사용되지는 않고 있다. 본 논문에서는 적재 가능한 커널 모듈(LKM) 메커니즘을 사용하여 리눅스 상에서 파일 보호 기능을 제공하는 커널 모듈을 구현하였다. 주기적인 파일시스템에 대한 이미지 백업을 통하여, 침입으로 인한 손상이 발생한 경우 쉽게 손상된 파일 시스템을 복구한다.

• 한국정보과학회논문지:정보통신
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• 제33권4호
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• pp.333-342
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• 2006

cdma2000 lxEV - DO 이동통신 시스템은 멀티미디어 데이타 전송에 대한 요구 증가를 수용하기 위하여 브로드캐스트와 멀티캐스트 서비스 (BCMCS)를 제공한다. 이러한 데이타 브로드캐스트 서비스를 제공하기 위해서는 무선 전송 채널의 특성 즉 유선에 비해서 에러 발생 빈도가 높고 신뢰성이 떨어진 다는 사실을 고려해야 한다. 따라서 전송 에러의 복구를 위해 MAC 계층에서 순방향 에러 교정 (FEC: Forward Error Correction)을 사용하며, BCMCS 에서는 순방향 에러 교정을 위해 리드-솔로몬 (Reed - Solomon) 코팅을 사용한다. 본 논문에서는 먼저 리드 솔로몬 코딩의 성능을 분석하였고, 그 결과 이 방식이 천천히 움직이는 모바일 노드에 대해 취약함을 확인하였다. 따라서 이러한 점을 해결하고 에러 복구 성능을 향상시켜서 MPEG-4 FGS 비디오의 재생 품질을 개선하기 위하여 리드-솔로몬 코딩과 재전송 방법을 혼용한 하이브리드 방식의 에러 복구 기법을 제안하였다. 이는 리드-솔로몬의 코딩 오버헤드를 줄이는 대신, 그 결과로 얻어진 전송 슬롯을 활용하는 방법이다. 이렇게 얻어진 전송 슬롯은 제한적이기 때문에 활용도가 큰 패킷을 우선적으로 재전송 할 필요가 있다. 이를 위해 유틸리티 함수를 제안하였으며, 함수 값은 각 모바일 노드의 에러 제어 블록 (ECB: Error Control Block)을 이용해서 계산할 수 있다. 또한 하이브리드 방식의 에러 복구 기법은 MPEG-4 FGS의 특정을 활용하며, 이를 통해 채널의 상태가 불리할 경우는 물론 그렇지 않은 경우에 대해서도 비디오의 평균 재생 품질을 크게 향상시킬 수 있다.

• Journal of Ginseng Research
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• 제43권2호
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• pp.272-281
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• 2019

Background: Diabetic sensorineural damage is a complication of the sensory neural system, resulting from long-term hyperglycemia. Red ginseng (RG) has shown efficacy for treatment of various diseases, including diabetes mellitus; however, there is little research about its benefit for treating sensorineural damage. Therefore, we aim to evaluate RG efficacy in alloxan-induced diabetic neuromast (AIDN) zebrafish. Methods: In this study, we developed and validated an AIDN zebrafish model. To assess RG effectiveness, we observed morphological changes in live neuromast zebrafish. Also, zebrafish has been observed to have an ultrastructure of hair-cell cilia under scanning electron microscopy. Thus, we recorded these physiological traits to assess hair cell function. Finally, we confirmed that RG promoted neuromast recovery via nerve growth factor signaling pathway markers. Results: First, we established an AIDN zebrafish model. Using this model, we showed via live neuromast imaging that RG fostered recovery of sensorineural damage. Damaged hair cell cilia were recovered in AIDN zebrafish. Furthermore, RG rescued damaged hair cell function through cell membrane ion balance. Conclusion: Our data suggest that RG potentially facilitates recovery in AIDN zebrafish, and its mechanism seems to be promotion of the nerve growth factor pathway through increased expression of topomyosin receptor kinase A, transient receptor potential channel vanilloid subfamily type 1, and mitogen-activated protein kinase phosphorylation.

• 한방재활의학과학회지
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• 제19권2호
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• pp.1-25
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• 2009

Objectives : The purpose of this study was to investigate the effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang, YGKT) and electrical acupuncture treatment in spinal cord injury(SCI)-induced rats. Methods : The subjects were divided into 5 groups ; Normal, Control-no treatment after SCI, Experimental I(Exp. I)-taken with YGKT 500 mg/kg $0.5m{\ell}$ daily after SCI. Experimental II(Exp. II)-taken with electrical acupuncture after SCI and Experimental III(Exp. III)-taken with YGKT 500 mg/kg $0.5m{\ell}$ and electrical acupuncture after SCI. After each operation, the present author observed cytological changes, the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, EMG, hematological(AST, ALT, WBC), histological and immunological changes. Rats were tested by Motor behavior test at 1st, 3rd, 7th, 14th and 21st day. Results : 1. All the experimental groups were improved compared with control group in the motor behavior tests including Tarlov test, Basso-Beattle-Bresnahan locomotor rating scale, modified inclined plane test, open field test, grid walk test and narrow beam test. Especially Exp. III was significantly improved among other groups. 2. In EMG test, H and M wave were significantly increased in Exp. III. 3. All the experimental groups were significantly decreased compared with control group in AST, ALT and WBC. 4. NGF, BDNF and Trk B of spinal cord gray matter in all the experimental groups were increased compared with control group. Especially, Exp. III was more effective. 5. In histological observations, muscle contraction and denaturation of gastrocnemius muscle of all the experimental groups were inhibited. Especially, those of Exp. III was more effective. On the observations of liver and kidney, cell atrophy and apoptosis of all the experimental groups were decreased compared with control group. Especially, those of Exp. III was more effective. Conclusions : It can be suggested that YGKT and electrical acupuncture may improve motor behavior, EMG, hematological, histological and immunological findings in SCI-induced rats. Especially, combination of these two treatments will be somewhat better in spinal nerve recovery and motor function improvement.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.108-109
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• 2003

Ursolic acid (UA) and Oleanolic acid (ONA), known as urson, micromerol, prunol and malol, are pentacyclic triterpenoid compounds which naturally occur in a large number of vegetarian foods, medicinal herbs, and plants. They may occur in their free acid form or as aglycones for triterpenoid saponins, which are comprised of a triterpenoid aglycone, linked to one or more sugar moieties. Therefore UA and ON A are similar in pharmacological activity. Lately scientific research, which led to the identification of UA and ONA, revealed that several pharmacological effects, such as antitumor, hepatoprotective, anti-inflammatory, antimicrobial, and anti-hyperlipidemic could be attributed to UA and ONA. Here, we introduced the effects of UA and ONA on acute barrier disruption and normal epidermal permeability barrier function. To clarify the effects of UA and ONA on skin barrier recovery, both flank skin of 8-12 weeks hairless mice were topically treated with samples (2mg/ml) after tape stripping, then measured recovery rate using TEWL on hairless mice. The recovery rate increased in UA and ONA treated groups at 6h more than 20% compared to vehicle treated group (p <0.05). For verifying the effects of UA and ONA on normal epidermal barrier, hydration and TEWL were measured for 1 and 3 weeks after UA and ONA applications (2mg/ml per day). We also investigated the features of epidermis and dermis using electron microscopy (EM) and light microscopy (LM). Both samples increased hydration compared to Vehicle group from 1 week without TEWL alteration (p<0.005). EM examination using Ru04 and OsO4 fixation revealed that secretion and numbers of lamellar bodies and complete formation of lipid bilayers were most prominent (ONA$\geq$UA>Vehicle). LM finding showed that stratum corneum was slightly increased and especially epidermal thickening and flattening was observed (UA>ONA>Vehicle). Using Masson-trichrome and elastic fiber staining, we observed collagen thickening and elastic fiber increasing by UA and ONA treatments. In vitro results of collagen and elastin synthesis and elastase inhibitory experiments were also confirmed in vivo findings. This result suggested that the effects of UA and ONA related to not only skin barrier but also collagen and elastic fibers. Taken together, UA and ONA can be relevant candidates to improve barrier function and pertinent agents for cosmetic applications.

• 대한지역사회작업치료학회지
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• 제6권1호
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• pp.41-48
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• 2016

목적 : 본 연구의 목적은 허혈성 뇌손상시 회복의 지연을 초래하는 당뇨에 복합운동프로그램을 적용하였을 때, 신경학적 효과와 당뇨의 개선효과를 확인하고자 하였다. 연구방법 : 본 연구는 경상북도 소재의 동물실험 연구실에서 실시하였고 허혈성 뇌손상 모델의 흰쥐에게 STZ(streptozotocin)를 투여하고 당뇨를 유발한 흰쥐 10마리를 사용하였다. 흰쥐에게는 4주간 복합운동프로그램을 실시하여 뇌기능회복을 확인하기 위해 미로검사(maze test)를 실시하였고, 당뇨의 개선효과를 보기위해서 혈당을 확인하였다. 결과 : 허혈성 뇌손상 모델 당뇨쥐에게 복합운동프로그램을 적용한 결과, 뇌기능회복을 확인하기 위한 미로검사에서는 실패횟수(error)가 3주 후부터 유의하게 감소하였고(p<.05) 탈출시간은 1주 후부터 유의하게 감소하였다(p<.05). 그리고 당뇨의 개선효과를 확인하기 위한 혈당 검사에서는 대조군에서는 유의한 변화가 없었고 복합운동프로그램을 적용한 실험군에서는 4주 후부터 유의한 효과가 있음을 알 수 있었다(p<.05). 결론 : 뇌졸중, 당뇨 등의 성인, 노인성 질환이 증가되고 있는 현 시점에서 환자들에게 재활은 여명수명동안 삶의 질 개선에 매우 중요하다. 본 연구는 허혈성 뇌졸중과 당뇨를 모두 가지고 있는 동물모델에게 치료사가 쉽게 시행할 수 있는 복합운동프로그램 적용을 통하여 뇌기능회복과 당뇨 개선효과를 확인할 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제28권5호
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• pp.618-627
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• 2007

As our society progresses rapidly toward an aged society, there is a stiff increase in the population of the aged persons who have difficulties in adjusting themselves to environments due to declines of their physical functions. Therefore, there is a great need for the concept of 'Universal Design' that demands the design of overall social structure to care for the elderly. Due to this reason, the physical function of the aged persons should thoroughly be studied for the development of rehabilitation and training equipments to help the recovery of physical functions of the elderly. Among the variety of physical functions of the elderly, visual functions, motion characteristics, hearing functions, and somatosensory functions have significant influence toward everyday lives and are physical functions to study for the construction of urgently needed physical function databases of the elderly. This study concentrates on visual functions among the variety of physical functions of the elderly. To measure various visual functions of the elderly, a measurement room for the elderly has been developed, which can mimic everyday lives and perform measurements of visual functions with subjects in seated position. The measurement items for the construction of the database were capabilities in everyday vision according to changes in arrangement of colors and light intensity and capabilities in everyday vision, color distinction, dark adaptation, and light glare against changes in contrast.

• Reproductive and Developmental Biology
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• 제35권2호
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• pp.167-174
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• 2011

Acute ischemic stroke results from sudden decrease or loss of blood supply to an area of the brain, resulting in a coinciding loss of neurological function. The antioxidant action of melatonin is an important mechanism among its known effects to protective activity during ischemic/reperfusion injury. The focus of this research, therapeutic efficacy of melatonin on recovery of neurological function following long term treatment in ischemic brain injured rats. Male Sprague-Dawley rats (n=40; 8 weeks old) were divided into the control group, and MCAo groups (Vehicle, MT7 : MCAo+ melatonin injection at 7:00, MT19 : MCAo+melatonin injection at 19:00, and MT7,19 : MCAo+melatonin injection at 7:00 and 19:00). Rat body weight and neurological function were measured every week for 8 weeks. After 8 weeks, the rats were anesthetized with a mixture of zoletil (40 mg/kg) and xylazine (10 mg/kg) and sacrificed for further analysis. Tissues were then collected for RNA isolation from brain tissue. Also, brain tissues were analyzed by histological procedures. We elucidated that melatonin was not toxic in vital organs. MT7,19 was the most rapidly got back to mild symptom on test of neurological parameter. Also, exogenous melatonin induces both the down-regulation of detrimental genes, such as NOSs and the up-regulation of beneficial gene, including BDNF during long term administration after focal cerebral ischemia. Melatonin treatment reduced the loss of primary motor cortex. Therefore, we suggest that melatonin could be act as prophylactic as well as therapeutic agent for neurorehabilitative intervention.

• 한국건설관리학회논문집
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• 제23권6호
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• pp.111-118
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• 2022

최근에 우리나라의 도로 하부에 매설된 지하시설물이 노후화되면서, 지하시설물 유지보수 공사 물량이 급증하고 있다. 이러한 도로지하 시설물의 유지관리를 위해서는 도로포장의 절단작업이 선행되어야 한다. 그런데 우리나라에서 사용되는 기존 도로절단기는 친환경적이지 못하며 소음과 절단슬러지(비산먼지)가 많이 발생하는 것이 현실이다. 이에 본 연구에서는 절단슬러지 회수장치의 개념을 도출하고, 이 기능을 포함하는 친환경 도로절단기를 설계·제작하였다. 개발된 장비는 1m를 100~150mm 깊이로 절단하는 데에 20~30초 가량 소요되었다. 또 대부분의 구간에서 슬러지 흡입 성능은 양호하였으며, 2m 거리에서 약식 측정한 장비의 소음도는 평균 82.7dB 수준이었다. 다만 개발된 장비가 1차 프로토타입 수준이라는 한계로 인하여 구동안정성이 다소 낮았고, 시동꺼짐, 슬러지 회수성능 저하 등의 이상현상이 발생하는 경우가 있었다. 향후 개발된 프로토타입의 튜닝 및 개선을 통해 절단성능과 슬러지 회수 기능을 보다 안정시킬 예정이다. 그리고 개선된 프로토타입을 실제 현장 상황에 적용하여, 생산성 등을 정량적으로 비교·분석할 계획이다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제3권1호
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• pp.47-55
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• 2000

Purpose: The aim of this research is to examine the abnormal liver function complicated with Kawasaki disease (KD) and to analyze its clinical characteristics and complications. Methods: Ninty eight cases were diagnosed as having KD, among which thirty four cases had abnormal alanine aminotransferase (ALT) (>30 IU/L). These abnormal ALT cases were evaluated in terms of age and sex distribution, major symptoms, complications, laboratory and histopathologic findings. Results: Male to female ratio was 2.4:1 and most patients (91.2%) were under 5 years of age. Cervical lymphadenopathy was observed in 3 cases (8.8%); and recurred cases were two (5.8%). Average fever duration was 8 days; average length of hospitalization was 9 days; and average recovery period was 13 days. Immediately after admission, positive CRP was observed in 31 cases (91.2%), leukocytosis (> $10,000/mm^3$) in 26 cases (76.0%), thrombocytosis (> $450,000/mm^3$) in 7 cases (20.6%), and anemia (<10 gm/dl) in 7 cases (20.6%), respectively. GB hydrops or cholecystitis were noted in 3 cases (8.8%), abnormal ECG finding in 1 case (2.9%), coronary dilatation or aneurysm in 2 cases (5.9%). Liver biopsy was done in four cases and revealed mild infiltration of lymphocytes on the portal area and mild bile duct proliferations. Conclusion: The abnormal liver function was noted in 34.7% of KD patients, and subsided all within one month. But the liver function test should be checked closely in patients of the abnormal liver function test complicated with KD despite of its good prognosis.